Reperfusion Injury: How Can We Reduce It by Pre-, Per-, and Postconditioning

While early coronary reperfusion via primary percutaneous coronary intervention (pPCI) is established as the most efficacious therapy for minimizing infarct size (IS) in acute ST-elevation myocardial infarction (STEMI), the restoration of blood flow also introduces myocardial ischemia-reperfusion in...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Maria Buske [verfasserIn] Steffen Desch [verfasserIn] Gerd Heusch [verfasserIn] Tienush Rassaf [verfasserIn] Ingo Eitel [verfasserIn] Holger Thiele [verfasserIn] Hans-Josef Feistritzer [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	ischemia-reperfusion injury acute myocardial infarction infarct size myocardial injury ischemic conditioning percutaneous coronary intervention

Übergeordnetes Werk:	In: Journal of Clinical Medicine - MDPI AG, 2013, 13(2023), 1, p 159
Übergeordnetes Werk:	volume:13 ; year:2023 ; number:1, p 159

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jcm13010159

Katalog-ID:	DOAJ097789135

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520			\|a While early coronary reperfusion via primary percutaneous coronary intervention (pPCI) is established as the most efficacious therapy for minimizing infarct size (IS) in acute ST-elevation myocardial infarction (STEMI), the restoration of blood flow also introduces myocardial ischemia-reperfusion injury (IRI), leading to cardiomyocyte death. Among diverse methods, ischemic conditioning (IC), achieved through repetitive cycles of ischemia and reperfusion, has emerged as the most promising method to mitigate IRI. IC can be performed by applying the protective stimulus directly to the affected myocardium or indirectly to non-affected tissue, which is known as remote ischemic conditioning (RIC). In clinical practice, RIC is often applied by serial inflations and deflations of a blood pressure cuff on a limb. Despite encouraging preclinical studies, as well as clinical studies demonstrating reductions in enzymatic IS and myocardial injury on imaging, the observed impact on clinical outcome has been disappointing so far. Nevertheless, previous studies indicate a potential benefit of IC in high-risk STEMI patients. Additional research is needed to evaluate the impact of IC in such high-risk cohorts. The objective of this review is to summarize the pathophysiological background and preclinical and clinical data of IRI reduction by IC.
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allfields	10.3390/jcm13010159 doi (DE-627)DOAJ097789135 (DE-599)DOAJ2d6552aa96654b65977c4bded41e043e DE-627 ger DE-627 rakwb eng Maria Buske verfasserin aut Reperfusion Injury: How Can We Reduce It by Pre-, Per-, and Postconditioning 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier While early coronary reperfusion via primary percutaneous coronary intervention (pPCI) is established as the most efficacious therapy for minimizing infarct size (IS) in acute ST-elevation myocardial infarction (STEMI), the restoration of blood flow also introduces myocardial ischemia-reperfusion injury (IRI), leading to cardiomyocyte death. Among diverse methods, ischemic conditioning (IC), achieved through repetitive cycles of ischemia and reperfusion, has emerged as the most promising method to mitigate IRI. IC can be performed by applying the protective stimulus directly to the affected myocardium or indirectly to non-affected tissue, which is known as remote ischemic conditioning (RIC). In clinical practice, RIC is often applied by serial inflations and deflations of a blood pressure cuff on a limb. Despite encouraging preclinical studies, as well as clinical studies demonstrating reductions in enzymatic IS and myocardial injury on imaging, the observed impact on clinical outcome has been disappointing so far. Nevertheless, previous studies indicate a potential benefit of IC in high-risk STEMI patients. Additional research is needed to evaluate the impact of IC in such high-risk cohorts. The objective of this review is to summarize the pathophysiological background and preclinical and clinical data of IRI reduction by IC. ischemia-reperfusion injury acute myocardial infarction infarct size myocardial injury ischemic conditioning percutaneous coronary intervention Medicine R Steffen Desch verfasserin aut Gerd Heusch verfasserin aut Tienush Rassaf verfasserin aut Ingo Eitel verfasserin aut Holger Thiele verfasserin aut Hans-Josef Feistritzer verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 13(2023), 1, p 159 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:13 year:2023 number:1, p 159 https://doi.org/10.3390/jcm13010159 kostenfrei https://doaj.org/article/2d6552aa96654b65977c4bded41e043e kostenfrei https://www.mdpi.com/2077-0383/13/1/159 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 1, p 159
spelling	10.3390/jcm13010159 doi (DE-627)DOAJ097789135 (DE-599)DOAJ2d6552aa96654b65977c4bded41e043e DE-627 ger DE-627 rakwb eng Maria Buske verfasserin aut Reperfusion Injury: How Can We Reduce It by Pre-, Per-, and Postconditioning 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier While early coronary reperfusion via primary percutaneous coronary intervention (pPCI) is established as the most efficacious therapy for minimizing infarct size (IS) in acute ST-elevation myocardial infarction (STEMI), the restoration of blood flow also introduces myocardial ischemia-reperfusion injury (IRI), leading to cardiomyocyte death. Among diverse methods, ischemic conditioning (IC), achieved through repetitive cycles of ischemia and reperfusion, has emerged as the most promising method to mitigate IRI. IC can be performed by applying the protective stimulus directly to the affected myocardium or indirectly to non-affected tissue, which is known as remote ischemic conditioning (RIC). In clinical practice, RIC is often applied by serial inflations and deflations of a blood pressure cuff on a limb. Despite encouraging preclinical studies, as well as clinical studies demonstrating reductions in enzymatic IS and myocardial injury on imaging, the observed impact on clinical outcome has been disappointing so far. Nevertheless, previous studies indicate a potential benefit of IC in high-risk STEMI patients. Additional research is needed to evaluate the impact of IC in such high-risk cohorts. The objective of this review is to summarize the pathophysiological background and preclinical and clinical data of IRI reduction by IC. ischemia-reperfusion injury acute myocardial infarction infarct size myocardial injury ischemic conditioning percutaneous coronary intervention Medicine R Steffen Desch verfasserin aut Gerd Heusch verfasserin aut Tienush Rassaf verfasserin aut Ingo Eitel verfasserin aut Holger Thiele verfasserin aut Hans-Josef Feistritzer verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 13(2023), 1, p 159 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:13 year:2023 number:1, p 159 https://doi.org/10.3390/jcm13010159 kostenfrei https://doaj.org/article/2d6552aa96654b65977c4bded41e043e kostenfrei https://www.mdpi.com/2077-0383/13/1/159 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 1, p 159
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allfieldsGer	10.3390/jcm13010159 doi (DE-627)DOAJ097789135 (DE-599)DOAJ2d6552aa96654b65977c4bded41e043e DE-627 ger DE-627 rakwb eng Maria Buske verfasserin aut Reperfusion Injury: How Can We Reduce It by Pre-, Per-, and Postconditioning 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier While early coronary reperfusion via primary percutaneous coronary intervention (pPCI) is established as the most efficacious therapy for minimizing infarct size (IS) in acute ST-elevation myocardial infarction (STEMI), the restoration of blood flow also introduces myocardial ischemia-reperfusion injury (IRI), leading to cardiomyocyte death. Among diverse methods, ischemic conditioning (IC), achieved through repetitive cycles of ischemia and reperfusion, has emerged as the most promising method to mitigate IRI. IC can be performed by applying the protective stimulus directly to the affected myocardium or indirectly to non-affected tissue, which is known as remote ischemic conditioning (RIC). In clinical practice, RIC is often applied by serial inflations and deflations of a blood pressure cuff on a limb. Despite encouraging preclinical studies, as well as clinical studies demonstrating reductions in enzymatic IS and myocardial injury on imaging, the observed impact on clinical outcome has been disappointing so far. Nevertheless, previous studies indicate a potential benefit of IC in high-risk STEMI patients. Additional research is needed to evaluate the impact of IC in such high-risk cohorts. The objective of this review is to summarize the pathophysiological background and preclinical and clinical data of IRI reduction by IC. ischemia-reperfusion injury acute myocardial infarction infarct size myocardial injury ischemic conditioning percutaneous coronary intervention Medicine R Steffen Desch verfasserin aut Gerd Heusch verfasserin aut Tienush Rassaf verfasserin aut Ingo Eitel verfasserin aut Holger Thiele verfasserin aut Hans-Josef Feistritzer verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 13(2023), 1, p 159 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:13 year:2023 number:1, p 159 https://doi.org/10.3390/jcm13010159 kostenfrei https://doaj.org/article/2d6552aa96654b65977c4bded41e043e kostenfrei https://www.mdpi.com/2077-0383/13/1/159 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 1, p 159
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authorswithroles_txt_mv	Maria Buske @@aut@@ Steffen Desch @@aut@@ Gerd Heusch @@aut@@ Tienush Rassaf @@aut@@ Ingo Eitel @@aut@@ Holger Thiele @@aut@@ Hans-Josef Feistritzer @@aut@@
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author	Maria Buske
spellingShingle	Maria Buske misc ischemia-reperfusion injury misc acute myocardial infarction misc infarct size misc myocardial injury misc ischemic conditioning misc percutaneous coronary intervention misc Medicine misc R Reperfusion Injury: How Can We Reduce It by Pre-, Per-, and Postconditioning
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topic_title	Reperfusion Injury: How Can We Reduce It by Pre-, Per-, and Postconditioning ischemia-reperfusion injury acute myocardial infarction infarct size myocardial injury ischemic conditioning percutaneous coronary intervention
topic	misc ischemia-reperfusion injury misc acute myocardial infarction misc infarct size misc myocardial injury misc ischemic conditioning misc percutaneous coronary intervention misc Medicine misc R
topic_unstemmed	misc ischemia-reperfusion injury misc acute myocardial infarction misc infarct size misc myocardial injury misc ischemic conditioning misc percutaneous coronary intervention misc Medicine misc R
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title	Reperfusion Injury: How Can We Reduce It by Pre-, Per-, and Postconditioning
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title_sort	reperfusion injury: how can we reduce it by pre-, per-, and postconditioning
title_auth	Reperfusion Injury: How Can We Reduce It by Pre-, Per-, and Postconditioning
abstract	While early coronary reperfusion via primary percutaneous coronary intervention (pPCI) is established as the most efficacious therapy for minimizing infarct size (IS) in acute ST-elevation myocardial infarction (STEMI), the restoration of blood flow also introduces myocardial ischemia-reperfusion injury (IRI), leading to cardiomyocyte death. Among diverse methods, ischemic conditioning (IC), achieved through repetitive cycles of ischemia and reperfusion, has emerged as the most promising method to mitigate IRI. IC can be performed by applying the protective stimulus directly to the affected myocardium or indirectly to non-affected tissue, which is known as remote ischemic conditioning (RIC). In clinical practice, RIC is often applied by serial inflations and deflations of a blood pressure cuff on a limb. Despite encouraging preclinical studies, as well as clinical studies demonstrating reductions in enzymatic IS and myocardial injury on imaging, the observed impact on clinical outcome has been disappointing so far. Nevertheless, previous studies indicate a potential benefit of IC in high-risk STEMI patients. Additional research is needed to evaluate the impact of IC in such high-risk cohorts. The objective of this review is to summarize the pathophysiological background and preclinical and clinical data of IRI reduction by IC.
abstractGer	While early coronary reperfusion via primary percutaneous coronary intervention (pPCI) is established as the most efficacious therapy for minimizing infarct size (IS) in acute ST-elevation myocardial infarction (STEMI), the restoration of blood flow also introduces myocardial ischemia-reperfusion injury (IRI), leading to cardiomyocyte death. Among diverse methods, ischemic conditioning (IC), achieved through repetitive cycles of ischemia and reperfusion, has emerged as the most promising method to mitigate IRI. IC can be performed by applying the protective stimulus directly to the affected myocardium or indirectly to non-affected tissue, which is known as remote ischemic conditioning (RIC). In clinical practice, RIC is often applied by serial inflations and deflations of a blood pressure cuff on a limb. Despite encouraging preclinical studies, as well as clinical studies demonstrating reductions in enzymatic IS and myocardial injury on imaging, the observed impact on clinical outcome has been disappointing so far. Nevertheless, previous studies indicate a potential benefit of IC in high-risk STEMI patients. Additional research is needed to evaluate the impact of IC in such high-risk cohorts. The objective of this review is to summarize the pathophysiological background and preclinical and clinical data of IRI reduction by IC.
abstract_unstemmed	While early coronary reperfusion via primary percutaneous coronary intervention (pPCI) is established as the most efficacious therapy for minimizing infarct size (IS) in acute ST-elevation myocardial infarction (STEMI), the restoration of blood flow also introduces myocardial ischemia-reperfusion injury (IRI), leading to cardiomyocyte death. Among diverse methods, ischemic conditioning (IC), achieved through repetitive cycles of ischemia and reperfusion, has emerged as the most promising method to mitigate IRI. IC can be performed by applying the protective stimulus directly to the affected myocardium or indirectly to non-affected tissue, which is known as remote ischemic conditioning (RIC). In clinical practice, RIC is often applied by serial inflations and deflations of a blood pressure cuff on a limb. Despite encouraging preclinical studies, as well as clinical studies demonstrating reductions in enzymatic IS and myocardial injury on imaging, the observed impact on clinical outcome has been disappointing so far. Nevertheless, previous studies indicate a potential benefit of IC in high-risk STEMI patients. Additional research is needed to evaluate the impact of IC in such high-risk cohorts. The objective of this review is to summarize the pathophysiological background and preclinical and clinical data of IRI reduction by IC.
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title_short	Reperfusion Injury: How Can We Reduce It by Pre-, Per-, and Postconditioning
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