The Importance of Reading the Skin: Cutaneous Metastases of Pancreatic Cancer, a Systematic Review

Background: Pancreatic cancer is notorious for its aggressive nature and low survival rate, with less than 10% of patients surviving beyond five years. Early detection is difficult, but skin metastases can be a rare but significant indicator. This systematic review focuses on the epidemiology, clinical features, and histology of skin metastases from pancreatic cancer to determine their importance in early diagnosis and overall management of the disease. Materials and methods: Following PRISMA guidelines, we conducted an exhaustive search of MEDLINE/PubMed, EMBASE, and SCOPUS databases up to June 2023, using specific keywords. Four independent investigators screened the studies using predefined criteria, and two investigators checked the accuracy and consistency of the data extraction. We assessed the quality of the trials using adapted criteria from the Joanna Briggs Institute. A narrative synthesis rather than a meta-analysis was chosen because of the different study designs. Results: The final analysis included 57 patients with skin metastases from pancreatic cancer. Cutaneous metastases, although rare, presented with approximately equal gender distribution and a mean age of 63.4 years. Predominantly non-umbilical (77%), these metastases showed clinical diversity, ranging from asymptomatic nodules to painful or ulcerated lesions. Notably, skin metastases often preceded the diagnosis of primary pancreatic cancer (58%). Primary tumor characteristics revealed different localizations, with adenocarcinoma being the most prevalent histological type (77%). A significant association (<i<p</i< = 0.008) was observed between pancreatic tumor location and the timing of presentation of skin metastases. Tumors located in the body and tail of the pancreas were more likely to manifest skin metastases as an initial clinical manifestation (62.2%) than those in the head of the pancreas (20.8%). Conclusions: In conclusion, although skin metastases are rare, they are important indicators of pancreatic cancer, highlighting the need for multidisciplinary healthcare collaboration and thorough skin examination. Recognizing them could lead to earlier diagnosis, which is crucial in a cancer with limited treatment options. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Fortunato Cassalia [verfasserIn] Anna Bolzon [verfasserIn] Monica Ponzano [verfasserIn] Laura Ventura [verfasserIn] Andrea Danese [verfasserIn] Paolo Del Fiore [verfasserIn] Anna Belloni Fortina [verfasserIn] Elio Jovine [verfasserIn] Giampaolo Perri [verfasserIn] Umberto Cillo [verfasserIn] Giovanni Marchegiani [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	cutaneous metastasis skin metastasis pancreatic cancer pancreatic skin metastasis pancreas skin cancer

Übergeordnetes Werk:	In: Journal of Clinical Medicine - MDPI AG, 2013, 13(2023), 1, p 104
Übergeordnetes Werk:	volume:13 ; year:2023 ; number:1, p 104

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jcm13010104

Katalog-ID:	DOAJ09778964X

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allfields	10.3390/jcm13010104 doi (DE-627)DOAJ09778964X (DE-599)DOAJce02e3e05fbf4ed7b3b9872c40fffab8 DE-627 ger DE-627 rakwb eng Fortunato Cassalia verfasserin aut The Importance of Reading the Skin: Cutaneous Metastases of Pancreatic Cancer, a Systematic Review 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Pancreatic cancer is notorious for its aggressive nature and low survival rate, with less than 10% of patients surviving beyond five years. Early detection is difficult, but skin metastases can be a rare but significant indicator. This systematic review focuses on the epidemiology, clinical features, and histology of skin metastases from pancreatic cancer to determine their importance in early diagnosis and overall management of the disease. Materials and methods: Following PRISMA guidelines, we conducted an exhaustive search of MEDLINE/PubMed, EMBASE, and SCOPUS databases up to June 2023, using specific keywords. Four independent investigators screened the studies using predefined criteria, and two investigators checked the accuracy and consistency of the data extraction. We assessed the quality of the trials using adapted criteria from the Joanna Briggs Institute. A narrative synthesis rather than a meta-analysis was chosen because of the different study designs. Results: The final analysis included 57 patients with skin metastases from pancreatic cancer. Cutaneous metastases, although rare, presented with approximately equal gender distribution and a mean age of 63.4 years. Predominantly non-umbilical (77%), these metastases showed clinical diversity, ranging from asymptomatic nodules to painful or ulcerated lesions. Notably, skin metastases often preceded the diagnosis of primary pancreatic cancer (58%). Primary tumor characteristics revealed different localizations, with adenocarcinoma being the most prevalent histological type (77%). A significant association (<i<p</i< = 0.008) was observed between pancreatic tumor location and the timing of presentation of skin metastases. Tumors located in the body and tail of the pancreas were more likely to manifest skin metastases as an initial clinical manifestation (62.2%) than those in the head of the pancreas (20.8%). Conclusions: In conclusion, although skin metastases are rare, they are important indicators of pancreatic cancer, highlighting the need for multidisciplinary healthcare collaboration and thorough skin examination. Recognizing them could lead to earlier diagnosis, which is crucial in a cancer with limited treatment options. cutaneous metastasis skin metastasis pancreatic cancer pancreatic skin metastasis pancreas skin cancer Medicine R Anna Bolzon verfasserin aut Monica Ponzano verfasserin aut Laura Ventura verfasserin aut Andrea Danese verfasserin aut Paolo Del Fiore verfasserin aut Anna Belloni Fortina verfasserin aut Elio Jovine verfasserin aut Giampaolo Perri verfasserin aut Umberto Cillo verfasserin aut Giovanni Marchegiani verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 13(2023), 1, p 104 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:13 year:2023 number:1, p 104 https://doi.org/10.3390/jcm13010104 kostenfrei https://doaj.org/article/ce02e3e05fbf4ed7b3b9872c40fffab8 kostenfrei https://www.mdpi.com/2077-0383/13/1/104 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 1, p 104
spelling	10.3390/jcm13010104 doi (DE-627)DOAJ09778964X (DE-599)DOAJce02e3e05fbf4ed7b3b9872c40fffab8 DE-627 ger DE-627 rakwb eng Fortunato Cassalia verfasserin aut The Importance of Reading the Skin: Cutaneous Metastases of Pancreatic Cancer, a Systematic Review 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Pancreatic cancer is notorious for its aggressive nature and low survival rate, with less than 10% of patients surviving beyond five years. Early detection is difficult, but skin metastases can be a rare but significant indicator. This systematic review focuses on the epidemiology, clinical features, and histology of skin metastases from pancreatic cancer to determine their importance in early diagnosis and overall management of the disease. Materials and methods: Following PRISMA guidelines, we conducted an exhaustive search of MEDLINE/PubMed, EMBASE, and SCOPUS databases up to June 2023, using specific keywords. Four independent investigators screened the studies using predefined criteria, and two investigators checked the accuracy and consistency of the data extraction. We assessed the quality of the trials using adapted criteria from the Joanna Briggs Institute. A narrative synthesis rather than a meta-analysis was chosen because of the different study designs. Results: The final analysis included 57 patients with skin metastases from pancreatic cancer. Cutaneous metastases, although rare, presented with approximately equal gender distribution and a mean age of 63.4 years. Predominantly non-umbilical (77%), these metastases showed clinical diversity, ranging from asymptomatic nodules to painful or ulcerated lesions. Notably, skin metastases often preceded the diagnosis of primary pancreatic cancer (58%). Primary tumor characteristics revealed different localizations, with adenocarcinoma being the most prevalent histological type (77%). A significant association (<i<p</i< = 0.008) was observed between pancreatic tumor location and the timing of presentation of skin metastases. Tumors located in the body and tail of the pancreas were more likely to manifest skin metastases as an initial clinical manifestation (62.2%) than those in the head of the pancreas (20.8%). Conclusions: In conclusion, although skin metastases are rare, they are important indicators of pancreatic cancer, highlighting the need for multidisciplinary healthcare collaboration and thorough skin examination. Recognizing them could lead to earlier diagnosis, which is crucial in a cancer with limited treatment options. cutaneous metastasis skin metastasis pancreatic cancer pancreatic skin metastasis pancreas skin cancer Medicine R Anna Bolzon verfasserin aut Monica Ponzano verfasserin aut Laura Ventura verfasserin aut Andrea Danese verfasserin aut Paolo Del Fiore verfasserin aut Anna Belloni Fortina verfasserin aut Elio Jovine verfasserin aut Giampaolo Perri verfasserin aut Umberto Cillo verfasserin aut Giovanni Marchegiani verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 13(2023), 1, p 104 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:13 year:2023 number:1, p 104 https://doi.org/10.3390/jcm13010104 kostenfrei https://doaj.org/article/ce02e3e05fbf4ed7b3b9872c40fffab8 kostenfrei https://www.mdpi.com/2077-0383/13/1/104 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 1, p 104
allfields_unstemmed	10.3390/jcm13010104 doi (DE-627)DOAJ09778964X (DE-599)DOAJce02e3e05fbf4ed7b3b9872c40fffab8 DE-627 ger DE-627 rakwb eng Fortunato Cassalia verfasserin aut The Importance of Reading the Skin: Cutaneous Metastases of Pancreatic Cancer, a Systematic Review 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Pancreatic cancer is notorious for its aggressive nature and low survival rate, with less than 10% of patients surviving beyond five years. Early detection is difficult, but skin metastases can be a rare but significant indicator. This systematic review focuses on the epidemiology, clinical features, and histology of skin metastases from pancreatic cancer to determine their importance in early diagnosis and overall management of the disease. Materials and methods: Following PRISMA guidelines, we conducted an exhaustive search of MEDLINE/PubMed, EMBASE, and SCOPUS databases up to June 2023, using specific keywords. Four independent investigators screened the studies using predefined criteria, and two investigators checked the accuracy and consistency of the data extraction. We assessed the quality of the trials using adapted criteria from the Joanna Briggs Institute. A narrative synthesis rather than a meta-analysis was chosen because of the different study designs. Results: The final analysis included 57 patients with skin metastases from pancreatic cancer. Cutaneous metastases, although rare, presented with approximately equal gender distribution and a mean age of 63.4 years. Predominantly non-umbilical (77%), these metastases showed clinical diversity, ranging from asymptomatic nodules to painful or ulcerated lesions. Notably, skin metastases often preceded the diagnosis of primary pancreatic cancer (58%). Primary tumor characteristics revealed different localizations, with adenocarcinoma being the most prevalent histological type (77%). A significant association (<i<p</i< = 0.008) was observed between pancreatic tumor location and the timing of presentation of skin metastases. Tumors located in the body and tail of the pancreas were more likely to manifest skin metastases as an initial clinical manifestation (62.2%) than those in the head of the pancreas (20.8%). Conclusions: In conclusion, although skin metastases are rare, they are important indicators of pancreatic cancer, highlighting the need for multidisciplinary healthcare collaboration and thorough skin examination. Recognizing them could lead to earlier diagnosis, which is crucial in a cancer with limited treatment options. cutaneous metastasis skin metastasis pancreatic cancer pancreatic skin metastasis pancreas skin cancer Medicine R Anna Bolzon verfasserin aut Monica Ponzano verfasserin aut Laura Ventura verfasserin aut Andrea Danese verfasserin aut Paolo Del Fiore verfasserin aut Anna Belloni Fortina verfasserin aut Elio Jovine verfasserin aut Giampaolo Perri verfasserin aut Umberto Cillo verfasserin aut Giovanni Marchegiani verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 13(2023), 1, p 104 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:13 year:2023 number:1, p 104 https://doi.org/10.3390/jcm13010104 kostenfrei https://doaj.org/article/ce02e3e05fbf4ed7b3b9872c40fffab8 kostenfrei https://www.mdpi.com/2077-0383/13/1/104 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 1, p 104
allfieldsGer	10.3390/jcm13010104 doi (DE-627)DOAJ09778964X (DE-599)DOAJce02e3e05fbf4ed7b3b9872c40fffab8 DE-627 ger DE-627 rakwb eng Fortunato Cassalia verfasserin aut The Importance of Reading the Skin: Cutaneous Metastases of Pancreatic Cancer, a Systematic Review 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Pancreatic cancer is notorious for its aggressive nature and low survival rate, with less than 10% of patients surviving beyond five years. Early detection is difficult, but skin metastases can be a rare but significant indicator. This systematic review focuses on the epidemiology, clinical features, and histology of skin metastases from pancreatic cancer to determine their importance in early diagnosis and overall management of the disease. Materials and methods: Following PRISMA guidelines, we conducted an exhaustive search of MEDLINE/PubMed, EMBASE, and SCOPUS databases up to June 2023, using specific keywords. Four independent investigators screened the studies using predefined criteria, and two investigators checked the accuracy and consistency of the data extraction. We assessed the quality of the trials using adapted criteria from the Joanna Briggs Institute. A narrative synthesis rather than a meta-analysis was chosen because of the different study designs. Results: The final analysis included 57 patients with skin metastases from pancreatic cancer. Cutaneous metastases, although rare, presented with approximately equal gender distribution and a mean age of 63.4 years. Predominantly non-umbilical (77%), these metastases showed clinical diversity, ranging from asymptomatic nodules to painful or ulcerated lesions. Notably, skin metastases often preceded the diagnosis of primary pancreatic cancer (58%). Primary tumor characteristics revealed different localizations, with adenocarcinoma being the most prevalent histological type (77%). A significant association (<i<p</i< = 0.008) was observed between pancreatic tumor location and the timing of presentation of skin metastases. Tumors located in the body and tail of the pancreas were more likely to manifest skin metastases as an initial clinical manifestation (62.2%) than those in the head of the pancreas (20.8%). Conclusions: In conclusion, although skin metastases are rare, they are important indicators of pancreatic cancer, highlighting the need for multidisciplinary healthcare collaboration and thorough skin examination. Recognizing them could lead to earlier diagnosis, which is crucial in a cancer with limited treatment options. cutaneous metastasis skin metastasis pancreatic cancer pancreatic skin metastasis pancreas skin cancer Medicine R Anna Bolzon verfasserin aut Monica Ponzano verfasserin aut Laura Ventura verfasserin aut Andrea Danese verfasserin aut Paolo Del Fiore verfasserin aut Anna Belloni Fortina verfasserin aut Elio Jovine verfasserin aut Giampaolo Perri verfasserin aut Umberto Cillo verfasserin aut Giovanni Marchegiani verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 13(2023), 1, p 104 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:13 year:2023 number:1, p 104 https://doi.org/10.3390/jcm13010104 kostenfrei https://doaj.org/article/ce02e3e05fbf4ed7b3b9872c40fffab8 kostenfrei https://www.mdpi.com/2077-0383/13/1/104 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 1, p 104
allfieldsSound	10.3390/jcm13010104 doi (DE-627)DOAJ09778964X (DE-599)DOAJce02e3e05fbf4ed7b3b9872c40fffab8 DE-627 ger DE-627 rakwb eng Fortunato Cassalia verfasserin aut The Importance of Reading the Skin: Cutaneous Metastases of Pancreatic Cancer, a Systematic Review 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Pancreatic cancer is notorious for its aggressive nature and low survival rate, with less than 10% of patients surviving beyond five years. Early detection is difficult, but skin metastases can be a rare but significant indicator. This systematic review focuses on the epidemiology, clinical features, and histology of skin metastases from pancreatic cancer to determine their importance in early diagnosis and overall management of the disease. Materials and methods: Following PRISMA guidelines, we conducted an exhaustive search of MEDLINE/PubMed, EMBASE, and SCOPUS databases up to June 2023, using specific keywords. Four independent investigators screened the studies using predefined criteria, and two investigators checked the accuracy and consistency of the data extraction. We assessed the quality of the trials using adapted criteria from the Joanna Briggs Institute. A narrative synthesis rather than a meta-analysis was chosen because of the different study designs. Results: The final analysis included 57 patients with skin metastases from pancreatic cancer. Cutaneous metastases, although rare, presented with approximately equal gender distribution and a mean age of 63.4 years. Predominantly non-umbilical (77%), these metastases showed clinical diversity, ranging from asymptomatic nodules to painful or ulcerated lesions. Notably, skin metastases often preceded the diagnosis of primary pancreatic cancer (58%). Primary tumor characteristics revealed different localizations, with adenocarcinoma being the most prevalent histological type (77%). A significant association (<i<p</i< = 0.008) was observed between pancreatic tumor location and the timing of presentation of skin metastases. Tumors located in the body and tail of the pancreas were more likely to manifest skin metastases as an initial clinical manifestation (62.2%) than those in the head of the pancreas (20.8%). Conclusions: In conclusion, although skin metastases are rare, they are important indicators of pancreatic cancer, highlighting the need for multidisciplinary healthcare collaboration and thorough skin examination. Recognizing them could lead to earlier diagnosis, which is crucial in a cancer with limited treatment options. cutaneous metastasis skin metastasis pancreatic cancer pancreatic skin metastasis pancreas skin cancer Medicine R Anna Bolzon verfasserin aut Monica Ponzano verfasserin aut Laura Ventura verfasserin aut Andrea Danese verfasserin aut Paolo Del Fiore verfasserin aut Anna Belloni Fortina verfasserin aut Elio Jovine verfasserin aut Giampaolo Perri verfasserin aut Umberto Cillo verfasserin aut Giovanni Marchegiani verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 13(2023), 1, p 104 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:13 year:2023 number:1, p 104 https://doi.org/10.3390/jcm13010104 kostenfrei https://doaj.org/article/ce02e3e05fbf4ed7b3b9872c40fffab8 kostenfrei https://www.mdpi.com/2077-0383/13/1/104 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 1, p 104
language	English
source	In Journal of Clinical Medicine 13(2023), 1, p 104 volume:13 year:2023 number:1, p 104
sourceStr	In Journal of Clinical Medicine 13(2023), 1, p 104 volume:13 year:2023 number:1, p 104
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topic_facet	cutaneous metastasis skin metastasis pancreatic cancer pancreatic skin metastasis pancreas skin cancer Medicine R
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authorswithroles_txt_mv	Fortunato Cassalia @@aut@@ Anna Bolzon @@aut@@ Monica Ponzano @@aut@@ Laura Ventura @@aut@@ Andrea Danese @@aut@@ Paolo Del Fiore @@aut@@ Anna Belloni Fortina @@aut@@ Elio Jovine @@aut@@ Giampaolo Perri @@aut@@ Umberto Cillo @@aut@@ Giovanni Marchegiani @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
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topic_title	The Importance of Reading the Skin: Cutaneous Metastases of Pancreatic Cancer, a Systematic Review cutaneous metastasis skin metastasis pancreatic cancer pancreatic skin metastasis pancreas skin cancer
topic	misc cutaneous metastasis misc skin metastasis misc pancreatic cancer misc pancreatic skin metastasis misc pancreas misc skin cancer misc Medicine misc R
topic_unstemmed	misc cutaneous metastasis misc skin metastasis misc pancreatic cancer misc pancreatic skin metastasis misc pancreas misc skin cancer misc Medicine misc R
topic_browse	misc cutaneous metastasis misc skin metastasis misc pancreatic cancer misc pancreatic skin metastasis misc pancreas misc skin cancer misc Medicine misc R
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title	The Importance of Reading the Skin: Cutaneous Metastases of Pancreatic Cancer, a Systematic Review
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title_full	The Importance of Reading the Skin: Cutaneous Metastases of Pancreatic Cancer, a Systematic Review
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author_browse	Fortunato Cassalia Anna Bolzon Monica Ponzano Laura Ventura Andrea Danese Paolo Del Fiore Anna Belloni Fortina Elio Jovine Giampaolo Perri Umberto Cillo Giovanni Marchegiani
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title_sort	importance of reading the skin: cutaneous metastases of pancreatic cancer, a systematic review
title_auth	The Importance of Reading the Skin: Cutaneous Metastases of Pancreatic Cancer, a Systematic Review
abstract	Background: Pancreatic cancer is notorious for its aggressive nature and low survival rate, with less than 10% of patients surviving beyond five years. Early detection is difficult, but skin metastases can be a rare but significant indicator. This systematic review focuses on the epidemiology, clinical features, and histology of skin metastases from pancreatic cancer to determine their importance in early diagnosis and overall management of the disease. Materials and methods: Following PRISMA guidelines, we conducted an exhaustive search of MEDLINE/PubMed, EMBASE, and SCOPUS databases up to June 2023, using specific keywords. Four independent investigators screened the studies using predefined criteria, and two investigators checked the accuracy and consistency of the data extraction. We assessed the quality of the trials using adapted criteria from the Joanna Briggs Institute. A narrative synthesis rather than a meta-analysis was chosen because of the different study designs. Results: The final analysis included 57 patients with skin metastases from pancreatic cancer. Cutaneous metastases, although rare, presented with approximately equal gender distribution and a mean age of 63.4 years. Predominantly non-umbilical (77%), these metastases showed clinical diversity, ranging from asymptomatic nodules to painful or ulcerated lesions. Notably, skin metastases often preceded the diagnosis of primary pancreatic cancer (58%). Primary tumor characteristics revealed different localizations, with adenocarcinoma being the most prevalent histological type (77%). A significant association (<i<p</i< = 0.008) was observed between pancreatic tumor location and the timing of presentation of skin metastases. Tumors located in the body and tail of the pancreas were more likely to manifest skin metastases as an initial clinical manifestation (62.2%) than those in the head of the pancreas (20.8%). Conclusions: In conclusion, although skin metastases are rare, they are important indicators of pancreatic cancer, highlighting the need for multidisciplinary healthcare collaboration and thorough skin examination. Recognizing them could lead to earlier diagnosis, which is crucial in a cancer with limited treatment options.
abstractGer	Background: Pancreatic cancer is notorious for its aggressive nature and low survival rate, with less than 10% of patients surviving beyond five years. Early detection is difficult, but skin metastases can be a rare but significant indicator. This systematic review focuses on the epidemiology, clinical features, and histology of skin metastases from pancreatic cancer to determine their importance in early diagnosis and overall management of the disease. Materials and methods: Following PRISMA guidelines, we conducted an exhaustive search of MEDLINE/PubMed, EMBASE, and SCOPUS databases up to June 2023, using specific keywords. Four independent investigators screened the studies using predefined criteria, and two investigators checked the accuracy and consistency of the data extraction. We assessed the quality of the trials using adapted criteria from the Joanna Briggs Institute. A narrative synthesis rather than a meta-analysis was chosen because of the different study designs. Results: The final analysis included 57 patients with skin metastases from pancreatic cancer. Cutaneous metastases, although rare, presented with approximately equal gender distribution and a mean age of 63.4 years. Predominantly non-umbilical (77%), these metastases showed clinical diversity, ranging from asymptomatic nodules to painful or ulcerated lesions. Notably, skin metastases often preceded the diagnosis of primary pancreatic cancer (58%). Primary tumor characteristics revealed different localizations, with adenocarcinoma being the most prevalent histological type (77%). A significant association (<i<p</i< = 0.008) was observed between pancreatic tumor location and the timing of presentation of skin metastases. Tumors located in the body and tail of the pancreas were more likely to manifest skin metastases as an initial clinical manifestation (62.2%) than those in the head of the pancreas (20.8%). Conclusions: In conclusion, although skin metastases are rare, they are important indicators of pancreatic cancer, highlighting the need for multidisciplinary healthcare collaboration and thorough skin examination. Recognizing them could lead to earlier diagnosis, which is crucial in a cancer with limited treatment options.
abstract_unstemmed	Background: Pancreatic cancer is notorious for its aggressive nature and low survival rate, with less than 10% of patients surviving beyond five years. Early detection is difficult, but skin metastases can be a rare but significant indicator. This systematic review focuses on the epidemiology, clinical features, and histology of skin metastases from pancreatic cancer to determine their importance in early diagnosis and overall management of the disease. Materials and methods: Following PRISMA guidelines, we conducted an exhaustive search of MEDLINE/PubMed, EMBASE, and SCOPUS databases up to June 2023, using specific keywords. Four independent investigators screened the studies using predefined criteria, and two investigators checked the accuracy and consistency of the data extraction. We assessed the quality of the trials using adapted criteria from the Joanna Briggs Institute. A narrative synthesis rather than a meta-analysis was chosen because of the different study designs. Results: The final analysis included 57 patients with skin metastases from pancreatic cancer. Cutaneous metastases, although rare, presented with approximately equal gender distribution and a mean age of 63.4 years. Predominantly non-umbilical (77%), these metastases showed clinical diversity, ranging from asymptomatic nodules to painful or ulcerated lesions. Notably, skin metastases often preceded the diagnosis of primary pancreatic cancer (58%). Primary tumor characteristics revealed different localizations, with adenocarcinoma being the most prevalent histological type (77%). A significant association (<i<p</i< = 0.008) was observed between pancreatic tumor location and the timing of presentation of skin metastases. Tumors located in the body and tail of the pancreas were more likely to manifest skin metastases as an initial clinical manifestation (62.2%) than those in the head of the pancreas (20.8%). Conclusions: In conclusion, although skin metastases are rare, they are important indicators of pancreatic cancer, highlighting the need for multidisciplinary healthcare collaboration and thorough skin examination. Recognizing them could lead to earlier diagnosis, which is crucial in a cancer with limited treatment options.
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title_short	The Importance of Reading the Skin: Cutaneous Metastases of Pancreatic Cancer, a Systematic Review
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