Progress on the pathological roles of immune checkpoint CD276 protein in tumorigenesis and development
The immune checkpoint CD276 protein, belonging to the B7 family molecules, could interact with important signaling pathways, such as phosphatidylinositol 3 kinase/protein kinase B(PI3K/AKT)signaling pathway, resulting to the regulation of tumor energy metabolism, inhibition of the anti-tumor activit...
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| Autor*in: |
CHEN Zhongjie, HUANG Jiaru, HU Qing, ZHAO Zhenqin, CHEN Qiaoqiao, SUN Junyuan, JIA Jing [verfasserIn] |
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| Format: |
E-Artikel |
|---|---|
| Sprache: |
Chinesisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
cd276|tumor immune escape|tumor pathological mechanism|tumor immunotherapy|immune checkpoint |
|---|
| Übergeordnetes Werk: |
In: Jichu yixue yu linchuang ; 43(2023), 7, Seite 1143-1147 volume:43 ; year:2023 ; number:7 ; pages:1143-1147 |
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| Links: |
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| DOI / URN: |
10.16352/j.issn.1001-6325.2023.07.1143 |
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DOAJ097902918 |
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10.16352/j.issn.1001-6325.2023.07.1143 doi (DE-627)DOAJ097902918 (DE-599)DOAJf397958d76a743dc83cd5688d22313c7 DE-627 ger DE-627 rakwb chi CHEN Zhongjie, HUANG Jiaru, HU Qing, ZHAO Zhenqin, CHEN Qiaoqiao, SUN Junyuan, JIA Jing verfasserin aut Progress on the pathological roles of immune checkpoint CD276 protein in tumorigenesis and development 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The immune checkpoint CD276 protein, belonging to the B7 family molecules, could interact with important signaling pathways, such as phosphatidylinositol 3 kinase/protein kinase B(PI3K/AKT)signaling pathway, resulting to the regulation of tumor energy metabolism, inhibition of the anti-tumor activity of immune cells, promotion of tumor angiogenesis, and the assistance of tumor immune escape and metastasis. CD276 also potentially related to tumor stemness and chemotherapy resistance closely. Several antibody drugs and cell therapy methods targeting at CD276 have been proved in clinical trials. CD276 can also be used as a biomarker for tumor diagnosis and subtyping. The upstream regulatory mechanisms of CD276 include transcriptional level regulation mediated by non-coding RNA and transcription factors, and post-translational modification level regulation mediated by methylation and glycosylation. cd276|tumor immune escape|tumor pathological mechanism|tumor immunotherapy|immune checkpoint Medicine R In Jichu yixue yu linchuang 43(2023), 7, Seite 1143-1147 volume:43 year:2023 number:7 pages:1143-1147 https://doi.org/10.16352/j.issn.1001-6325.2023.07.1143 kostenfrei https://doaj.org/article/f397958d76a743dc83cd5688d22313c7 kostenfrei http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-43-7-1143.pdf kostenfrei https://doaj.org/toc/1001-6325 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 43 2023 7 1143-1147 |
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10.16352/j.issn.1001-6325.2023.07.1143 doi (DE-627)DOAJ097902918 (DE-599)DOAJf397958d76a743dc83cd5688d22313c7 DE-627 ger DE-627 rakwb chi CHEN Zhongjie, HUANG Jiaru, HU Qing, ZHAO Zhenqin, CHEN Qiaoqiao, SUN Junyuan, JIA Jing verfasserin aut Progress on the pathological roles of immune checkpoint CD276 protein in tumorigenesis and development 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The immune checkpoint CD276 protein, belonging to the B7 family molecules, could interact with important signaling pathways, such as phosphatidylinositol 3 kinase/protein kinase B(PI3K/AKT)signaling pathway, resulting to the regulation of tumor energy metabolism, inhibition of the anti-tumor activity of immune cells, promotion of tumor angiogenesis, and the assistance of tumor immune escape and metastasis. CD276 also potentially related to tumor stemness and chemotherapy resistance closely. Several antibody drugs and cell therapy methods targeting at CD276 have been proved in clinical trials. CD276 can also be used as a biomarker for tumor diagnosis and subtyping. The upstream regulatory mechanisms of CD276 include transcriptional level regulation mediated by non-coding RNA and transcription factors, and post-translational modification level regulation mediated by methylation and glycosylation. cd276|tumor immune escape|tumor pathological mechanism|tumor immunotherapy|immune checkpoint Medicine R In Jichu yixue yu linchuang 43(2023), 7, Seite 1143-1147 volume:43 year:2023 number:7 pages:1143-1147 https://doi.org/10.16352/j.issn.1001-6325.2023.07.1143 kostenfrei https://doaj.org/article/f397958d76a743dc83cd5688d22313c7 kostenfrei http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-43-7-1143.pdf kostenfrei https://doaj.org/toc/1001-6325 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 43 2023 7 1143-1147 |
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10.16352/j.issn.1001-6325.2023.07.1143 doi (DE-627)DOAJ097902918 (DE-599)DOAJf397958d76a743dc83cd5688d22313c7 DE-627 ger DE-627 rakwb chi CHEN Zhongjie, HUANG Jiaru, HU Qing, ZHAO Zhenqin, CHEN Qiaoqiao, SUN Junyuan, JIA Jing verfasserin aut Progress on the pathological roles of immune checkpoint CD276 protein in tumorigenesis and development 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The immune checkpoint CD276 protein, belonging to the B7 family molecules, could interact with important signaling pathways, such as phosphatidylinositol 3 kinase/protein kinase B(PI3K/AKT)signaling pathway, resulting to the regulation of tumor energy metabolism, inhibition of the anti-tumor activity of immune cells, promotion of tumor angiogenesis, and the assistance of tumor immune escape and metastasis. CD276 also potentially related to tumor stemness and chemotherapy resistance closely. Several antibody drugs and cell therapy methods targeting at CD276 have been proved in clinical trials. CD276 can also be used as a biomarker for tumor diagnosis and subtyping. The upstream regulatory mechanisms of CD276 include transcriptional level regulation mediated by non-coding RNA and transcription factors, and post-translational modification level regulation mediated by methylation and glycosylation. cd276|tumor immune escape|tumor pathological mechanism|tumor immunotherapy|immune checkpoint Medicine R In Jichu yixue yu linchuang 43(2023), 7, Seite 1143-1147 volume:43 year:2023 number:7 pages:1143-1147 https://doi.org/10.16352/j.issn.1001-6325.2023.07.1143 kostenfrei https://doaj.org/article/f397958d76a743dc83cd5688d22313c7 kostenfrei http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-43-7-1143.pdf kostenfrei https://doaj.org/toc/1001-6325 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 43 2023 7 1143-1147 |
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10.16352/j.issn.1001-6325.2023.07.1143 doi (DE-627)DOAJ097902918 (DE-599)DOAJf397958d76a743dc83cd5688d22313c7 DE-627 ger DE-627 rakwb chi CHEN Zhongjie, HUANG Jiaru, HU Qing, ZHAO Zhenqin, CHEN Qiaoqiao, SUN Junyuan, JIA Jing verfasserin aut Progress on the pathological roles of immune checkpoint CD276 protein in tumorigenesis and development 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The immune checkpoint CD276 protein, belonging to the B7 family molecules, could interact with important signaling pathways, such as phosphatidylinositol 3 kinase/protein kinase B(PI3K/AKT)signaling pathway, resulting to the regulation of tumor energy metabolism, inhibition of the anti-tumor activity of immune cells, promotion of tumor angiogenesis, and the assistance of tumor immune escape and metastasis. CD276 also potentially related to tumor stemness and chemotherapy resistance closely. Several antibody drugs and cell therapy methods targeting at CD276 have been proved in clinical trials. CD276 can also be used as a biomarker for tumor diagnosis and subtyping. The upstream regulatory mechanisms of CD276 include transcriptional level regulation mediated by non-coding RNA and transcription factors, and post-translational modification level regulation mediated by methylation and glycosylation. cd276|tumor immune escape|tumor pathological mechanism|tumor immunotherapy|immune checkpoint Medicine R In Jichu yixue yu linchuang 43(2023), 7, Seite 1143-1147 volume:43 year:2023 number:7 pages:1143-1147 https://doi.org/10.16352/j.issn.1001-6325.2023.07.1143 kostenfrei https://doaj.org/article/f397958d76a743dc83cd5688d22313c7 kostenfrei http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-43-7-1143.pdf kostenfrei https://doaj.org/toc/1001-6325 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 43 2023 7 1143-1147 |
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10.16352/j.issn.1001-6325.2023.07.1143 doi (DE-627)DOAJ097902918 (DE-599)DOAJf397958d76a743dc83cd5688d22313c7 DE-627 ger DE-627 rakwb chi CHEN Zhongjie, HUANG Jiaru, HU Qing, ZHAO Zhenqin, CHEN Qiaoqiao, SUN Junyuan, JIA Jing verfasserin aut Progress on the pathological roles of immune checkpoint CD276 protein in tumorigenesis and development 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The immune checkpoint CD276 protein, belonging to the B7 family molecules, could interact with important signaling pathways, such as phosphatidylinositol 3 kinase/protein kinase B(PI3K/AKT)signaling pathway, resulting to the regulation of tumor energy metabolism, inhibition of the anti-tumor activity of immune cells, promotion of tumor angiogenesis, and the assistance of tumor immune escape and metastasis. CD276 also potentially related to tumor stemness and chemotherapy resistance closely. Several antibody drugs and cell therapy methods targeting at CD276 have been proved in clinical trials. CD276 can also be used as a biomarker for tumor diagnosis and subtyping. The upstream regulatory mechanisms of CD276 include transcriptional level regulation mediated by non-coding RNA and transcription factors, and post-translational modification level regulation mediated by methylation and glycosylation. cd276|tumor immune escape|tumor pathological mechanism|tumor immunotherapy|immune checkpoint Medicine R In Jichu yixue yu linchuang 43(2023), 7, Seite 1143-1147 volume:43 year:2023 number:7 pages:1143-1147 https://doi.org/10.16352/j.issn.1001-6325.2023.07.1143 kostenfrei https://doaj.org/article/f397958d76a743dc83cd5688d22313c7 kostenfrei http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-43-7-1143.pdf kostenfrei https://doaj.org/toc/1001-6325 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 43 2023 7 1143-1147 |
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progress on the pathological roles of immune checkpoint cd276 protein in tumorigenesis and development |
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Progress on the pathological roles of immune checkpoint CD276 protein in tumorigenesis and development |
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The immune checkpoint CD276 protein, belonging to the B7 family molecules, could interact with important signaling pathways, such as phosphatidylinositol 3 kinase/protein kinase B(PI3K/AKT)signaling pathway, resulting to the regulation of tumor energy metabolism, inhibition of the anti-tumor activity of immune cells, promotion of tumor angiogenesis, and the assistance of tumor immune escape and metastasis. CD276 also potentially related to tumor stemness and chemotherapy resistance closely. Several antibody drugs and cell therapy methods targeting at CD276 have been proved in clinical trials. CD276 can also be used as a biomarker for tumor diagnosis and subtyping. The upstream regulatory mechanisms of CD276 include transcriptional level regulation mediated by non-coding RNA and transcription factors, and post-translational modification level regulation mediated by methylation and glycosylation. |
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The immune checkpoint CD276 protein, belonging to the B7 family molecules, could interact with important signaling pathways, such as phosphatidylinositol 3 kinase/protein kinase B(PI3K/AKT)signaling pathway, resulting to the regulation of tumor energy metabolism, inhibition of the anti-tumor activity of immune cells, promotion of tumor angiogenesis, and the assistance of tumor immune escape and metastasis. CD276 also potentially related to tumor stemness and chemotherapy resistance closely. Several antibody drugs and cell therapy methods targeting at CD276 have been proved in clinical trials. CD276 can also be used as a biomarker for tumor diagnosis and subtyping. The upstream regulatory mechanisms of CD276 include transcriptional level regulation mediated by non-coding RNA and transcription factors, and post-translational modification level regulation mediated by methylation and glycosylation. |
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The immune checkpoint CD276 protein, belonging to the B7 family molecules, could interact with important signaling pathways, such as phosphatidylinositol 3 kinase/protein kinase B(PI3K/AKT)signaling pathway, resulting to the regulation of tumor energy metabolism, inhibition of the anti-tumor activity of immune cells, promotion of tumor angiogenesis, and the assistance of tumor immune escape and metastasis. CD276 also potentially related to tumor stemness and chemotherapy resistance closely. Several antibody drugs and cell therapy methods targeting at CD276 have been proved in clinical trials. CD276 can also be used as a biomarker for tumor diagnosis and subtyping. The upstream regulatory mechanisms of CD276 include transcriptional level regulation mediated by non-coding RNA and transcription factors, and post-translational modification level regulation mediated by methylation and glycosylation. |
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