Potential therapeutic target for polysaccharide inhibition of colon cancer progression

In recent years, colon cancer has become one of the most common malignant tumors worldwide, posing a great threat to human health. Studies have shown that natural polysaccharides have rich biological activities and medicinal value, such as anti-inflammatory, anti-cancer, anti-oxidation, and immune-e...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Jiawei Fan [verfasserIn] Jianshu Zhu [verfasserIn] He Zhu [verfasserIn] Yinmeng Zhang [verfasserIn] Hong Xu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	colon cancer polysaccharide immunity intestinal microbiota apoptosis

Übergeordnetes Werk:	In: Frontiers in Medicine - Frontiers Media S.A., 2014, 10(2024)
Übergeordnetes Werk:	volume:10 ; year:2024

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fmed.2023.1325491

Katalog-ID:	DOAJ097940852

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allfields	10.3389/fmed.2023.1325491 doi (DE-627)DOAJ097940852 (DE-599)DOAJ102c7911a6354390ba76f7eed1c7c86a DE-627 ger DE-627 rakwb eng R5-920 Jiawei Fan verfasserin aut Potential therapeutic target for polysaccharide inhibition of colon cancer progression 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In recent years, colon cancer has become one of the most common malignant tumors worldwide, posing a great threat to human health. Studies have shown that natural polysaccharides have rich biological activities and medicinal value, such as anti-inflammatory, anti-cancer, anti-oxidation, and immune-enhancing effects, especially with potential anti-colon cancer mechanisms. Natural polysaccharides can not only protect and enhance the homeostasis of the intestinal environment but also exert a direct inhibition effect on cancer cells, making it a promising strategy for treating colon cancer. Preliminary clinical experiments have demonstrated that oral administration of low and high doses of citrus pectin polysaccharides can reduce tumor volume in mice by 38% (p < 0.02) and 70% (p < 0.001), respectively. These results are encouraging. However, there are relatively few clinical studies on the effectiveness of polysaccharide therapy for colon cancer, and ensuring the effective bioavailability of polysaccharides in the body remains a challenge. In this article, we elucidate the impact of the physicochemical factors of polysaccharides on their anticancer effects and then reveal the anti-tumor effects and mechanisms of natural polysaccharides on colon cancer. Finally, we emphasize the challenges of using polysaccharides in the treatment of colon cancer and discuss future applications. colon cancer polysaccharide immunity intestinal microbiota apoptosis Medicine (General) Jianshu Zhu verfasserin aut He Zhu verfasserin aut Yinmeng Zhang verfasserin aut Hong Xu verfasserin aut In Frontiers in Medicine Frontiers Media S.A., 2014 10(2024) (DE-627)789482991 (DE-600)2775999-4 2296858X nnns volume:10 year:2024 https://doi.org/10.3389/fmed.2023.1325491 kostenfrei https://doaj.org/article/102c7911a6354390ba76f7eed1c7c86a kostenfrei https://www.frontiersin.org/articles/10.3389/fmed.2023.1325491/full kostenfrei https://doaj.org/toc/2296-858X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2024
spelling	10.3389/fmed.2023.1325491 doi (DE-627)DOAJ097940852 (DE-599)DOAJ102c7911a6354390ba76f7eed1c7c86a DE-627 ger DE-627 rakwb eng R5-920 Jiawei Fan verfasserin aut Potential therapeutic target for polysaccharide inhibition of colon cancer progression 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In recent years, colon cancer has become one of the most common malignant tumors worldwide, posing a great threat to human health. Studies have shown that natural polysaccharides have rich biological activities and medicinal value, such as anti-inflammatory, anti-cancer, anti-oxidation, and immune-enhancing effects, especially with potential anti-colon cancer mechanisms. Natural polysaccharides can not only protect and enhance the homeostasis of the intestinal environment but also exert a direct inhibition effect on cancer cells, making it a promising strategy for treating colon cancer. Preliminary clinical experiments have demonstrated that oral administration of low and high doses of citrus pectin polysaccharides can reduce tumor volume in mice by 38% (p < 0.02) and 70% (p < 0.001), respectively. These results are encouraging. However, there are relatively few clinical studies on the effectiveness of polysaccharide therapy for colon cancer, and ensuring the effective bioavailability of polysaccharides in the body remains a challenge. In this article, we elucidate the impact of the physicochemical factors of polysaccharides on their anticancer effects and then reveal the anti-tumor effects and mechanisms of natural polysaccharides on colon cancer. Finally, we emphasize the challenges of using polysaccharides in the treatment of colon cancer and discuss future applications. colon cancer polysaccharide immunity intestinal microbiota apoptosis Medicine (General) Jianshu Zhu verfasserin aut He Zhu verfasserin aut Yinmeng Zhang verfasserin aut Hong Xu verfasserin aut In Frontiers in Medicine Frontiers Media S.A., 2014 10(2024) (DE-627)789482991 (DE-600)2775999-4 2296858X nnns volume:10 year:2024 https://doi.org/10.3389/fmed.2023.1325491 kostenfrei https://doaj.org/article/102c7911a6354390ba76f7eed1c7c86a kostenfrei https://www.frontiersin.org/articles/10.3389/fmed.2023.1325491/full kostenfrei https://doaj.org/toc/2296-858X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2024
allfields_unstemmed	10.3389/fmed.2023.1325491 doi (DE-627)DOAJ097940852 (DE-599)DOAJ102c7911a6354390ba76f7eed1c7c86a DE-627 ger DE-627 rakwb eng R5-920 Jiawei Fan verfasserin aut Potential therapeutic target for polysaccharide inhibition of colon cancer progression 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In recent years, colon cancer has become one of the most common malignant tumors worldwide, posing a great threat to human health. Studies have shown that natural polysaccharides have rich biological activities and medicinal value, such as anti-inflammatory, anti-cancer, anti-oxidation, and immune-enhancing effects, especially with potential anti-colon cancer mechanisms. Natural polysaccharides can not only protect and enhance the homeostasis of the intestinal environment but also exert a direct inhibition effect on cancer cells, making it a promising strategy for treating colon cancer. Preliminary clinical experiments have demonstrated that oral administration of low and high doses of citrus pectin polysaccharides can reduce tumor volume in mice by 38% (p < 0.02) and 70% (p < 0.001), respectively. These results are encouraging. However, there are relatively few clinical studies on the effectiveness of polysaccharide therapy for colon cancer, and ensuring the effective bioavailability of polysaccharides in the body remains a challenge. In this article, we elucidate the impact of the physicochemical factors of polysaccharides on their anticancer effects and then reveal the anti-tumor effects and mechanisms of natural polysaccharides on colon cancer. Finally, we emphasize the challenges of using polysaccharides in the treatment of colon cancer and discuss future applications. colon cancer polysaccharide immunity intestinal microbiota apoptosis Medicine (General) Jianshu Zhu verfasserin aut He Zhu verfasserin aut Yinmeng Zhang verfasserin aut Hong Xu verfasserin aut In Frontiers in Medicine Frontiers Media S.A., 2014 10(2024) (DE-627)789482991 (DE-600)2775999-4 2296858X nnns volume:10 year:2024 https://doi.org/10.3389/fmed.2023.1325491 kostenfrei https://doaj.org/article/102c7911a6354390ba76f7eed1c7c86a kostenfrei https://www.frontiersin.org/articles/10.3389/fmed.2023.1325491/full kostenfrei https://doaj.org/toc/2296-858X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2024
allfieldsGer	10.3389/fmed.2023.1325491 doi (DE-627)DOAJ097940852 (DE-599)DOAJ102c7911a6354390ba76f7eed1c7c86a DE-627 ger DE-627 rakwb eng R5-920 Jiawei Fan verfasserin aut Potential therapeutic target for polysaccharide inhibition of colon cancer progression 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In recent years, colon cancer has become one of the most common malignant tumors worldwide, posing a great threat to human health. Studies have shown that natural polysaccharides have rich biological activities and medicinal value, such as anti-inflammatory, anti-cancer, anti-oxidation, and immune-enhancing effects, especially with potential anti-colon cancer mechanisms. Natural polysaccharides can not only protect and enhance the homeostasis of the intestinal environment but also exert a direct inhibition effect on cancer cells, making it a promising strategy for treating colon cancer. Preliminary clinical experiments have demonstrated that oral administration of low and high doses of citrus pectin polysaccharides can reduce tumor volume in mice by 38% (p < 0.02) and 70% (p < 0.001), respectively. These results are encouraging. However, there are relatively few clinical studies on the effectiveness of polysaccharide therapy for colon cancer, and ensuring the effective bioavailability of polysaccharides in the body remains a challenge. In this article, we elucidate the impact of the physicochemical factors of polysaccharides on their anticancer effects and then reveal the anti-tumor effects and mechanisms of natural polysaccharides on colon cancer. Finally, we emphasize the challenges of using polysaccharides in the treatment of colon cancer and discuss future applications. colon cancer polysaccharide immunity intestinal microbiota apoptosis Medicine (General) Jianshu Zhu verfasserin aut He Zhu verfasserin aut Yinmeng Zhang verfasserin aut Hong Xu verfasserin aut In Frontiers in Medicine Frontiers Media S.A., 2014 10(2024) (DE-627)789482991 (DE-600)2775999-4 2296858X nnns volume:10 year:2024 https://doi.org/10.3389/fmed.2023.1325491 kostenfrei https://doaj.org/article/102c7911a6354390ba76f7eed1c7c86a kostenfrei https://www.frontiersin.org/articles/10.3389/fmed.2023.1325491/full kostenfrei https://doaj.org/toc/2296-858X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2024
allfieldsSound	10.3389/fmed.2023.1325491 doi (DE-627)DOAJ097940852 (DE-599)DOAJ102c7911a6354390ba76f7eed1c7c86a DE-627 ger DE-627 rakwb eng R5-920 Jiawei Fan verfasserin aut Potential therapeutic target for polysaccharide inhibition of colon cancer progression 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In recent years, colon cancer has become one of the most common malignant tumors worldwide, posing a great threat to human health. Studies have shown that natural polysaccharides have rich biological activities and medicinal value, such as anti-inflammatory, anti-cancer, anti-oxidation, and immune-enhancing effects, especially with potential anti-colon cancer mechanisms. Natural polysaccharides can not only protect and enhance the homeostasis of the intestinal environment but also exert a direct inhibition effect on cancer cells, making it a promising strategy for treating colon cancer. Preliminary clinical experiments have demonstrated that oral administration of low and high doses of citrus pectin polysaccharides can reduce tumor volume in mice by 38% (p < 0.02) and 70% (p < 0.001), respectively. These results are encouraging. However, there are relatively few clinical studies on the effectiveness of polysaccharide therapy for colon cancer, and ensuring the effective bioavailability of polysaccharides in the body remains a challenge. In this article, we elucidate the impact of the physicochemical factors of polysaccharides on their anticancer effects and then reveal the anti-tumor effects and mechanisms of natural polysaccharides on colon cancer. Finally, we emphasize the challenges of using polysaccharides in the treatment of colon cancer and discuss future applications. colon cancer polysaccharide immunity intestinal microbiota apoptosis Medicine (General) Jianshu Zhu verfasserin aut He Zhu verfasserin aut Yinmeng Zhang verfasserin aut Hong Xu verfasserin aut In Frontiers in Medicine Frontiers Media S.A., 2014 10(2024) (DE-627)789482991 (DE-600)2775999-4 2296858X nnns volume:10 year:2024 https://doi.org/10.3389/fmed.2023.1325491 kostenfrei https://doaj.org/article/102c7911a6354390ba76f7eed1c7c86a kostenfrei https://www.frontiersin.org/articles/10.3389/fmed.2023.1325491/full kostenfrei https://doaj.org/toc/2296-858X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2024
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callnumber-first	R - Medicine
author	Jiawei Fan
spellingShingle	Jiawei Fan misc R5-920 misc colon cancer misc polysaccharide misc immunity misc intestinal microbiota misc apoptosis misc Medicine (General) Potential therapeutic target for polysaccharide inhibition of colon cancer progression
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topic_title	R5-920 Potential therapeutic target for polysaccharide inhibition of colon cancer progression colon cancer polysaccharide immunity intestinal microbiota apoptosis
topic	misc R5-920 misc colon cancer misc polysaccharide misc immunity misc intestinal microbiota misc apoptosis misc Medicine (General)
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title	Potential therapeutic target for polysaccharide inhibition of colon cancer progression
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title_full	Potential therapeutic target for polysaccharide inhibition of colon cancer progression
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title_sort	potential therapeutic target for polysaccharide inhibition of colon cancer progression
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title_auth	Potential therapeutic target for polysaccharide inhibition of colon cancer progression
abstract	In recent years, colon cancer has become one of the most common malignant tumors worldwide, posing a great threat to human health. Studies have shown that natural polysaccharides have rich biological activities and medicinal value, such as anti-inflammatory, anti-cancer, anti-oxidation, and immune-enhancing effects, especially with potential anti-colon cancer mechanisms. Natural polysaccharides can not only protect and enhance the homeostasis of the intestinal environment but also exert a direct inhibition effect on cancer cells, making it a promising strategy for treating colon cancer. Preliminary clinical experiments have demonstrated that oral administration of low and high doses of citrus pectin polysaccharides can reduce tumor volume in mice by 38% (p < 0.02) and 70% (p < 0.001), respectively. These results are encouraging. However, there are relatively few clinical studies on the effectiveness of polysaccharide therapy for colon cancer, and ensuring the effective bioavailability of polysaccharides in the body remains a challenge. In this article, we elucidate the impact of the physicochemical factors of polysaccharides on their anticancer effects and then reveal the anti-tumor effects and mechanisms of natural polysaccharides on colon cancer. Finally, we emphasize the challenges of using polysaccharides in the treatment of colon cancer and discuss future applications.
abstractGer	In recent years, colon cancer has become one of the most common malignant tumors worldwide, posing a great threat to human health. Studies have shown that natural polysaccharides have rich biological activities and medicinal value, such as anti-inflammatory, anti-cancer, anti-oxidation, and immune-enhancing effects, especially with potential anti-colon cancer mechanisms. Natural polysaccharides can not only protect and enhance the homeostasis of the intestinal environment but also exert a direct inhibition effect on cancer cells, making it a promising strategy for treating colon cancer. Preliminary clinical experiments have demonstrated that oral administration of low and high doses of citrus pectin polysaccharides can reduce tumor volume in mice by 38% (p < 0.02) and 70% (p < 0.001), respectively. These results are encouraging. However, there are relatively few clinical studies on the effectiveness of polysaccharide therapy for colon cancer, and ensuring the effective bioavailability of polysaccharides in the body remains a challenge. In this article, we elucidate the impact of the physicochemical factors of polysaccharides on their anticancer effects and then reveal the anti-tumor effects and mechanisms of natural polysaccharides on colon cancer. Finally, we emphasize the challenges of using polysaccharides in the treatment of colon cancer and discuss future applications.
abstract_unstemmed	In recent years, colon cancer has become one of the most common malignant tumors worldwide, posing a great threat to human health. Studies have shown that natural polysaccharides have rich biological activities and medicinal value, such as anti-inflammatory, anti-cancer, anti-oxidation, and immune-enhancing effects, especially with potential anti-colon cancer mechanisms. Natural polysaccharides can not only protect and enhance the homeostasis of the intestinal environment but also exert a direct inhibition effect on cancer cells, making it a promising strategy for treating colon cancer. Preliminary clinical experiments have demonstrated that oral administration of low and high doses of citrus pectin polysaccharides can reduce tumor volume in mice by 38% (p < 0.02) and 70% (p < 0.001), respectively. These results are encouraging. However, there are relatively few clinical studies on the effectiveness of polysaccharide therapy for colon cancer, and ensuring the effective bioavailability of polysaccharides in the body remains a challenge. In this article, we elucidate the impact of the physicochemical factors of polysaccharides on their anticancer effects and then reveal the anti-tumor effects and mechanisms of natural polysaccharides on colon cancer. Finally, we emphasize the challenges of using polysaccharides in the treatment of colon cancer and discuss future applications.
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title_short	Potential therapeutic target for polysaccharide inhibition of colon cancer progression
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Potential therapeutic target for polysaccharide inhibition of colon cancer progression

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