High‐mobility group box 1 emerges as a therapeutic target for asthma

Abstract High‐mobility group box 1 (HMGB1) is a highly conserved nonhistone nuclear protein found in the calf thymus and participates in a variety of intracellular processes such as DNA transcription, replication and repair. In the cytoplasm, HMGB1 promotes mitochondrial autophagy and is involved in...
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Autor*in:	Qianni Yang [verfasserIn] Min Li [verfasserIn] Yunjiao Hou [verfasserIn] Huilin He [verfasserIn] Shibo Sun [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	asthma autophagy HMGB1 inflammation

Übergeordnetes Werk:	In: Immunity, Inflammation and Disease - Wiley, 2014, 11(2023), 12, Seite n/a-n/a
Übergeordnetes Werk:	volume:11 ; year:2023 ; number:12 ; pages:n/a-n/a

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1002/iid3.1124

Katalog-ID:	DOAJ097996661

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520			\|a Abstract High‐mobility group box 1 (HMGB1) is a highly conserved nonhistone nuclear protein found in the calf thymus and participates in a variety of intracellular processes such as DNA transcription, replication and repair. In the cytoplasm, HMGB1 promotes mitochondrial autophagy and is involved in in cellular stress response. Once released into the extracellular, HMGB1 becomes an inflammatory factor that triggers inflammatory responses and a variety of immune responses. In addition, HMGB1 binding with the corresponding receptor can activate the downstream substrate to carry out several biological effects. Meanwhile, HMGB1 is involved in various signaling pathways, such as the HMGB1/RAGE pathway, HMGB1/NF‐κB pathway, and HMGB1/JAK/STAT pathway, which ultimately promote inflammation. Moreover, HMGB1 may be involved in the pathogenesis of asthma by regulating downstream signaling pathways through corresponding receptors and mediates a number of signaling pathways in asthma, such as HMGB1/TLR4/NF‐κB, HMGB1/RAGE, HMGB1/TGF‐β, and so forth. Accordingly, HMGB1 emerges as a therapeutic target for asthma.
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allfields	10.1002/iid3.1124 doi (DE-627)DOAJ097996661 (DE-599)DOAJa8dbd61fc8404fd4ae653a3da50e485b DE-627 ger DE-627 rakwb eng RC581-607 Qianni Yang verfasserin aut High‐mobility group box 1 emerges as a therapeutic target for asthma 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract High‐mobility group box 1 (HMGB1) is a highly conserved nonhistone nuclear protein found in the calf thymus and participates in a variety of intracellular processes such as DNA transcription, replication and repair. In the cytoplasm, HMGB1 promotes mitochondrial autophagy and is involved in in cellular stress response. Once released into the extracellular, HMGB1 becomes an inflammatory factor that triggers inflammatory responses and a variety of immune responses. In addition, HMGB1 binding with the corresponding receptor can activate the downstream substrate to carry out several biological effects. Meanwhile, HMGB1 is involved in various signaling pathways, such as the HMGB1/RAGE pathway, HMGB1/NF‐κB pathway, and HMGB1/JAK/STAT pathway, which ultimately promote inflammation. Moreover, HMGB1 may be involved in the pathogenesis of asthma by regulating downstream signaling pathways through corresponding receptors and mediates a number of signaling pathways in asthma, such as HMGB1/TLR4/NF‐κB, HMGB1/RAGE, HMGB1/TGF‐β, and so forth. Accordingly, HMGB1 emerges as a therapeutic target for asthma. asthma autophagy HMGB1 inflammation Immunologic diseases. Allergy Min Li verfasserin aut Yunjiao Hou verfasserin aut Huilin He verfasserin aut Shibo Sun verfasserin aut In Immunity, Inflammation and Disease Wiley, 2014 11(2023), 12, Seite n/a-n/a (DE-627)771394616 (DE-600)2740382-8 20504527 nnns volume:11 year:2023 number:12 pages:n/a-n/a https://doi.org/10.1002/iid3.1124 kostenfrei https://doaj.org/article/a8dbd61fc8404fd4ae653a3da50e485b kostenfrei https://doi.org/10.1002/iid3.1124 kostenfrei https://doaj.org/toc/2050-4527 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2023 12 n/a-n/a
spelling	10.1002/iid3.1124 doi (DE-627)DOAJ097996661 (DE-599)DOAJa8dbd61fc8404fd4ae653a3da50e485b DE-627 ger DE-627 rakwb eng RC581-607 Qianni Yang verfasserin aut High‐mobility group box 1 emerges as a therapeutic target for asthma 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract High‐mobility group box 1 (HMGB1) is a highly conserved nonhistone nuclear protein found in the calf thymus and participates in a variety of intracellular processes such as DNA transcription, replication and repair. In the cytoplasm, HMGB1 promotes mitochondrial autophagy and is involved in in cellular stress response. Once released into the extracellular, HMGB1 becomes an inflammatory factor that triggers inflammatory responses and a variety of immune responses. In addition, HMGB1 binding with the corresponding receptor can activate the downstream substrate to carry out several biological effects. Meanwhile, HMGB1 is involved in various signaling pathways, such as the HMGB1/RAGE pathway, HMGB1/NF‐κB pathway, and HMGB1/JAK/STAT pathway, which ultimately promote inflammation. Moreover, HMGB1 may be involved in the pathogenesis of asthma by regulating downstream signaling pathways through corresponding receptors and mediates a number of signaling pathways in asthma, such as HMGB1/TLR4/NF‐κB, HMGB1/RAGE, HMGB1/TGF‐β, and so forth. Accordingly, HMGB1 emerges as a therapeutic target for asthma. asthma autophagy HMGB1 inflammation Immunologic diseases. Allergy Min Li verfasserin aut Yunjiao Hou verfasserin aut Huilin He verfasserin aut Shibo Sun verfasserin aut In Immunity, Inflammation and Disease Wiley, 2014 11(2023), 12, Seite n/a-n/a (DE-627)771394616 (DE-600)2740382-8 20504527 nnns volume:11 year:2023 number:12 pages:n/a-n/a https://doi.org/10.1002/iid3.1124 kostenfrei https://doaj.org/article/a8dbd61fc8404fd4ae653a3da50e485b kostenfrei https://doi.org/10.1002/iid3.1124 kostenfrei https://doaj.org/toc/2050-4527 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2023 12 n/a-n/a
allfields_unstemmed	10.1002/iid3.1124 doi (DE-627)DOAJ097996661 (DE-599)DOAJa8dbd61fc8404fd4ae653a3da50e485b DE-627 ger DE-627 rakwb eng RC581-607 Qianni Yang verfasserin aut High‐mobility group box 1 emerges as a therapeutic target for asthma 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract High‐mobility group box 1 (HMGB1) is a highly conserved nonhistone nuclear protein found in the calf thymus and participates in a variety of intracellular processes such as DNA transcription, replication and repair. In the cytoplasm, HMGB1 promotes mitochondrial autophagy and is involved in in cellular stress response. Once released into the extracellular, HMGB1 becomes an inflammatory factor that triggers inflammatory responses and a variety of immune responses. In addition, HMGB1 binding with the corresponding receptor can activate the downstream substrate to carry out several biological effects. Meanwhile, HMGB1 is involved in various signaling pathways, such as the HMGB1/RAGE pathway, HMGB1/NF‐κB pathway, and HMGB1/JAK/STAT pathway, which ultimately promote inflammation. Moreover, HMGB1 may be involved in the pathogenesis of asthma by regulating downstream signaling pathways through corresponding receptors and mediates a number of signaling pathways in asthma, such as HMGB1/TLR4/NF‐κB, HMGB1/RAGE, HMGB1/TGF‐β, and so forth. Accordingly, HMGB1 emerges as a therapeutic target for asthma. asthma autophagy HMGB1 inflammation Immunologic diseases. Allergy Min Li verfasserin aut Yunjiao Hou verfasserin aut Huilin He verfasserin aut Shibo Sun verfasserin aut In Immunity, Inflammation and Disease Wiley, 2014 11(2023), 12, Seite n/a-n/a (DE-627)771394616 (DE-600)2740382-8 20504527 nnns volume:11 year:2023 number:12 pages:n/a-n/a https://doi.org/10.1002/iid3.1124 kostenfrei https://doaj.org/article/a8dbd61fc8404fd4ae653a3da50e485b kostenfrei https://doi.org/10.1002/iid3.1124 kostenfrei https://doaj.org/toc/2050-4527 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2023 12 n/a-n/a
allfieldsGer	10.1002/iid3.1124 doi (DE-627)DOAJ097996661 (DE-599)DOAJa8dbd61fc8404fd4ae653a3da50e485b DE-627 ger DE-627 rakwb eng RC581-607 Qianni Yang verfasserin aut High‐mobility group box 1 emerges as a therapeutic target for asthma 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract High‐mobility group box 1 (HMGB1) is a highly conserved nonhistone nuclear protein found in the calf thymus and participates in a variety of intracellular processes such as DNA transcription, replication and repair. In the cytoplasm, HMGB1 promotes mitochondrial autophagy and is involved in in cellular stress response. Once released into the extracellular, HMGB1 becomes an inflammatory factor that triggers inflammatory responses and a variety of immune responses. In addition, HMGB1 binding with the corresponding receptor can activate the downstream substrate to carry out several biological effects. Meanwhile, HMGB1 is involved in various signaling pathways, such as the HMGB1/RAGE pathway, HMGB1/NF‐κB pathway, and HMGB1/JAK/STAT pathway, which ultimately promote inflammation. Moreover, HMGB1 may be involved in the pathogenesis of asthma by regulating downstream signaling pathways through corresponding receptors and mediates a number of signaling pathways in asthma, such as HMGB1/TLR4/NF‐κB, HMGB1/RAGE, HMGB1/TGF‐β, and so forth. Accordingly, HMGB1 emerges as a therapeutic target for asthma. asthma autophagy HMGB1 inflammation Immunologic diseases. Allergy Min Li verfasserin aut Yunjiao Hou verfasserin aut Huilin He verfasserin aut Shibo Sun verfasserin aut In Immunity, Inflammation and Disease Wiley, 2014 11(2023), 12, Seite n/a-n/a (DE-627)771394616 (DE-600)2740382-8 20504527 nnns volume:11 year:2023 number:12 pages:n/a-n/a https://doi.org/10.1002/iid3.1124 kostenfrei https://doaj.org/article/a8dbd61fc8404fd4ae653a3da50e485b kostenfrei https://doi.org/10.1002/iid3.1124 kostenfrei https://doaj.org/toc/2050-4527 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2023 12 n/a-n/a
allfieldsSound	10.1002/iid3.1124 doi (DE-627)DOAJ097996661 (DE-599)DOAJa8dbd61fc8404fd4ae653a3da50e485b DE-627 ger DE-627 rakwb eng RC581-607 Qianni Yang verfasserin aut High‐mobility group box 1 emerges as a therapeutic target for asthma 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract High‐mobility group box 1 (HMGB1) is a highly conserved nonhistone nuclear protein found in the calf thymus and participates in a variety of intracellular processes such as DNA transcription, replication and repair. In the cytoplasm, HMGB1 promotes mitochondrial autophagy and is involved in in cellular stress response. Once released into the extracellular, HMGB1 becomes an inflammatory factor that triggers inflammatory responses and a variety of immune responses. In addition, HMGB1 binding with the corresponding receptor can activate the downstream substrate to carry out several biological effects. Meanwhile, HMGB1 is involved in various signaling pathways, such as the HMGB1/RAGE pathway, HMGB1/NF‐κB pathway, and HMGB1/JAK/STAT pathway, which ultimately promote inflammation. Moreover, HMGB1 may be involved in the pathogenesis of asthma by regulating downstream signaling pathways through corresponding receptors and mediates a number of signaling pathways in asthma, such as HMGB1/TLR4/NF‐κB, HMGB1/RAGE, HMGB1/TGF‐β, and so forth. Accordingly, HMGB1 emerges as a therapeutic target for asthma. asthma autophagy HMGB1 inflammation Immunologic diseases. Allergy Min Li verfasserin aut Yunjiao Hou verfasserin aut Huilin He verfasserin aut Shibo Sun verfasserin aut In Immunity, Inflammation and Disease Wiley, 2014 11(2023), 12, Seite n/a-n/a (DE-627)771394616 (DE-600)2740382-8 20504527 nnns volume:11 year:2023 number:12 pages:n/a-n/a https://doi.org/10.1002/iid3.1124 kostenfrei https://doaj.org/article/a8dbd61fc8404fd4ae653a3da50e485b kostenfrei https://doi.org/10.1002/iid3.1124 kostenfrei https://doaj.org/toc/2050-4527 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2023 12 n/a-n/a
language	English
source	In Immunity, Inflammation and Disease 11(2023), 12, Seite n/a-n/a volume:11 year:2023 number:12 pages:n/a-n/a
sourceStr	In Immunity, Inflammation and Disease 11(2023), 12, Seite n/a-n/a volume:11 year:2023 number:12 pages:n/a-n/a
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	asthma autophagy HMGB1 inflammation Immunologic diseases. Allergy
isfreeaccess_bool	true
container_title	Immunity, Inflammation and Disease
authorswithroles_txt_mv	Qianni Yang @@aut@@ Min Li @@aut@@ Yunjiao Hou @@aut@@ Huilin He @@aut@@ Shibo Sun @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	771394616
id	DOAJ097996661
language_de	englisch
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callnumber-first	R - Medicine
author	Qianni Yang
spellingShingle	Qianni Yang misc RC581-607 misc asthma misc autophagy misc HMGB1 misc inflammation misc Immunologic diseases. Allergy High‐mobility group box 1 emerges as a therapeutic target for asthma
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topic_title	RC581-607 High‐mobility group box 1 emerges as a therapeutic target for asthma asthma autophagy HMGB1 inflammation
topic	misc RC581-607 misc asthma misc autophagy misc HMGB1 misc inflammation misc Immunologic diseases. Allergy
topic_unstemmed	misc RC581-607 misc asthma misc autophagy misc HMGB1 misc inflammation misc Immunologic diseases. Allergy
topic_browse	misc RC581-607 misc asthma misc autophagy misc HMGB1 misc inflammation misc Immunologic diseases. Allergy
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title	High‐mobility group box 1 emerges as a therapeutic target for asthma
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title_full	High‐mobility group box 1 emerges as a therapeutic target for asthma
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author_browse	Qianni Yang Min Li Yunjiao Hou Huilin He Shibo Sun
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title_sort	high‐mobility group box 1 emerges as a therapeutic target for asthma
callnumber	RC581-607
title_auth	High‐mobility group box 1 emerges as a therapeutic target for asthma
abstract	Abstract High‐mobility group box 1 (HMGB1) is a highly conserved nonhistone nuclear protein found in the calf thymus and participates in a variety of intracellular processes such as DNA transcription, replication and repair. In the cytoplasm, HMGB1 promotes mitochondrial autophagy and is involved in in cellular stress response. Once released into the extracellular, HMGB1 becomes an inflammatory factor that triggers inflammatory responses and a variety of immune responses. In addition, HMGB1 binding with the corresponding receptor can activate the downstream substrate to carry out several biological effects. Meanwhile, HMGB1 is involved in various signaling pathways, such as the HMGB1/RAGE pathway, HMGB1/NF‐κB pathway, and HMGB1/JAK/STAT pathway, which ultimately promote inflammation. Moreover, HMGB1 may be involved in the pathogenesis of asthma by regulating downstream signaling pathways through corresponding receptors and mediates a number of signaling pathways in asthma, such as HMGB1/TLR4/NF‐κB, HMGB1/RAGE, HMGB1/TGF‐β, and so forth. Accordingly, HMGB1 emerges as a therapeutic target for asthma.
abstractGer	Abstract High‐mobility group box 1 (HMGB1) is a highly conserved nonhistone nuclear protein found in the calf thymus and participates in a variety of intracellular processes such as DNA transcription, replication and repair. In the cytoplasm, HMGB1 promotes mitochondrial autophagy and is involved in in cellular stress response. Once released into the extracellular, HMGB1 becomes an inflammatory factor that triggers inflammatory responses and a variety of immune responses. In addition, HMGB1 binding with the corresponding receptor can activate the downstream substrate to carry out several biological effects. Meanwhile, HMGB1 is involved in various signaling pathways, such as the HMGB1/RAGE pathway, HMGB1/NF‐κB pathway, and HMGB1/JAK/STAT pathway, which ultimately promote inflammation. Moreover, HMGB1 may be involved in the pathogenesis of asthma by regulating downstream signaling pathways through corresponding receptors and mediates a number of signaling pathways in asthma, such as HMGB1/TLR4/NF‐κB, HMGB1/RAGE, HMGB1/TGF‐β, and so forth. Accordingly, HMGB1 emerges as a therapeutic target for asthma.
abstract_unstemmed	Abstract High‐mobility group box 1 (HMGB1) is a highly conserved nonhistone nuclear protein found in the calf thymus and participates in a variety of intracellular processes such as DNA transcription, replication and repair. In the cytoplasm, HMGB1 promotes mitochondrial autophagy and is involved in in cellular stress response. Once released into the extracellular, HMGB1 becomes an inflammatory factor that triggers inflammatory responses and a variety of immune responses. In addition, HMGB1 binding with the corresponding receptor can activate the downstream substrate to carry out several biological effects. Meanwhile, HMGB1 is involved in various signaling pathways, such as the HMGB1/RAGE pathway, HMGB1/NF‐κB pathway, and HMGB1/JAK/STAT pathway, which ultimately promote inflammation. Moreover, HMGB1 may be involved in the pathogenesis of asthma by regulating downstream signaling pathways through corresponding receptors and mediates a number of signaling pathways in asthma, such as HMGB1/TLR4/NF‐κB, HMGB1/RAGE, HMGB1/TGF‐β, and so forth. Accordingly, HMGB1 emerges as a therapeutic target for asthma.
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container_issue	12
title_short	High‐mobility group box 1 emerges as a therapeutic target for asthma
url	https://doi.org/10.1002/iid3.1124 https://doaj.org/article/a8dbd61fc8404fd4ae653a3da50e485b https://doaj.org/toc/2050-4527
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up_date	2024-07-03T14:52:41.666Z
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High‐mobility group box 1 emerges as a therapeutic target for asthma

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