Exploring the genetic diversity of the Japanese population: Insights from a large-scale whole genome sequencing analysis.

The Japanese archipelago is a terminal location for human migration, and the contemporary Japanese people represent a unique population whose genomic diversity has been shaped by multiple migrations from Eurasia. We analyzed the genomic characteristics that define the genetic makeup of the modern Ja...
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Autor*in:	Yosuke Kawai [verfasserIn] Yusuke Watanabe [verfasserIn] Yosuke Omae [verfasserIn] Reiko Miyahara [verfasserIn] Seik-Soon Khor [verfasserIn] Eisei Noiri [verfasserIn] Koji Kitajima [verfasserIn] Hideyuki Shimanuki [verfasserIn] Hiroyuki Gatanaga [verfasserIn] Kenichiro Hata [verfasserIn] Kotaro Hattori [verfasserIn] Aritoshi Iida [verfasserIn] Hatsue Ishibashi-Ueda [verfasserIn] Tadashi Kaname [verfasserIn] Tatsuya Kanto [verfasserIn] Ryo Matsumura [verfasserIn] Kengo Miyo [verfasserIn] Michio Noguchi [verfasserIn] Kouichi Ozaki [verfasserIn] Masaya Sugiyama [verfasserIn] Ayako Takahashi [verfasserIn] Haruhiko Tokuda [verfasserIn] Tsutomu Tomita [verfasserIn] Akihiro Umezawa [verfasserIn] Hiroshi Watanabe [verfasserIn] Sumiko Yoshida [verfasserIn] Yu-Ichi Goto [verfasserIn] Yutaka Maruoka [verfasserIn] Yoichi Matsubara [verfasserIn] Shumpei Niida [verfasserIn] Masashi Mizokami [verfasserIn] Katsushi Tokunaga [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Übergeordnetes Werk:	In: PLoS Genetics - Public Library of Science (PLoS), 2005, 19(2023), 12, p e1010625
Übergeordnetes Werk:	volume:19 ; year:2023 ; number:12, p e1010625

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1371/journal.pgen.1010625

Katalog-ID:	DOAJ098131303

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allfields	10.1371/journal.pgen.1010625 doi (DE-627)DOAJ098131303 (DE-599)DOAJ687445c603e447609e3532d4d0fb3522 DE-627 ger DE-627 rakwb eng QH426-470 Yosuke Kawai verfasserin aut Exploring the genetic diversity of the Japanese population: Insights from a large-scale whole genome sequencing analysis. 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The Japanese archipelago is a terminal location for human migration, and the contemporary Japanese people represent a unique population whose genomic diversity has been shaped by multiple migrations from Eurasia. We analyzed the genomic characteristics that define the genetic makeup of the modern Japanese population from a population genetics perspective from the genomic data of 9,287 samples obtained by high-coverage whole-genome sequencing (WGS) by the National Center Biobank Network. The dataset comprised populations from the Ryukyu Islands and other parts of the Japanese archipelago (Hondo). The Hondo population underwent two episodes of population decline during the Jomon period, corresponding to the Late Neolithic, and the Edo period, corresponding to the Early Modern era, while the Ryukyu population experienced a population decline during the shell midden period of the Late Neolithic in this region. Haplotype analysis suggested increased allele frequencies for genes related to alcohol and fatty acid metabolism, which were reported as loci that had experienced positive natural selection. Two genes related to alcohol metabolism were found to be 12,500 years out of phase with the time when they began to increase in the allele frequency; this finding indicates that the genomic diversity of Japanese people has been shaped by events closely related to agriculture and food production. Genetics Yusuke Watanabe verfasserin aut Yosuke Omae verfasserin aut Reiko Miyahara verfasserin aut Seik-Soon Khor verfasserin aut Eisei Noiri verfasserin aut Koji Kitajima verfasserin aut Hideyuki Shimanuki verfasserin aut Hiroyuki Gatanaga verfasserin aut Kenichiro Hata verfasserin aut Kotaro Hattori verfasserin aut Aritoshi Iida verfasserin aut Hatsue Ishibashi-Ueda verfasserin aut Tadashi Kaname verfasserin aut Tatsuya Kanto verfasserin aut Ryo Matsumura verfasserin aut Kengo Miyo verfasserin aut Michio Noguchi verfasserin aut Kouichi Ozaki verfasserin aut Masaya Sugiyama verfasserin aut Ayako Takahashi verfasserin aut Haruhiko Tokuda verfasserin aut Tsutomu Tomita verfasserin aut Akihiro Umezawa verfasserin aut Hiroshi Watanabe verfasserin aut Sumiko Yoshida verfasserin aut Yu-Ichi Goto verfasserin aut Yutaka Maruoka verfasserin aut Yoichi Matsubara verfasserin aut Shumpei Niida verfasserin aut Masashi Mizokami verfasserin aut Katsushi Tokunaga verfasserin aut In PLoS Genetics Public Library of Science (PLoS), 2005 19(2023), 12, p e1010625 (DE-627)485248026 (DE-600)2186725-2 15537404 nnns volume:19 year:2023 number:12, p e1010625 https://doi.org/10.1371/journal.pgen.1010625 kostenfrei https://doaj.org/article/687445c603e447609e3532d4d0fb3522 kostenfrei https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010625&type=printable kostenfrei https://doaj.org/toc/1553-7390 Journal toc kostenfrei https://doaj.org/toc/1553-7404 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2023 12, p e1010625
spelling	10.1371/journal.pgen.1010625 doi (DE-627)DOAJ098131303 (DE-599)DOAJ687445c603e447609e3532d4d0fb3522 DE-627 ger DE-627 rakwb eng QH426-470 Yosuke Kawai verfasserin aut Exploring the genetic diversity of the Japanese population: Insights from a large-scale whole genome sequencing analysis. 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The Japanese archipelago is a terminal location for human migration, and the contemporary Japanese people represent a unique population whose genomic diversity has been shaped by multiple migrations from Eurasia. We analyzed the genomic characteristics that define the genetic makeup of the modern Japanese population from a population genetics perspective from the genomic data of 9,287 samples obtained by high-coverage whole-genome sequencing (WGS) by the National Center Biobank Network. The dataset comprised populations from the Ryukyu Islands and other parts of the Japanese archipelago (Hondo). The Hondo population underwent two episodes of population decline during the Jomon period, corresponding to the Late Neolithic, and the Edo period, corresponding to the Early Modern era, while the Ryukyu population experienced a population decline during the shell midden period of the Late Neolithic in this region. Haplotype analysis suggested increased allele frequencies for genes related to alcohol and fatty acid metabolism, which were reported as loci that had experienced positive natural selection. Two genes related to alcohol metabolism were found to be 12,500 years out of phase with the time when they began to increase in the allele frequency; this finding indicates that the genomic diversity of Japanese people has been shaped by events closely related to agriculture and food production. Genetics Yusuke Watanabe verfasserin aut Yosuke Omae verfasserin aut Reiko Miyahara verfasserin aut Seik-Soon Khor verfasserin aut Eisei Noiri verfasserin aut Koji Kitajima verfasserin aut Hideyuki Shimanuki verfasserin aut Hiroyuki Gatanaga verfasserin aut Kenichiro Hata verfasserin aut Kotaro Hattori verfasserin aut Aritoshi Iida verfasserin aut Hatsue Ishibashi-Ueda verfasserin aut Tadashi Kaname verfasserin aut Tatsuya Kanto verfasserin aut Ryo Matsumura verfasserin aut Kengo Miyo verfasserin aut Michio Noguchi verfasserin aut Kouichi Ozaki verfasserin aut Masaya Sugiyama verfasserin aut Ayako Takahashi verfasserin aut Haruhiko Tokuda verfasserin aut Tsutomu Tomita verfasserin aut Akihiro Umezawa verfasserin aut Hiroshi Watanabe verfasserin aut Sumiko Yoshida verfasserin aut Yu-Ichi Goto verfasserin aut Yutaka Maruoka verfasserin aut Yoichi Matsubara verfasserin aut Shumpei Niida verfasserin aut Masashi Mizokami verfasserin aut Katsushi Tokunaga verfasserin aut In PLoS Genetics Public Library of Science (PLoS), 2005 19(2023), 12, p e1010625 (DE-627)485248026 (DE-600)2186725-2 15537404 nnns volume:19 year:2023 number:12, p e1010625 https://doi.org/10.1371/journal.pgen.1010625 kostenfrei https://doaj.org/article/687445c603e447609e3532d4d0fb3522 kostenfrei https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010625&type=printable kostenfrei https://doaj.org/toc/1553-7390 Journal toc kostenfrei https://doaj.org/toc/1553-7404 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2023 12, p e1010625
allfields_unstemmed	10.1371/journal.pgen.1010625 doi (DE-627)DOAJ098131303 (DE-599)DOAJ687445c603e447609e3532d4d0fb3522 DE-627 ger DE-627 rakwb eng QH426-470 Yosuke Kawai verfasserin aut Exploring the genetic diversity of the Japanese population: Insights from a large-scale whole genome sequencing analysis. 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The Japanese archipelago is a terminal location for human migration, and the contemporary Japanese people represent a unique population whose genomic diversity has been shaped by multiple migrations from Eurasia. We analyzed the genomic characteristics that define the genetic makeup of the modern Japanese population from a population genetics perspective from the genomic data of 9,287 samples obtained by high-coverage whole-genome sequencing (WGS) by the National Center Biobank Network. The dataset comprised populations from the Ryukyu Islands and other parts of the Japanese archipelago (Hondo). The Hondo population underwent two episodes of population decline during the Jomon period, corresponding to the Late Neolithic, and the Edo period, corresponding to the Early Modern era, while the Ryukyu population experienced a population decline during the shell midden period of the Late Neolithic in this region. Haplotype analysis suggested increased allele frequencies for genes related to alcohol and fatty acid metabolism, which were reported as loci that had experienced positive natural selection. Two genes related to alcohol metabolism were found to be 12,500 years out of phase with the time when they began to increase in the allele frequency; this finding indicates that the genomic diversity of Japanese people has been shaped by events closely related to agriculture and food production. Genetics Yusuke Watanabe verfasserin aut Yosuke Omae verfasserin aut Reiko Miyahara verfasserin aut Seik-Soon Khor verfasserin aut Eisei Noiri verfasserin aut Koji Kitajima verfasserin aut Hideyuki Shimanuki verfasserin aut Hiroyuki Gatanaga verfasserin aut Kenichiro Hata verfasserin aut Kotaro Hattori verfasserin aut Aritoshi Iida verfasserin aut Hatsue Ishibashi-Ueda verfasserin aut Tadashi Kaname verfasserin aut Tatsuya Kanto verfasserin aut Ryo Matsumura verfasserin aut Kengo Miyo verfasserin aut Michio Noguchi verfasserin aut Kouichi Ozaki verfasserin aut Masaya Sugiyama verfasserin aut Ayako Takahashi verfasserin aut Haruhiko Tokuda verfasserin aut Tsutomu Tomita verfasserin aut Akihiro Umezawa verfasserin aut Hiroshi Watanabe verfasserin aut Sumiko Yoshida verfasserin aut Yu-Ichi Goto verfasserin aut Yutaka Maruoka verfasserin aut Yoichi Matsubara verfasserin aut Shumpei Niida verfasserin aut Masashi Mizokami verfasserin aut Katsushi Tokunaga verfasserin aut In PLoS Genetics Public Library of Science (PLoS), 2005 19(2023), 12, p e1010625 (DE-627)485248026 (DE-600)2186725-2 15537404 nnns volume:19 year:2023 number:12, p e1010625 https://doi.org/10.1371/journal.pgen.1010625 kostenfrei https://doaj.org/article/687445c603e447609e3532d4d0fb3522 kostenfrei https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010625&type=printable kostenfrei https://doaj.org/toc/1553-7390 Journal toc kostenfrei https://doaj.org/toc/1553-7404 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2023 12, p e1010625
allfieldsGer	10.1371/journal.pgen.1010625 doi (DE-627)DOAJ098131303 (DE-599)DOAJ687445c603e447609e3532d4d0fb3522 DE-627 ger DE-627 rakwb eng QH426-470 Yosuke Kawai verfasserin aut Exploring the genetic diversity of the Japanese population: Insights from a large-scale whole genome sequencing analysis. 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The Japanese archipelago is a terminal location for human migration, and the contemporary Japanese people represent a unique population whose genomic diversity has been shaped by multiple migrations from Eurasia. We analyzed the genomic characteristics that define the genetic makeup of the modern Japanese population from a population genetics perspective from the genomic data of 9,287 samples obtained by high-coverage whole-genome sequencing (WGS) by the National Center Biobank Network. The dataset comprised populations from the Ryukyu Islands and other parts of the Japanese archipelago (Hondo). The Hondo population underwent two episodes of population decline during the Jomon period, corresponding to the Late Neolithic, and the Edo period, corresponding to the Early Modern era, while the Ryukyu population experienced a population decline during the shell midden period of the Late Neolithic in this region. Haplotype analysis suggested increased allele frequencies for genes related to alcohol and fatty acid metabolism, which were reported as loci that had experienced positive natural selection. Two genes related to alcohol metabolism were found to be 12,500 years out of phase with the time when they began to increase in the allele frequency; this finding indicates that the genomic diversity of Japanese people has been shaped by events closely related to agriculture and food production. Genetics Yusuke Watanabe verfasserin aut Yosuke Omae verfasserin aut Reiko Miyahara verfasserin aut Seik-Soon Khor verfasserin aut Eisei Noiri verfasserin aut Koji Kitajima verfasserin aut Hideyuki Shimanuki verfasserin aut Hiroyuki Gatanaga verfasserin aut Kenichiro Hata verfasserin aut Kotaro Hattori verfasserin aut Aritoshi Iida verfasserin aut Hatsue Ishibashi-Ueda verfasserin aut Tadashi Kaname verfasserin aut Tatsuya Kanto verfasserin aut Ryo Matsumura verfasserin aut Kengo Miyo verfasserin aut Michio Noguchi verfasserin aut Kouichi Ozaki verfasserin aut Masaya Sugiyama verfasserin aut Ayako Takahashi verfasserin aut Haruhiko Tokuda verfasserin aut Tsutomu Tomita verfasserin aut Akihiro Umezawa verfasserin aut Hiroshi Watanabe verfasserin aut Sumiko Yoshida verfasserin aut Yu-Ichi Goto verfasserin aut Yutaka Maruoka verfasserin aut Yoichi Matsubara verfasserin aut Shumpei Niida verfasserin aut Masashi Mizokami verfasserin aut Katsushi Tokunaga verfasserin aut In PLoS Genetics Public Library of Science (PLoS), 2005 19(2023), 12, p e1010625 (DE-627)485248026 (DE-600)2186725-2 15537404 nnns volume:19 year:2023 number:12, p e1010625 https://doi.org/10.1371/journal.pgen.1010625 kostenfrei https://doaj.org/article/687445c603e447609e3532d4d0fb3522 kostenfrei https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010625&type=printable kostenfrei https://doaj.org/toc/1553-7390 Journal toc kostenfrei https://doaj.org/toc/1553-7404 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2023 12, p e1010625
allfieldsSound	10.1371/journal.pgen.1010625 doi (DE-627)DOAJ098131303 (DE-599)DOAJ687445c603e447609e3532d4d0fb3522 DE-627 ger DE-627 rakwb eng QH426-470 Yosuke Kawai verfasserin aut Exploring the genetic diversity of the Japanese population: Insights from a large-scale whole genome sequencing analysis. 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The Japanese archipelago is a terminal location for human migration, and the contemporary Japanese people represent a unique population whose genomic diversity has been shaped by multiple migrations from Eurasia. We analyzed the genomic characteristics that define the genetic makeup of the modern Japanese population from a population genetics perspective from the genomic data of 9,287 samples obtained by high-coverage whole-genome sequencing (WGS) by the National Center Biobank Network. The dataset comprised populations from the Ryukyu Islands and other parts of the Japanese archipelago (Hondo). The Hondo population underwent two episodes of population decline during the Jomon period, corresponding to the Late Neolithic, and the Edo period, corresponding to the Early Modern era, while the Ryukyu population experienced a population decline during the shell midden period of the Late Neolithic in this region. Haplotype analysis suggested increased allele frequencies for genes related to alcohol and fatty acid metabolism, which were reported as loci that had experienced positive natural selection. Two genes related to alcohol metabolism were found to be 12,500 years out of phase with the time when they began to increase in the allele frequency; this finding indicates that the genomic diversity of Japanese people has been shaped by events closely related to agriculture and food production. Genetics Yusuke Watanabe verfasserin aut Yosuke Omae verfasserin aut Reiko Miyahara verfasserin aut Seik-Soon Khor verfasserin aut Eisei Noiri verfasserin aut Koji Kitajima verfasserin aut Hideyuki Shimanuki verfasserin aut Hiroyuki Gatanaga verfasserin aut Kenichiro Hata verfasserin aut Kotaro Hattori verfasserin aut Aritoshi Iida verfasserin aut Hatsue Ishibashi-Ueda verfasserin aut Tadashi Kaname verfasserin aut Tatsuya Kanto verfasserin aut Ryo Matsumura verfasserin aut Kengo Miyo verfasserin aut Michio Noguchi verfasserin aut Kouichi Ozaki verfasserin aut Masaya Sugiyama verfasserin aut Ayako Takahashi verfasserin aut Haruhiko Tokuda verfasserin aut Tsutomu Tomita verfasserin aut Akihiro Umezawa verfasserin aut Hiroshi Watanabe verfasserin aut Sumiko Yoshida verfasserin aut Yu-Ichi Goto verfasserin aut Yutaka Maruoka verfasserin aut Yoichi Matsubara verfasserin aut Shumpei Niida verfasserin aut Masashi Mizokami verfasserin aut Katsushi Tokunaga verfasserin aut In PLoS Genetics Public Library of Science (PLoS), 2005 19(2023), 12, p e1010625 (DE-627)485248026 (DE-600)2186725-2 15537404 nnns volume:19 year:2023 number:12, p e1010625 https://doi.org/10.1371/journal.pgen.1010625 kostenfrei https://doaj.org/article/687445c603e447609e3532d4d0fb3522 kostenfrei https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010625&type=printable kostenfrei https://doaj.org/toc/1553-7390 Journal toc kostenfrei https://doaj.org/toc/1553-7404 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2023 12, p e1010625
language	English
source	In PLoS Genetics 19(2023), 12, p e1010625 volume:19 year:2023 number:12, p e1010625
sourceStr	In PLoS Genetics 19(2023), 12, p e1010625 volume:19 year:2023 number:12, p e1010625
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Genetics
isfreeaccess_bool	true
container_title	PLoS Genetics
authorswithroles_txt_mv	Yosuke Kawai @@aut@@ Yusuke Watanabe @@aut@@ Yosuke Omae @@aut@@ Reiko Miyahara @@aut@@ Seik-Soon Khor @@aut@@ Eisei Noiri @@aut@@ Koji Kitajima @@aut@@ Hideyuki Shimanuki @@aut@@ Hiroyuki Gatanaga @@aut@@ Kenichiro Hata @@aut@@ Kotaro Hattori @@aut@@ Aritoshi Iida @@aut@@ Hatsue Ishibashi-Ueda @@aut@@ Tadashi Kaname @@aut@@ Tatsuya Kanto @@aut@@ Ryo Matsumura @@aut@@ Kengo Miyo @@aut@@ Michio Noguchi @@aut@@ Kouichi Ozaki @@aut@@ Masaya Sugiyama @@aut@@ Ayako Takahashi @@aut@@ Haruhiko Tokuda @@aut@@ Tsutomu Tomita @@aut@@ Akihiro Umezawa @@aut@@ Hiroshi Watanabe @@aut@@ Sumiko Yoshida @@aut@@ Yu-Ichi Goto @@aut@@ Yutaka Maruoka @@aut@@ Yoichi Matsubara @@aut@@ Shumpei Niida @@aut@@ Masashi Mizokami @@aut@@ Katsushi Tokunaga @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	485248026
id	DOAJ098131303
language_de	englisch
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author	Yosuke Kawai
spellingShingle	Yosuke Kawai misc QH426-470 misc Genetics Exploring the genetic diversity of the Japanese population: Insights from a large-scale whole genome sequencing analysis.
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topic_title	QH426-470 Exploring the genetic diversity of the Japanese population: Insights from a large-scale whole genome sequencing analysis
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title	Exploring the genetic diversity of the Japanese population: Insights from a large-scale whole genome sequencing analysis.
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title_full	Exploring the genetic diversity of the Japanese population: Insights from a large-scale whole genome sequencing analysis
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author_browse	Yosuke Kawai Yusuke Watanabe Yosuke Omae Reiko Miyahara Seik-Soon Khor Eisei Noiri Koji Kitajima Hideyuki Shimanuki Hiroyuki Gatanaga Kenichiro Hata Kotaro Hattori Aritoshi Iida Hatsue Ishibashi-Ueda Tadashi Kaname Tatsuya Kanto Ryo Matsumura Kengo Miyo Michio Noguchi Kouichi Ozaki Masaya Sugiyama Ayako Takahashi Haruhiko Tokuda Tsutomu Tomita Akihiro Umezawa Hiroshi Watanabe Sumiko Yoshida Yu-Ichi Goto Yutaka Maruoka Yoichi Matsubara Shumpei Niida Masashi Mizokami Katsushi Tokunaga
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title_sort	exploring the genetic diversity of the japanese population: insights from a large-scale whole genome sequencing analysis
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title_auth	Exploring the genetic diversity of the Japanese population: Insights from a large-scale whole genome sequencing analysis.
abstract	The Japanese archipelago is a terminal location for human migration, and the contemporary Japanese people represent a unique population whose genomic diversity has been shaped by multiple migrations from Eurasia. We analyzed the genomic characteristics that define the genetic makeup of the modern Japanese population from a population genetics perspective from the genomic data of 9,287 samples obtained by high-coverage whole-genome sequencing (WGS) by the National Center Biobank Network. The dataset comprised populations from the Ryukyu Islands and other parts of the Japanese archipelago (Hondo). The Hondo population underwent two episodes of population decline during the Jomon period, corresponding to the Late Neolithic, and the Edo period, corresponding to the Early Modern era, while the Ryukyu population experienced a population decline during the shell midden period of the Late Neolithic in this region. Haplotype analysis suggested increased allele frequencies for genes related to alcohol and fatty acid metabolism, which were reported as loci that had experienced positive natural selection. Two genes related to alcohol metabolism were found to be 12,500 years out of phase with the time when they began to increase in the allele frequency; this finding indicates that the genomic diversity of Japanese people has been shaped by events closely related to agriculture and food production.
abstractGer	The Japanese archipelago is a terminal location for human migration, and the contemporary Japanese people represent a unique population whose genomic diversity has been shaped by multiple migrations from Eurasia. We analyzed the genomic characteristics that define the genetic makeup of the modern Japanese population from a population genetics perspective from the genomic data of 9,287 samples obtained by high-coverage whole-genome sequencing (WGS) by the National Center Biobank Network. The dataset comprised populations from the Ryukyu Islands and other parts of the Japanese archipelago (Hondo). The Hondo population underwent two episodes of population decline during the Jomon period, corresponding to the Late Neolithic, and the Edo period, corresponding to the Early Modern era, while the Ryukyu population experienced a population decline during the shell midden period of the Late Neolithic in this region. Haplotype analysis suggested increased allele frequencies for genes related to alcohol and fatty acid metabolism, which were reported as loci that had experienced positive natural selection. Two genes related to alcohol metabolism were found to be 12,500 years out of phase with the time when they began to increase in the allele frequency; this finding indicates that the genomic diversity of Japanese people has been shaped by events closely related to agriculture and food production.
abstract_unstemmed	The Japanese archipelago is a terminal location for human migration, and the contemporary Japanese people represent a unique population whose genomic diversity has been shaped by multiple migrations from Eurasia. We analyzed the genomic characteristics that define the genetic makeup of the modern Japanese population from a population genetics perspective from the genomic data of 9,287 samples obtained by high-coverage whole-genome sequencing (WGS) by the National Center Biobank Network. The dataset comprised populations from the Ryukyu Islands and other parts of the Japanese archipelago (Hondo). The Hondo population underwent two episodes of population decline during the Jomon period, corresponding to the Late Neolithic, and the Edo period, corresponding to the Early Modern era, while the Ryukyu population experienced a population decline during the shell midden period of the Late Neolithic in this region. Haplotype analysis suggested increased allele frequencies for genes related to alcohol and fatty acid metabolism, which were reported as loci that had experienced positive natural selection. Two genes related to alcohol metabolism were found to be 12,500 years out of phase with the time when they began to increase in the allele frequency; this finding indicates that the genomic diversity of Japanese people has been shaped by events closely related to agriculture and food production.
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title_short	Exploring the genetic diversity of the Japanese population: Insights from a large-scale whole genome sequencing analysis.
url	https://doi.org/10.1371/journal.pgen.1010625 https://doaj.org/article/687445c603e447609e3532d4d0fb3522 https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010625&type=printable https://doaj.org/toc/1553-7390 https://doaj.org/toc/1553-7404
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up_date	2024-07-03T15:35:11.838Z
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Exploring the genetic diversity of the Japanese population: Insights from a large-scale whole genome sequencing analysis.

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