Non-cellular immunotherapies in pediatric central nervous system tumors

Central nervous system (CNS) tumors are the second most common type of cancer and the most common cause of cancer death in pediatric patients. New therapies are desperately needed for some of the most malignant of all cancers. Immunotherapy has emerged in the past two decades as an additional avenue...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Sarah Rumler [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	pediatric oncology neuro-oncology pediatric neuro-oncology immune-oncology immune checkpoint inhibitors cancer vaccines

Übergeordnetes Werk:	In: Frontiers in Immunology - Frontiers Media S.A., 2011, 14(2023)
Übergeordnetes Werk:	volume:14 ; year:2023

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fimmu.2023.1242911

Katalog-ID:	DOAJ09833431X

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callnumber-first	R - Medicine
author	Sarah Rumler
spellingShingle	Sarah Rumler misc RC581-607 misc pediatric oncology misc neuro-oncology misc pediatric neuro-oncology misc immune-oncology misc immune checkpoint inhibitors misc cancer vaccines misc Immunologic diseases. Allergy Non-cellular immunotherapies in pediatric central nervous system tumors
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topic_title	RC581-607 Non-cellular immunotherapies in pediatric central nervous system tumors pediatric oncology neuro-oncology pediatric neuro-oncology immune-oncology immune checkpoint inhibitors cancer vaccines
topic	misc RC581-607 misc pediatric oncology misc neuro-oncology misc pediatric neuro-oncology misc immune-oncology misc immune checkpoint inhibitors misc cancer vaccines misc Immunologic diseases. Allergy
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title	Non-cellular immunotherapies in pediatric central nervous system tumors
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title_sort	non-cellular immunotherapies in pediatric central nervous system tumors
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title_auth	Non-cellular immunotherapies in pediatric central nervous system tumors
abstract	Central nervous system (CNS) tumors are the second most common type of cancer and the most common cause of cancer death in pediatric patients. New therapies are desperately needed for some of the most malignant of all cancers. Immunotherapy has emerged in the past two decades as an additional avenue to augment/replace traditional therapies (such as chemotherapy, surgery, and radiation therapy). This article first discusses the unique nature of the pediatric CNS immune system and how it interacts with the systemic immune system. It then goes on to review three important and widely studied types of immune therapies: checkpoint inhibitors, vaccines, and radiation therapy, and touches on early studies of antibody-mediated immunogenic therapies, Finally, the article discusses the importance of combination immunotherapy for pediatric CNS tumors, and addresses the neurologic toxicities associated with immunotherapies.
abstractGer	Central nervous system (CNS) tumors are the second most common type of cancer and the most common cause of cancer death in pediatric patients. New therapies are desperately needed for some of the most malignant of all cancers. Immunotherapy has emerged in the past two decades as an additional avenue to augment/replace traditional therapies (such as chemotherapy, surgery, and radiation therapy). This article first discusses the unique nature of the pediatric CNS immune system and how it interacts with the systemic immune system. It then goes on to review three important and widely studied types of immune therapies: checkpoint inhibitors, vaccines, and radiation therapy, and touches on early studies of antibody-mediated immunogenic therapies, Finally, the article discusses the importance of combination immunotherapy for pediatric CNS tumors, and addresses the neurologic toxicities associated with immunotherapies.
abstract_unstemmed	Central nervous system (CNS) tumors are the second most common type of cancer and the most common cause of cancer death in pediatric patients. New therapies are desperately needed for some of the most malignant of all cancers. Immunotherapy has emerged in the past two decades as an additional avenue to augment/replace traditional therapies (such as chemotherapy, surgery, and radiation therapy). This article first discusses the unique nature of the pediatric CNS immune system and how it interacts with the systemic immune system. It then goes on to review three important and widely studied types of immune therapies: checkpoint inhibitors, vaccines, and radiation therapy, and touches on early studies of antibody-mediated immunogenic therapies, Finally, the article discusses the importance of combination immunotherapy for pediatric CNS tumors, and addresses the neurologic toxicities associated with immunotherapies.
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title_short	Non-cellular immunotherapies in pediatric central nervous system tumors
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