Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
Abstract Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady y...
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In: Journal of Extracellular Vesicles - Wiley, 2012, 13(2024), 2, Seite n/a-n/a |
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volume:13 ; year:2024 ; number:2 ; pages:n/a-n/a |
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| DOI / URN: |
10.1002/jev2.12404 |
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DOAJ098400452 |
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| 520 | |a Abstract Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year‐on‐year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non‐vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its ‘Minimal Information for Studies of Extracellular Vesicles’, which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly. | ||
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10.1002/jev2.12404 doi (DE-627)DOAJ098400452 (DE-599)DOAJ62d9f58d0f2b47e292d51b7893a73080 DE-627 ger DE-627 rakwb eng QH573-671 Joshua A. Welsh verfasserin aut Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year‐on‐year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non‐vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its ‘Minimal Information for Studies of Extracellular Vesicles’, which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly. ectosomes exosomes extracellular vesicles extracellular particles guidelines microparticles Cytology Deborah C. I. Goberdhan verfasserin aut Lorraine O'Driscoll verfasserin aut Edit I. Buzas verfasserin aut Cherie Blenkiron verfasserin aut Benedetta Bussolati verfasserin aut Houjian Cai verfasserin aut Dolores Di Vizio verfasserin aut Tom A. P. Driedonks verfasserin aut Uta Erdbrügger verfasserin aut Juan M. Falcon‐Perez verfasserin aut Qing‐Ling Fu verfasserin aut Andrew F. Hill verfasserin aut Metka Lenassi verfasserin aut Sai Kiang Lim verfasserin aut Mỹ G. Mahoney verfasserin aut Sujata Mohanty verfasserin aut Andreas Möller verfasserin aut Rienk Nieuwland verfasserin aut Takahiro Ochiya verfasserin aut Susmita Sahoo verfasserin aut Ana C. Torrecilhas verfasserin aut Lei Zheng verfasserin aut Andries Zijlstra verfasserin aut Sarah Abuelreich verfasserin aut Reem Bagabas verfasserin aut Paolo Bergese verfasserin aut Esther M. Bridges verfasserin aut Marco Brucale verfasserin aut Dylan Burger verfasserin aut Randy P. Carney verfasserin aut Emanuele Cocucci verfasserin aut Rossella Crescitelli verfasserin aut Edveena Hanser verfasserin aut Adrian L. Harris verfasserin aut Norman J. Haughey verfasserin aut An Hendrix verfasserin aut Alexander R. Ivanov verfasserin aut Tijana Jovanovic‐Talisman verfasserin aut Nicole A. Kruh‐Garcia verfasserin aut Vroniqa Ku'ulei‐Lyn Faustino verfasserin aut Diego Kyburz verfasserin aut Cecilia Lässer verfasserin aut Kathleen M. Lennon verfasserin aut Jan Lötvall verfasserin aut Adam L. Maddox verfasserin aut Elena S. Martens‐Uzunova verfasserin aut Rachel R. Mizenko verfasserin aut Lauren A. Newman verfasserin aut Andrea Ridolfi verfasserin aut Eva Rohde verfasserin aut Tatu Rojalin verfasserin aut Andrew Rowland verfasserin aut Andras Saftics verfasserin aut Ursula S. Sandau verfasserin aut Julie A. Saugstad verfasserin aut Faezeh Shekari verfasserin aut Simon Swift verfasserin aut Dmitry Ter‐Ovanesyan verfasserin aut Juan P. Tosar verfasserin aut Zivile Useckaite verfasserin aut Francesco Valle verfasserin aut Zoltan Varga verfasserin aut Edwin van derPol verfasserin aut Martijn J. C. vanHerwijnen verfasserin aut Marca H. M. Wauben verfasserin aut Ann M. Wehman verfasserin aut Sarah Williams verfasserin aut Andrea Zendrini verfasserin aut Alan J. Zimmerman verfasserin aut MISEV Consortium verfasserin aut Clotilde Théry verfasserin aut Kenneth W. Witwer verfasserin aut In Journal of Extracellular Vesicles Wiley, 2012 13(2024), 2, Seite n/a-n/a (DE-627)726923710 (DE-600)2683797-3 20013078 nnns volume:13 year:2024 number:2 pages:n/a-n/a https://doi.org/10.1002/jev2.12404 kostenfrei https://doaj.org/article/62d9f58d0f2b47e292d51b7893a73080 kostenfrei https://doi.org/10.1002/jev2.12404 kostenfrei https://doaj.org/toc/2001-3078 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2024 2 n/a-n/a |
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10.1002/jev2.12404 doi (DE-627)DOAJ098400452 (DE-599)DOAJ62d9f58d0f2b47e292d51b7893a73080 DE-627 ger DE-627 rakwb eng QH573-671 Joshua A. Welsh verfasserin aut Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year‐on‐year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non‐vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its ‘Minimal Information for Studies of Extracellular Vesicles’, which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly. ectosomes exosomes extracellular vesicles extracellular particles guidelines microparticles Cytology Deborah C. I. Goberdhan verfasserin aut Lorraine O'Driscoll verfasserin aut Edit I. Buzas verfasserin aut Cherie Blenkiron verfasserin aut Benedetta Bussolati verfasserin aut Houjian Cai verfasserin aut Dolores Di Vizio verfasserin aut Tom A. P. Driedonks verfasserin aut Uta Erdbrügger verfasserin aut Juan M. Falcon‐Perez verfasserin aut Qing‐Ling Fu verfasserin aut Andrew F. Hill verfasserin aut Metka Lenassi verfasserin aut Sai Kiang Lim verfasserin aut Mỹ G. Mahoney verfasserin aut Sujata Mohanty verfasserin aut Andreas Möller verfasserin aut Rienk Nieuwland verfasserin aut Takahiro Ochiya verfasserin aut Susmita Sahoo verfasserin aut Ana C. Torrecilhas verfasserin aut Lei Zheng verfasserin aut Andries Zijlstra verfasserin aut Sarah Abuelreich verfasserin aut Reem Bagabas verfasserin aut Paolo Bergese verfasserin aut Esther M. Bridges verfasserin aut Marco Brucale verfasserin aut Dylan Burger verfasserin aut Randy P. Carney verfasserin aut Emanuele Cocucci verfasserin aut Rossella Crescitelli verfasserin aut Edveena Hanser verfasserin aut Adrian L. Harris verfasserin aut Norman J. Haughey verfasserin aut An Hendrix verfasserin aut Alexander R. Ivanov verfasserin aut Tijana Jovanovic‐Talisman verfasserin aut Nicole A. Kruh‐Garcia verfasserin aut Vroniqa Ku'ulei‐Lyn Faustino verfasserin aut Diego Kyburz verfasserin aut Cecilia Lässer verfasserin aut Kathleen M. Lennon verfasserin aut Jan Lötvall verfasserin aut Adam L. Maddox verfasserin aut Elena S. Martens‐Uzunova verfasserin aut Rachel R. Mizenko verfasserin aut Lauren A. Newman verfasserin aut Andrea Ridolfi verfasserin aut Eva Rohde verfasserin aut Tatu Rojalin verfasserin aut Andrew Rowland verfasserin aut Andras Saftics verfasserin aut Ursula S. Sandau verfasserin aut Julie A. Saugstad verfasserin aut Faezeh Shekari verfasserin aut Simon Swift verfasserin aut Dmitry Ter‐Ovanesyan verfasserin aut Juan P. Tosar verfasserin aut Zivile Useckaite verfasserin aut Francesco Valle verfasserin aut Zoltan Varga verfasserin aut Edwin van derPol verfasserin aut Martijn J. C. vanHerwijnen verfasserin aut Marca H. M. Wauben verfasserin aut Ann M. Wehman verfasserin aut Sarah Williams verfasserin aut Andrea Zendrini verfasserin aut Alan J. Zimmerman verfasserin aut MISEV Consortium verfasserin aut Clotilde Théry verfasserin aut Kenneth W. Witwer verfasserin aut In Journal of Extracellular Vesicles Wiley, 2012 13(2024), 2, Seite n/a-n/a (DE-627)726923710 (DE-600)2683797-3 20013078 nnns volume:13 year:2024 number:2 pages:n/a-n/a https://doi.org/10.1002/jev2.12404 kostenfrei https://doaj.org/article/62d9f58d0f2b47e292d51b7893a73080 kostenfrei https://doi.org/10.1002/jev2.12404 kostenfrei https://doaj.org/toc/2001-3078 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2024 2 n/a-n/a |
| allfields_unstemmed |
10.1002/jev2.12404 doi (DE-627)DOAJ098400452 (DE-599)DOAJ62d9f58d0f2b47e292d51b7893a73080 DE-627 ger DE-627 rakwb eng QH573-671 Joshua A. Welsh verfasserin aut Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year‐on‐year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non‐vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its ‘Minimal Information for Studies of Extracellular Vesicles’, which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly. ectosomes exosomes extracellular vesicles extracellular particles guidelines microparticles Cytology Deborah C. I. Goberdhan verfasserin aut Lorraine O'Driscoll verfasserin aut Edit I. Buzas verfasserin aut Cherie Blenkiron verfasserin aut Benedetta Bussolati verfasserin aut Houjian Cai verfasserin aut Dolores Di Vizio verfasserin aut Tom A. P. Driedonks verfasserin aut Uta Erdbrügger verfasserin aut Juan M. Falcon‐Perez verfasserin aut Qing‐Ling Fu verfasserin aut Andrew F. Hill verfasserin aut Metka Lenassi verfasserin aut Sai Kiang Lim verfasserin aut Mỹ G. Mahoney verfasserin aut Sujata Mohanty verfasserin aut Andreas Möller verfasserin aut Rienk Nieuwland verfasserin aut Takahiro Ochiya verfasserin aut Susmita Sahoo verfasserin aut Ana C. Torrecilhas verfasserin aut Lei Zheng verfasserin aut Andries Zijlstra verfasserin aut Sarah Abuelreich verfasserin aut Reem Bagabas verfasserin aut Paolo Bergese verfasserin aut Esther M. Bridges verfasserin aut Marco Brucale verfasserin aut Dylan Burger verfasserin aut Randy P. Carney verfasserin aut Emanuele Cocucci verfasserin aut Rossella Crescitelli verfasserin aut Edveena Hanser verfasserin aut Adrian L. Harris verfasserin aut Norman J. Haughey verfasserin aut An Hendrix verfasserin aut Alexander R. Ivanov verfasserin aut Tijana Jovanovic‐Talisman verfasserin aut Nicole A. Kruh‐Garcia verfasserin aut Vroniqa Ku'ulei‐Lyn Faustino verfasserin aut Diego Kyburz verfasserin aut Cecilia Lässer verfasserin aut Kathleen M. Lennon verfasserin aut Jan Lötvall verfasserin aut Adam L. Maddox verfasserin aut Elena S. Martens‐Uzunova verfasserin aut Rachel R. Mizenko verfasserin aut Lauren A. Newman verfasserin aut Andrea Ridolfi verfasserin aut Eva Rohde verfasserin aut Tatu Rojalin verfasserin aut Andrew Rowland verfasserin aut Andras Saftics verfasserin aut Ursula S. Sandau verfasserin aut Julie A. Saugstad verfasserin aut Faezeh Shekari verfasserin aut Simon Swift verfasserin aut Dmitry Ter‐Ovanesyan verfasserin aut Juan P. Tosar verfasserin aut Zivile Useckaite verfasserin aut Francesco Valle verfasserin aut Zoltan Varga verfasserin aut Edwin van derPol verfasserin aut Martijn J. C. vanHerwijnen verfasserin aut Marca H. M. Wauben verfasserin aut Ann M. Wehman verfasserin aut Sarah Williams verfasserin aut Andrea Zendrini verfasserin aut Alan J. Zimmerman verfasserin aut MISEV Consortium verfasserin aut Clotilde Théry verfasserin aut Kenneth W. Witwer verfasserin aut In Journal of Extracellular Vesicles Wiley, 2012 13(2024), 2, Seite n/a-n/a (DE-627)726923710 (DE-600)2683797-3 20013078 nnns volume:13 year:2024 number:2 pages:n/a-n/a https://doi.org/10.1002/jev2.12404 kostenfrei https://doaj.org/article/62d9f58d0f2b47e292d51b7893a73080 kostenfrei https://doi.org/10.1002/jev2.12404 kostenfrei https://doaj.org/toc/2001-3078 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2024 2 n/a-n/a |
| allfieldsGer |
10.1002/jev2.12404 doi (DE-627)DOAJ098400452 (DE-599)DOAJ62d9f58d0f2b47e292d51b7893a73080 DE-627 ger DE-627 rakwb eng QH573-671 Joshua A. Welsh verfasserin aut Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year‐on‐year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non‐vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its ‘Minimal Information for Studies of Extracellular Vesicles’, which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly. ectosomes exosomes extracellular vesicles extracellular particles guidelines microparticles Cytology Deborah C. I. Goberdhan verfasserin aut Lorraine O'Driscoll verfasserin aut Edit I. Buzas verfasserin aut Cherie Blenkiron verfasserin aut Benedetta Bussolati verfasserin aut Houjian Cai verfasserin aut Dolores Di Vizio verfasserin aut Tom A. P. Driedonks verfasserin aut Uta Erdbrügger verfasserin aut Juan M. Falcon‐Perez verfasserin aut Qing‐Ling Fu verfasserin aut Andrew F. Hill verfasserin aut Metka Lenassi verfasserin aut Sai Kiang Lim verfasserin aut Mỹ G. Mahoney verfasserin aut Sujata Mohanty verfasserin aut Andreas Möller verfasserin aut Rienk Nieuwland verfasserin aut Takahiro Ochiya verfasserin aut Susmita Sahoo verfasserin aut Ana C. Torrecilhas verfasserin aut Lei Zheng verfasserin aut Andries Zijlstra verfasserin aut Sarah Abuelreich verfasserin aut Reem Bagabas verfasserin aut Paolo Bergese verfasserin aut Esther M. Bridges verfasserin aut Marco Brucale verfasserin aut Dylan Burger verfasserin aut Randy P. Carney verfasserin aut Emanuele Cocucci verfasserin aut Rossella Crescitelli verfasserin aut Edveena Hanser verfasserin aut Adrian L. Harris verfasserin aut Norman J. Haughey verfasserin aut An Hendrix verfasserin aut Alexander R. Ivanov verfasserin aut Tijana Jovanovic‐Talisman verfasserin aut Nicole A. Kruh‐Garcia verfasserin aut Vroniqa Ku'ulei‐Lyn Faustino verfasserin aut Diego Kyburz verfasserin aut Cecilia Lässer verfasserin aut Kathleen M. Lennon verfasserin aut Jan Lötvall verfasserin aut Adam L. Maddox verfasserin aut Elena S. Martens‐Uzunova verfasserin aut Rachel R. Mizenko verfasserin aut Lauren A. Newman verfasserin aut Andrea Ridolfi verfasserin aut Eva Rohde verfasserin aut Tatu Rojalin verfasserin aut Andrew Rowland verfasserin aut Andras Saftics verfasserin aut Ursula S. Sandau verfasserin aut Julie A. Saugstad verfasserin aut Faezeh Shekari verfasserin aut Simon Swift verfasserin aut Dmitry Ter‐Ovanesyan verfasserin aut Juan P. Tosar verfasserin aut Zivile Useckaite verfasserin aut Francesco Valle verfasserin aut Zoltan Varga verfasserin aut Edwin van derPol verfasserin aut Martijn J. C. vanHerwijnen verfasserin aut Marca H. M. Wauben verfasserin aut Ann M. Wehman verfasserin aut Sarah Williams verfasserin aut Andrea Zendrini verfasserin aut Alan J. Zimmerman verfasserin aut MISEV Consortium verfasserin aut Clotilde Théry verfasserin aut Kenneth W. Witwer verfasserin aut In Journal of Extracellular Vesicles Wiley, 2012 13(2024), 2, Seite n/a-n/a (DE-627)726923710 (DE-600)2683797-3 20013078 nnns volume:13 year:2024 number:2 pages:n/a-n/a https://doi.org/10.1002/jev2.12404 kostenfrei https://doaj.org/article/62d9f58d0f2b47e292d51b7893a73080 kostenfrei https://doi.org/10.1002/jev2.12404 kostenfrei https://doaj.org/toc/2001-3078 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2024 2 n/a-n/a |
| allfieldsSound |
10.1002/jev2.12404 doi (DE-627)DOAJ098400452 (DE-599)DOAJ62d9f58d0f2b47e292d51b7893a73080 DE-627 ger DE-627 rakwb eng QH573-671 Joshua A. Welsh verfasserin aut Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year‐on‐year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non‐vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its ‘Minimal Information for Studies of Extracellular Vesicles’, which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly. ectosomes exosomes extracellular vesicles extracellular particles guidelines microparticles Cytology Deborah C. I. Goberdhan verfasserin aut Lorraine O'Driscoll verfasserin aut Edit I. Buzas verfasserin aut Cherie Blenkiron verfasserin aut Benedetta Bussolati verfasserin aut Houjian Cai verfasserin aut Dolores Di Vizio verfasserin aut Tom A. P. Driedonks verfasserin aut Uta Erdbrügger verfasserin aut Juan M. Falcon‐Perez verfasserin aut Qing‐Ling Fu verfasserin aut Andrew F. Hill verfasserin aut Metka Lenassi verfasserin aut Sai Kiang Lim verfasserin aut Mỹ G. Mahoney verfasserin aut Sujata Mohanty verfasserin aut Andreas Möller verfasserin aut Rienk Nieuwland verfasserin aut Takahiro Ochiya verfasserin aut Susmita Sahoo verfasserin aut Ana C. Torrecilhas verfasserin aut Lei Zheng verfasserin aut Andries Zijlstra verfasserin aut Sarah Abuelreich verfasserin aut Reem Bagabas verfasserin aut Paolo Bergese verfasserin aut Esther M. Bridges verfasserin aut Marco Brucale verfasserin aut Dylan Burger verfasserin aut Randy P. Carney verfasserin aut Emanuele Cocucci verfasserin aut Rossella Crescitelli verfasserin aut Edveena Hanser verfasserin aut Adrian L. Harris verfasserin aut Norman J. Haughey verfasserin aut An Hendrix verfasserin aut Alexander R. Ivanov verfasserin aut Tijana Jovanovic‐Talisman verfasserin aut Nicole A. Kruh‐Garcia verfasserin aut Vroniqa Ku'ulei‐Lyn Faustino verfasserin aut Diego Kyburz verfasserin aut Cecilia Lässer verfasserin aut Kathleen M. Lennon verfasserin aut Jan Lötvall verfasserin aut Adam L. Maddox verfasserin aut Elena S. Martens‐Uzunova verfasserin aut Rachel R. Mizenko verfasserin aut Lauren A. Newman verfasserin aut Andrea Ridolfi verfasserin aut Eva Rohde verfasserin aut Tatu Rojalin verfasserin aut Andrew Rowland verfasserin aut Andras Saftics verfasserin aut Ursula S. Sandau verfasserin aut Julie A. Saugstad verfasserin aut Faezeh Shekari verfasserin aut Simon Swift verfasserin aut Dmitry Ter‐Ovanesyan verfasserin aut Juan P. Tosar verfasserin aut Zivile Useckaite verfasserin aut Francesco Valle verfasserin aut Zoltan Varga verfasserin aut Edwin van derPol verfasserin aut Martijn J. C. vanHerwijnen verfasserin aut Marca H. M. Wauben verfasserin aut Ann M. Wehman verfasserin aut Sarah Williams verfasserin aut Andrea Zendrini verfasserin aut Alan J. Zimmerman verfasserin aut MISEV Consortium verfasserin aut Clotilde Théry verfasserin aut Kenneth W. Witwer verfasserin aut In Journal of Extracellular Vesicles Wiley, 2012 13(2024), 2, Seite n/a-n/a (DE-627)726923710 (DE-600)2683797-3 20013078 nnns volume:13 year:2024 number:2 pages:n/a-n/a https://doi.org/10.1002/jev2.12404 kostenfrei https://doaj.org/article/62d9f58d0f2b47e292d51b7893a73080 kostenfrei https://doi.org/10.1002/jev2.12404 kostenfrei https://doaj.org/toc/2001-3078 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2024 2 n/a-n/a |
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Joshua A. Welsh @@aut@@ Deborah C. I. Goberdhan @@aut@@ Lorraine O'Driscoll @@aut@@ Edit I. Buzas @@aut@@ Cherie Blenkiron @@aut@@ Benedetta Bussolati @@aut@@ Houjian Cai @@aut@@ Dolores Di Vizio @@aut@@ Tom A. P. Driedonks @@aut@@ Uta Erdbrügger @@aut@@ Juan M. Falcon‐Perez @@aut@@ Qing‐Ling Fu @@aut@@ Andrew F. Hill @@aut@@ Metka Lenassi @@aut@@ Sai Kiang Lim @@aut@@ Mỹ G. Mahoney @@aut@@ Sujata Mohanty @@aut@@ Andreas Möller @@aut@@ Rienk Nieuwland @@aut@@ Takahiro Ochiya @@aut@@ Susmita Sahoo @@aut@@ Ana C. Torrecilhas @@aut@@ Lei Zheng @@aut@@ Andries Zijlstra @@aut@@ Sarah Abuelreich @@aut@@ Reem Bagabas @@aut@@ Paolo Bergese @@aut@@ Esther M. Bridges @@aut@@ Marco Brucale @@aut@@ Dylan Burger @@aut@@ Randy P. Carney @@aut@@ Emanuele Cocucci @@aut@@ Rossella Crescitelli @@aut@@ Edveena Hanser @@aut@@ Adrian L. Harris @@aut@@ Norman J. Haughey @@aut@@ An Hendrix @@aut@@ Alexander R. Ivanov @@aut@@ Tijana Jovanovic‐Talisman @@aut@@ Nicole A. Kruh‐Garcia @@aut@@ Vroniqa Ku'ulei‐Lyn Faustino @@aut@@ Diego Kyburz @@aut@@ Cecilia Lässer @@aut@@ Kathleen M. Lennon @@aut@@ Jan Lötvall @@aut@@ Adam L. Maddox @@aut@@ Elena S. Martens‐Uzunova @@aut@@ Rachel R. Mizenko @@aut@@ Lauren A. Newman @@aut@@ Andrea Ridolfi @@aut@@ Eva Rohde @@aut@@ Tatu Rojalin @@aut@@ Andrew Rowland @@aut@@ Andras Saftics @@aut@@ Ursula S. Sandau @@aut@@ Julie A. Saugstad @@aut@@ Faezeh Shekari @@aut@@ Simon Swift @@aut@@ Dmitry Ter‐Ovanesyan @@aut@@ Juan P. Tosar @@aut@@ Zivile Useckaite @@aut@@ Francesco Valle @@aut@@ Zoltan Varga @@aut@@ Edwin van derPol @@aut@@ Martijn J. C. vanHerwijnen @@aut@@ Marca H. M. Wauben @@aut@@ Ann M. Wehman @@aut@@ Sarah Williams @@aut@@ Andrea Zendrini @@aut@@ Alan J. Zimmerman @@aut@@ MISEV Consortium @@aut@@ Clotilde Théry @@aut@@ Kenneth W. Witwer @@aut@@ |
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Welsh</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2024</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. 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Joshua A. Welsh Deborah C. I. Goberdhan Lorraine O'Driscoll Edit I. Buzas Cherie Blenkiron Benedetta Bussolati Houjian Cai Dolores Di Vizio Tom A. P. Driedonks Uta Erdbrügger Juan M. Falcon‐Perez Qing‐Ling Fu Andrew F. Hill Metka Lenassi Sai Kiang Lim Mỹ G. Mahoney Sujata Mohanty Andreas Möller Rienk Nieuwland Takahiro Ochiya Susmita Sahoo Ana C. Torrecilhas Lei Zheng Andries Zijlstra Sarah Abuelreich Reem Bagabas Paolo Bergese Esther M. Bridges Marco Brucale Dylan Burger Randy P. Carney Emanuele Cocucci Rossella Crescitelli Edveena Hanser Adrian L. Harris Norman J. Haughey An Hendrix Alexander R. Ivanov Tijana Jovanovic‐Talisman Nicole A. Kruh‐Garcia Vroniqa Ku'ulei‐Lyn Faustino Diego Kyburz Cecilia Lässer Kathleen M. Lennon Jan Lötvall Adam L. Maddox Elena S. Martens‐Uzunova Rachel R. Mizenko Lauren A. Newman Andrea Ridolfi Eva Rohde Tatu Rojalin Andrew Rowland Andras Saftics Ursula S. Sandau Julie A. Saugstad Faezeh Shekari Simon Swift Dmitry Ter‐Ovanesyan Juan P. Tosar Zivile Useckaite Francesco Valle Zoltan Varga Edwin van derPol Martijn J. C. vanHerwijnen Marca H. M. Wauben Ann M. Wehman Sarah Williams Andrea Zendrini Alan J. Zimmerman MISEV Consortium Clotilde Théry Kenneth W. Witwer |
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Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches |
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Abstract Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year‐on‐year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non‐vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its ‘Minimal Information for Studies of Extracellular Vesicles’, which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly. |
| abstractGer |
Abstract Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year‐on‐year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non‐vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its ‘Minimal Information for Studies of Extracellular Vesicles’, which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly. |
| abstract_unstemmed |
Abstract Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year‐on‐year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non‐vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its ‘Minimal Information for Studies of Extracellular Vesicles’, which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly. |
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Deborah C. I. Goberdhan Lorraine O'Driscoll Edit I. Buzas Cherie Blenkiron Benedetta Bussolati Houjian Cai Dolores Di Vizio Tom A. P. Driedonks Uta Erdbrügger Juan M. Falcon‐Perez Qing‐Ling Fu Andrew F. Hill Metka Lenassi Sai Kiang Lim Mỹ G. Mahoney Sujata Mohanty Andreas Möller Rienk Nieuwland Takahiro Ochiya Susmita Sahoo Ana C. Torrecilhas Lei Zheng Andries Zijlstra Sarah Abuelreich Reem Bagabas Paolo Bergese Esther M. Bridges Marco Brucale Dylan Burger Randy P. Carney Emanuele Cocucci Rossella Crescitelli Edveena Hanser Adrian L. Harris Norman J. Haughey An Hendrix Alexander R. Ivanov Tijana Jovanovic‐Talisman Nicole A. Kruh‐Garcia Vroniqa Ku'ulei‐Lyn Faustino Diego Kyburz Cecilia Lässer Kathleen M. Lennon Jan Lötvall Adam L. Maddox Elena S. Martens‐Uzunova Rachel R. Mizenko Lauren A. Newman Andrea Ridolfi Eva Rohde Tatu Rojalin Andrew Rowland Andras Saftics Ursula S. Sandau Julie A. Saugstad Faezeh Shekari Simon Swift Dmitry Ter‐Ovanesyan Juan P. Tosar Zivile Useckaite Francesco Valle Zoltan Varga Edwin van derPol Martijn J. C. vanHerwijnen Marca H. M. Wauben Ann M. Wehman Sarah Williams Andrea Zendrini Alan J. Zimmerman MISEV Consortium Clotilde Théry Kenneth W. Witwer |
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Deborah C. I. Goberdhan Lorraine O'Driscoll Edit I. Buzas Cherie Blenkiron Benedetta Bussolati Houjian Cai Dolores Di Vizio Tom A. P. Driedonks Uta Erdbrügger Juan M. Falcon‐Perez Qing‐Ling Fu Andrew F. Hill Metka Lenassi Sai Kiang Lim Mỹ G. Mahoney Sujata Mohanty Andreas Möller Rienk Nieuwland Takahiro Ochiya Susmita Sahoo Ana C. Torrecilhas Lei Zheng Andries Zijlstra Sarah Abuelreich Reem Bagabas Paolo Bergese Esther M. Bridges Marco Brucale Dylan Burger Randy P. Carney Emanuele Cocucci Rossella Crescitelli Edveena Hanser Adrian L. Harris Norman J. Haughey An Hendrix Alexander R. Ivanov Tijana Jovanovic‐Talisman Nicole A. Kruh‐Garcia Vroniqa Ku'ulei‐Lyn Faustino Diego Kyburz Cecilia Lässer Kathleen M. Lennon Jan Lötvall Adam L. Maddox Elena S. Martens‐Uzunova Rachel R. Mizenko Lauren A. Newman Andrea Ridolfi Eva Rohde Tatu Rojalin Andrew Rowland Andras Saftics Ursula S. Sandau Julie A. Saugstad Faezeh Shekari Simon Swift Dmitry Ter‐Ovanesyan Juan P. Tosar Zivile Useckaite Francesco Valle Zoltan Varga Edwin van derPol Martijn J. C. vanHerwijnen Marca H. M. Wauben Ann M. Wehman Sarah Williams Andrea Zendrini Alan J. Zimmerman MISEV Consortium Clotilde Théry Kenneth W. Witwer |
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2024-07-03T17:02:47.777Z |
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| score |
7.4006186 |