Sulfated Glycans Inhibit the Interaction of MERS-CoV Receptor Binding Domain with Heparin

Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus with high contagion and mortality rates. Heparan sulfate proteoglycans (HSPGs) are ubiquitously expressed on the surface of mammalian cells. Owing to its high negatively charged property, heparan sulfate (HS) on the surface...
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Autor*in:	Jiyuan Yang [verfasserIn] Yuefan Song [verfasserIn] Weihua Jin [verfasserIn] Ke Xia [verfasserIn] Grace C. Burnett [verfasserIn] Wanjin Qiao [verfasserIn] John T. Bates [verfasserIn] Vitor H. Pomin [verfasserIn] Chunyu Wang [verfasserIn] Mingqiang Qiao [verfasserIn] Robert J. Linhardt [verfasserIn] Jonathan S. Dordick [verfasserIn] Fuming Zhang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	HSPGs heparin MERS-CoV sulfated glycans surface plasmon resonance

Übergeordnetes Werk:	In: Viruses - MDPI AG, 2009, 16(2024), 2, p 237
Übergeordnetes Werk:	volume:16 ; year:2024 ; number:2, p 237

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/v16020237

Katalog-ID:	DOAJ098434829

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520			\|a Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus with high contagion and mortality rates. Heparan sulfate proteoglycans (HSPGs) are ubiquitously expressed on the surface of mammalian cells. Owing to its high negatively charged property, heparan sulfate (HS) on the surface of host cells is used by many viruses as cofactor to facilitate viral attachment and initiate cellular entry. Therefore, inhibition of the interaction between viruses and HS could be a promising target to inhibit viral infection. In the current study, the interaction between the receptor-binding domain (RBD) of MERS-CoV and heparin was exploited to assess the inhibitory activity of various sulfated glycans such as glycosaminoglycans, marine-sourced glycans (sulfated fucans, fucosylated chondroitin sulfates, fucoidans, and rhamnan sulfate), pentosan polysulfate, and mucopolysaccharide using Surface Plasmon Resonance. We believe this study provides valuable insights for the development of sulfated glycan-based inhibitors as potential antiviral agents.
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allfields	10.3390/v16020237 doi (DE-627)DOAJ098434829 (DE-599)DOAJa85e0c11f5ad435dbfcfef4089272a77 DE-627 ger DE-627 rakwb eng QR1-502 Jiyuan Yang verfasserin aut Sulfated Glycans Inhibit the Interaction of MERS-CoV Receptor Binding Domain with Heparin 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus with high contagion and mortality rates. Heparan sulfate proteoglycans (HSPGs) are ubiquitously expressed on the surface of mammalian cells. Owing to its high negatively charged property, heparan sulfate (HS) on the surface of host cells is used by many viruses as cofactor to facilitate viral attachment and initiate cellular entry. Therefore, inhibition of the interaction between viruses and HS could be a promising target to inhibit viral infection. In the current study, the interaction between the receptor-binding domain (RBD) of MERS-CoV and heparin was exploited to assess the inhibitory activity of various sulfated glycans such as glycosaminoglycans, marine-sourced glycans (sulfated fucans, fucosylated chondroitin sulfates, fucoidans, and rhamnan sulfate), pentosan polysulfate, and mucopolysaccharide using Surface Plasmon Resonance. We believe this study provides valuable insights for the development of sulfated glycan-based inhibitors as potential antiviral agents. HSPGs heparin MERS-CoV sulfated glycans surface plasmon resonance Microbiology Yuefan Song verfasserin aut Weihua Jin verfasserin aut Ke Xia verfasserin aut Grace C. Burnett verfasserin aut Wanjin Qiao verfasserin aut John T. Bates verfasserin aut Vitor H. Pomin verfasserin aut Chunyu Wang verfasserin aut Mingqiang Qiao verfasserin aut Robert J. Linhardt verfasserin aut Jonathan S. Dordick verfasserin aut Fuming Zhang verfasserin aut In Viruses MDPI AG, 2009 16(2024), 2, p 237 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:16 year:2024 number:2, p 237 https://doi.org/10.3390/v16020237 kostenfrei https://doaj.org/article/a85e0c11f5ad435dbfcfef4089272a77 kostenfrei https://www.mdpi.com/1999-4915/16/2/237 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2024 2, p 237
spelling	10.3390/v16020237 doi (DE-627)DOAJ098434829 (DE-599)DOAJa85e0c11f5ad435dbfcfef4089272a77 DE-627 ger DE-627 rakwb eng QR1-502 Jiyuan Yang verfasserin aut Sulfated Glycans Inhibit the Interaction of MERS-CoV Receptor Binding Domain with Heparin 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus with high contagion and mortality rates. Heparan sulfate proteoglycans (HSPGs) are ubiquitously expressed on the surface of mammalian cells. Owing to its high negatively charged property, heparan sulfate (HS) on the surface of host cells is used by many viruses as cofactor to facilitate viral attachment and initiate cellular entry. Therefore, inhibition of the interaction between viruses and HS could be a promising target to inhibit viral infection. In the current study, the interaction between the receptor-binding domain (RBD) of MERS-CoV and heparin was exploited to assess the inhibitory activity of various sulfated glycans such as glycosaminoglycans, marine-sourced glycans (sulfated fucans, fucosylated chondroitin sulfates, fucoidans, and rhamnan sulfate), pentosan polysulfate, and mucopolysaccharide using Surface Plasmon Resonance. We believe this study provides valuable insights for the development of sulfated glycan-based inhibitors as potential antiviral agents. HSPGs heparin MERS-CoV sulfated glycans surface plasmon resonance Microbiology Yuefan Song verfasserin aut Weihua Jin verfasserin aut Ke Xia verfasserin aut Grace C. Burnett verfasserin aut Wanjin Qiao verfasserin aut John T. Bates verfasserin aut Vitor H. Pomin verfasserin aut Chunyu Wang verfasserin aut Mingqiang Qiao verfasserin aut Robert J. Linhardt verfasserin aut Jonathan S. Dordick verfasserin aut Fuming Zhang verfasserin aut In Viruses MDPI AG, 2009 16(2024), 2, p 237 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:16 year:2024 number:2, p 237 https://doi.org/10.3390/v16020237 kostenfrei https://doaj.org/article/a85e0c11f5ad435dbfcfef4089272a77 kostenfrei https://www.mdpi.com/1999-4915/16/2/237 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2024 2, p 237
allfields_unstemmed	10.3390/v16020237 doi (DE-627)DOAJ098434829 (DE-599)DOAJa85e0c11f5ad435dbfcfef4089272a77 DE-627 ger DE-627 rakwb eng QR1-502 Jiyuan Yang verfasserin aut Sulfated Glycans Inhibit the Interaction of MERS-CoV Receptor Binding Domain with Heparin 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus with high contagion and mortality rates. Heparan sulfate proteoglycans (HSPGs) are ubiquitously expressed on the surface of mammalian cells. Owing to its high negatively charged property, heparan sulfate (HS) on the surface of host cells is used by many viruses as cofactor to facilitate viral attachment and initiate cellular entry. Therefore, inhibition of the interaction between viruses and HS could be a promising target to inhibit viral infection. In the current study, the interaction between the receptor-binding domain (RBD) of MERS-CoV and heparin was exploited to assess the inhibitory activity of various sulfated glycans such as glycosaminoglycans, marine-sourced glycans (sulfated fucans, fucosylated chondroitin sulfates, fucoidans, and rhamnan sulfate), pentosan polysulfate, and mucopolysaccharide using Surface Plasmon Resonance. We believe this study provides valuable insights for the development of sulfated glycan-based inhibitors as potential antiviral agents. HSPGs heparin MERS-CoV sulfated glycans surface plasmon resonance Microbiology Yuefan Song verfasserin aut Weihua Jin verfasserin aut Ke Xia verfasserin aut Grace C. Burnett verfasserin aut Wanjin Qiao verfasserin aut John T. Bates verfasserin aut Vitor H. Pomin verfasserin aut Chunyu Wang verfasserin aut Mingqiang Qiao verfasserin aut Robert J. Linhardt verfasserin aut Jonathan S. Dordick verfasserin aut Fuming Zhang verfasserin aut In Viruses MDPI AG, 2009 16(2024), 2, p 237 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:16 year:2024 number:2, p 237 https://doi.org/10.3390/v16020237 kostenfrei https://doaj.org/article/a85e0c11f5ad435dbfcfef4089272a77 kostenfrei https://www.mdpi.com/1999-4915/16/2/237 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2024 2, p 237
allfieldsGer	10.3390/v16020237 doi (DE-627)DOAJ098434829 (DE-599)DOAJa85e0c11f5ad435dbfcfef4089272a77 DE-627 ger DE-627 rakwb eng QR1-502 Jiyuan Yang verfasserin aut Sulfated Glycans Inhibit the Interaction of MERS-CoV Receptor Binding Domain with Heparin 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus with high contagion and mortality rates. Heparan sulfate proteoglycans (HSPGs) are ubiquitously expressed on the surface of mammalian cells. Owing to its high negatively charged property, heparan sulfate (HS) on the surface of host cells is used by many viruses as cofactor to facilitate viral attachment and initiate cellular entry. Therefore, inhibition of the interaction between viruses and HS could be a promising target to inhibit viral infection. In the current study, the interaction between the receptor-binding domain (RBD) of MERS-CoV and heparin was exploited to assess the inhibitory activity of various sulfated glycans such as glycosaminoglycans, marine-sourced glycans (sulfated fucans, fucosylated chondroitin sulfates, fucoidans, and rhamnan sulfate), pentosan polysulfate, and mucopolysaccharide using Surface Plasmon Resonance. We believe this study provides valuable insights for the development of sulfated glycan-based inhibitors as potential antiviral agents. HSPGs heparin MERS-CoV sulfated glycans surface plasmon resonance Microbiology Yuefan Song verfasserin aut Weihua Jin verfasserin aut Ke Xia verfasserin aut Grace C. Burnett verfasserin aut Wanjin Qiao verfasserin aut John T. Bates verfasserin aut Vitor H. Pomin verfasserin aut Chunyu Wang verfasserin aut Mingqiang Qiao verfasserin aut Robert J. Linhardt verfasserin aut Jonathan S. Dordick verfasserin aut Fuming Zhang verfasserin aut In Viruses MDPI AG, 2009 16(2024), 2, p 237 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:16 year:2024 number:2, p 237 https://doi.org/10.3390/v16020237 kostenfrei https://doaj.org/article/a85e0c11f5ad435dbfcfef4089272a77 kostenfrei https://www.mdpi.com/1999-4915/16/2/237 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2024 2, p 237
allfieldsSound	10.3390/v16020237 doi (DE-627)DOAJ098434829 (DE-599)DOAJa85e0c11f5ad435dbfcfef4089272a77 DE-627 ger DE-627 rakwb eng QR1-502 Jiyuan Yang verfasserin aut Sulfated Glycans Inhibit the Interaction of MERS-CoV Receptor Binding Domain with Heparin 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus with high contagion and mortality rates. Heparan sulfate proteoglycans (HSPGs) are ubiquitously expressed on the surface of mammalian cells. Owing to its high negatively charged property, heparan sulfate (HS) on the surface of host cells is used by many viruses as cofactor to facilitate viral attachment and initiate cellular entry. Therefore, inhibition of the interaction between viruses and HS could be a promising target to inhibit viral infection. In the current study, the interaction between the receptor-binding domain (RBD) of MERS-CoV and heparin was exploited to assess the inhibitory activity of various sulfated glycans such as glycosaminoglycans, marine-sourced glycans (sulfated fucans, fucosylated chondroitin sulfates, fucoidans, and rhamnan sulfate), pentosan polysulfate, and mucopolysaccharide using Surface Plasmon Resonance. We believe this study provides valuable insights for the development of sulfated glycan-based inhibitors as potential antiviral agents. HSPGs heparin MERS-CoV sulfated glycans surface plasmon resonance Microbiology Yuefan Song verfasserin aut Weihua Jin verfasserin aut Ke Xia verfasserin aut Grace C. Burnett verfasserin aut Wanjin Qiao verfasserin aut John T. Bates verfasserin aut Vitor H. Pomin verfasserin aut Chunyu Wang verfasserin aut Mingqiang Qiao verfasserin aut Robert J. Linhardt verfasserin aut Jonathan S. Dordick verfasserin aut Fuming Zhang verfasserin aut In Viruses MDPI AG, 2009 16(2024), 2, p 237 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:16 year:2024 number:2, p 237 https://doi.org/10.3390/v16020237 kostenfrei https://doaj.org/article/a85e0c11f5ad435dbfcfef4089272a77 kostenfrei https://www.mdpi.com/1999-4915/16/2/237 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2024 2, p 237
language	English
source	In Viruses 16(2024), 2, p 237 volume:16 year:2024 number:2, p 237
sourceStr	In Viruses 16(2024), 2, p 237 volume:16 year:2024 number:2, p 237
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topic_facet	HSPGs heparin MERS-CoV sulfated glycans surface plasmon resonance Microbiology
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authorswithroles_txt_mv	Jiyuan Yang @@aut@@ Yuefan Song @@aut@@ Weihua Jin @@aut@@ Ke Xia @@aut@@ Grace C. Burnett @@aut@@ Wanjin Qiao @@aut@@ John T. Bates @@aut@@ Vitor H. Pomin @@aut@@ Chunyu Wang @@aut@@ Mingqiang Qiao @@aut@@ Robert J. Linhardt @@aut@@ Jonathan S. Dordick @@aut@@ Fuming Zhang @@aut@@
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callnumber-first	Q - Science
author	Jiyuan Yang
spellingShingle	Jiyuan Yang misc QR1-502 misc HSPGs misc heparin misc MERS-CoV misc sulfated glycans misc surface plasmon resonance misc Microbiology Sulfated Glycans Inhibit the Interaction of MERS-CoV Receptor Binding Domain with Heparin
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topic_title	QR1-502 Sulfated Glycans Inhibit the Interaction of MERS-CoV Receptor Binding Domain with Heparin HSPGs heparin MERS-CoV sulfated glycans surface plasmon resonance
topic	misc QR1-502 misc HSPGs misc heparin misc MERS-CoV misc sulfated glycans misc surface plasmon resonance misc Microbiology
topic_unstemmed	misc QR1-502 misc HSPGs misc heparin misc MERS-CoV misc sulfated glycans misc surface plasmon resonance misc Microbiology
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title	Sulfated Glycans Inhibit the Interaction of MERS-CoV Receptor Binding Domain with Heparin
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title_full	Sulfated Glycans Inhibit the Interaction of MERS-CoV Receptor Binding Domain with Heparin
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author_browse	Jiyuan Yang Yuefan Song Weihua Jin Ke Xia Grace C. Burnett Wanjin Qiao John T. Bates Vitor H. Pomin Chunyu Wang Mingqiang Qiao Robert J. Linhardt Jonathan S. Dordick Fuming Zhang
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title_sort	sulfated glycans inhibit the interaction of mers-cov receptor binding domain with heparin
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title_auth	Sulfated Glycans Inhibit the Interaction of MERS-CoV Receptor Binding Domain with Heparin
abstract	Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus with high contagion and mortality rates. Heparan sulfate proteoglycans (HSPGs) are ubiquitously expressed on the surface of mammalian cells. Owing to its high negatively charged property, heparan sulfate (HS) on the surface of host cells is used by many viruses as cofactor to facilitate viral attachment and initiate cellular entry. Therefore, inhibition of the interaction between viruses and HS could be a promising target to inhibit viral infection. In the current study, the interaction between the receptor-binding domain (RBD) of MERS-CoV and heparin was exploited to assess the inhibitory activity of various sulfated glycans such as glycosaminoglycans, marine-sourced glycans (sulfated fucans, fucosylated chondroitin sulfates, fucoidans, and rhamnan sulfate), pentosan polysulfate, and mucopolysaccharide using Surface Plasmon Resonance. We believe this study provides valuable insights for the development of sulfated glycan-based inhibitors as potential antiviral agents.
abstractGer	Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus with high contagion and mortality rates. Heparan sulfate proteoglycans (HSPGs) are ubiquitously expressed on the surface of mammalian cells. Owing to its high negatively charged property, heparan sulfate (HS) on the surface of host cells is used by many viruses as cofactor to facilitate viral attachment and initiate cellular entry. Therefore, inhibition of the interaction between viruses and HS could be a promising target to inhibit viral infection. In the current study, the interaction between the receptor-binding domain (RBD) of MERS-CoV and heparin was exploited to assess the inhibitory activity of various sulfated glycans such as glycosaminoglycans, marine-sourced glycans (sulfated fucans, fucosylated chondroitin sulfates, fucoidans, and rhamnan sulfate), pentosan polysulfate, and mucopolysaccharide using Surface Plasmon Resonance. We believe this study provides valuable insights for the development of sulfated glycan-based inhibitors as potential antiviral agents.
abstract_unstemmed	Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus with high contagion and mortality rates. Heparan sulfate proteoglycans (HSPGs) are ubiquitously expressed on the surface of mammalian cells. Owing to its high negatively charged property, heparan sulfate (HS) on the surface of host cells is used by many viruses as cofactor to facilitate viral attachment and initiate cellular entry. Therefore, inhibition of the interaction between viruses and HS could be a promising target to inhibit viral infection. In the current study, the interaction between the receptor-binding domain (RBD) of MERS-CoV and heparin was exploited to assess the inhibitory activity of various sulfated glycans such as glycosaminoglycans, marine-sourced glycans (sulfated fucans, fucosylated chondroitin sulfates, fucoidans, and rhamnan sulfate), pentosan polysulfate, and mucopolysaccharide using Surface Plasmon Resonance. We believe this study provides valuable insights for the development of sulfated glycan-based inhibitors as potential antiviral agents.
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title_short	Sulfated Glycans Inhibit the Interaction of MERS-CoV Receptor Binding Domain with Heparin
url	https://doi.org/10.3390/v16020237 https://doaj.org/article/a85e0c11f5ad435dbfcfef4089272a77 https://www.mdpi.com/1999-4915/16/2/237 https://doaj.org/toc/1999-4915
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up_date	2024-07-03T17:13:53.612Z
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Heparan sulfate proteoglycans (HSPGs) are ubiquitously expressed on the surface of mammalian cells. Owing to its high negatively charged property, heparan sulfate (HS) on the surface of host cells is used by many viruses as cofactor to facilitate viral attachment and initiate cellular entry. Therefore, inhibition of the interaction between viruses and HS could be a promising target to inhibit viral infection. In the current study, the interaction between the receptor-binding domain (RBD) of MERS-CoV and heparin was exploited to assess the inhibitory activity of various sulfated glycans such as glycosaminoglycans, marine-sourced glycans (sulfated fucans, fucosylated chondroitin sulfates, fucoidans, and rhamnan sulfate), pentosan polysulfate, and mucopolysaccharide using Surface Plasmon Resonance. 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Sulfated Glycans Inhibit the Interaction of MERS-CoV Receptor Binding Domain with Heparin

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