Deciphering the Dual Role of <i<Heligmosomoides polygyrus</i< Antigens in Macrophage Modulation and Breast Cancer Cell Growth

In our study, we explored how parasitic nematodes, specifically <i<Heligmosomoides polygyrus</i<, influence the immune response, focusing on their potential role in tumor growth. The study aimed to understand the mechanisms by which these parasites modify immune cell activation, particul...
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Autor*in:	Patryk Firmanty [verfasserIn] Maria Doligalska [verfasserIn] Magdalena Krol [verfasserIn] Bartlomiej Taciak [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	parasitic nematodes immune response modulation macrophage activation breast cancer cell proliferation

Übergeordnetes Werk:	In: Veterinary Sciences - MDPI AG, 2014, 11(2024), 2, p 69
Übergeordnetes Werk:	volume:11 ; year:2024 ; number:2, p 69

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/vetsci11020069

Katalog-ID:	DOAJ098435787

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allfieldsSound	10.3390/vetsci11020069 doi (DE-627)DOAJ098435787 (DE-599)DOAJd57f93e0057a49a6a668655c336327ee DE-627 ger DE-627 rakwb eng SF600-1100 Patryk Firmanty verfasserin aut Deciphering the Dual Role of <i<Heligmosomoides polygyrus</i< Antigens in Macrophage Modulation and Breast Cancer Cell Growth 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In our study, we explored how parasitic nematodes, specifically <i<Heligmosomoides polygyrus</i<, influence the immune response, focusing on their potential role in tumor growth. The study aimed to understand the mechanisms by which these parasites modify immune cell activation, particularly in macrophages, and how this might create an environment conducive to tumor growth. Our methods involved analyzing the effects of <i<H. polygyrus</i< excretory-secretory antigens on macrophage activation and their subsequent impact on breast cancer cell lines EMT6 and 4T1. We observed that these antigens significantly increased the expression of genes associated with both pro-inflammatory and anti-inflammatory molecules, such as inducible nitric oxide synthase, TNF-α, (Tumor Necrosis Factor) Il-6 (Interleukin), and arginase. Additionally, we observed changes in the expression of macrophage surface receptors like CD11b, F4/80, and TLR4 (Toll-like receptor 4). Our findings indicate that the antigens from <i<H. polygyrus</i< markedly alter macrophage behavior and increase the proliferation of breast cancer cells in a laboratory setting. This study contributes to a deeper understanding of the complex interactions between parasitic infections and cancer development, highlighting the need for further research in this area to develop potential new strategies for cancer treatment. parasitic nematodes immune response modulation macrophage activation breast cancer cell proliferation Veterinary medicine Maria Doligalska verfasserin aut Magdalena Krol verfasserin aut Bartlomiej Taciak verfasserin aut In Veterinary Sciences MDPI AG, 2014 11(2024), 2, p 69 (DE-627)785698477 (DE-600)2768971-2 23067381 nnns volume:11 year:2024 number:2, p 69 https://doi.org/10.3390/vetsci11020069 kostenfrei https://doaj.org/article/d57f93e0057a49a6a668655c336327ee kostenfrei https://www.mdpi.com/2306-7381/11/2/69 kostenfrei https://doaj.org/toc/2306-7381 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2446 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2024 2, p 69
language	English
source	In Veterinary Sciences 11(2024), 2, p 69 volume:11 year:2024 number:2, p 69
sourceStr	In Veterinary Sciences 11(2024), 2, p 69 volume:11 year:2024 number:2, p 69
format_phy_str_mv	Article
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topic_facet	parasitic nematodes immune response modulation macrophage activation breast cancer cell proliferation Veterinary medicine
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container_title	Veterinary Sciences
authorswithroles_txt_mv	Patryk Firmanty @@aut@@ Maria Doligalska @@aut@@ Magdalena Krol @@aut@@ Bartlomiej Taciak @@aut@@
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callnumber-first	S - Agriculture
author	Patryk Firmanty
spellingShingle	Patryk Firmanty misc SF600-1100 misc parasitic nematodes misc immune response modulation misc macrophage activation misc breast cancer cell proliferation misc Veterinary medicine Deciphering the Dual Role of <i<Heligmosomoides polygyrus</i< Antigens in Macrophage Modulation and Breast Cancer Cell Growth
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topic_title	SF600-1100 Deciphering the Dual Role of <i<Heligmosomoides polygyrus</i< Antigens in Macrophage Modulation and Breast Cancer Cell Growth parasitic nematodes immune response modulation macrophage activation breast cancer cell proliferation
topic	misc SF600-1100 misc parasitic nematodes misc immune response modulation misc macrophage activation misc breast cancer cell proliferation misc Veterinary medicine
topic_unstemmed	misc SF600-1100 misc parasitic nematodes misc immune response modulation misc macrophage activation misc breast cancer cell proliferation misc Veterinary medicine
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title	Deciphering the Dual Role of <i<Heligmosomoides polygyrus</i< Antigens in Macrophage Modulation and Breast Cancer Cell Growth
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title_sort	deciphering the dual role of <i<heligmosomoides polygyrus</i< antigens in macrophage modulation and breast cancer cell growth
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title_auth	Deciphering the Dual Role of <i<Heligmosomoides polygyrus</i< Antigens in Macrophage Modulation and Breast Cancer Cell Growth
abstract	In our study, we explored how parasitic nematodes, specifically <i<Heligmosomoides polygyrus</i<, influence the immune response, focusing on their potential role in tumor growth. The study aimed to understand the mechanisms by which these parasites modify immune cell activation, particularly in macrophages, and how this might create an environment conducive to tumor growth. Our methods involved analyzing the effects of <i<H. polygyrus</i< excretory-secretory antigens on macrophage activation and their subsequent impact on breast cancer cell lines EMT6 and 4T1. We observed that these antigens significantly increased the expression of genes associated with both pro-inflammatory and anti-inflammatory molecules, such as inducible nitric oxide synthase, TNF-α, (Tumor Necrosis Factor) Il-6 (Interleukin), and arginase. Additionally, we observed changes in the expression of macrophage surface receptors like CD11b, F4/80, and TLR4 (Toll-like receptor 4). Our findings indicate that the antigens from <i<H. polygyrus</i< markedly alter macrophage behavior and increase the proliferation of breast cancer cells in a laboratory setting. This study contributes to a deeper understanding of the complex interactions between parasitic infections and cancer development, highlighting the need for further research in this area to develop potential new strategies for cancer treatment.
abstractGer	In our study, we explored how parasitic nematodes, specifically <i<Heligmosomoides polygyrus</i<, influence the immune response, focusing on their potential role in tumor growth. The study aimed to understand the mechanisms by which these parasites modify immune cell activation, particularly in macrophages, and how this might create an environment conducive to tumor growth. Our methods involved analyzing the effects of <i<H. polygyrus</i< excretory-secretory antigens on macrophage activation and their subsequent impact on breast cancer cell lines EMT6 and 4T1. We observed that these antigens significantly increased the expression of genes associated with both pro-inflammatory and anti-inflammatory molecules, such as inducible nitric oxide synthase, TNF-α, (Tumor Necrosis Factor) Il-6 (Interleukin), and arginase. Additionally, we observed changes in the expression of macrophage surface receptors like CD11b, F4/80, and TLR4 (Toll-like receptor 4). Our findings indicate that the antigens from <i<H. polygyrus</i< markedly alter macrophage behavior and increase the proliferation of breast cancer cells in a laboratory setting. This study contributes to a deeper understanding of the complex interactions between parasitic infections and cancer development, highlighting the need for further research in this area to develop potential new strategies for cancer treatment.
abstract_unstemmed	In our study, we explored how parasitic nematodes, specifically <i<Heligmosomoides polygyrus</i<, influence the immune response, focusing on their potential role in tumor growth. The study aimed to understand the mechanisms by which these parasites modify immune cell activation, particularly in macrophages, and how this might create an environment conducive to tumor growth. Our methods involved analyzing the effects of <i<H. polygyrus</i< excretory-secretory antigens on macrophage activation and their subsequent impact on breast cancer cell lines EMT6 and 4T1. We observed that these antigens significantly increased the expression of genes associated with both pro-inflammatory and anti-inflammatory molecules, such as inducible nitric oxide synthase, TNF-α, (Tumor Necrosis Factor) Il-6 (Interleukin), and arginase. Additionally, we observed changes in the expression of macrophage surface receptors like CD11b, F4/80, and TLR4 (Toll-like receptor 4). Our findings indicate that the antigens from <i<H. polygyrus</i< markedly alter macrophage behavior and increase the proliferation of breast cancer cells in a laboratory setting. This study contributes to a deeper understanding of the complex interactions between parasitic infections and cancer development, highlighting the need for further research in this area to develop potential new strategies for cancer treatment.
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title_short	Deciphering the Dual Role of <i<Heligmosomoides polygyrus</i< Antigens in Macrophage Modulation and Breast Cancer Cell Growth
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