Immune Responses in Oral Papillomavirus Clearance in the MmuPV1 Mouse Model

Human papillomavirus (HPV)-induced oropharyngeal cancer now exceeds HPV-induced cervical cancer, with a noticeable sex bias. Although it is well established that women have a more proficient immune system, it remains unclear whether immune control of oral papillomavirus infections differs between se...
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Gespeichert in:

Autor*in:	Sarah A. Brendle [verfasserIn] Jingwei J. Li [verfasserIn] Vonn Walter [verfasserIn] Todd D. Schell [verfasserIn] Michael Kozak [verfasserIn] Karla K. Balogh [verfasserIn] Song Lu [verfasserIn] Neil D. Christensen [verfasserIn] Yusheng Zhu [verfasserIn] Karam El-Bayoumy [verfasserIn] Jiafen Hu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	human papillomavirus mouse papillomavirus infections innate adaptive viral clearance

Übergeordnetes Werk:	In: Pathogens - MDPI AG, 2012, 12(2023), 12, p 1452
Übergeordnetes Werk:	volume:12 ; year:2023 ; number:12, p 1452

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/pathogens12121452

Katalog-ID:	DOAJ098813501

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spelling	10.3390/pathogens12121452 doi (DE-627)DOAJ098813501 (DE-599)DOAJ149d7cf9818e413ba9c00c4e24f6679d DE-627 ger DE-627 rakwb eng Sarah A. Brendle verfasserin aut Immune Responses in Oral Papillomavirus Clearance in the MmuPV1 Mouse Model 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Human papillomavirus (HPV)-induced oropharyngeal cancer now exceeds HPV-induced cervical cancer, with a noticeable sex bias. Although it is well established that women have a more proficient immune system, it remains unclear whether immune control of oral papillomavirus infections differs between sexes. In the current study, we use genetically modified mice to target CCR2 and Stat1 pathways, with the aim of investigating the role of both innate and adaptive immune responses in clearing oral papillomavirus, using our established papillomavirus (MmuPV1) infection model. Persistent oral MmuPV1 infection was detected in Rag1ko mice with T and B cell deficiencies. Meanwhile, other tested mice were susceptible to MmuPV1 infections but were able to clear the virus. We found sex differences in key myeloid cells, including macrophages, neutrophils, and dendritic cells in the infected tongues of wild type and Stat1ko mice but these differences were not observed in CCR2ko mice. Intriguingly, we also observed a sex difference in anti-MmuPV1 E4 antibody levels, especially for two IgG isotypes: IgG2b and IgG3. However, we found comparable numbers of interferon-gamma-producing CD8 T cells stimulated by E6 and E7 in both sexes. These findings suggest that males and females may use different components of innate and adaptive immune responses to control papillomavirus infections in the MmuPV1 mouse model. The observed sex difference in immune responses, especially in myeloid cells including dendritic cell (DC) subsets, may have potential diagnostic and prognostic values for HPV-associated oropharyngeal cancer. human papillomavirus mouse papillomavirus infections innate adaptive viral clearance Medicine R Jingwei J. Li verfasserin aut Vonn Walter verfasserin aut Todd D. Schell verfasserin aut Michael Kozak verfasserin aut Karla K. Balogh verfasserin aut Song Lu verfasserin aut Neil D. Christensen verfasserin aut Yusheng Zhu verfasserin aut Karam El-Bayoumy verfasserin aut Jiafen Hu verfasserin aut In Pathogens MDPI AG, 2012 12(2023), 12, p 1452 (DE-627)732627885 (DE-600)2695572-6 20760817 nnns volume:12 year:2023 number:12, p 1452 https://doi.org/10.3390/pathogens12121452 kostenfrei https://doaj.org/article/149d7cf9818e413ba9c00c4e24f6679d kostenfrei https://www.mdpi.com/2076-0817/12/12/1452 kostenfrei https://doaj.org/toc/2076-0817 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 12, p 1452
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allfieldsSound	10.3390/pathogens12121452 doi (DE-627)DOAJ098813501 (DE-599)DOAJ149d7cf9818e413ba9c00c4e24f6679d DE-627 ger DE-627 rakwb eng Sarah A. Brendle verfasserin aut Immune Responses in Oral Papillomavirus Clearance in the MmuPV1 Mouse Model 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Human papillomavirus (HPV)-induced oropharyngeal cancer now exceeds HPV-induced cervical cancer, with a noticeable sex bias. Although it is well established that women have a more proficient immune system, it remains unclear whether immune control of oral papillomavirus infections differs between sexes. In the current study, we use genetically modified mice to target CCR2 and Stat1 pathways, with the aim of investigating the role of both innate and adaptive immune responses in clearing oral papillomavirus, using our established papillomavirus (MmuPV1) infection model. Persistent oral MmuPV1 infection was detected in Rag1ko mice with T and B cell deficiencies. Meanwhile, other tested mice were susceptible to MmuPV1 infections but were able to clear the virus. We found sex differences in key myeloid cells, including macrophages, neutrophils, and dendritic cells in the infected tongues of wild type and Stat1ko mice but these differences were not observed in CCR2ko mice. Intriguingly, we also observed a sex difference in anti-MmuPV1 E4 antibody levels, especially for two IgG isotypes: IgG2b and IgG3. However, we found comparable numbers of interferon-gamma-producing CD8 T cells stimulated by E6 and E7 in both sexes. These findings suggest that males and females may use different components of innate and adaptive immune responses to control papillomavirus infections in the MmuPV1 mouse model. The observed sex difference in immune responses, especially in myeloid cells including dendritic cell (DC) subsets, may have potential diagnostic and prognostic values for HPV-associated oropharyngeal cancer. human papillomavirus mouse papillomavirus infections innate adaptive viral clearance Medicine R Jingwei J. Li verfasserin aut Vonn Walter verfasserin aut Todd D. Schell verfasserin aut Michael Kozak verfasserin aut Karla K. Balogh verfasserin aut Song Lu verfasserin aut Neil D. Christensen verfasserin aut Yusheng Zhu verfasserin aut Karam El-Bayoumy verfasserin aut Jiafen Hu verfasserin aut In Pathogens MDPI AG, 2012 12(2023), 12, p 1452 (DE-627)732627885 (DE-600)2695572-6 20760817 nnns volume:12 year:2023 number:12, p 1452 https://doi.org/10.3390/pathogens12121452 kostenfrei https://doaj.org/article/149d7cf9818e413ba9c00c4e24f6679d kostenfrei https://www.mdpi.com/2076-0817/12/12/1452 kostenfrei https://doaj.org/toc/2076-0817 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 12, p 1452
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author	Sarah A. Brendle
spellingShingle	Sarah A. Brendle misc human papillomavirus misc mouse papillomavirus misc infections misc innate misc adaptive misc viral clearance misc Medicine misc R Immune Responses in Oral Papillomavirus Clearance in the MmuPV1 Mouse Model
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topic_title	Immune Responses in Oral Papillomavirus Clearance in the MmuPV1 Mouse Model human papillomavirus mouse papillomavirus infections innate adaptive viral clearance
topic	misc human papillomavirus misc mouse papillomavirus misc infections misc innate misc adaptive misc viral clearance misc Medicine misc R
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title	Immune Responses in Oral Papillomavirus Clearance in the MmuPV1 Mouse Model
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author_browse	Sarah A. Brendle Jingwei J. Li Vonn Walter Todd D. Schell Michael Kozak Karla K. Balogh Song Lu Neil D. Christensen Yusheng Zhu Karam El-Bayoumy Jiafen Hu
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title_sort	immune responses in oral papillomavirus clearance in the mmupv1 mouse model
title_auth	Immune Responses in Oral Papillomavirus Clearance in the MmuPV1 Mouse Model
abstract	Human papillomavirus (HPV)-induced oropharyngeal cancer now exceeds HPV-induced cervical cancer, with a noticeable sex bias. Although it is well established that women have a more proficient immune system, it remains unclear whether immune control of oral papillomavirus infections differs between sexes. In the current study, we use genetically modified mice to target CCR2 and Stat1 pathways, with the aim of investigating the role of both innate and adaptive immune responses in clearing oral papillomavirus, using our established papillomavirus (MmuPV1) infection model. Persistent oral MmuPV1 infection was detected in Rag1ko mice with T and B cell deficiencies. Meanwhile, other tested mice were susceptible to MmuPV1 infections but were able to clear the virus. We found sex differences in key myeloid cells, including macrophages, neutrophils, and dendritic cells in the infected tongues of wild type and Stat1ko mice but these differences were not observed in CCR2ko mice. Intriguingly, we also observed a sex difference in anti-MmuPV1 E4 antibody levels, especially for two IgG isotypes: IgG2b and IgG3. However, we found comparable numbers of interferon-gamma-producing CD8 T cells stimulated by E6 and E7 in both sexes. These findings suggest that males and females may use different components of innate and adaptive immune responses to control papillomavirus infections in the MmuPV1 mouse model. The observed sex difference in immune responses, especially in myeloid cells including dendritic cell (DC) subsets, may have potential diagnostic and prognostic values for HPV-associated oropharyngeal cancer.
abstractGer	Human papillomavirus (HPV)-induced oropharyngeal cancer now exceeds HPV-induced cervical cancer, with a noticeable sex bias. Although it is well established that women have a more proficient immune system, it remains unclear whether immune control of oral papillomavirus infections differs between sexes. In the current study, we use genetically modified mice to target CCR2 and Stat1 pathways, with the aim of investigating the role of both innate and adaptive immune responses in clearing oral papillomavirus, using our established papillomavirus (MmuPV1) infection model. Persistent oral MmuPV1 infection was detected in Rag1ko mice with T and B cell deficiencies. Meanwhile, other tested mice were susceptible to MmuPV1 infections but were able to clear the virus. We found sex differences in key myeloid cells, including macrophages, neutrophils, and dendritic cells in the infected tongues of wild type and Stat1ko mice but these differences were not observed in CCR2ko mice. Intriguingly, we also observed a sex difference in anti-MmuPV1 E4 antibody levels, especially for two IgG isotypes: IgG2b and IgG3. However, we found comparable numbers of interferon-gamma-producing CD8 T cells stimulated by E6 and E7 in both sexes. These findings suggest that males and females may use different components of innate and adaptive immune responses to control papillomavirus infections in the MmuPV1 mouse model. The observed sex difference in immune responses, especially in myeloid cells including dendritic cell (DC) subsets, may have potential diagnostic and prognostic values for HPV-associated oropharyngeal cancer.
abstract_unstemmed	Human papillomavirus (HPV)-induced oropharyngeal cancer now exceeds HPV-induced cervical cancer, with a noticeable sex bias. Although it is well established that women have a more proficient immune system, it remains unclear whether immune control of oral papillomavirus infections differs between sexes. In the current study, we use genetically modified mice to target CCR2 and Stat1 pathways, with the aim of investigating the role of both innate and adaptive immune responses in clearing oral papillomavirus, using our established papillomavirus (MmuPV1) infection model. Persistent oral MmuPV1 infection was detected in Rag1ko mice with T and B cell deficiencies. Meanwhile, other tested mice were susceptible to MmuPV1 infections but were able to clear the virus. We found sex differences in key myeloid cells, including macrophages, neutrophils, and dendritic cells in the infected tongues of wild type and Stat1ko mice but these differences were not observed in CCR2ko mice. Intriguingly, we also observed a sex difference in anti-MmuPV1 E4 antibody levels, especially for two IgG isotypes: IgG2b and IgG3. However, we found comparable numbers of interferon-gamma-producing CD8 T cells stimulated by E6 and E7 in both sexes. These findings suggest that males and females may use different components of innate and adaptive immune responses to control papillomavirus infections in the MmuPV1 mouse model. The observed sex difference in immune responses, especially in myeloid cells including dendritic cell (DC) subsets, may have potential diagnostic and prognostic values for HPV-associated oropharyngeal cancer.
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title_short	Immune Responses in Oral Papillomavirus Clearance in the MmuPV1 Mouse Model
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author2	Jingwei J. Li Vonn Walter Todd D. Schell Michael Kozak Karla K. Balogh Song Lu Neil D. Christensen Yusheng Zhu Karam El-Bayoumy Jiafen Hu
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up_date	2024-07-03T19:22:04.330Z
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However, we found comparable numbers of interferon-gamma-producing CD8 T cells stimulated by E6 and E7 in both sexes. These findings suggest that males and females may use different components of innate and adaptive immune responses to control papillomavirus infections in the MmuPV1 mouse model. 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Immune Responses in Oral Papillomavirus Clearance in the MmuPV1 Mouse Model

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