Synthesis and In Silico Drug-Likeness Modeling of 5-FU/ASA Hybrids

A series of 5-FU-ASA hybrids were synthesized with good yields using click chemistry as the key step. The structures of these compounds were elucidated by spectroscopic analysis. Finally, an optimal pharmacokinetic profile was also estimated for each synthetized hybrid. Taken together, hybrids <b...
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Autor*in:	Wilson Castrillón-López [verfasserIn] Andrés F. Yepes [verfasserIn] Wilson Cardona-Galeano [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	5-FU ASA hybrid compounds click chemistry drug-likeness modeling

Übergeordnetes Werk:	In: Molbank - MDPI AG, 2004, (2023), 4, p M1745
Übergeordnetes Werk:	year:2023 ; number:4, p M1745

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/M1745

Katalog-ID:	DOAJ09882290X

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callnumber-first	Q - Science
author	Wilson Castrillón-López
spellingShingle	Wilson Castrillón-López misc QD146-197 misc 5-FU misc ASA misc hybrid compounds misc click chemistry misc drug-likeness modeling misc Inorganic chemistry Synthesis and In Silico Drug-Likeness Modeling of 5-FU/ASA Hybrids
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topic	misc QD146-197 misc 5-FU misc ASA misc hybrid compounds misc click chemistry misc drug-likeness modeling misc Inorganic chemistry
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title	Synthesis and In Silico Drug-Likeness Modeling of 5-FU/ASA Hybrids
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title_full	Synthesis and In Silico Drug-Likeness Modeling of 5-FU/ASA Hybrids
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author_browse	Wilson Castrillón-López Andrés F. Yepes Wilson Cardona-Galeano
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title_sort	synthesis and in silico drug-likeness modeling of 5-fu/asa hybrids
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title_auth	Synthesis and In Silico Drug-Likeness Modeling of 5-FU/ASA Hybrids
abstract	A series of 5-FU-ASA hybrids were synthesized with good yields using click chemistry as the key step. The structures of these compounds were elucidated by spectroscopic analysis. Finally, an optimal pharmacokinetic profile was also estimated for each synthetized hybrid. Taken together, hybrids <b<4a</b<–<b<h</b< could be used as starting points for further pharmacological studies concerning therapeutic cancer intervention.
abstractGer	A series of 5-FU-ASA hybrids were synthesized with good yields using click chemistry as the key step. The structures of these compounds were elucidated by spectroscopic analysis. Finally, an optimal pharmacokinetic profile was also estimated for each synthetized hybrid. Taken together, hybrids <b<4a</b<–<b<h</b< could be used as starting points for further pharmacological studies concerning therapeutic cancer intervention.
abstract_unstemmed	A series of 5-FU-ASA hybrids were synthesized with good yields using click chemistry as the key step. The structures of these compounds were elucidated by spectroscopic analysis. Finally, an optimal pharmacokinetic profile was also estimated for each synthetized hybrid. Taken together, hybrids <b<4a</b<–<b<h</b< could be used as starting points for further pharmacological studies concerning therapeutic cancer intervention.
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title_short	Synthesis and In Silico Drug-Likeness Modeling of 5-FU/ASA Hybrids
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