Extrapulmonary Neuroendocrine Carcinomas: Current Management and Future Perspectives
Neuroendocrine carcinomas (NECs) are poorly differentiated and highly aggressive epithelial neuroendocrine neoplasms. The most common primary site is the lung, but they may arise in every organ. Approximately 37% of extrapulmonary NECs (EP-NECs) occur in the gastroenteropancreatic (GEP) tract, follo...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Sara Stumpo [verfasserIn] Maria Giovanna Formelli [verfasserIn] Irene Persano [verfasserIn] Elena Parlagreco [verfasserIn] Eleonora Lauricella [verfasserIn] Maria Grazia Rodriquenz [verfasserIn] Luigi Pio Guerrera [verfasserIn] Ina Valeria Zurlo [verfasserIn] Davide Campana [verfasserIn] Maria Pia Brizzi [verfasserIn] Mauro Cives [verfasserIn] Anna La Salvia [verfasserIn] Giuseppe Lamberti [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Journal of Clinical Medicine - MDPI AG, 2013, 12(2023), 24, p 7715 |
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| Übergeordnetes Werk: |
volume:12 ; year:2023 ; number:24, p 7715 |
| Links: |
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| DOI / URN: |
10.3390/jcm12247715 |
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DOAJ09884816X |
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| 520 | |a Neuroendocrine carcinomas (NECs) are poorly differentiated and highly aggressive epithelial neuroendocrine neoplasms. The most common primary site is the lung, but they may arise in every organ. Approximately 37% of extrapulmonary NECs (EP-NECs) occur in the gastroenteropancreatic (GEP) tract, followed by the genitourinary (GU) system and gynecological tract. As a result of their rarity, there is scant evidence to guide treatment recommendations, and a multidisciplinary approach is essential for the management of such patients. Platinum-based chemotherapy currently represents the standard of care for EP-NECs of any site, mirroring the management of small-cell lung cancer (SCLC), but further approaches are still under investigation. Indeed, ongoing trials evaluating targeted therapies, immune checkpoint inhibitors (ICIs), and radionuclide therapy could provide potentially breakthrough therapeutic options. Given the relative dearth of evidence-based literature on these orphan diseases, the aim of this review is to provide an overview of the pathology and current treatment options, as well as to shed light on the most pressing unmet needs in the field. | ||
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10.3390/jcm12247715 doi (DE-627)DOAJ09884816X (DE-599)DOAJ584e62acd0784356a335a067d6bc9f7b DE-627 ger DE-627 rakwb eng Sara Stumpo verfasserin aut Extrapulmonary Neuroendocrine Carcinomas: Current Management and Future Perspectives 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Neuroendocrine carcinomas (NECs) are poorly differentiated and highly aggressive epithelial neuroendocrine neoplasms. The most common primary site is the lung, but they may arise in every organ. Approximately 37% of extrapulmonary NECs (EP-NECs) occur in the gastroenteropancreatic (GEP) tract, followed by the genitourinary (GU) system and gynecological tract. As a result of their rarity, there is scant evidence to guide treatment recommendations, and a multidisciplinary approach is essential for the management of such patients. Platinum-based chemotherapy currently represents the standard of care for EP-NECs of any site, mirroring the management of small-cell lung cancer (SCLC), but further approaches are still under investigation. Indeed, ongoing trials evaluating targeted therapies, immune checkpoint inhibitors (ICIs), and radionuclide therapy could provide potentially breakthrough therapeutic options. Given the relative dearth of evidence-based literature on these orphan diseases, the aim of this review is to provide an overview of the pathology and current treatment options, as well as to shed light on the most pressing unmet needs in the field. extrapulmonary neuroendocrine carcinomas chemotherapy gastroenteropancreatic tract gynecologic tract genitourinary tract Medicine R Maria Giovanna Formelli verfasserin aut Irene Persano verfasserin aut Elena Parlagreco verfasserin aut Eleonora Lauricella verfasserin aut Maria Grazia Rodriquenz verfasserin aut Luigi Pio Guerrera verfasserin aut Ina Valeria Zurlo verfasserin aut Davide Campana verfasserin aut Maria Pia Brizzi verfasserin aut Mauro Cives verfasserin aut Anna La Salvia verfasserin aut Giuseppe Lamberti verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 12(2023), 24, p 7715 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:12 year:2023 number:24, p 7715 https://doi.org/10.3390/jcm12247715 kostenfrei https://doaj.org/article/584e62acd0784356a335a067d6bc9f7b kostenfrei https://www.mdpi.com/2077-0383/12/24/7715 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 24, p 7715 |
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10.3390/jcm12247715 doi (DE-627)DOAJ09884816X (DE-599)DOAJ584e62acd0784356a335a067d6bc9f7b DE-627 ger DE-627 rakwb eng Sara Stumpo verfasserin aut Extrapulmonary Neuroendocrine Carcinomas: Current Management and Future Perspectives 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Neuroendocrine carcinomas (NECs) are poorly differentiated and highly aggressive epithelial neuroendocrine neoplasms. The most common primary site is the lung, but they may arise in every organ. Approximately 37% of extrapulmonary NECs (EP-NECs) occur in the gastroenteropancreatic (GEP) tract, followed by the genitourinary (GU) system and gynecological tract. As a result of their rarity, there is scant evidence to guide treatment recommendations, and a multidisciplinary approach is essential for the management of such patients. Platinum-based chemotherapy currently represents the standard of care for EP-NECs of any site, mirroring the management of small-cell lung cancer (SCLC), but further approaches are still under investigation. Indeed, ongoing trials evaluating targeted therapies, immune checkpoint inhibitors (ICIs), and radionuclide therapy could provide potentially breakthrough therapeutic options. Given the relative dearth of evidence-based literature on these orphan diseases, the aim of this review is to provide an overview of the pathology and current treatment options, as well as to shed light on the most pressing unmet needs in the field. extrapulmonary neuroendocrine carcinomas chemotherapy gastroenteropancreatic tract gynecologic tract genitourinary tract Medicine R Maria Giovanna Formelli verfasserin aut Irene Persano verfasserin aut Elena Parlagreco verfasserin aut Eleonora Lauricella verfasserin aut Maria Grazia Rodriquenz verfasserin aut Luigi Pio Guerrera verfasserin aut Ina Valeria Zurlo verfasserin aut Davide Campana verfasserin aut Maria Pia Brizzi verfasserin aut Mauro Cives verfasserin aut Anna La Salvia verfasserin aut Giuseppe Lamberti verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 12(2023), 24, p 7715 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:12 year:2023 number:24, p 7715 https://doi.org/10.3390/jcm12247715 kostenfrei https://doaj.org/article/584e62acd0784356a335a067d6bc9f7b kostenfrei https://www.mdpi.com/2077-0383/12/24/7715 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 24, p 7715 |
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10.3390/jcm12247715 doi (DE-627)DOAJ09884816X (DE-599)DOAJ584e62acd0784356a335a067d6bc9f7b DE-627 ger DE-627 rakwb eng Sara Stumpo verfasserin aut Extrapulmonary Neuroendocrine Carcinomas: Current Management and Future Perspectives 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Neuroendocrine carcinomas (NECs) are poorly differentiated and highly aggressive epithelial neuroendocrine neoplasms. The most common primary site is the lung, but they may arise in every organ. Approximately 37% of extrapulmonary NECs (EP-NECs) occur in the gastroenteropancreatic (GEP) tract, followed by the genitourinary (GU) system and gynecological tract. As a result of their rarity, there is scant evidence to guide treatment recommendations, and a multidisciplinary approach is essential for the management of such patients. Platinum-based chemotherapy currently represents the standard of care for EP-NECs of any site, mirroring the management of small-cell lung cancer (SCLC), but further approaches are still under investigation. Indeed, ongoing trials evaluating targeted therapies, immune checkpoint inhibitors (ICIs), and radionuclide therapy could provide potentially breakthrough therapeutic options. Given the relative dearth of evidence-based literature on these orphan diseases, the aim of this review is to provide an overview of the pathology and current treatment options, as well as to shed light on the most pressing unmet needs in the field. extrapulmonary neuroendocrine carcinomas chemotherapy gastroenteropancreatic tract gynecologic tract genitourinary tract Medicine R Maria Giovanna Formelli verfasserin aut Irene Persano verfasserin aut Elena Parlagreco verfasserin aut Eleonora Lauricella verfasserin aut Maria Grazia Rodriquenz verfasserin aut Luigi Pio Guerrera verfasserin aut Ina Valeria Zurlo verfasserin aut Davide Campana verfasserin aut Maria Pia Brizzi verfasserin aut Mauro Cives verfasserin aut Anna La Salvia verfasserin aut Giuseppe Lamberti verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 12(2023), 24, p 7715 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:12 year:2023 number:24, p 7715 https://doi.org/10.3390/jcm12247715 kostenfrei https://doaj.org/article/584e62acd0784356a335a067d6bc9f7b kostenfrei https://www.mdpi.com/2077-0383/12/24/7715 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 24, p 7715 |
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10.3390/jcm12247715 doi (DE-627)DOAJ09884816X (DE-599)DOAJ584e62acd0784356a335a067d6bc9f7b DE-627 ger DE-627 rakwb eng Sara Stumpo verfasserin aut Extrapulmonary Neuroendocrine Carcinomas: Current Management and Future Perspectives 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Neuroendocrine carcinomas (NECs) are poorly differentiated and highly aggressive epithelial neuroendocrine neoplasms. The most common primary site is the lung, but they may arise in every organ. Approximately 37% of extrapulmonary NECs (EP-NECs) occur in the gastroenteropancreatic (GEP) tract, followed by the genitourinary (GU) system and gynecological tract. As a result of their rarity, there is scant evidence to guide treatment recommendations, and a multidisciplinary approach is essential for the management of such patients. Platinum-based chemotherapy currently represents the standard of care for EP-NECs of any site, mirroring the management of small-cell lung cancer (SCLC), but further approaches are still under investigation. Indeed, ongoing trials evaluating targeted therapies, immune checkpoint inhibitors (ICIs), and radionuclide therapy could provide potentially breakthrough therapeutic options. Given the relative dearth of evidence-based literature on these orphan diseases, the aim of this review is to provide an overview of the pathology and current treatment options, as well as to shed light on the most pressing unmet needs in the field. extrapulmonary neuroendocrine carcinomas chemotherapy gastroenteropancreatic tract gynecologic tract genitourinary tract Medicine R Maria Giovanna Formelli verfasserin aut Irene Persano verfasserin aut Elena Parlagreco verfasserin aut Eleonora Lauricella verfasserin aut Maria Grazia Rodriquenz verfasserin aut Luigi Pio Guerrera verfasserin aut Ina Valeria Zurlo verfasserin aut Davide Campana verfasserin aut Maria Pia Brizzi verfasserin aut Mauro Cives verfasserin aut Anna La Salvia verfasserin aut Giuseppe Lamberti verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 12(2023), 24, p 7715 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:12 year:2023 number:24, p 7715 https://doi.org/10.3390/jcm12247715 kostenfrei https://doaj.org/article/584e62acd0784356a335a067d6bc9f7b kostenfrei https://www.mdpi.com/2077-0383/12/24/7715 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 24, p 7715 |
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Neuroendocrine carcinomas (NECs) are poorly differentiated and highly aggressive epithelial neuroendocrine neoplasms. The most common primary site is the lung, but they may arise in every organ. Approximately 37% of extrapulmonary NECs (EP-NECs) occur in the gastroenteropancreatic (GEP) tract, followed by the genitourinary (GU) system and gynecological tract. As a result of their rarity, there is scant evidence to guide treatment recommendations, and a multidisciplinary approach is essential for the management of such patients. Platinum-based chemotherapy currently represents the standard of care for EP-NECs of any site, mirroring the management of small-cell lung cancer (SCLC), but further approaches are still under investigation. Indeed, ongoing trials evaluating targeted therapies, immune checkpoint inhibitors (ICIs), and radionuclide therapy could provide potentially breakthrough therapeutic options. Given the relative dearth of evidence-based literature on these orphan diseases, the aim of this review is to provide an overview of the pathology and current treatment options, as well as to shed light on the most pressing unmet needs in the field. |
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Neuroendocrine carcinomas (NECs) are poorly differentiated and highly aggressive epithelial neuroendocrine neoplasms. The most common primary site is the lung, but they may arise in every organ. Approximately 37% of extrapulmonary NECs (EP-NECs) occur in the gastroenteropancreatic (GEP) tract, followed by the genitourinary (GU) system and gynecological tract. As a result of their rarity, there is scant evidence to guide treatment recommendations, and a multidisciplinary approach is essential for the management of such patients. Platinum-based chemotherapy currently represents the standard of care for EP-NECs of any site, mirroring the management of small-cell lung cancer (SCLC), but further approaches are still under investigation. Indeed, ongoing trials evaluating targeted therapies, immune checkpoint inhibitors (ICIs), and radionuclide therapy could provide potentially breakthrough therapeutic options. Given the relative dearth of evidence-based literature on these orphan diseases, the aim of this review is to provide an overview of the pathology and current treatment options, as well as to shed light on the most pressing unmet needs in the field. |
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Neuroendocrine carcinomas (NECs) are poorly differentiated and highly aggressive epithelial neuroendocrine neoplasms. The most common primary site is the lung, but they may arise in every organ. Approximately 37% of extrapulmonary NECs (EP-NECs) occur in the gastroenteropancreatic (GEP) tract, followed by the genitourinary (GU) system and gynecological tract. As a result of their rarity, there is scant evidence to guide treatment recommendations, and a multidisciplinary approach is essential for the management of such patients. Platinum-based chemotherapy currently represents the standard of care for EP-NECs of any site, mirroring the management of small-cell lung cancer (SCLC), but further approaches are still under investigation. Indeed, ongoing trials evaluating targeted therapies, immune checkpoint inhibitors (ICIs), and radionuclide therapy could provide potentially breakthrough therapeutic options. Given the relative dearth of evidence-based literature on these orphan diseases, the aim of this review is to provide an overview of the pathology and current treatment options, as well as to shed light on the most pressing unmet needs in the field. |
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