Tasks and Experiences of the Prospective, Longitudinal, Multicenter MoMar (Molecular Markers) Study for the Early Detection of Mesothelioma in Individuals Formerly Exposed to Asbestos Using Liquid Biopsies

Mesothelioma is an aggressive cancer, strongly associated with prior exposure to asbestos. Commonly, tumors are detected at late stages of the disease. Detection at early stages might be meaningful, because therapies might be more effective when the tumor burden is relatively low and the tumor has n...
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Gespeichert in:

Autor*in:	Daniel Gilbert Weber [verfasserIn] Swaantje Casjens [verfasserIn] Katharina Wichert [verfasserIn] Martin Lehnert [verfasserIn] Dirk Taeger [verfasserIn] Hans-Peter Rihs [verfasserIn] Thomas Brüning [verfasserIn] Georg Johnen [verfasserIn] the MoMar Study Group [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	asbestos biomarker blood-based calretinin cancer cohort

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 15(2023), 24, p 5896
Übergeordnetes Werk:	volume:15 ; year:2023 ; number:24, p 5896

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers15245896

Katalog-ID:	DOAJ098897292

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allfieldsGer	10.3390/cancers15245896 doi (DE-627)DOAJ098897292 (DE-599)DOAJ6c6210d648324ea3bbf66ad0da380b7c DE-627 ger DE-627 rakwb eng RC254-282 Daniel Gilbert Weber verfasserin aut Tasks and Experiences of the Prospective, Longitudinal, Multicenter MoMar (Molecular Markers) Study for the Early Detection of Mesothelioma in Individuals Formerly Exposed to Asbestos Using Liquid Biopsies 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Mesothelioma is an aggressive cancer, strongly associated with prior exposure to asbestos. Commonly, tumors are detected at late stages of the disease. Detection at early stages might be meaningful, because therapies might be more effective when the tumor burden is relatively low and the tumor has not spread to distant sites. Circulating biomarkers in blood might be a promising tool to improve the early detection of mesothelioma, but for screening in asymptomatic subjects, candidate biomarkers need to be validated in appropriate studies. This study was conducted to assess the performance of biomarkers in liquid biopsies to detect mesothelioma at early stages. Over a period of 10 years, 2769 volunteers formerly exposed to asbestos were annually examined and liquid biopsies were collected. A follow-up was completed 17 months after the last blood collection. The article provides a detailed overview of our lessons learned and experiences of conducting a prospective, longitudinal, multicenter study. The existing cohort of individuals at risk is highly suitable for the validation of blood-based biomarkers for the early detection of mesothelioma as well as lung cancer. asbestos biomarker blood-based calretinin cancer cohort Neoplasms. Tumors. Oncology. Including cancer and carcinogens Swaantje Casjens verfasserin aut Katharina Wichert verfasserin aut Martin Lehnert verfasserin aut Dirk Taeger verfasserin aut Hans-Peter Rihs verfasserin aut Thomas Brüning verfasserin aut Georg Johnen verfasserin aut the MoMar Study Group verfasserin aut In Cancers MDPI AG, 2010 15(2023), 24, p 5896 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:15 year:2023 number:24, p 5896 https://doi.org/10.3390/cancers15245896 kostenfrei https://doaj.org/article/6c6210d648324ea3bbf66ad0da380b7c kostenfrei https://www.mdpi.com/2072-6694/15/24/5896 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 24, p 5896
allfieldsSound	10.3390/cancers15245896 doi (DE-627)DOAJ098897292 (DE-599)DOAJ6c6210d648324ea3bbf66ad0da380b7c DE-627 ger DE-627 rakwb eng RC254-282 Daniel Gilbert Weber verfasserin aut Tasks and Experiences of the Prospective, Longitudinal, Multicenter MoMar (Molecular Markers) Study for the Early Detection of Mesothelioma in Individuals Formerly Exposed to Asbestos Using Liquid Biopsies 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Mesothelioma is an aggressive cancer, strongly associated with prior exposure to asbestos. Commonly, tumors are detected at late stages of the disease. Detection at early stages might be meaningful, because therapies might be more effective when the tumor burden is relatively low and the tumor has not spread to distant sites. Circulating biomarkers in blood might be a promising tool to improve the early detection of mesothelioma, but for screening in asymptomatic subjects, candidate biomarkers need to be validated in appropriate studies. This study was conducted to assess the performance of biomarkers in liquid biopsies to detect mesothelioma at early stages. Over a period of 10 years, 2769 volunteers formerly exposed to asbestos were annually examined and liquid biopsies were collected. A follow-up was completed 17 months after the last blood collection. The article provides a detailed overview of our lessons learned and experiences of conducting a prospective, longitudinal, multicenter study. The existing cohort of individuals at risk is highly suitable for the validation of blood-based biomarkers for the early detection of mesothelioma as well as lung cancer. asbestos biomarker blood-based calretinin cancer cohort Neoplasms. Tumors. Oncology. Including cancer and carcinogens Swaantje Casjens verfasserin aut Katharina Wichert verfasserin aut Martin Lehnert verfasserin aut Dirk Taeger verfasserin aut Hans-Peter Rihs verfasserin aut Thomas Brüning verfasserin aut Georg Johnen verfasserin aut the MoMar Study Group verfasserin aut In Cancers MDPI AG, 2010 15(2023), 24, p 5896 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:15 year:2023 number:24, p 5896 https://doi.org/10.3390/cancers15245896 kostenfrei https://doaj.org/article/6c6210d648324ea3bbf66ad0da380b7c kostenfrei https://www.mdpi.com/2072-6694/15/24/5896 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 24, p 5896
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authorswithroles_txt_mv	Daniel Gilbert Weber @@aut@@ Swaantje Casjens @@aut@@ Katharina Wichert @@aut@@ Martin Lehnert @@aut@@ Dirk Taeger @@aut@@ Hans-Peter Rihs @@aut@@ Thomas Brüning @@aut@@ Georg Johnen @@aut@@ the MoMar Study Group @@aut@@
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callnumber-first	R - Medicine
author	Daniel Gilbert Weber
spellingShingle	Daniel Gilbert Weber misc RC254-282 misc asbestos misc biomarker misc blood-based misc calretinin misc cancer misc cohort misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Tasks and Experiences of the Prospective, Longitudinal, Multicenter MoMar (Molecular Markers) Study for the Early Detection of Mesothelioma in Individuals Formerly Exposed to Asbestos Using Liquid Biopsies
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topic_title	RC254-282 Tasks and Experiences of the Prospective, Longitudinal, Multicenter MoMar (Molecular Markers) Study for the Early Detection of Mesothelioma in Individuals Formerly Exposed to Asbestos Using Liquid Biopsies asbestos biomarker blood-based calretinin cancer cohort
topic	misc RC254-282 misc asbestos misc biomarker misc blood-based misc calretinin misc cancer misc cohort misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc asbestos misc biomarker misc blood-based misc calretinin misc cancer misc cohort misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Tasks and Experiences of the Prospective, Longitudinal, Multicenter MoMar (Molecular Markers) Study for the Early Detection of Mesothelioma in Individuals Formerly Exposed to Asbestos Using Liquid Biopsies
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title_full	Tasks and Experiences of the Prospective, Longitudinal, Multicenter MoMar (Molecular Markers) Study for the Early Detection of Mesothelioma in Individuals Formerly Exposed to Asbestos Using Liquid Biopsies
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author_browse	Daniel Gilbert Weber Swaantje Casjens Katharina Wichert Martin Lehnert Dirk Taeger Hans-Peter Rihs Thomas Brüning Georg Johnen the MoMar Study Group
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title_sort	tasks and experiences of the prospective, longitudinal, multicenter momar (molecular markers) study for the early detection of mesothelioma in individuals formerly exposed to asbestos using liquid biopsies
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title_auth	Tasks and Experiences of the Prospective, Longitudinal, Multicenter MoMar (Molecular Markers) Study for the Early Detection of Mesothelioma in Individuals Formerly Exposed to Asbestos Using Liquid Biopsies
abstract	Mesothelioma is an aggressive cancer, strongly associated with prior exposure to asbestos. Commonly, tumors are detected at late stages of the disease. Detection at early stages might be meaningful, because therapies might be more effective when the tumor burden is relatively low and the tumor has not spread to distant sites. Circulating biomarkers in blood might be a promising tool to improve the early detection of mesothelioma, but for screening in asymptomatic subjects, candidate biomarkers need to be validated in appropriate studies. This study was conducted to assess the performance of biomarkers in liquid biopsies to detect mesothelioma at early stages. Over a period of 10 years, 2769 volunteers formerly exposed to asbestos were annually examined and liquid biopsies were collected. A follow-up was completed 17 months after the last blood collection. The article provides a detailed overview of our lessons learned and experiences of conducting a prospective, longitudinal, multicenter study. The existing cohort of individuals at risk is highly suitable for the validation of blood-based biomarkers for the early detection of mesothelioma as well as lung cancer.
abstractGer	Mesothelioma is an aggressive cancer, strongly associated with prior exposure to asbestos. Commonly, tumors are detected at late stages of the disease. Detection at early stages might be meaningful, because therapies might be more effective when the tumor burden is relatively low and the tumor has not spread to distant sites. Circulating biomarkers in blood might be a promising tool to improve the early detection of mesothelioma, but for screening in asymptomatic subjects, candidate biomarkers need to be validated in appropriate studies. This study was conducted to assess the performance of biomarkers in liquid biopsies to detect mesothelioma at early stages. Over a period of 10 years, 2769 volunteers formerly exposed to asbestos were annually examined and liquid biopsies were collected. A follow-up was completed 17 months after the last blood collection. The article provides a detailed overview of our lessons learned and experiences of conducting a prospective, longitudinal, multicenter study. The existing cohort of individuals at risk is highly suitable for the validation of blood-based biomarkers for the early detection of mesothelioma as well as lung cancer.
abstract_unstemmed	Mesothelioma is an aggressive cancer, strongly associated with prior exposure to asbestos. Commonly, tumors are detected at late stages of the disease. Detection at early stages might be meaningful, because therapies might be more effective when the tumor burden is relatively low and the tumor has not spread to distant sites. Circulating biomarkers in blood might be a promising tool to improve the early detection of mesothelioma, but for screening in asymptomatic subjects, candidate biomarkers need to be validated in appropriate studies. This study was conducted to assess the performance of biomarkers in liquid biopsies to detect mesothelioma at early stages. Over a period of 10 years, 2769 volunteers formerly exposed to asbestos were annually examined and liquid biopsies were collected. A follow-up was completed 17 months after the last blood collection. The article provides a detailed overview of our lessons learned and experiences of conducting a prospective, longitudinal, multicenter study. The existing cohort of individuals at risk is highly suitable for the validation of blood-based biomarkers for the early detection of mesothelioma as well as lung cancer.
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title_short	Tasks and Experiences of the Prospective, Longitudinal, Multicenter MoMar (Molecular Markers) Study for the Early Detection of Mesothelioma in Individuals Formerly Exposed to Asbestos Using Liquid Biopsies
url	https://doi.org/10.3390/cancers15245896 https://doaj.org/article/6c6210d648324ea3bbf66ad0da380b7c https://www.mdpi.com/2072-6694/15/24/5896 https://doaj.org/toc/2072-6694
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up_date	2024-07-03T19:51:29.844Z
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Tasks and Experiences of the Prospective, Longitudinal, Multicenter MoMar (Molecular Markers) Study for the Early Detection of Mesothelioma in Individuals Formerly Exposed to Asbestos Using Liquid Biopsies

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