Neoadjuvant Chemotherapy Followed by Gastrectomy for Cytology-Positive Gastric Cancer without Any Other Non-Curative Factors in a Western Setting: An International Eastern European Cohort Study

The optimal approach for treating cytology-positive (Cy1) gastric cancer (GC) patients without additional non-curative factors remains uncertain. While neoadjuvant chemotherapy followed by gastrectomy shows promise, its suitability for Western patients is not well supported by existing data. To addr...
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Autor*in:	Augustinas Bausys [verfasserIn] Toomas Ümarik [verfasserIn] Oleksii Dobrzhanskyi [verfasserIn] Martynas Luksta [verfasserIn] Yourii Kondratskyi [verfasserIn] Arvo Reinsoo [verfasserIn] Mihhail Vassiljev [verfasserIn] Bernardas Bausys [verfasserIn] Klaudija Bickaite [verfasserIn] Kornelija Rauduvyte [verfasserIn] Raminta Luksaite-Lukste [verfasserIn] Rimantas Bausys [verfasserIn] Kestutis Strupas [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	gastric cancer positive cytology neoadjuvant chemotherapy pathological response

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 15(2023), 24, p 5794
Übergeordnetes Werk:	volume:15 ; year:2023 ; number:24, p 5794

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers15245794

Katalog-ID:	DOAJ098898345

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allfields	10.3390/cancers15245794 doi (DE-627)DOAJ098898345 (DE-599)DOAJ5facaa9093d741b4b319d9bf2e113616 DE-627 ger DE-627 rakwb eng RC254-282 Augustinas Bausys verfasserin aut Neoadjuvant Chemotherapy Followed by Gastrectomy for Cytology-Positive Gastric Cancer without Any Other Non-Curative Factors in a Western Setting: An International Eastern European Cohort Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The optimal approach for treating cytology-positive (Cy1) gastric cancer (GC) patients without additional non-curative factors remains uncertain. While neoadjuvant chemotherapy followed by gastrectomy shows promise, its suitability for Western patients is not well supported by existing data. To address this knowledge gap, a cohort study was conducted across four major GC treatment centers in Lithuania, Estonia, and Ukraine. Forty-three consecutive Cy1 GC patients who underwent neoadjuvant chemotherapy between 2016 and 2020 were enrolled. The study evaluated overall survival (OS), progression-free survival (PFS), cytology status conversion, and major pathological response rates, along with the factors influencing these outcomes. All patients underwent surgery post-neoadjuvant chemotherapy, with 53.5% experiencing cytological status conversion and 23.3% achieving a major pathological response. The median OS and PFS were 20 (95% CI: 16–25) and 19 (95% CI: 11–20) months, respectively. Conversion to negative cytology significantly reduced the relative risk of peritoneal progression (RR: 0.11; 95% CI: 0.03–0.47, <i<p</i< = 0.002). The study suggests that neoadjuvant chemotherapy followed by gastrectomy holds promise as a treatment option for Cy1 GC without additional non-curative factors, associating cytology status conversion with improved long-term outcomes and reduced peritoneal relapse risk. gastric cancer positive cytology neoadjuvant chemotherapy pathological response Neoplasms. Tumors. Oncology. Including cancer and carcinogens Toomas Ümarik verfasserin aut Oleksii Dobrzhanskyi verfasserin aut Martynas Luksta verfasserin aut Yourii Kondratskyi verfasserin aut Arvo Reinsoo verfasserin aut Mihhail Vassiljev verfasserin aut Bernardas Bausys verfasserin aut Klaudija Bickaite verfasserin aut Kornelija Rauduvyte verfasserin aut Raminta Luksaite-Lukste verfasserin aut Rimantas Bausys verfasserin aut Kestutis Strupas verfasserin aut In Cancers MDPI AG, 2010 15(2023), 24, p 5794 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:15 year:2023 number:24, p 5794 https://doi.org/10.3390/cancers15245794 kostenfrei https://doaj.org/article/5facaa9093d741b4b319d9bf2e113616 kostenfrei https://www.mdpi.com/2072-6694/15/24/5794 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 24, p 5794
spelling	10.3390/cancers15245794 doi (DE-627)DOAJ098898345 (DE-599)DOAJ5facaa9093d741b4b319d9bf2e113616 DE-627 ger DE-627 rakwb eng RC254-282 Augustinas Bausys verfasserin aut Neoadjuvant Chemotherapy Followed by Gastrectomy for Cytology-Positive Gastric Cancer without Any Other Non-Curative Factors in a Western Setting: An International Eastern European Cohort Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The optimal approach for treating cytology-positive (Cy1) gastric cancer (GC) patients without additional non-curative factors remains uncertain. While neoadjuvant chemotherapy followed by gastrectomy shows promise, its suitability for Western patients is not well supported by existing data. To address this knowledge gap, a cohort study was conducted across four major GC treatment centers in Lithuania, Estonia, and Ukraine. Forty-three consecutive Cy1 GC patients who underwent neoadjuvant chemotherapy between 2016 and 2020 were enrolled. The study evaluated overall survival (OS), progression-free survival (PFS), cytology status conversion, and major pathological response rates, along with the factors influencing these outcomes. All patients underwent surgery post-neoadjuvant chemotherapy, with 53.5% experiencing cytological status conversion and 23.3% achieving a major pathological response. The median OS and PFS were 20 (95% CI: 16–25) and 19 (95% CI: 11–20) months, respectively. Conversion to negative cytology significantly reduced the relative risk of peritoneal progression (RR: 0.11; 95% CI: 0.03–0.47, <i<p</i< = 0.002). The study suggests that neoadjuvant chemotherapy followed by gastrectomy holds promise as a treatment option for Cy1 GC without additional non-curative factors, associating cytology status conversion with improved long-term outcomes and reduced peritoneal relapse risk. gastric cancer positive cytology neoadjuvant chemotherapy pathological response Neoplasms. Tumors. Oncology. Including cancer and carcinogens Toomas Ümarik verfasserin aut Oleksii Dobrzhanskyi verfasserin aut Martynas Luksta verfasserin aut Yourii Kondratskyi verfasserin aut Arvo Reinsoo verfasserin aut Mihhail Vassiljev verfasserin aut Bernardas Bausys verfasserin aut Klaudija Bickaite verfasserin aut Kornelija Rauduvyte verfasserin aut Raminta Luksaite-Lukste verfasserin aut Rimantas Bausys verfasserin aut Kestutis Strupas verfasserin aut In Cancers MDPI AG, 2010 15(2023), 24, p 5794 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:15 year:2023 number:24, p 5794 https://doi.org/10.3390/cancers15245794 kostenfrei https://doaj.org/article/5facaa9093d741b4b319d9bf2e113616 kostenfrei https://www.mdpi.com/2072-6694/15/24/5794 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 24, p 5794
allfields_unstemmed	10.3390/cancers15245794 doi (DE-627)DOAJ098898345 (DE-599)DOAJ5facaa9093d741b4b319d9bf2e113616 DE-627 ger DE-627 rakwb eng RC254-282 Augustinas Bausys verfasserin aut Neoadjuvant Chemotherapy Followed by Gastrectomy for Cytology-Positive Gastric Cancer without Any Other Non-Curative Factors in a Western Setting: An International Eastern European Cohort Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The optimal approach for treating cytology-positive (Cy1) gastric cancer (GC) patients without additional non-curative factors remains uncertain. While neoadjuvant chemotherapy followed by gastrectomy shows promise, its suitability for Western patients is not well supported by existing data. To address this knowledge gap, a cohort study was conducted across four major GC treatment centers in Lithuania, Estonia, and Ukraine. Forty-three consecutive Cy1 GC patients who underwent neoadjuvant chemotherapy between 2016 and 2020 were enrolled. The study evaluated overall survival (OS), progression-free survival (PFS), cytology status conversion, and major pathological response rates, along with the factors influencing these outcomes. All patients underwent surgery post-neoadjuvant chemotherapy, with 53.5% experiencing cytological status conversion and 23.3% achieving a major pathological response. The median OS and PFS were 20 (95% CI: 16–25) and 19 (95% CI: 11–20) months, respectively. Conversion to negative cytology significantly reduced the relative risk of peritoneal progression (RR: 0.11; 95% CI: 0.03–0.47, <i<p</i< = 0.002). The study suggests that neoadjuvant chemotherapy followed by gastrectomy holds promise as a treatment option for Cy1 GC without additional non-curative factors, associating cytology status conversion with improved long-term outcomes and reduced peritoneal relapse risk. gastric cancer positive cytology neoadjuvant chemotherapy pathological response Neoplasms. Tumors. Oncology. Including cancer and carcinogens Toomas Ümarik verfasserin aut Oleksii Dobrzhanskyi verfasserin aut Martynas Luksta verfasserin aut Yourii Kondratskyi verfasserin aut Arvo Reinsoo verfasserin aut Mihhail Vassiljev verfasserin aut Bernardas Bausys verfasserin aut Klaudija Bickaite verfasserin aut Kornelija Rauduvyte verfasserin aut Raminta Luksaite-Lukste verfasserin aut Rimantas Bausys verfasserin aut Kestutis Strupas verfasserin aut In Cancers MDPI AG, 2010 15(2023), 24, p 5794 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:15 year:2023 number:24, p 5794 https://doi.org/10.3390/cancers15245794 kostenfrei https://doaj.org/article/5facaa9093d741b4b319d9bf2e113616 kostenfrei https://www.mdpi.com/2072-6694/15/24/5794 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 24, p 5794
allfieldsGer	10.3390/cancers15245794 doi (DE-627)DOAJ098898345 (DE-599)DOAJ5facaa9093d741b4b319d9bf2e113616 DE-627 ger DE-627 rakwb eng RC254-282 Augustinas Bausys verfasserin aut Neoadjuvant Chemotherapy Followed by Gastrectomy for Cytology-Positive Gastric Cancer without Any Other Non-Curative Factors in a Western Setting: An International Eastern European Cohort Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The optimal approach for treating cytology-positive (Cy1) gastric cancer (GC) patients without additional non-curative factors remains uncertain. While neoadjuvant chemotherapy followed by gastrectomy shows promise, its suitability for Western patients is not well supported by existing data. To address this knowledge gap, a cohort study was conducted across four major GC treatment centers in Lithuania, Estonia, and Ukraine. Forty-three consecutive Cy1 GC patients who underwent neoadjuvant chemotherapy between 2016 and 2020 were enrolled. The study evaluated overall survival (OS), progression-free survival (PFS), cytology status conversion, and major pathological response rates, along with the factors influencing these outcomes. All patients underwent surgery post-neoadjuvant chemotherapy, with 53.5% experiencing cytological status conversion and 23.3% achieving a major pathological response. The median OS and PFS were 20 (95% CI: 16–25) and 19 (95% CI: 11–20) months, respectively. Conversion to negative cytology significantly reduced the relative risk of peritoneal progression (RR: 0.11; 95% CI: 0.03–0.47, <i<p</i< = 0.002). The study suggests that neoadjuvant chemotherapy followed by gastrectomy holds promise as a treatment option for Cy1 GC without additional non-curative factors, associating cytology status conversion with improved long-term outcomes and reduced peritoneal relapse risk. gastric cancer positive cytology neoadjuvant chemotherapy pathological response Neoplasms. Tumors. Oncology. Including cancer and carcinogens Toomas Ümarik verfasserin aut Oleksii Dobrzhanskyi verfasserin aut Martynas Luksta verfasserin aut Yourii Kondratskyi verfasserin aut Arvo Reinsoo verfasserin aut Mihhail Vassiljev verfasserin aut Bernardas Bausys verfasserin aut Klaudija Bickaite verfasserin aut Kornelija Rauduvyte verfasserin aut Raminta Luksaite-Lukste verfasserin aut Rimantas Bausys verfasserin aut Kestutis Strupas verfasserin aut In Cancers MDPI AG, 2010 15(2023), 24, p 5794 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:15 year:2023 number:24, p 5794 https://doi.org/10.3390/cancers15245794 kostenfrei https://doaj.org/article/5facaa9093d741b4b319d9bf2e113616 kostenfrei https://www.mdpi.com/2072-6694/15/24/5794 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 24, p 5794
allfieldsSound	10.3390/cancers15245794 doi (DE-627)DOAJ098898345 (DE-599)DOAJ5facaa9093d741b4b319d9bf2e113616 DE-627 ger DE-627 rakwb eng RC254-282 Augustinas Bausys verfasserin aut Neoadjuvant Chemotherapy Followed by Gastrectomy for Cytology-Positive Gastric Cancer without Any Other Non-Curative Factors in a Western Setting: An International Eastern European Cohort Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The optimal approach for treating cytology-positive (Cy1) gastric cancer (GC) patients without additional non-curative factors remains uncertain. While neoadjuvant chemotherapy followed by gastrectomy shows promise, its suitability for Western patients is not well supported by existing data. To address this knowledge gap, a cohort study was conducted across four major GC treatment centers in Lithuania, Estonia, and Ukraine. Forty-three consecutive Cy1 GC patients who underwent neoadjuvant chemotherapy between 2016 and 2020 were enrolled. The study evaluated overall survival (OS), progression-free survival (PFS), cytology status conversion, and major pathological response rates, along with the factors influencing these outcomes. All patients underwent surgery post-neoadjuvant chemotherapy, with 53.5% experiencing cytological status conversion and 23.3% achieving a major pathological response. The median OS and PFS were 20 (95% CI: 16–25) and 19 (95% CI: 11–20) months, respectively. Conversion to negative cytology significantly reduced the relative risk of peritoneal progression (RR: 0.11; 95% CI: 0.03–0.47, <i<p</i< = 0.002). The study suggests that neoadjuvant chemotherapy followed by gastrectomy holds promise as a treatment option for Cy1 GC without additional non-curative factors, associating cytology status conversion with improved long-term outcomes and reduced peritoneal relapse risk. gastric cancer positive cytology neoadjuvant chemotherapy pathological response Neoplasms. Tumors. Oncology. Including cancer and carcinogens Toomas Ümarik verfasserin aut Oleksii Dobrzhanskyi verfasserin aut Martynas Luksta verfasserin aut Yourii Kondratskyi verfasserin aut Arvo Reinsoo verfasserin aut Mihhail Vassiljev verfasserin aut Bernardas Bausys verfasserin aut Klaudija Bickaite verfasserin aut Kornelija Rauduvyte verfasserin aut Raminta Luksaite-Lukste verfasserin aut Rimantas Bausys verfasserin aut Kestutis Strupas verfasserin aut In Cancers MDPI AG, 2010 15(2023), 24, p 5794 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:15 year:2023 number:24, p 5794 https://doi.org/10.3390/cancers15245794 kostenfrei https://doaj.org/article/5facaa9093d741b4b319d9bf2e113616 kostenfrei https://www.mdpi.com/2072-6694/15/24/5794 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 24, p 5794
language	English
source	In Cancers 15(2023), 24, p 5794 volume:15 year:2023 number:24, p 5794
sourceStr	In Cancers 15(2023), 24, p 5794 volume:15 year:2023 number:24, p 5794
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	gastric cancer positive cytology neoadjuvant chemotherapy pathological response Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	Cancers
authorswithroles_txt_mv	Augustinas Bausys @@aut@@ Toomas Ümarik @@aut@@ Oleksii Dobrzhanskyi @@aut@@ Martynas Luksta @@aut@@ Yourii Kondratskyi @@aut@@ Arvo Reinsoo @@aut@@ Mihhail Vassiljev @@aut@@ Bernardas Bausys @@aut@@ Klaudija Bickaite @@aut@@ Kornelija Rauduvyte @@aut@@ Raminta Luksaite-Lukste @@aut@@ Rimantas Bausys @@aut@@ Kestutis Strupas @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	614095670
id	DOAJ098898345
language_de	englisch
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callnumber-first	R - Medicine
author	Augustinas Bausys
spellingShingle	Augustinas Bausys misc RC254-282 misc gastric cancer misc positive cytology misc neoadjuvant chemotherapy misc pathological response misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Neoadjuvant Chemotherapy Followed by Gastrectomy for Cytology-Positive Gastric Cancer without Any Other Non-Curative Factors in a Western Setting: An International Eastern European Cohort Study
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topic_title	RC254-282 Neoadjuvant Chemotherapy Followed by Gastrectomy for Cytology-Positive Gastric Cancer without Any Other Non-Curative Factors in a Western Setting: An International Eastern European Cohort Study gastric cancer positive cytology neoadjuvant chemotherapy pathological response
topic	misc RC254-282 misc gastric cancer misc positive cytology misc neoadjuvant chemotherapy misc pathological response misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc gastric cancer misc positive cytology misc neoadjuvant chemotherapy misc pathological response misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc gastric cancer misc positive cytology misc neoadjuvant chemotherapy misc pathological response misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Neoadjuvant Chemotherapy Followed by Gastrectomy for Cytology-Positive Gastric Cancer without Any Other Non-Curative Factors in a Western Setting: An International Eastern European Cohort Study
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title_full	Neoadjuvant Chemotherapy Followed by Gastrectomy for Cytology-Positive Gastric Cancer without Any Other Non-Curative Factors in a Western Setting: An International Eastern European Cohort Study
author_sort	Augustinas Bausys
journal	Cancers
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author_browse	Augustinas Bausys Toomas Ümarik Oleksii Dobrzhanskyi Martynas Luksta Yourii Kondratskyi Arvo Reinsoo Mihhail Vassiljev Bernardas Bausys Klaudija Bickaite Kornelija Rauduvyte Raminta Luksaite-Lukste Rimantas Bausys Kestutis Strupas
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title_sort	neoadjuvant chemotherapy followed by gastrectomy for cytology-positive gastric cancer without any other non-curative factors in a western setting: an international eastern european cohort study
callnumber	RC254-282
title_auth	Neoadjuvant Chemotherapy Followed by Gastrectomy for Cytology-Positive Gastric Cancer without Any Other Non-Curative Factors in a Western Setting: An International Eastern European Cohort Study
abstract	The optimal approach for treating cytology-positive (Cy1) gastric cancer (GC) patients without additional non-curative factors remains uncertain. While neoadjuvant chemotherapy followed by gastrectomy shows promise, its suitability for Western patients is not well supported by existing data. To address this knowledge gap, a cohort study was conducted across four major GC treatment centers in Lithuania, Estonia, and Ukraine. Forty-three consecutive Cy1 GC patients who underwent neoadjuvant chemotherapy between 2016 and 2020 were enrolled. The study evaluated overall survival (OS), progression-free survival (PFS), cytology status conversion, and major pathological response rates, along with the factors influencing these outcomes. All patients underwent surgery post-neoadjuvant chemotherapy, with 53.5% experiencing cytological status conversion and 23.3% achieving a major pathological response. The median OS and PFS were 20 (95% CI: 16–25) and 19 (95% CI: 11–20) months, respectively. Conversion to negative cytology significantly reduced the relative risk of peritoneal progression (RR: 0.11; 95% CI: 0.03–0.47, <i<p</i< = 0.002). The study suggests that neoadjuvant chemotherapy followed by gastrectomy holds promise as a treatment option for Cy1 GC without additional non-curative factors, associating cytology status conversion with improved long-term outcomes and reduced peritoneal relapse risk.
abstractGer	The optimal approach for treating cytology-positive (Cy1) gastric cancer (GC) patients without additional non-curative factors remains uncertain. While neoadjuvant chemotherapy followed by gastrectomy shows promise, its suitability for Western patients is not well supported by existing data. To address this knowledge gap, a cohort study was conducted across four major GC treatment centers in Lithuania, Estonia, and Ukraine. Forty-three consecutive Cy1 GC patients who underwent neoadjuvant chemotherapy between 2016 and 2020 were enrolled. The study evaluated overall survival (OS), progression-free survival (PFS), cytology status conversion, and major pathological response rates, along with the factors influencing these outcomes. All patients underwent surgery post-neoadjuvant chemotherapy, with 53.5% experiencing cytological status conversion and 23.3% achieving a major pathological response. The median OS and PFS were 20 (95% CI: 16–25) and 19 (95% CI: 11–20) months, respectively. Conversion to negative cytology significantly reduced the relative risk of peritoneal progression (RR: 0.11; 95% CI: 0.03–0.47, <i<p</i< = 0.002). The study suggests that neoadjuvant chemotherapy followed by gastrectomy holds promise as a treatment option for Cy1 GC without additional non-curative factors, associating cytology status conversion with improved long-term outcomes and reduced peritoneal relapse risk.
abstract_unstemmed	The optimal approach for treating cytology-positive (Cy1) gastric cancer (GC) patients without additional non-curative factors remains uncertain. While neoadjuvant chemotherapy followed by gastrectomy shows promise, its suitability for Western patients is not well supported by existing data. To address this knowledge gap, a cohort study was conducted across four major GC treatment centers in Lithuania, Estonia, and Ukraine. Forty-three consecutive Cy1 GC patients who underwent neoadjuvant chemotherapy between 2016 and 2020 were enrolled. The study evaluated overall survival (OS), progression-free survival (PFS), cytology status conversion, and major pathological response rates, along with the factors influencing these outcomes. All patients underwent surgery post-neoadjuvant chemotherapy, with 53.5% experiencing cytological status conversion and 23.3% achieving a major pathological response. The median OS and PFS were 20 (95% CI: 16–25) and 19 (95% CI: 11–20) months, respectively. Conversion to negative cytology significantly reduced the relative risk of peritoneal progression (RR: 0.11; 95% CI: 0.03–0.47, <i<p</i< = 0.002). The study suggests that neoadjuvant chemotherapy followed by gastrectomy holds promise as a treatment option for Cy1 GC without additional non-curative factors, associating cytology status conversion with improved long-term outcomes and reduced peritoneal relapse risk.
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container_issue	24, p 5794
title_short	Neoadjuvant Chemotherapy Followed by Gastrectomy for Cytology-Positive Gastric Cancer without Any Other Non-Curative Factors in a Western Setting: An International Eastern European Cohort Study
url	https://doi.org/10.3390/cancers15245794 https://doaj.org/article/5facaa9093d741b4b319d9bf2e113616 https://www.mdpi.com/2072-6694/15/24/5794 https://doaj.org/toc/2072-6694
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author2	Toomas Ümarik Oleksii Dobrzhanskyi Martynas Luksta Yourii Kondratskyi Arvo Reinsoo Mihhail Vassiljev Bernardas Bausys Klaudija Bickaite Kornelija Rauduvyte Raminta Luksaite-Lukste Rimantas Bausys Kestutis Strupas
author2Str	Toomas Ümarik Oleksii Dobrzhanskyi Martynas Luksta Yourii Kondratskyi Arvo Reinsoo Mihhail Vassiljev Bernardas Bausys Klaudija Bickaite Kornelija Rauduvyte Raminta Luksaite-Lukste Rimantas Bausys Kestutis Strupas
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up_date	2024-07-03T19:51:52.258Z
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