Low-Grade Gliomas: Histological Subtypes, Molecular Mechanisms, and Treatment Strategies

Low-Grade Gliomas (LGGs) represent a diverse group of brain tumors originating from glial cells, characterized by their unique histopathological and molecular features. This article offers a comprehensive exploration of LGGs, shedding light on their subtypes, histological and molecular aspects. By d...
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Autor*in:	Corneliu Toader [verfasserIn] Lucian Eva [verfasserIn] Daniel Costea [verfasserIn] Antonio Daniel Corlatescu [verfasserIn] Razvan-Adrian Covache-Busuioc [verfasserIn] Bogdan-Gabriel Bratu [verfasserIn] Luca Andrei Glavan [verfasserIn] Horia Petre Costin [verfasserIn] Andrei Adrian Popa [verfasserIn] Alexandru Vlad Ciurea [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	low-grade gliomas astrocytoma oligodendroglioma ependymoma rare low-grade gliomas pediatric low-grade gliomas

Übergeordnetes Werk:	In: Brain Sciences - MDPI AG, 2012, 13(2023), 12, p 1700
Übergeordnetes Werk:	volume:13 ; year:2023 ; number:12, p 1700

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/brainsci13121700

Katalog-ID:	DOAJ098901974

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author	Corneliu Toader
spellingShingle	Corneliu Toader misc RC321-571 misc low-grade gliomas misc astrocytoma misc oligodendroglioma misc ependymoma misc rare low-grade gliomas misc pediatric low-grade gliomas misc Neurosciences. Biological psychiatry. Neuropsychiatry Low-Grade Gliomas: Histological Subtypes, Molecular Mechanisms, and Treatment Strategies
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topic_title	RC321-571 Low-Grade Gliomas: Histological Subtypes, Molecular Mechanisms, and Treatment Strategies low-grade gliomas astrocytoma oligodendroglioma ependymoma rare low-grade gliomas pediatric low-grade gliomas
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title	Low-Grade Gliomas: Histological Subtypes, Molecular Mechanisms, and Treatment Strategies
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title_sort	low-grade gliomas: histological subtypes, molecular mechanisms, and treatment strategies
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title_auth	Low-Grade Gliomas: Histological Subtypes, Molecular Mechanisms, and Treatment Strategies
abstract	Low-Grade Gliomas (LGGs) represent a diverse group of brain tumors originating from glial cells, characterized by their unique histopathological and molecular features. This article offers a comprehensive exploration of LGGs, shedding light on their subtypes, histological and molecular aspects. By delving into the World Health Organization’s grading system, 5th edition, various specificities were added due to an in-depth understanding of emerging laboratory techniques, especially genomic analysis. Moreover, treatment modalities are extensively discussed. The degree of surgical resection should always be considered according to postoperative quality of life and cognitive status. Adjuvant therapies focused on chemotherapy and radiotherapy depend on tumor grading and invasiveness. In the current literature, emerging targeted molecular therapies are well discussed due to their succinctly therapeutic effect; in our article, those therapies are summarized based on posttreatment results and possible adverse effects. This review serves as a valuable resource for clinicians, researchers, and medical professionals aiming to deepen their knowledge on LGGs and enhance patient care.
abstractGer	Low-Grade Gliomas (LGGs) represent a diverse group of brain tumors originating from glial cells, characterized by their unique histopathological and molecular features. This article offers a comprehensive exploration of LGGs, shedding light on their subtypes, histological and molecular aspects. By delving into the World Health Organization’s grading system, 5th edition, various specificities were added due to an in-depth understanding of emerging laboratory techniques, especially genomic analysis. Moreover, treatment modalities are extensively discussed. The degree of surgical resection should always be considered according to postoperative quality of life and cognitive status. Adjuvant therapies focused on chemotherapy and radiotherapy depend on tumor grading and invasiveness. In the current literature, emerging targeted molecular therapies are well discussed due to their succinctly therapeutic effect; in our article, those therapies are summarized based on posttreatment results and possible adverse effects. This review serves as a valuable resource for clinicians, researchers, and medical professionals aiming to deepen their knowledge on LGGs and enhance patient care.
abstract_unstemmed	Low-Grade Gliomas (LGGs) represent a diverse group of brain tumors originating from glial cells, characterized by their unique histopathological and molecular features. This article offers a comprehensive exploration of LGGs, shedding light on their subtypes, histological and molecular aspects. By delving into the World Health Organization’s grading system, 5th edition, various specificities were added due to an in-depth understanding of emerging laboratory techniques, especially genomic analysis. Moreover, treatment modalities are extensively discussed. The degree of surgical resection should always be considered according to postoperative quality of life and cognitive status. Adjuvant therapies focused on chemotherapy and radiotherapy depend on tumor grading and invasiveness. In the current literature, emerging targeted molecular therapies are well discussed due to their succinctly therapeutic effect; in our article, those therapies are summarized based on posttreatment results and possible adverse effects. This review serves as a valuable resource for clinicians, researchers, and medical professionals aiming to deepen their knowledge on LGGs and enhance patient care.
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title_short	Low-Grade Gliomas: Histological Subtypes, Molecular Mechanisms, and Treatment Strategies
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