Signs of Alveolar Collapse in Idiopathic Pulmonary Fibrosis, Hypersensitivity Pneumonitis and Systemic Sclerosis Revealed by Inspiration and Expiration Computed Tomography

Idiopathic pulmonary fibrosis (IPF), hypersensitivity pneumonitis (HP) and systemic sclerosis (SSc) are among the most common entities that cause pulmonary fibrosis. Alveolar collapse with subsequent collapse induration of lung tissue is thought to contribute to the fibrotic transformation. The purp...
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Autor*in:	Marco Fabian Wittwer [verfasserIn] Soung-Yung Kim [verfasserIn] Alexander Leichtle [verfasserIn] Sabina Berezowska [verfasserIn] Sabina A. Guler [verfasserIn] Thomas Geiser [verfasserIn] Johannes Heverhagen [verfasserIn] Britta Maurer [verfasserIn] Alexander Poellinger [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	idiopathic pulmonary fibrosis hypersensitivity pneumonitis systemic sclerosis computed tomography quantitative analysis

Übergeordnetes Werk:	In: BioMed - MDPI AG, 2023, 3(2023), 4, Seite 471-483
Übergeordnetes Werk:	volume:3 ; year:2023 ; number:4 ; pages:471-483

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/biomed3040038

Katalog-ID:	DOAJ098908480

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allfields	10.3390/biomed3040038 doi (DE-627)DOAJ098908480 (DE-599)DOAJad4982136e424f3ea5c297a4db050213 DE-627 ger DE-627 rakwb eng TP248.13-248.65 Marco Fabian Wittwer verfasserin aut Signs of Alveolar Collapse in Idiopathic Pulmonary Fibrosis, Hypersensitivity Pneumonitis and Systemic Sclerosis Revealed by Inspiration and Expiration Computed Tomography 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Idiopathic pulmonary fibrosis (IPF), hypersensitivity pneumonitis (HP) and systemic sclerosis (SSc) are among the most common entities that cause pulmonary fibrosis. Alveolar collapse with subsequent collapse induration of lung tissue is thought to contribute to the fibrotic transformation. The purpose of this study was to examine lung tissue in computed tomography (CT) of non-diseased appearance during expiration for signs of increased density suggesting collapsibility in fibrosing lung diseases. We further analyzed the diaphragmatic movements during the respiratory cycle to determine relationships between density differences and the apex–diaphragm diameter. Significant differences in attenuation changes between inspiration and expiration of unaffected lung parenchyma were detected between IPF and controls and between HP and controls for all lung lobes (<i<p</i< < 0.001). Only minor differences were found between SSc and controls. There was no clinically relevant difference between patients with IPF and those with HP. The measured absolute apex–diaphragm diameter in inspiration and expiration demonstrated a statistically significant difference between patients with IPF versus normal controls. However, the diaphragmatic excursions were not different between these groups. Compared to controls, CT lung density increases significantly more during expiration in the fibrotic lungs of IPF and HP patients. The observed increase in density might indicate the collapse of alveoli during expiration and may represent a common pathophysiologic feature of fibrosing lung diseases. The density changes and lung extensions do not have the same ratios across different diseases and controls. idiopathic pulmonary fibrosis hypersensitivity pneumonitis systemic sclerosis computed tomography quantitative analysis Biotechnology Medicine R Soung-Yung Kim verfasserin aut Alexander Leichtle verfasserin aut Sabina Berezowska verfasserin aut Sabina A. Guler verfasserin aut Thomas Geiser verfasserin aut Johannes Heverhagen verfasserin aut Britta Maurer verfasserin aut Alexander Poellinger verfasserin aut In BioMed MDPI AG, 2023 3(2023), 4, Seite 471-483 (DE-627)1817822616 26738430 nnns volume:3 year:2023 number:4 pages:471-483 https://doi.org/10.3390/biomed3040038 kostenfrei https://doaj.org/article/ad4982136e424f3ea5c297a4db050213 kostenfrei https://www.mdpi.com/2673-8430/3/4/38 kostenfrei https://doaj.org/toc/2673-8430 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2023 4 471-483
spelling	10.3390/biomed3040038 doi (DE-627)DOAJ098908480 (DE-599)DOAJad4982136e424f3ea5c297a4db050213 DE-627 ger DE-627 rakwb eng TP248.13-248.65 Marco Fabian Wittwer verfasserin aut Signs of Alveolar Collapse in Idiopathic Pulmonary Fibrosis, Hypersensitivity Pneumonitis and Systemic Sclerosis Revealed by Inspiration and Expiration Computed Tomography 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Idiopathic pulmonary fibrosis (IPF), hypersensitivity pneumonitis (HP) and systemic sclerosis (SSc) are among the most common entities that cause pulmonary fibrosis. Alveolar collapse with subsequent collapse induration of lung tissue is thought to contribute to the fibrotic transformation. The purpose of this study was to examine lung tissue in computed tomography (CT) of non-diseased appearance during expiration for signs of increased density suggesting collapsibility in fibrosing lung diseases. We further analyzed the diaphragmatic movements during the respiratory cycle to determine relationships between density differences and the apex–diaphragm diameter. Significant differences in attenuation changes between inspiration and expiration of unaffected lung parenchyma were detected between IPF and controls and between HP and controls for all lung lobes (<i<p</i< < 0.001). Only minor differences were found between SSc and controls. There was no clinically relevant difference between patients with IPF and those with HP. The measured absolute apex–diaphragm diameter in inspiration and expiration demonstrated a statistically significant difference between patients with IPF versus normal controls. However, the diaphragmatic excursions were not different between these groups. Compared to controls, CT lung density increases significantly more during expiration in the fibrotic lungs of IPF and HP patients. The observed increase in density might indicate the collapse of alveoli during expiration and may represent a common pathophysiologic feature of fibrosing lung diseases. The density changes and lung extensions do not have the same ratios across different diseases and controls. idiopathic pulmonary fibrosis hypersensitivity pneumonitis systemic sclerosis computed tomography quantitative analysis Biotechnology Medicine R Soung-Yung Kim verfasserin aut Alexander Leichtle verfasserin aut Sabina Berezowska verfasserin aut Sabina A. Guler verfasserin aut Thomas Geiser verfasserin aut Johannes Heverhagen verfasserin aut Britta Maurer verfasserin aut Alexander Poellinger verfasserin aut In BioMed MDPI AG, 2023 3(2023), 4, Seite 471-483 (DE-627)1817822616 26738430 nnns volume:3 year:2023 number:4 pages:471-483 https://doi.org/10.3390/biomed3040038 kostenfrei https://doaj.org/article/ad4982136e424f3ea5c297a4db050213 kostenfrei https://www.mdpi.com/2673-8430/3/4/38 kostenfrei https://doaj.org/toc/2673-8430 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2023 4 471-483
allfields_unstemmed	10.3390/biomed3040038 doi (DE-627)DOAJ098908480 (DE-599)DOAJad4982136e424f3ea5c297a4db050213 DE-627 ger DE-627 rakwb eng TP248.13-248.65 Marco Fabian Wittwer verfasserin aut Signs of Alveolar Collapse in Idiopathic Pulmonary Fibrosis, Hypersensitivity Pneumonitis and Systemic Sclerosis Revealed by Inspiration and Expiration Computed Tomography 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Idiopathic pulmonary fibrosis (IPF), hypersensitivity pneumonitis (HP) and systemic sclerosis (SSc) are among the most common entities that cause pulmonary fibrosis. Alveolar collapse with subsequent collapse induration of lung tissue is thought to contribute to the fibrotic transformation. The purpose of this study was to examine lung tissue in computed tomography (CT) of non-diseased appearance during expiration for signs of increased density suggesting collapsibility in fibrosing lung diseases. We further analyzed the diaphragmatic movements during the respiratory cycle to determine relationships between density differences and the apex–diaphragm diameter. Significant differences in attenuation changes between inspiration and expiration of unaffected lung parenchyma were detected between IPF and controls and between HP and controls for all lung lobes (<i<p</i< < 0.001). Only minor differences were found between SSc and controls. There was no clinically relevant difference between patients with IPF and those with HP. The measured absolute apex–diaphragm diameter in inspiration and expiration demonstrated a statistically significant difference between patients with IPF versus normal controls. However, the diaphragmatic excursions were not different between these groups. Compared to controls, CT lung density increases significantly more during expiration in the fibrotic lungs of IPF and HP patients. The observed increase in density might indicate the collapse of alveoli during expiration and may represent a common pathophysiologic feature of fibrosing lung diseases. The density changes and lung extensions do not have the same ratios across different diseases and controls. idiopathic pulmonary fibrosis hypersensitivity pneumonitis systemic sclerosis computed tomography quantitative analysis Biotechnology Medicine R Soung-Yung Kim verfasserin aut Alexander Leichtle verfasserin aut Sabina Berezowska verfasserin aut Sabina A. Guler verfasserin aut Thomas Geiser verfasserin aut Johannes Heverhagen verfasserin aut Britta Maurer verfasserin aut Alexander Poellinger verfasserin aut In BioMed MDPI AG, 2023 3(2023), 4, Seite 471-483 (DE-627)1817822616 26738430 nnns volume:3 year:2023 number:4 pages:471-483 https://doi.org/10.3390/biomed3040038 kostenfrei https://doaj.org/article/ad4982136e424f3ea5c297a4db050213 kostenfrei https://www.mdpi.com/2673-8430/3/4/38 kostenfrei https://doaj.org/toc/2673-8430 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2023 4 471-483
allfieldsGer	10.3390/biomed3040038 doi (DE-627)DOAJ098908480 (DE-599)DOAJad4982136e424f3ea5c297a4db050213 DE-627 ger DE-627 rakwb eng TP248.13-248.65 Marco Fabian Wittwer verfasserin aut Signs of Alveolar Collapse in Idiopathic Pulmonary Fibrosis, Hypersensitivity Pneumonitis and Systemic Sclerosis Revealed by Inspiration and Expiration Computed Tomography 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Idiopathic pulmonary fibrosis (IPF), hypersensitivity pneumonitis (HP) and systemic sclerosis (SSc) are among the most common entities that cause pulmonary fibrosis. Alveolar collapse with subsequent collapse induration of lung tissue is thought to contribute to the fibrotic transformation. The purpose of this study was to examine lung tissue in computed tomography (CT) of non-diseased appearance during expiration for signs of increased density suggesting collapsibility in fibrosing lung diseases. We further analyzed the diaphragmatic movements during the respiratory cycle to determine relationships between density differences and the apex–diaphragm diameter. Significant differences in attenuation changes between inspiration and expiration of unaffected lung parenchyma were detected between IPF and controls and between HP and controls for all lung lobes (<i<p</i< < 0.001). Only minor differences were found between SSc and controls. There was no clinically relevant difference between patients with IPF and those with HP. The measured absolute apex–diaphragm diameter in inspiration and expiration demonstrated a statistically significant difference between patients with IPF versus normal controls. However, the diaphragmatic excursions were not different between these groups. Compared to controls, CT lung density increases significantly more during expiration in the fibrotic lungs of IPF and HP patients. The observed increase in density might indicate the collapse of alveoli during expiration and may represent a common pathophysiologic feature of fibrosing lung diseases. The density changes and lung extensions do not have the same ratios across different diseases and controls. idiopathic pulmonary fibrosis hypersensitivity pneumonitis systemic sclerosis computed tomography quantitative analysis Biotechnology Medicine R Soung-Yung Kim verfasserin aut Alexander Leichtle verfasserin aut Sabina Berezowska verfasserin aut Sabina A. Guler verfasserin aut Thomas Geiser verfasserin aut Johannes Heverhagen verfasserin aut Britta Maurer verfasserin aut Alexander Poellinger verfasserin aut In BioMed MDPI AG, 2023 3(2023), 4, Seite 471-483 (DE-627)1817822616 26738430 nnns volume:3 year:2023 number:4 pages:471-483 https://doi.org/10.3390/biomed3040038 kostenfrei https://doaj.org/article/ad4982136e424f3ea5c297a4db050213 kostenfrei https://www.mdpi.com/2673-8430/3/4/38 kostenfrei https://doaj.org/toc/2673-8430 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2023 4 471-483
allfieldsSound	10.3390/biomed3040038 doi (DE-627)DOAJ098908480 (DE-599)DOAJad4982136e424f3ea5c297a4db050213 DE-627 ger DE-627 rakwb eng TP248.13-248.65 Marco Fabian Wittwer verfasserin aut Signs of Alveolar Collapse in Idiopathic Pulmonary Fibrosis, Hypersensitivity Pneumonitis and Systemic Sclerosis Revealed by Inspiration and Expiration Computed Tomography 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Idiopathic pulmonary fibrosis (IPF), hypersensitivity pneumonitis (HP) and systemic sclerosis (SSc) are among the most common entities that cause pulmonary fibrosis. Alveolar collapse with subsequent collapse induration of lung tissue is thought to contribute to the fibrotic transformation. The purpose of this study was to examine lung tissue in computed tomography (CT) of non-diseased appearance during expiration for signs of increased density suggesting collapsibility in fibrosing lung diseases. We further analyzed the diaphragmatic movements during the respiratory cycle to determine relationships between density differences and the apex–diaphragm diameter. Significant differences in attenuation changes between inspiration and expiration of unaffected lung parenchyma were detected between IPF and controls and between HP and controls for all lung lobes (<i<p</i< < 0.001). Only minor differences were found between SSc and controls. There was no clinically relevant difference between patients with IPF and those with HP. The measured absolute apex–diaphragm diameter in inspiration and expiration demonstrated a statistically significant difference between patients with IPF versus normal controls. However, the diaphragmatic excursions were not different between these groups. Compared to controls, CT lung density increases significantly more during expiration in the fibrotic lungs of IPF and HP patients. The observed increase in density might indicate the collapse of alveoli during expiration and may represent a common pathophysiologic feature of fibrosing lung diseases. The density changes and lung extensions do not have the same ratios across different diseases and controls. idiopathic pulmonary fibrosis hypersensitivity pneumonitis systemic sclerosis computed tomography quantitative analysis Biotechnology Medicine R Soung-Yung Kim verfasserin aut Alexander Leichtle verfasserin aut Sabina Berezowska verfasserin aut Sabina A. Guler verfasserin aut Thomas Geiser verfasserin aut Johannes Heverhagen verfasserin aut Britta Maurer verfasserin aut Alexander Poellinger verfasserin aut In BioMed MDPI AG, 2023 3(2023), 4, Seite 471-483 (DE-627)1817822616 26738430 nnns volume:3 year:2023 number:4 pages:471-483 https://doi.org/10.3390/biomed3040038 kostenfrei https://doaj.org/article/ad4982136e424f3ea5c297a4db050213 kostenfrei https://www.mdpi.com/2673-8430/3/4/38 kostenfrei https://doaj.org/toc/2673-8430 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2023 4 471-483
language	English
source	In BioMed 3(2023), 4, Seite 471-483 volume:3 year:2023 number:4 pages:471-483
sourceStr	In BioMed 3(2023), 4, Seite 471-483 volume:3 year:2023 number:4 pages:471-483
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	idiopathic pulmonary fibrosis hypersensitivity pneumonitis systemic sclerosis computed tomography quantitative analysis Biotechnology Medicine R
isfreeaccess_bool	true
container_title	BioMed
authorswithroles_txt_mv	Marco Fabian Wittwer @@aut@@ Soung-Yung Kim @@aut@@ Alexander Leichtle @@aut@@ Sabina Berezowska @@aut@@ Sabina A. Guler @@aut@@ Thomas Geiser @@aut@@ Johannes Heverhagen @@aut@@ Britta Maurer @@aut@@ Alexander Poellinger @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	1817822616
id	DOAJ098908480
language_de	englisch
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callnumber-first	T - Technology
author	Marco Fabian Wittwer
spellingShingle	Marco Fabian Wittwer misc TP248.13-248.65 misc idiopathic pulmonary fibrosis misc hypersensitivity pneumonitis misc systemic sclerosis misc computed tomography misc quantitative analysis misc Biotechnology misc Medicine misc R Signs of Alveolar Collapse in Idiopathic Pulmonary Fibrosis, Hypersensitivity Pneumonitis and Systemic Sclerosis Revealed by Inspiration and Expiration Computed Tomography
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topic_title	TP248.13-248.65 Signs of Alveolar Collapse in Idiopathic Pulmonary Fibrosis, Hypersensitivity Pneumonitis and Systemic Sclerosis Revealed by Inspiration and Expiration Computed Tomography idiopathic pulmonary fibrosis hypersensitivity pneumonitis systemic sclerosis computed tomography quantitative analysis
topic	misc TP248.13-248.65 misc idiopathic pulmonary fibrosis misc hypersensitivity pneumonitis misc systemic sclerosis misc computed tomography misc quantitative analysis misc Biotechnology misc Medicine misc R
topic_unstemmed	misc TP248.13-248.65 misc idiopathic pulmonary fibrosis misc hypersensitivity pneumonitis misc systemic sclerosis misc computed tomography misc quantitative analysis misc Biotechnology misc Medicine misc R
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title	Signs of Alveolar Collapse in Idiopathic Pulmonary Fibrosis, Hypersensitivity Pneumonitis and Systemic Sclerosis Revealed by Inspiration and Expiration Computed Tomography
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title_full	Signs of Alveolar Collapse in Idiopathic Pulmonary Fibrosis, Hypersensitivity Pneumonitis and Systemic Sclerosis Revealed by Inspiration and Expiration Computed Tomography
author_sort	Marco Fabian Wittwer
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author_browse	Marco Fabian Wittwer Soung-Yung Kim Alexander Leichtle Sabina Berezowska Sabina A. Guler Thomas Geiser Johannes Heverhagen Britta Maurer Alexander Poellinger
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title_sort	signs of alveolar collapse in idiopathic pulmonary fibrosis, hypersensitivity pneumonitis and systemic sclerosis revealed by inspiration and expiration computed tomography
callnumber	TP248.13-248.65
title_auth	Signs of Alveolar Collapse in Idiopathic Pulmonary Fibrosis, Hypersensitivity Pneumonitis and Systemic Sclerosis Revealed by Inspiration and Expiration Computed Tomography
abstract	Idiopathic pulmonary fibrosis (IPF), hypersensitivity pneumonitis (HP) and systemic sclerosis (SSc) are among the most common entities that cause pulmonary fibrosis. Alveolar collapse with subsequent collapse induration of lung tissue is thought to contribute to the fibrotic transformation. The purpose of this study was to examine lung tissue in computed tomography (CT) of non-diseased appearance during expiration for signs of increased density suggesting collapsibility in fibrosing lung diseases. We further analyzed the diaphragmatic movements during the respiratory cycle to determine relationships between density differences and the apex–diaphragm diameter. Significant differences in attenuation changes between inspiration and expiration of unaffected lung parenchyma were detected between IPF and controls and between HP and controls for all lung lobes (<i<p</i< < 0.001). Only minor differences were found between SSc and controls. There was no clinically relevant difference between patients with IPF and those with HP. The measured absolute apex–diaphragm diameter in inspiration and expiration demonstrated a statistically significant difference between patients with IPF versus normal controls. However, the diaphragmatic excursions were not different between these groups. Compared to controls, CT lung density increases significantly more during expiration in the fibrotic lungs of IPF and HP patients. The observed increase in density might indicate the collapse of alveoli during expiration and may represent a common pathophysiologic feature of fibrosing lung diseases. The density changes and lung extensions do not have the same ratios across different diseases and controls.
abstractGer	Idiopathic pulmonary fibrosis (IPF), hypersensitivity pneumonitis (HP) and systemic sclerosis (SSc) are among the most common entities that cause pulmonary fibrosis. Alveolar collapse with subsequent collapse induration of lung tissue is thought to contribute to the fibrotic transformation. The purpose of this study was to examine lung tissue in computed tomography (CT) of non-diseased appearance during expiration for signs of increased density suggesting collapsibility in fibrosing lung diseases. We further analyzed the diaphragmatic movements during the respiratory cycle to determine relationships between density differences and the apex–diaphragm diameter. Significant differences in attenuation changes between inspiration and expiration of unaffected lung parenchyma were detected between IPF and controls and between HP and controls for all lung lobes (<i<p</i< < 0.001). Only minor differences were found between SSc and controls. There was no clinically relevant difference between patients with IPF and those with HP. The measured absolute apex–diaphragm diameter in inspiration and expiration demonstrated a statistically significant difference between patients with IPF versus normal controls. However, the diaphragmatic excursions were not different between these groups. Compared to controls, CT lung density increases significantly more during expiration in the fibrotic lungs of IPF and HP patients. The observed increase in density might indicate the collapse of alveoli during expiration and may represent a common pathophysiologic feature of fibrosing lung diseases. The density changes and lung extensions do not have the same ratios across different diseases and controls.
abstract_unstemmed	Idiopathic pulmonary fibrosis (IPF), hypersensitivity pneumonitis (HP) and systemic sclerosis (SSc) are among the most common entities that cause pulmonary fibrosis. Alveolar collapse with subsequent collapse induration of lung tissue is thought to contribute to the fibrotic transformation. The purpose of this study was to examine lung tissue in computed tomography (CT) of non-diseased appearance during expiration for signs of increased density suggesting collapsibility in fibrosing lung diseases. We further analyzed the diaphragmatic movements during the respiratory cycle to determine relationships between density differences and the apex–diaphragm diameter. Significant differences in attenuation changes between inspiration and expiration of unaffected lung parenchyma were detected between IPF and controls and between HP and controls for all lung lobes (<i<p</i< < 0.001). Only minor differences were found between SSc and controls. There was no clinically relevant difference between patients with IPF and those with HP. The measured absolute apex–diaphragm diameter in inspiration and expiration demonstrated a statistically significant difference between patients with IPF versus normal controls. However, the diaphragmatic excursions were not different between these groups. Compared to controls, CT lung density increases significantly more during expiration in the fibrotic lungs of IPF and HP patients. The observed increase in density might indicate the collapse of alveoli during expiration and may represent a common pathophysiologic feature of fibrosing lung diseases. The density changes and lung extensions do not have the same ratios across different diseases and controls.
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title_short	Signs of Alveolar Collapse in Idiopathic Pulmonary Fibrosis, Hypersensitivity Pneumonitis and Systemic Sclerosis Revealed by Inspiration and Expiration Computed Tomography
url	https://doi.org/10.3390/biomed3040038 https://doaj.org/article/ad4982136e424f3ea5c297a4db050213 https://www.mdpi.com/2673-8430/3/4/38 https://doaj.org/toc/2673-8430
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author2	Soung-Yung Kim Alexander Leichtle Sabina Berezowska Sabina A. Guler Thomas Geiser Johannes Heverhagen Britta Maurer Alexander Poellinger
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up_date	2024-07-03T19:55:28.137Z
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Signs of Alveolar Collapse in Idiopathic Pulmonary Fibrosis, Hypersensitivity Pneumonitis and Systemic Sclerosis Revealed by Inspiration and Expiration Computed Tomography

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