Advances in fluorescence imaging of malignant tumors
Malignant tumors are common diseases that threaten human health. Early diagnosis and complete resection can significantly improve the prognosis of patients with malignant tumors. At present, the imaging techniques used clinically for malignant tumor detection have problems such as poor sensitivity a...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
WANG Wenbo [verfasserIn] ZHANG Fangrong [verfasserIn] SHI Tingwang [verfasserIn] CHEN Yunfeng [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Chinesisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Shanghai Jiaotong Daxue xuebao. Yixue ban - Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science), 2022, 43(2023), 4, Seite 474-479 |
|---|---|
| Übergeordnetes Werk: |
volume:43 ; year:2023 ; number:4 ; pages:474-479 |
| Links: |
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| DOI / URN: |
10.3969/j.issn.1674-8115.2023.04.010 |
|---|
| Katalog-ID: |
DOAJ099036932 |
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| 520 | |a Malignant tumors are common diseases that threaten human health. Early diagnosis and complete resection can significantly improve the prognosis of patients with malignant tumors. At present, the imaging techniques used clinically for malignant tumor detection have problems such as poor sensitivity and temporal-spatial resolution, long scanning time, etc., which cannot achieve early diagnosis and meet the requirements of surgical navigation. As a new imaging technology with excellent imaging characteristics, fluorescence imaging can perform real-time imaging of the structure and function of biological tissues and organs. It can realize the accurate detection of malignant tumors by designing fluorescent probes with high sensitivity, high selectivity and specificity. The sensitivity of fluorescence imaging mainly depends on the fluorophore of the probe, and the selectivity and specificity mainly depend on whether the probe adopts an effective targeting strategy. Studies have shown that near infrared fluorophores with emission wavelengths in the near infrared window, especially those in the near infrared Ⅱ window, have excellent optical properties, which can effectively improve the sensitivity of fluorescence imaging of malignant tumors; at the same time, based on the unique structure and metabolic features of malignant tumors, various targeting strategies have been developed to design "always-on" fluorescent probes and "turn-on" fluorescent probes, which significantly improved the selectivity and specificity of fluorescent imaging of malignant tumors. In this paper, the newly developed near infrared fluorophores and the strategies of fluorescent probes targeting malignant tumors are reviewed. | ||
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10.3969/j.issn.1674-8115.2023.04.010 doi (DE-627)DOAJ099036932 (DE-599)DOAJ3c2782386b6e4900bcc689ab9213bf81 DE-627 ger DE-627 rakwb chi WANG Wenbo verfasserin aut Advances in fluorescence imaging of malignant tumors 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Malignant tumors are common diseases that threaten human health. Early diagnosis and complete resection can significantly improve the prognosis of patients with malignant tumors. At present, the imaging techniques used clinically for malignant tumor detection have problems such as poor sensitivity and temporal-spatial resolution, long scanning time, etc., which cannot achieve early diagnosis and meet the requirements of surgical navigation. As a new imaging technology with excellent imaging characteristics, fluorescence imaging can perform real-time imaging of the structure and function of biological tissues and organs. It can realize the accurate detection of malignant tumors by designing fluorescent probes with high sensitivity, high selectivity and specificity. The sensitivity of fluorescence imaging mainly depends on the fluorophore of the probe, and the selectivity and specificity mainly depend on whether the probe adopts an effective targeting strategy. Studies have shown that near infrared fluorophores with emission wavelengths in the near infrared window, especially those in the near infrared Ⅱ window, have excellent optical properties, which can effectively improve the sensitivity of fluorescence imaging of malignant tumors; at the same time, based on the unique structure and metabolic features of malignant tumors, various targeting strategies have been developed to design "always-on" fluorescent probes and "turn-on" fluorescent probes, which significantly improved the selectivity and specificity of fluorescent imaging of malignant tumors. In this paper, the newly developed near infrared fluorophores and the strategies of fluorescent probes targeting malignant tumors are reviewed. fluorescence imaging malignant tumor near infrared fluorophore "always on" fluorescent probe "turn on" fluorescent probe Medicine R ZHANG Fangrong verfasserin aut SHI Tingwang verfasserin aut CHEN Yunfeng verfasserin aut In Shanghai Jiaotong Daxue xuebao. Yixue ban Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science), 2022 43(2023), 4, Seite 474-479 (DE-627)DOAJ000153230 16748115 nnns volume:43 year:2023 number:4 pages:474-479 https://doi.org/10.3969/j.issn.1674-8115.2023.04.010 kostenfrei https://doaj.org/article/3c2782386b6e4900bcc689ab9213bf81 kostenfrei https://xuebao.shsmu.edu.cn/article/2023/1674-8115/1674-8115-2023-43-4-474.shtml kostenfrei https://doaj.org/toc/1674-8115 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 43 2023 4 474-479 |
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10.3969/j.issn.1674-8115.2023.04.010 doi (DE-627)DOAJ099036932 (DE-599)DOAJ3c2782386b6e4900bcc689ab9213bf81 DE-627 ger DE-627 rakwb chi WANG Wenbo verfasserin aut Advances in fluorescence imaging of malignant tumors 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Malignant tumors are common diseases that threaten human health. Early diagnosis and complete resection can significantly improve the prognosis of patients with malignant tumors. At present, the imaging techniques used clinically for malignant tumor detection have problems such as poor sensitivity and temporal-spatial resolution, long scanning time, etc., which cannot achieve early diagnosis and meet the requirements of surgical navigation. As a new imaging technology with excellent imaging characteristics, fluorescence imaging can perform real-time imaging of the structure and function of biological tissues and organs. It can realize the accurate detection of malignant tumors by designing fluorescent probes with high sensitivity, high selectivity and specificity. The sensitivity of fluorescence imaging mainly depends on the fluorophore of the probe, and the selectivity and specificity mainly depend on whether the probe adopts an effective targeting strategy. Studies have shown that near infrared fluorophores with emission wavelengths in the near infrared window, especially those in the near infrared Ⅱ window, have excellent optical properties, which can effectively improve the sensitivity of fluorescence imaging of malignant tumors; at the same time, based on the unique structure and metabolic features of malignant tumors, various targeting strategies have been developed to design "always-on" fluorescent probes and "turn-on" fluorescent probes, which significantly improved the selectivity and specificity of fluorescent imaging of malignant tumors. In this paper, the newly developed near infrared fluorophores and the strategies of fluorescent probes targeting malignant tumors are reviewed. fluorescence imaging malignant tumor near infrared fluorophore "always on" fluorescent probe "turn on" fluorescent probe Medicine R ZHANG Fangrong verfasserin aut SHI Tingwang verfasserin aut CHEN Yunfeng verfasserin aut In Shanghai Jiaotong Daxue xuebao. Yixue ban Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science), 2022 43(2023), 4, Seite 474-479 (DE-627)DOAJ000153230 16748115 nnns volume:43 year:2023 number:4 pages:474-479 https://doi.org/10.3969/j.issn.1674-8115.2023.04.010 kostenfrei https://doaj.org/article/3c2782386b6e4900bcc689ab9213bf81 kostenfrei https://xuebao.shsmu.edu.cn/article/2023/1674-8115/1674-8115-2023-43-4-474.shtml kostenfrei https://doaj.org/toc/1674-8115 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 43 2023 4 474-479 |
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10.3969/j.issn.1674-8115.2023.04.010 doi (DE-627)DOAJ099036932 (DE-599)DOAJ3c2782386b6e4900bcc689ab9213bf81 DE-627 ger DE-627 rakwb chi WANG Wenbo verfasserin aut Advances in fluorescence imaging of malignant tumors 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Malignant tumors are common diseases that threaten human health. Early diagnosis and complete resection can significantly improve the prognosis of patients with malignant tumors. At present, the imaging techniques used clinically for malignant tumor detection have problems such as poor sensitivity and temporal-spatial resolution, long scanning time, etc., which cannot achieve early diagnosis and meet the requirements of surgical navigation. As a new imaging technology with excellent imaging characteristics, fluorescence imaging can perform real-time imaging of the structure and function of biological tissues and organs. It can realize the accurate detection of malignant tumors by designing fluorescent probes with high sensitivity, high selectivity and specificity. The sensitivity of fluorescence imaging mainly depends on the fluorophore of the probe, and the selectivity and specificity mainly depend on whether the probe adopts an effective targeting strategy. Studies have shown that near infrared fluorophores with emission wavelengths in the near infrared window, especially those in the near infrared Ⅱ window, have excellent optical properties, which can effectively improve the sensitivity of fluorescence imaging of malignant tumors; at the same time, based on the unique structure and metabolic features of malignant tumors, various targeting strategies have been developed to design "always-on" fluorescent probes and "turn-on" fluorescent probes, which significantly improved the selectivity and specificity of fluorescent imaging of malignant tumors. In this paper, the newly developed near infrared fluorophores and the strategies of fluorescent probes targeting malignant tumors are reviewed. fluorescence imaging malignant tumor near infrared fluorophore "always on" fluorescent probe "turn on" fluorescent probe Medicine R ZHANG Fangrong verfasserin aut SHI Tingwang verfasserin aut CHEN Yunfeng verfasserin aut In Shanghai Jiaotong Daxue xuebao. Yixue ban Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science), 2022 43(2023), 4, Seite 474-479 (DE-627)DOAJ000153230 16748115 nnns volume:43 year:2023 number:4 pages:474-479 https://doi.org/10.3969/j.issn.1674-8115.2023.04.010 kostenfrei https://doaj.org/article/3c2782386b6e4900bcc689ab9213bf81 kostenfrei https://xuebao.shsmu.edu.cn/article/2023/1674-8115/1674-8115-2023-43-4-474.shtml kostenfrei https://doaj.org/toc/1674-8115 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 43 2023 4 474-479 |
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10.3969/j.issn.1674-8115.2023.04.010 doi (DE-627)DOAJ099036932 (DE-599)DOAJ3c2782386b6e4900bcc689ab9213bf81 DE-627 ger DE-627 rakwb chi WANG Wenbo verfasserin aut Advances in fluorescence imaging of malignant tumors 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Malignant tumors are common diseases that threaten human health. Early diagnosis and complete resection can significantly improve the prognosis of patients with malignant tumors. At present, the imaging techniques used clinically for malignant tumor detection have problems such as poor sensitivity and temporal-spatial resolution, long scanning time, etc., which cannot achieve early diagnosis and meet the requirements of surgical navigation. As a new imaging technology with excellent imaging characteristics, fluorescence imaging can perform real-time imaging of the structure and function of biological tissues and organs. It can realize the accurate detection of malignant tumors by designing fluorescent probes with high sensitivity, high selectivity and specificity. The sensitivity of fluorescence imaging mainly depends on the fluorophore of the probe, and the selectivity and specificity mainly depend on whether the probe adopts an effective targeting strategy. Studies have shown that near infrared fluorophores with emission wavelengths in the near infrared window, especially those in the near infrared Ⅱ window, have excellent optical properties, which can effectively improve the sensitivity of fluorescence imaging of malignant tumors; at the same time, based on the unique structure and metabolic features of malignant tumors, various targeting strategies have been developed to design "always-on" fluorescent probes and "turn-on" fluorescent probes, which significantly improved the selectivity and specificity of fluorescent imaging of malignant tumors. In this paper, the newly developed near infrared fluorophores and the strategies of fluorescent probes targeting malignant tumors are reviewed. fluorescence imaging malignant tumor near infrared fluorophore "always on" fluorescent probe "turn on" fluorescent probe Medicine R ZHANG Fangrong verfasserin aut SHI Tingwang verfasserin aut CHEN Yunfeng verfasserin aut In Shanghai Jiaotong Daxue xuebao. Yixue ban Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science), 2022 43(2023), 4, Seite 474-479 (DE-627)DOAJ000153230 16748115 nnns volume:43 year:2023 number:4 pages:474-479 https://doi.org/10.3969/j.issn.1674-8115.2023.04.010 kostenfrei https://doaj.org/article/3c2782386b6e4900bcc689ab9213bf81 kostenfrei https://xuebao.shsmu.edu.cn/article/2023/1674-8115/1674-8115-2023-43-4-474.shtml kostenfrei https://doaj.org/toc/1674-8115 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 43 2023 4 474-479 |
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10.3969/j.issn.1674-8115.2023.04.010 doi (DE-627)DOAJ099036932 (DE-599)DOAJ3c2782386b6e4900bcc689ab9213bf81 DE-627 ger DE-627 rakwb chi WANG Wenbo verfasserin aut Advances in fluorescence imaging of malignant tumors 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Malignant tumors are common diseases that threaten human health. Early diagnosis and complete resection can significantly improve the prognosis of patients with malignant tumors. At present, the imaging techniques used clinically for malignant tumor detection have problems such as poor sensitivity and temporal-spatial resolution, long scanning time, etc., which cannot achieve early diagnosis and meet the requirements of surgical navigation. As a new imaging technology with excellent imaging characteristics, fluorescence imaging can perform real-time imaging of the structure and function of biological tissues and organs. It can realize the accurate detection of malignant tumors by designing fluorescent probes with high sensitivity, high selectivity and specificity. The sensitivity of fluorescence imaging mainly depends on the fluorophore of the probe, and the selectivity and specificity mainly depend on whether the probe adopts an effective targeting strategy. Studies have shown that near infrared fluorophores with emission wavelengths in the near infrared window, especially those in the near infrared Ⅱ window, have excellent optical properties, which can effectively improve the sensitivity of fluorescence imaging of malignant tumors; at the same time, based on the unique structure and metabolic features of malignant tumors, various targeting strategies have been developed to design "always-on" fluorescent probes and "turn-on" fluorescent probes, which significantly improved the selectivity and specificity of fluorescent imaging of malignant tumors. In this paper, the newly developed near infrared fluorophores and the strategies of fluorescent probes targeting malignant tumors are reviewed. fluorescence imaging malignant tumor near infrared fluorophore "always on" fluorescent probe "turn on" fluorescent probe Medicine R ZHANG Fangrong verfasserin aut SHI Tingwang verfasserin aut CHEN Yunfeng verfasserin aut In Shanghai Jiaotong Daxue xuebao. Yixue ban Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science), 2022 43(2023), 4, Seite 474-479 (DE-627)DOAJ000153230 16748115 nnns volume:43 year:2023 number:4 pages:474-479 https://doi.org/10.3969/j.issn.1674-8115.2023.04.010 kostenfrei https://doaj.org/article/3c2782386b6e4900bcc689ab9213bf81 kostenfrei https://xuebao.shsmu.edu.cn/article/2023/1674-8115/1674-8115-2023-43-4-474.shtml kostenfrei https://doaj.org/toc/1674-8115 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 43 2023 4 474-479 |
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WANG Wenbo |
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Shanghai Jiaotong Daxue xuebao. Yixue ban |
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WANG Wenbo ZHANG Fangrong SHI Tingwang CHEN Yunfeng |
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Elektronische Aufsätze |
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WANG Wenbo |
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10.3969/j.issn.1674-8115.2023.04.010 |
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advances in fluorescence imaging of malignant tumors |
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Advances in fluorescence imaging of malignant tumors |
| abstract |
Malignant tumors are common diseases that threaten human health. Early diagnosis and complete resection can significantly improve the prognosis of patients with malignant tumors. At present, the imaging techniques used clinically for malignant tumor detection have problems such as poor sensitivity and temporal-spatial resolution, long scanning time, etc., which cannot achieve early diagnosis and meet the requirements of surgical navigation. As a new imaging technology with excellent imaging characteristics, fluorescence imaging can perform real-time imaging of the structure and function of biological tissues and organs. It can realize the accurate detection of malignant tumors by designing fluorescent probes with high sensitivity, high selectivity and specificity. The sensitivity of fluorescence imaging mainly depends on the fluorophore of the probe, and the selectivity and specificity mainly depend on whether the probe adopts an effective targeting strategy. Studies have shown that near infrared fluorophores with emission wavelengths in the near infrared window, especially those in the near infrared Ⅱ window, have excellent optical properties, which can effectively improve the sensitivity of fluorescence imaging of malignant tumors; at the same time, based on the unique structure and metabolic features of malignant tumors, various targeting strategies have been developed to design "always-on" fluorescent probes and "turn-on" fluorescent probes, which significantly improved the selectivity and specificity of fluorescent imaging of malignant tumors. In this paper, the newly developed near infrared fluorophores and the strategies of fluorescent probes targeting malignant tumors are reviewed. |
| abstractGer |
Malignant tumors are common diseases that threaten human health. Early diagnosis and complete resection can significantly improve the prognosis of patients with malignant tumors. At present, the imaging techniques used clinically for malignant tumor detection have problems such as poor sensitivity and temporal-spatial resolution, long scanning time, etc., which cannot achieve early diagnosis and meet the requirements of surgical navigation. As a new imaging technology with excellent imaging characteristics, fluorescence imaging can perform real-time imaging of the structure and function of biological tissues and organs. It can realize the accurate detection of malignant tumors by designing fluorescent probes with high sensitivity, high selectivity and specificity. The sensitivity of fluorescence imaging mainly depends on the fluorophore of the probe, and the selectivity and specificity mainly depend on whether the probe adopts an effective targeting strategy. Studies have shown that near infrared fluorophores with emission wavelengths in the near infrared window, especially those in the near infrared Ⅱ window, have excellent optical properties, which can effectively improve the sensitivity of fluorescence imaging of malignant tumors; at the same time, based on the unique structure and metabolic features of malignant tumors, various targeting strategies have been developed to design "always-on" fluorescent probes and "turn-on" fluorescent probes, which significantly improved the selectivity and specificity of fluorescent imaging of malignant tumors. In this paper, the newly developed near infrared fluorophores and the strategies of fluorescent probes targeting malignant tumors are reviewed. |
| abstract_unstemmed |
Malignant tumors are common diseases that threaten human health. Early diagnosis and complete resection can significantly improve the prognosis of patients with malignant tumors. At present, the imaging techniques used clinically for malignant tumor detection have problems such as poor sensitivity and temporal-spatial resolution, long scanning time, etc., which cannot achieve early diagnosis and meet the requirements of surgical navigation. As a new imaging technology with excellent imaging characteristics, fluorescence imaging can perform real-time imaging of the structure and function of biological tissues and organs. It can realize the accurate detection of malignant tumors by designing fluorescent probes with high sensitivity, high selectivity and specificity. The sensitivity of fluorescence imaging mainly depends on the fluorophore of the probe, and the selectivity and specificity mainly depend on whether the probe adopts an effective targeting strategy. Studies have shown that near infrared fluorophores with emission wavelengths in the near infrared window, especially those in the near infrared Ⅱ window, have excellent optical properties, which can effectively improve the sensitivity of fluorescence imaging of malignant tumors; at the same time, based on the unique structure and metabolic features of malignant tumors, various targeting strategies have been developed to design "always-on" fluorescent probes and "turn-on" fluorescent probes, which significantly improved the selectivity and specificity of fluorescent imaging of malignant tumors. In this paper, the newly developed near infrared fluorophores and the strategies of fluorescent probes targeting malignant tumors are reviewed. |
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Advances in fluorescence imaging of malignant tumors |
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