Analysis of characteristics related to interstitial lung disease or pulmonary hypertension in patients with dermatomyositis
Abstract Introduction Dermatomyositis (DM) is often associated with interstitial lung disease (ILD) or pulmonary hypertension (PH). The aim of this study was to investigate the clinical characteristics of DM patients with ILD or PH. Methods This study retrospectively analysed the clinical characteri...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Chulin Wang [verfasserIn] Han Yang [verfasserIn] Tongfen Li [verfasserIn] Yiqiong Wen [verfasserIn] Heran Yang [verfasserIn] Weifeng Tang [verfasserIn] Lin Li [verfasserIn] Shibo Sun [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: The Clinical Respiratory Journal - Wiley, 2022, 17(2023), 12, Seite 1328-1340 |
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| Übergeordnetes Werk: |
volume:17 ; year:2023 ; number:12 ; pages:1328-1340 |
| Links: |
Link aufrufen |
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| DOI / URN: |
10.1111/crj.13720 |
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| Katalog-ID: |
DOAJ099043939 |
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| 245 | 1 | 0 | |a Analysis of characteristics related to interstitial lung disease or pulmonary hypertension in patients with dermatomyositis |
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| 520 | |a Abstract Introduction Dermatomyositis (DM) is often associated with interstitial lung disease (ILD) or pulmonary hypertension (PH). The aim of this study was to investigate the clinical characteristics of DM patients with ILD or PH. Methods This study retrospectively analysed the clinical characteristics of 372 patients with DM, including cytokines, lymphocyte subsets, immunoglobulin and complement. The DM patients were divided into different groups according to whether complicated with ILD, PH or anti‐melanoma differentiation‐associated gene 5 antibodies (MDA5). A qualitative and quantitative data analysis was performed. Results IgG, IgA and IgM in the DM‐associated ILD (ILD‐DM) were higher than that of the DM non‐complicating ILD (Non‐ILD‐DM) (p = 0.022, 0.002 and 0.029, respectively). Meanwhile, IL‐6 (p = 0.008) and IL‐10 (p = 0.001) were increased in the DM‐associated PH (PH‐DM) than in the DM non‐complicating PH (Non‐PH‐DM), while IL‐17 (p = 0.004), double positive (DP) cell ratio and B lymphocyte ratio were reduced in the PH‐DM. Moreover, the incidence of ILD and levels of C4 were higher in the DM with MDA5 (MDA5+ DM) than that of the DM without MDA5. Conclusion ILD‐DM has higher IgG, IgA and IgM than that of Non‐ILD‐DM. PH‐DM has higher IL‐6, IL‐10 and lower IL‐17, DP cell ratio and B lymphocyte ratio than that of Non‐PH‐DM. | ||
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| 650 | 4 | |a dermatomyositis | |
| 650 | 4 | |a interstitial lung disease | |
| 650 | 4 | |a pulmonary hypertension | |
| 653 | 0 | |a Diseases of the respiratory system | |
| 700 | 0 | |a Han Yang |e verfasserin |4 aut | |
| 700 | 0 | |a Tongfen Li |e verfasserin |4 aut | |
| 700 | 0 | |a Yiqiong Wen |e verfasserin |4 aut | |
| 700 | 0 | |a Heran Yang |e verfasserin |4 aut | |
| 700 | 0 | |a Weifeng Tang |e verfasserin |4 aut | |
| 700 | 0 | |a Lin Li |e verfasserin |4 aut | |
| 700 | 0 | |a Shibo Sun |e verfasserin |4 aut | |
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10.1111/crj.13720 doi (DE-627)DOAJ099043939 (DE-599)DOAJe94d2be4782541ad958568b78a4a96a0 DE-627 ger DE-627 rakwb eng RC705-779 Chulin Wang verfasserin aut Analysis of characteristics related to interstitial lung disease or pulmonary hypertension in patients with dermatomyositis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Introduction Dermatomyositis (DM) is often associated with interstitial lung disease (ILD) or pulmonary hypertension (PH). The aim of this study was to investigate the clinical characteristics of DM patients with ILD or PH. Methods This study retrospectively analysed the clinical characteristics of 372 patients with DM, including cytokines, lymphocyte subsets, immunoglobulin and complement. The DM patients were divided into different groups according to whether complicated with ILD, PH or anti‐melanoma differentiation‐associated gene 5 antibodies (MDA5). A qualitative and quantitative data analysis was performed. Results IgG, IgA and IgM in the DM‐associated ILD (ILD‐DM) were higher than that of the DM non‐complicating ILD (Non‐ILD‐DM) (p = 0.022, 0.002 and 0.029, respectively). Meanwhile, IL‐6 (p = 0.008) and IL‐10 (p = 0.001) were increased in the DM‐associated PH (PH‐DM) than in the DM non‐complicating PH (Non‐PH‐DM), while IL‐17 (p = 0.004), double positive (DP) cell ratio and B lymphocyte ratio were reduced in the PH‐DM. Moreover, the incidence of ILD and levels of C4 were higher in the DM with MDA5 (MDA5+ DM) than that of the DM without MDA5. Conclusion ILD‐DM has higher IgG, IgA and IgM than that of Non‐ILD‐DM. PH‐DM has higher IL‐6, IL‐10 and lower IL‐17, DP cell ratio and B lymphocyte ratio than that of Non‐PH‐DM. anti‐melanoma differentiation‐associated gene 5 antibodies dermatomyositis interstitial lung disease pulmonary hypertension Diseases of the respiratory system Han Yang verfasserin aut Tongfen Li verfasserin aut Yiqiong Wen verfasserin aut Heran Yang verfasserin aut Weifeng Tang verfasserin aut Lin Li verfasserin aut Shibo Sun verfasserin aut In The Clinical Respiratory Journal Wiley, 2022 17(2023), 12, Seite 1328-1340 (DE-627)573753598 (DE-600)2442214-9 1752699X nnns volume:17 year:2023 number:12 pages:1328-1340 https://doi.org/10.1111/crj.13720 kostenfrei https://doaj.org/article/e94d2be4782541ad958568b78a4a96a0 kostenfrei https://doi.org/10.1111/crj.13720 kostenfrei https://doaj.org/toc/1752-6981 Journal toc kostenfrei https://doaj.org/toc/1752-699X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 17 2023 12 1328-1340 |
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10.1111/crj.13720 doi (DE-627)DOAJ099043939 (DE-599)DOAJe94d2be4782541ad958568b78a4a96a0 DE-627 ger DE-627 rakwb eng RC705-779 Chulin Wang verfasserin aut Analysis of characteristics related to interstitial lung disease or pulmonary hypertension in patients with dermatomyositis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Introduction Dermatomyositis (DM) is often associated with interstitial lung disease (ILD) or pulmonary hypertension (PH). The aim of this study was to investigate the clinical characteristics of DM patients with ILD or PH. Methods This study retrospectively analysed the clinical characteristics of 372 patients with DM, including cytokines, lymphocyte subsets, immunoglobulin and complement. The DM patients were divided into different groups according to whether complicated with ILD, PH or anti‐melanoma differentiation‐associated gene 5 antibodies (MDA5). A qualitative and quantitative data analysis was performed. Results IgG, IgA and IgM in the DM‐associated ILD (ILD‐DM) were higher than that of the DM non‐complicating ILD (Non‐ILD‐DM) (p = 0.022, 0.002 and 0.029, respectively). Meanwhile, IL‐6 (p = 0.008) and IL‐10 (p = 0.001) were increased in the DM‐associated PH (PH‐DM) than in the DM non‐complicating PH (Non‐PH‐DM), while IL‐17 (p = 0.004), double positive (DP) cell ratio and B lymphocyte ratio were reduced in the PH‐DM. Moreover, the incidence of ILD and levels of C4 were higher in the DM with MDA5 (MDA5+ DM) than that of the DM without MDA5. Conclusion ILD‐DM has higher IgG, IgA and IgM than that of Non‐ILD‐DM. PH‐DM has higher IL‐6, IL‐10 and lower IL‐17, DP cell ratio and B lymphocyte ratio than that of Non‐PH‐DM. anti‐melanoma differentiation‐associated gene 5 antibodies dermatomyositis interstitial lung disease pulmonary hypertension Diseases of the respiratory system Han Yang verfasserin aut Tongfen Li verfasserin aut Yiqiong Wen verfasserin aut Heran Yang verfasserin aut Weifeng Tang verfasserin aut Lin Li verfasserin aut Shibo Sun verfasserin aut In The Clinical Respiratory Journal Wiley, 2022 17(2023), 12, Seite 1328-1340 (DE-627)573753598 (DE-600)2442214-9 1752699X nnns volume:17 year:2023 number:12 pages:1328-1340 https://doi.org/10.1111/crj.13720 kostenfrei https://doaj.org/article/e94d2be4782541ad958568b78a4a96a0 kostenfrei https://doi.org/10.1111/crj.13720 kostenfrei https://doaj.org/toc/1752-6981 Journal toc kostenfrei https://doaj.org/toc/1752-699X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 17 2023 12 1328-1340 |
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10.1111/crj.13720 doi (DE-627)DOAJ099043939 (DE-599)DOAJe94d2be4782541ad958568b78a4a96a0 DE-627 ger DE-627 rakwb eng RC705-779 Chulin Wang verfasserin aut Analysis of characteristics related to interstitial lung disease or pulmonary hypertension in patients with dermatomyositis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Introduction Dermatomyositis (DM) is often associated with interstitial lung disease (ILD) or pulmonary hypertension (PH). The aim of this study was to investigate the clinical characteristics of DM patients with ILD or PH. Methods This study retrospectively analysed the clinical characteristics of 372 patients with DM, including cytokines, lymphocyte subsets, immunoglobulin and complement. The DM patients were divided into different groups according to whether complicated with ILD, PH or anti‐melanoma differentiation‐associated gene 5 antibodies (MDA5). A qualitative and quantitative data analysis was performed. Results IgG, IgA and IgM in the DM‐associated ILD (ILD‐DM) were higher than that of the DM non‐complicating ILD (Non‐ILD‐DM) (p = 0.022, 0.002 and 0.029, respectively). Meanwhile, IL‐6 (p = 0.008) and IL‐10 (p = 0.001) were increased in the DM‐associated PH (PH‐DM) than in the DM non‐complicating PH (Non‐PH‐DM), while IL‐17 (p = 0.004), double positive (DP) cell ratio and B lymphocyte ratio were reduced in the PH‐DM. Moreover, the incidence of ILD and levels of C4 were higher in the DM with MDA5 (MDA5+ DM) than that of the DM without MDA5. Conclusion ILD‐DM has higher IgG, IgA and IgM than that of Non‐ILD‐DM. PH‐DM has higher IL‐6, IL‐10 and lower IL‐17, DP cell ratio and B lymphocyte ratio than that of Non‐PH‐DM. anti‐melanoma differentiation‐associated gene 5 antibodies dermatomyositis interstitial lung disease pulmonary hypertension Diseases of the respiratory system Han Yang verfasserin aut Tongfen Li verfasserin aut Yiqiong Wen verfasserin aut Heran Yang verfasserin aut Weifeng Tang verfasserin aut Lin Li verfasserin aut Shibo Sun verfasserin aut In The Clinical Respiratory Journal Wiley, 2022 17(2023), 12, Seite 1328-1340 (DE-627)573753598 (DE-600)2442214-9 1752699X nnns volume:17 year:2023 number:12 pages:1328-1340 https://doi.org/10.1111/crj.13720 kostenfrei https://doaj.org/article/e94d2be4782541ad958568b78a4a96a0 kostenfrei https://doi.org/10.1111/crj.13720 kostenfrei https://doaj.org/toc/1752-6981 Journal toc kostenfrei https://doaj.org/toc/1752-699X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 17 2023 12 1328-1340 |
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10.1111/crj.13720 doi (DE-627)DOAJ099043939 (DE-599)DOAJe94d2be4782541ad958568b78a4a96a0 DE-627 ger DE-627 rakwb eng RC705-779 Chulin Wang verfasserin aut Analysis of characteristics related to interstitial lung disease or pulmonary hypertension in patients with dermatomyositis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Introduction Dermatomyositis (DM) is often associated with interstitial lung disease (ILD) or pulmonary hypertension (PH). The aim of this study was to investigate the clinical characteristics of DM patients with ILD or PH. Methods This study retrospectively analysed the clinical characteristics of 372 patients with DM, including cytokines, lymphocyte subsets, immunoglobulin and complement. The DM patients were divided into different groups according to whether complicated with ILD, PH or anti‐melanoma differentiation‐associated gene 5 antibodies (MDA5). A qualitative and quantitative data analysis was performed. Results IgG, IgA and IgM in the DM‐associated ILD (ILD‐DM) were higher than that of the DM non‐complicating ILD (Non‐ILD‐DM) (p = 0.022, 0.002 and 0.029, respectively). Meanwhile, IL‐6 (p = 0.008) and IL‐10 (p = 0.001) were increased in the DM‐associated PH (PH‐DM) than in the DM non‐complicating PH (Non‐PH‐DM), while IL‐17 (p = 0.004), double positive (DP) cell ratio and B lymphocyte ratio were reduced in the PH‐DM. Moreover, the incidence of ILD and levels of C4 were higher in the DM with MDA5 (MDA5+ DM) than that of the DM without MDA5. Conclusion ILD‐DM has higher IgG, IgA and IgM than that of Non‐ILD‐DM. PH‐DM has higher IL‐6, IL‐10 and lower IL‐17, DP cell ratio and B lymphocyte ratio than that of Non‐PH‐DM. anti‐melanoma differentiation‐associated gene 5 antibodies dermatomyositis interstitial lung disease pulmonary hypertension Diseases of the respiratory system Han Yang verfasserin aut Tongfen Li verfasserin aut Yiqiong Wen verfasserin aut Heran Yang verfasserin aut Weifeng Tang verfasserin aut Lin Li verfasserin aut Shibo Sun verfasserin aut In The Clinical Respiratory Journal Wiley, 2022 17(2023), 12, Seite 1328-1340 (DE-627)573753598 (DE-600)2442214-9 1752699X nnns volume:17 year:2023 number:12 pages:1328-1340 https://doi.org/10.1111/crj.13720 kostenfrei https://doaj.org/article/e94d2be4782541ad958568b78a4a96a0 kostenfrei https://doi.org/10.1111/crj.13720 kostenfrei https://doaj.org/toc/1752-6981 Journal toc kostenfrei https://doaj.org/toc/1752-699X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 17 2023 12 1328-1340 |
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10.1111/crj.13720 doi (DE-627)DOAJ099043939 (DE-599)DOAJe94d2be4782541ad958568b78a4a96a0 DE-627 ger DE-627 rakwb eng RC705-779 Chulin Wang verfasserin aut Analysis of characteristics related to interstitial lung disease or pulmonary hypertension in patients with dermatomyositis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Introduction Dermatomyositis (DM) is often associated with interstitial lung disease (ILD) or pulmonary hypertension (PH). The aim of this study was to investigate the clinical characteristics of DM patients with ILD or PH. Methods This study retrospectively analysed the clinical characteristics of 372 patients with DM, including cytokines, lymphocyte subsets, immunoglobulin and complement. The DM patients were divided into different groups according to whether complicated with ILD, PH or anti‐melanoma differentiation‐associated gene 5 antibodies (MDA5). A qualitative and quantitative data analysis was performed. Results IgG, IgA and IgM in the DM‐associated ILD (ILD‐DM) were higher than that of the DM non‐complicating ILD (Non‐ILD‐DM) (p = 0.022, 0.002 and 0.029, respectively). Meanwhile, IL‐6 (p = 0.008) and IL‐10 (p = 0.001) were increased in the DM‐associated PH (PH‐DM) than in the DM non‐complicating PH (Non‐PH‐DM), while IL‐17 (p = 0.004), double positive (DP) cell ratio and B lymphocyte ratio were reduced in the PH‐DM. Moreover, the incidence of ILD and levels of C4 were higher in the DM with MDA5 (MDA5+ DM) than that of the DM without MDA5. Conclusion ILD‐DM has higher IgG, IgA and IgM than that of Non‐ILD‐DM. PH‐DM has higher IL‐6, IL‐10 and lower IL‐17, DP cell ratio and B lymphocyte ratio than that of Non‐PH‐DM. anti‐melanoma differentiation‐associated gene 5 antibodies dermatomyositis interstitial lung disease pulmonary hypertension Diseases of the respiratory system Han Yang verfasserin aut Tongfen Li verfasserin aut Yiqiong Wen verfasserin aut Heran Yang verfasserin aut Weifeng Tang verfasserin aut Lin Li verfasserin aut Shibo Sun verfasserin aut In The Clinical Respiratory Journal Wiley, 2022 17(2023), 12, Seite 1328-1340 (DE-627)573753598 (DE-600)2442214-9 1752699X nnns volume:17 year:2023 number:12 pages:1328-1340 https://doi.org/10.1111/crj.13720 kostenfrei https://doaj.org/article/e94d2be4782541ad958568b78a4a96a0 kostenfrei https://doi.org/10.1111/crj.13720 kostenfrei https://doaj.org/toc/1752-6981 Journal toc kostenfrei https://doaj.org/toc/1752-699X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 17 2023 12 1328-1340 |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">DOAJ099043939</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240414011454.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">240414s2023 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1111/crj.13720</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ099043939</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJe94d2be4782541ad958568b78a4a96a0</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC705-779</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Chulin Wang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Analysis of characteristics related to interstitial lung disease or pulmonary hypertension in patients with dermatomyositis</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2023</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Introduction Dermatomyositis (DM) is often associated with interstitial lung disease (ILD) or pulmonary hypertension (PH). The aim of this study was to investigate the clinical characteristics of DM patients with ILD or PH. Methods This study retrospectively analysed the clinical characteristics of 372 patients with DM, including cytokines, lymphocyte subsets, immunoglobulin and complement. The DM patients were divided into different groups according to whether complicated with ILD, PH or anti‐melanoma differentiation‐associated gene 5 antibodies (MDA5). A qualitative and quantitative data analysis was performed. Results IgG, IgA and IgM in the DM‐associated ILD (ILD‐DM) were higher than that of the DM non‐complicating ILD (Non‐ILD‐DM) (p = 0.022, 0.002 and 0.029, respectively). Meanwhile, IL‐6 (p = 0.008) and IL‐10 (p = 0.001) were increased in the DM‐associated PH (PH‐DM) than in the DM non‐complicating PH (Non‐PH‐DM), while IL‐17 (p = 0.004), double positive (DP) cell ratio and B lymphocyte ratio were reduced in the PH‐DM. Moreover, the incidence of ILD and levels of C4 were higher in the DM with MDA5 (MDA5+ DM) than that of the DM without MDA5. Conclusion ILD‐DM has higher IgG, IgA and IgM than that of Non‐ILD‐DM. 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R - Medicine |
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Chulin Wang |
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RC705-779 Analysis of characteristics related to interstitial lung disease or pulmonary hypertension in patients with dermatomyositis anti‐melanoma differentiation‐associated gene 5 antibodies dermatomyositis interstitial lung disease pulmonary hypertension |
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misc RC705-779 misc anti‐melanoma differentiation‐associated gene 5 antibodies misc dermatomyositis misc interstitial lung disease misc pulmonary hypertension misc Diseases of the respiratory system |
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analysis of characteristics related to interstitial lung disease or pulmonary hypertension in patients with dermatomyositis |
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RC705-779 |
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Analysis of characteristics related to interstitial lung disease or pulmonary hypertension in patients with dermatomyositis |
| abstract |
Abstract Introduction Dermatomyositis (DM) is often associated with interstitial lung disease (ILD) or pulmonary hypertension (PH). The aim of this study was to investigate the clinical characteristics of DM patients with ILD or PH. Methods This study retrospectively analysed the clinical characteristics of 372 patients with DM, including cytokines, lymphocyte subsets, immunoglobulin and complement. The DM patients were divided into different groups according to whether complicated with ILD, PH or anti‐melanoma differentiation‐associated gene 5 antibodies (MDA5). A qualitative and quantitative data analysis was performed. Results IgG, IgA and IgM in the DM‐associated ILD (ILD‐DM) were higher than that of the DM non‐complicating ILD (Non‐ILD‐DM) (p = 0.022, 0.002 and 0.029, respectively). Meanwhile, IL‐6 (p = 0.008) and IL‐10 (p = 0.001) were increased in the DM‐associated PH (PH‐DM) than in the DM non‐complicating PH (Non‐PH‐DM), while IL‐17 (p = 0.004), double positive (DP) cell ratio and B lymphocyte ratio were reduced in the PH‐DM. Moreover, the incidence of ILD and levels of C4 were higher in the DM with MDA5 (MDA5+ DM) than that of the DM without MDA5. Conclusion ILD‐DM has higher IgG, IgA and IgM than that of Non‐ILD‐DM. PH‐DM has higher IL‐6, IL‐10 and lower IL‐17, DP cell ratio and B lymphocyte ratio than that of Non‐PH‐DM. |
| abstractGer |
Abstract Introduction Dermatomyositis (DM) is often associated with interstitial lung disease (ILD) or pulmonary hypertension (PH). The aim of this study was to investigate the clinical characteristics of DM patients with ILD or PH. Methods This study retrospectively analysed the clinical characteristics of 372 patients with DM, including cytokines, lymphocyte subsets, immunoglobulin and complement. The DM patients were divided into different groups according to whether complicated with ILD, PH or anti‐melanoma differentiation‐associated gene 5 antibodies (MDA5). A qualitative and quantitative data analysis was performed. Results IgG, IgA and IgM in the DM‐associated ILD (ILD‐DM) were higher than that of the DM non‐complicating ILD (Non‐ILD‐DM) (p = 0.022, 0.002 and 0.029, respectively). Meanwhile, IL‐6 (p = 0.008) and IL‐10 (p = 0.001) were increased in the DM‐associated PH (PH‐DM) than in the DM non‐complicating PH (Non‐PH‐DM), while IL‐17 (p = 0.004), double positive (DP) cell ratio and B lymphocyte ratio were reduced in the PH‐DM. Moreover, the incidence of ILD and levels of C4 were higher in the DM with MDA5 (MDA5+ DM) than that of the DM without MDA5. Conclusion ILD‐DM has higher IgG, IgA and IgM than that of Non‐ILD‐DM. PH‐DM has higher IL‐6, IL‐10 and lower IL‐17, DP cell ratio and B lymphocyte ratio than that of Non‐PH‐DM. |
| abstract_unstemmed |
Abstract Introduction Dermatomyositis (DM) is often associated with interstitial lung disease (ILD) or pulmonary hypertension (PH). The aim of this study was to investigate the clinical characteristics of DM patients with ILD or PH. Methods This study retrospectively analysed the clinical characteristics of 372 patients with DM, including cytokines, lymphocyte subsets, immunoglobulin and complement. The DM patients were divided into different groups according to whether complicated with ILD, PH or anti‐melanoma differentiation‐associated gene 5 antibodies (MDA5). A qualitative and quantitative data analysis was performed. Results IgG, IgA and IgM in the DM‐associated ILD (ILD‐DM) were higher than that of the DM non‐complicating ILD (Non‐ILD‐DM) (p = 0.022, 0.002 and 0.029, respectively). Meanwhile, IL‐6 (p = 0.008) and IL‐10 (p = 0.001) were increased in the DM‐associated PH (PH‐DM) than in the DM non‐complicating PH (Non‐PH‐DM), while IL‐17 (p = 0.004), double positive (DP) cell ratio and B lymphocyte ratio were reduced in the PH‐DM. Moreover, the incidence of ILD and levels of C4 were higher in the DM with MDA5 (MDA5+ DM) than that of the DM without MDA5. Conclusion ILD‐DM has higher IgG, IgA and IgM than that of Non‐ILD‐DM. PH‐DM has higher IL‐6, IL‐10 and lower IL‐17, DP cell ratio and B lymphocyte ratio than that of Non‐PH‐DM. |
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12 |
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Analysis of characteristics related to interstitial lung disease or pulmonary hypertension in patients with dermatomyositis |
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https://doi.org/10.1111/crj.13720 https://doaj.org/article/e94d2be4782541ad958568b78a4a96a0 https://doaj.org/toc/1752-6981 https://doaj.org/toc/1752-699X |
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Han Yang Tongfen Li Yiqiong Wen Heran Yang Weifeng Tang Lin Li Shibo Sun |
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Han Yang Tongfen Li Yiqiong Wen Heran Yang Weifeng Tang Lin Li Shibo Sun |
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10.1111/crj.13720 |
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RC705-779 |
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2024-07-03T20:42:25.506Z |
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|
| score |
7.4011307 |