Sex differences in muscle health in simulated micro- and partial-gravity environments in rats

Skeletal muscle size and strength are important for overall health for astronauts. However, how male and female muscle may respond differently to micro- and partial-gravity environments is not fully understood. The purpose of this study was to determine how biological sex and sex steroid hormones in...
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Gespeichert in:

Autor*in:	Megan E. Rosa-Caldwell [verfasserIn] Marie Mortreux [verfasserIn] Anna Wadhwa [verfasserIn] Ursula B. Kaiser [verfasserIn] Dong-Min Sung [verfasserIn] Mary L. Bouxsein [verfasserIn] Seward B. Rutkove [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Sex differences Atrophy Muscle strength Plantar flexion Dorsiflexion

Übergeordnetes Werk:	In: Sports Medicine and Health Science - KeAi Communications Co., Ltd., 2020, 5(2023), 4, Seite 319-328
Übergeordnetes Werk:	volume:5 ; year:2023 ; number:4 ; pages:319-328

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.smhs.2023.09.002

Katalog-ID:	DOAJ099161141

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callnumber-first	R - Medicine
author	Megan E. Rosa-Caldwell
spellingShingle	Megan E. Rosa-Caldwell misc R5-920 misc Sex differences misc Atrophy misc Muscle strength misc Plantar flexion misc Dorsiflexion misc Medicine (General) Sex differences in muscle health in simulated micro- and partial-gravity environments in rats
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topic_title	R5-920 Sex differences in muscle health in simulated micro- and partial-gravity environments in rats Sex differences Atrophy Muscle strength Plantar flexion Dorsiflexion
topic	misc R5-920 misc Sex differences misc Atrophy misc Muscle strength misc Plantar flexion misc Dorsiflexion misc Medicine (General)
topic_unstemmed	misc R5-920 misc Sex differences misc Atrophy misc Muscle strength misc Plantar flexion misc Dorsiflexion misc Medicine (General)
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title	Sex differences in muscle health in simulated micro- and partial-gravity environments in rats
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title_full	Sex differences in muscle health in simulated micro- and partial-gravity environments in rats
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author_browse	Megan E. Rosa-Caldwell Marie Mortreux Anna Wadhwa Ursula B. Kaiser Dong-Min Sung Mary L. Bouxsein Seward B. Rutkove
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title_sort	sex differences in muscle health in simulated micro- and partial-gravity environments in rats
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title_auth	Sex differences in muscle health in simulated micro- and partial-gravity environments in rats
abstract	Skeletal muscle size and strength are important for overall health for astronauts. However, how male and female muscle may respond differently to micro- and partial-gravity environments is not fully understood. The purpose of this study was to determine how biological sex and sex steroid hormones influence the progression of muscle atrophy after long term exposure to micro and partial gravity environments in male and female rats. Male and female Fisher rats (n = 120) underwent either castration/ovariectomy or sham surgeries. After two weeks recovery, animals were divided into microgravity (0g), partial-gravity (40% of weight bearing, 0.4g), or full weight bearing (1g) interventions for 28 days. Measurements of muscle size and strength were evaluated prior to and after interventions. At 0g, females lost more dorsiflexion strength, plantar flexion strength, and other metrics of muscle size compared to males; castration/ovariectomy did not influence these differences. Additionally, at 0.4g, females lost more dorsiflexion strength, plantar flexion strength, and other metrics of muscle strength compared to males; castration/ovariectomy did not influence these differences. Females have greater musculoskeletal aberrations during exposure to both microgravity and partial-gravity environments; these differences are not dependent on the presence of sex steroid hormones. Correspondingly, additional interventions may be necessary to mitigate musculoskeletal loss in female astronauts to protect occupational and overall health.
abstractGer	Skeletal muscle size and strength are important for overall health for astronauts. However, how male and female muscle may respond differently to micro- and partial-gravity environments is not fully understood. The purpose of this study was to determine how biological sex and sex steroid hormones influence the progression of muscle atrophy after long term exposure to micro and partial gravity environments in male and female rats. Male and female Fisher rats (n = 120) underwent either castration/ovariectomy or sham surgeries. After two weeks recovery, animals were divided into microgravity (0g), partial-gravity (40% of weight bearing, 0.4g), or full weight bearing (1g) interventions for 28 days. Measurements of muscle size and strength were evaluated prior to and after interventions. At 0g, females lost more dorsiflexion strength, plantar flexion strength, and other metrics of muscle size compared to males; castration/ovariectomy did not influence these differences. Additionally, at 0.4g, females lost more dorsiflexion strength, plantar flexion strength, and other metrics of muscle strength compared to males; castration/ovariectomy did not influence these differences. Females have greater musculoskeletal aberrations during exposure to both microgravity and partial-gravity environments; these differences are not dependent on the presence of sex steroid hormones. Correspondingly, additional interventions may be necessary to mitigate musculoskeletal loss in female astronauts to protect occupational and overall health.
abstract_unstemmed	Skeletal muscle size and strength are important for overall health for astronauts. However, how male and female muscle may respond differently to micro- and partial-gravity environments is not fully understood. The purpose of this study was to determine how biological sex and sex steroid hormones influence the progression of muscle atrophy after long term exposure to micro and partial gravity environments in male and female rats. Male and female Fisher rats (n = 120) underwent either castration/ovariectomy or sham surgeries. After two weeks recovery, animals were divided into microgravity (0g), partial-gravity (40% of weight bearing, 0.4g), or full weight bearing (1g) interventions for 28 days. Measurements of muscle size and strength were evaluated prior to and after interventions. At 0g, females lost more dorsiflexion strength, plantar flexion strength, and other metrics of muscle size compared to males; castration/ovariectomy did not influence these differences. Additionally, at 0.4g, females lost more dorsiflexion strength, plantar flexion strength, and other metrics of muscle strength compared to males; castration/ovariectomy did not influence these differences. Females have greater musculoskeletal aberrations during exposure to both microgravity and partial-gravity environments; these differences are not dependent on the presence of sex steroid hormones. Correspondingly, additional interventions may be necessary to mitigate musculoskeletal loss in female astronauts to protect occupational and overall health.
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title_short	Sex differences in muscle health in simulated micro- and partial-gravity environments in rats
url	https://doi.org/10.1016/j.smhs.2023.09.002 https://doaj.org/article/1c575447124145448d1d74f58079d594 http://www.sciencedirect.com/science/article/pii/S2666337623000653 https://doaj.org/toc/2666-3376
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author2	Marie Mortreux Anna Wadhwa Ursula B. Kaiser Dong-Min Sung Mary L. Bouxsein Seward B. Rutkove
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up_date	2024-07-03T21:21:29.412Z
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Sex differences in muscle health in simulated micro- and partial-gravity environments in rats

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