A novel plasmonic optical-fiber-based point-of-care test for periodontal MIP-1α detection

Summary: The analysis of salivary biomarkers as expression of periodontal health conditions has been proposed as a useful aid to conventional diagnostic approaches. In this study, we present a point-of-care test (POCT) exploiting a surface plasmon resonance (SPR)-based optical biosensor to detect sa...
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Autor*in:	Marco Annunziata [verfasserIn] Francesco Arcadio [verfasserIn] Adriana Borriello [verfasserIn] Debora Bencivenga [verfasserIn] Angelantonio Piccirillo [verfasserIn] Emanuela Stampone [verfasserIn] Luigi Zeni [verfasserIn] Nunzio Cennamo [verfasserIn] Fulvio Della Ragione [verfasserIn] Luigi Guida [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Physics Optics Fiber optics

Übergeordnetes Werk:	In: iScience - Elsevier, 2019, 26(2023), 12, Seite 108539-
Übergeordnetes Werk:	volume:26 ; year:2023 ; number:12 ; pages:108539-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.isci.2023.108539

Katalog-ID:	DOAJ099162385

Internformat


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520			\|a Summary: The analysis of salivary biomarkers as expression of periodontal health conditions has been proposed as a useful aid to conventional diagnostic approaches. In this study, we present a point-of-care test (POCT) exploiting a surface plasmon resonance (SPR)-based optical biosensor to detect salivary macrophage inflammatory protein (MIP)-1α, a promising marker of periodontitis. A plastic optical fiber (POF) was suitably modified and functionalized by an antibody self-assembled monolayer against MIP-1α for plasmonic detection. The proposed SPR-POF biosensor showed high selectivity and very low limit of detection for MIP-1α of 129 fM (1.0 pg/mL) in phosphate-buffered saline and 346 fM (2.7 pg/mL) in saliva. As a proof of concept, this POCT was also able to discriminate between a periodontitis patient and a healthy subject. The obtained results support the future application of this technology for an on-site detection and real-time monitoring of periodontal health conditions for diagnostic and therapeutic purposes.
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allfields	10.1016/j.isci.2023.108539 doi (DE-627)DOAJ099162385 (DE-599)DOAJaea790aba1e0443197f77ea6317dac9e DE-627 ger DE-627 rakwb eng Marco Annunziata verfasserin aut A novel plasmonic optical-fiber-based point-of-care test for periodontal MIP-1α detection 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: The analysis of salivary biomarkers as expression of periodontal health conditions has been proposed as a useful aid to conventional diagnostic approaches. In this study, we present a point-of-care test (POCT) exploiting a surface plasmon resonance (SPR)-based optical biosensor to detect salivary macrophage inflammatory protein (MIP)-1α, a promising marker of periodontitis. A plastic optical fiber (POF) was suitably modified and functionalized by an antibody self-assembled monolayer against MIP-1α for plasmonic detection. The proposed SPR-POF biosensor showed high selectivity and very low limit of detection for MIP-1α of 129 fM (1.0 pg/mL) in phosphate-buffered saline and 346 fM (2.7 pg/mL) in saliva. As a proof of concept, this POCT was also able to discriminate between a periodontitis patient and a healthy subject. The obtained results support the future application of this technology for an on-site detection and real-time monitoring of periodontal health conditions for diagnostic and therapeutic purposes. Physics Optics Fiber optics Science Q Francesco Arcadio verfasserin aut Adriana Borriello verfasserin aut Debora Bencivenga verfasserin aut Angelantonio Piccirillo verfasserin aut Emanuela Stampone verfasserin aut Luigi Zeni verfasserin aut Nunzio Cennamo verfasserin aut Fulvio Della Ragione verfasserin aut Luigi Guida verfasserin aut In iScience Elsevier, 2019 26(2023), 12, Seite 108539- (DE-627)1019532106 25890042 nnns volume:26 year:2023 number:12 pages:108539- https://doi.org/10.1016/j.isci.2023.108539 kostenfrei https://doaj.org/article/aea790aba1e0443197f77ea6317dac9e kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004223026160 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 26 2023 12 108539-
spelling	10.1016/j.isci.2023.108539 doi (DE-627)DOAJ099162385 (DE-599)DOAJaea790aba1e0443197f77ea6317dac9e DE-627 ger DE-627 rakwb eng Marco Annunziata verfasserin aut A novel plasmonic optical-fiber-based point-of-care test for periodontal MIP-1α detection 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: The analysis of salivary biomarkers as expression of periodontal health conditions has been proposed as a useful aid to conventional diagnostic approaches. In this study, we present a point-of-care test (POCT) exploiting a surface plasmon resonance (SPR)-based optical biosensor to detect salivary macrophage inflammatory protein (MIP)-1α, a promising marker of periodontitis. A plastic optical fiber (POF) was suitably modified and functionalized by an antibody self-assembled monolayer against MIP-1α for plasmonic detection. The proposed SPR-POF biosensor showed high selectivity and very low limit of detection for MIP-1α of 129 fM (1.0 pg/mL) in phosphate-buffered saline and 346 fM (2.7 pg/mL) in saliva. As a proof of concept, this POCT was also able to discriminate between a periodontitis patient and a healthy subject. The obtained results support the future application of this technology for an on-site detection and real-time monitoring of periodontal health conditions for diagnostic and therapeutic purposes. Physics Optics Fiber optics Science Q Francesco Arcadio verfasserin aut Adriana Borriello verfasserin aut Debora Bencivenga verfasserin aut Angelantonio Piccirillo verfasserin aut Emanuela Stampone verfasserin aut Luigi Zeni verfasserin aut Nunzio Cennamo verfasserin aut Fulvio Della Ragione verfasserin aut Luigi Guida verfasserin aut In iScience Elsevier, 2019 26(2023), 12, Seite 108539- (DE-627)1019532106 25890042 nnns volume:26 year:2023 number:12 pages:108539- https://doi.org/10.1016/j.isci.2023.108539 kostenfrei https://doaj.org/article/aea790aba1e0443197f77ea6317dac9e kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004223026160 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 26 2023 12 108539-
allfields_unstemmed	10.1016/j.isci.2023.108539 doi (DE-627)DOAJ099162385 (DE-599)DOAJaea790aba1e0443197f77ea6317dac9e DE-627 ger DE-627 rakwb eng Marco Annunziata verfasserin aut A novel plasmonic optical-fiber-based point-of-care test for periodontal MIP-1α detection 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: The analysis of salivary biomarkers as expression of periodontal health conditions has been proposed as a useful aid to conventional diagnostic approaches. In this study, we present a point-of-care test (POCT) exploiting a surface plasmon resonance (SPR)-based optical biosensor to detect salivary macrophage inflammatory protein (MIP)-1α, a promising marker of periodontitis. A plastic optical fiber (POF) was suitably modified and functionalized by an antibody self-assembled monolayer against MIP-1α for plasmonic detection. The proposed SPR-POF biosensor showed high selectivity and very low limit of detection for MIP-1α of 129 fM (1.0 pg/mL) in phosphate-buffered saline and 346 fM (2.7 pg/mL) in saliva. As a proof of concept, this POCT was also able to discriminate between a periodontitis patient and a healthy subject. The obtained results support the future application of this technology for an on-site detection and real-time monitoring of periodontal health conditions for diagnostic and therapeutic purposes. Physics Optics Fiber optics Science Q Francesco Arcadio verfasserin aut Adriana Borriello verfasserin aut Debora Bencivenga verfasserin aut Angelantonio Piccirillo verfasserin aut Emanuela Stampone verfasserin aut Luigi Zeni verfasserin aut Nunzio Cennamo verfasserin aut Fulvio Della Ragione verfasserin aut Luigi Guida verfasserin aut In iScience Elsevier, 2019 26(2023), 12, Seite 108539- (DE-627)1019532106 25890042 nnns volume:26 year:2023 number:12 pages:108539- https://doi.org/10.1016/j.isci.2023.108539 kostenfrei https://doaj.org/article/aea790aba1e0443197f77ea6317dac9e kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004223026160 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 26 2023 12 108539-
allfieldsGer	10.1016/j.isci.2023.108539 doi (DE-627)DOAJ099162385 (DE-599)DOAJaea790aba1e0443197f77ea6317dac9e DE-627 ger DE-627 rakwb eng Marco Annunziata verfasserin aut A novel plasmonic optical-fiber-based point-of-care test for periodontal MIP-1α detection 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: The analysis of salivary biomarkers as expression of periodontal health conditions has been proposed as a useful aid to conventional diagnostic approaches. In this study, we present a point-of-care test (POCT) exploiting a surface plasmon resonance (SPR)-based optical biosensor to detect salivary macrophage inflammatory protein (MIP)-1α, a promising marker of periodontitis. A plastic optical fiber (POF) was suitably modified and functionalized by an antibody self-assembled monolayer against MIP-1α for plasmonic detection. The proposed SPR-POF biosensor showed high selectivity and very low limit of detection for MIP-1α of 129 fM (1.0 pg/mL) in phosphate-buffered saline and 346 fM (2.7 pg/mL) in saliva. As a proof of concept, this POCT was also able to discriminate between a periodontitis patient and a healthy subject. The obtained results support the future application of this technology for an on-site detection and real-time monitoring of periodontal health conditions for diagnostic and therapeutic purposes. Physics Optics Fiber optics Science Q Francesco Arcadio verfasserin aut Adriana Borriello verfasserin aut Debora Bencivenga verfasserin aut Angelantonio Piccirillo verfasserin aut Emanuela Stampone verfasserin aut Luigi Zeni verfasserin aut Nunzio Cennamo verfasserin aut Fulvio Della Ragione verfasserin aut Luigi Guida verfasserin aut In iScience Elsevier, 2019 26(2023), 12, Seite 108539- (DE-627)1019532106 25890042 nnns volume:26 year:2023 number:12 pages:108539- https://doi.org/10.1016/j.isci.2023.108539 kostenfrei https://doaj.org/article/aea790aba1e0443197f77ea6317dac9e kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004223026160 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 26 2023 12 108539-
allfieldsSound	10.1016/j.isci.2023.108539 doi (DE-627)DOAJ099162385 (DE-599)DOAJaea790aba1e0443197f77ea6317dac9e DE-627 ger DE-627 rakwb eng Marco Annunziata verfasserin aut A novel plasmonic optical-fiber-based point-of-care test for periodontal MIP-1α detection 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: The analysis of salivary biomarkers as expression of periodontal health conditions has been proposed as a useful aid to conventional diagnostic approaches. In this study, we present a point-of-care test (POCT) exploiting a surface plasmon resonance (SPR)-based optical biosensor to detect salivary macrophage inflammatory protein (MIP)-1α, a promising marker of periodontitis. A plastic optical fiber (POF) was suitably modified and functionalized by an antibody self-assembled monolayer against MIP-1α for plasmonic detection. The proposed SPR-POF biosensor showed high selectivity and very low limit of detection for MIP-1α of 129 fM (1.0 pg/mL) in phosphate-buffered saline and 346 fM (2.7 pg/mL) in saliva. As a proof of concept, this POCT was also able to discriminate between a periodontitis patient and a healthy subject. The obtained results support the future application of this technology for an on-site detection and real-time monitoring of periodontal health conditions for diagnostic and therapeutic purposes. Physics Optics Fiber optics Science Q Francesco Arcadio verfasserin aut Adriana Borriello verfasserin aut Debora Bencivenga verfasserin aut Angelantonio Piccirillo verfasserin aut Emanuela Stampone verfasserin aut Luigi Zeni verfasserin aut Nunzio Cennamo verfasserin aut Fulvio Della Ragione verfasserin aut Luigi Guida verfasserin aut In iScience Elsevier, 2019 26(2023), 12, Seite 108539- (DE-627)1019532106 25890042 nnns volume:26 year:2023 number:12 pages:108539- https://doi.org/10.1016/j.isci.2023.108539 kostenfrei https://doaj.org/article/aea790aba1e0443197f77ea6317dac9e kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004223026160 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 26 2023 12 108539-
language	English
source	In iScience 26(2023), 12, Seite 108539- volume:26 year:2023 number:12 pages:108539-
sourceStr	In iScience 26(2023), 12, Seite 108539- volume:26 year:2023 number:12 pages:108539-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Physics Optics Fiber optics Science Q
isfreeaccess_bool	true
container_title	iScience
authorswithroles_txt_mv	Marco Annunziata @@aut@@ Francesco Arcadio @@aut@@ Adriana Borriello @@aut@@ Debora Bencivenga @@aut@@ Angelantonio Piccirillo @@aut@@ Emanuela Stampone @@aut@@ Luigi Zeni @@aut@@ Nunzio Cennamo @@aut@@ Fulvio Della Ragione @@aut@@ Luigi Guida @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	1019532106
id	DOAJ099162385
language_de	englisch
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author	Marco Annunziata
spellingShingle	Marco Annunziata misc Physics misc Optics misc Fiber optics misc Science misc Q A novel plasmonic optical-fiber-based point-of-care test for periodontal MIP-1α detection
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topic_title	A novel plasmonic optical-fiber-based point-of-care test for periodontal MIP-1α detection Physics Optics Fiber optics
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title	A novel plasmonic optical-fiber-based point-of-care test for periodontal MIP-1α detection
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title_full	A novel plasmonic optical-fiber-based point-of-care test for periodontal MIP-1α detection
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author_browse	Marco Annunziata Francesco Arcadio Adriana Borriello Debora Bencivenga Angelantonio Piccirillo Emanuela Stampone Luigi Zeni Nunzio Cennamo Fulvio Della Ragione Luigi Guida
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title_sort	novel plasmonic optical-fiber-based point-of-care test for periodontal mip-1α detection
title_auth	A novel plasmonic optical-fiber-based point-of-care test for periodontal MIP-1α detection
abstract	Summary: The analysis of salivary biomarkers as expression of periodontal health conditions has been proposed as a useful aid to conventional diagnostic approaches. In this study, we present a point-of-care test (POCT) exploiting a surface plasmon resonance (SPR)-based optical biosensor to detect salivary macrophage inflammatory protein (MIP)-1α, a promising marker of periodontitis. A plastic optical fiber (POF) was suitably modified and functionalized by an antibody self-assembled monolayer against MIP-1α for plasmonic detection. The proposed SPR-POF biosensor showed high selectivity and very low limit of detection for MIP-1α of 129 fM (1.0 pg/mL) in phosphate-buffered saline and 346 fM (2.7 pg/mL) in saliva. As a proof of concept, this POCT was also able to discriminate between a periodontitis patient and a healthy subject. The obtained results support the future application of this technology for an on-site detection and real-time monitoring of periodontal health conditions for diagnostic and therapeutic purposes.
abstractGer	Summary: The analysis of salivary biomarkers as expression of periodontal health conditions has been proposed as a useful aid to conventional diagnostic approaches. In this study, we present a point-of-care test (POCT) exploiting a surface plasmon resonance (SPR)-based optical biosensor to detect salivary macrophage inflammatory protein (MIP)-1α, a promising marker of periodontitis. A plastic optical fiber (POF) was suitably modified and functionalized by an antibody self-assembled monolayer against MIP-1α for plasmonic detection. The proposed SPR-POF biosensor showed high selectivity and very low limit of detection for MIP-1α of 129 fM (1.0 pg/mL) in phosphate-buffered saline and 346 fM (2.7 pg/mL) in saliva. As a proof of concept, this POCT was also able to discriminate between a periodontitis patient and a healthy subject. The obtained results support the future application of this technology for an on-site detection and real-time monitoring of periodontal health conditions for diagnostic and therapeutic purposes.
abstract_unstemmed	Summary: The analysis of salivary biomarkers as expression of periodontal health conditions has been proposed as a useful aid to conventional diagnostic approaches. In this study, we present a point-of-care test (POCT) exploiting a surface plasmon resonance (SPR)-based optical biosensor to detect salivary macrophage inflammatory protein (MIP)-1α, a promising marker of periodontitis. A plastic optical fiber (POF) was suitably modified and functionalized by an antibody self-assembled monolayer against MIP-1α for plasmonic detection. The proposed SPR-POF biosensor showed high selectivity and very low limit of detection for MIP-1α of 129 fM (1.0 pg/mL) in phosphate-buffered saline and 346 fM (2.7 pg/mL) in saliva. As a proof of concept, this POCT was also able to discriminate between a periodontitis patient and a healthy subject. The obtained results support the future application of this technology for an on-site detection and real-time monitoring of periodontal health conditions for diagnostic and therapeutic purposes.
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title_short	A novel plasmonic optical-fiber-based point-of-care test for periodontal MIP-1α detection
url	https://doi.org/10.1016/j.isci.2023.108539 https://doaj.org/article/aea790aba1e0443197f77ea6317dac9e http://www.sciencedirect.com/science/article/pii/S2589004223026160 https://doaj.org/toc/2589-0042
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up_date	2024-07-03T21:22:02.699Z
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A novel plasmonic optical-fiber-based point-of-care test for periodontal MIP-1α detection

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