Preconception maternal retinal venular widening and steeper resistance increments in the utero-fetoplacental circulation in pregnancy

Summary: We investigated the relationship of preconception maternal retinal vasculature and utero-fetoplacental circulation in ensuing pregnancy. Embedded in a hospital-based, prospective preconception cohort, 396 women with a singleton live birth were included for analysis. We assessed retinal vasc...
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Autor*in:	Ling-Jun Li [verfasserIn] Mosammat Nazmun Nahar [verfasserIn] Ruochen Du [verfasserIn] Jerry Kok Yen Chan [verfasserIn] June Vic Khi Tan [verfasserIn] Johan G. Eriksson [verfasserIn] Tien Yin Wong [verfasserIn] Shiao-Yng Chan [verfasserIn] Lin Lin Su [verfasserIn] Yap Seng Chong [verfasserIn] Cuilin Zhang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Clinical finding Pregnancy

Übergeordnetes Werk:	In: iScience - Elsevier, 2019, 26(2023), 12, Seite 108535-
Übergeordnetes Werk:	volume:26 ; year:2023 ; number:12 ; pages:108535-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.isci.2023.108535

Katalog-ID:	DOAJ099162466

Internformat


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allfields	10.1016/j.isci.2023.108535 doi (DE-627)DOAJ099162466 (DE-599)DOAJ2bbfb40d842741f5b0f547fb5044c39e DE-627 ger DE-627 rakwb eng Ling-Jun Li verfasserin aut Preconception maternal retinal venular widening and steeper resistance increments in the utero-fetoplacental circulation in pregnancy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: We investigated the relationship of preconception maternal retinal vasculature and utero-fetoplacental circulation in ensuing pregnancy. Embedded in a hospital-based, prospective preconception cohort, 396 women with a singleton live birth were included for analysis. We assessed retinal vascular caliber during preconception phase and retrieved ultrasonogram results documenting utero-fetoplacental circulatory indices using Doppler ultrasonography and documented them at 18–21 weeks, 24–28 weeks, and 32–34 weeks where available. We performed a modified Poisson regression to estimate the relative risk of utero-fetoplacental abnormalities, adjusting for major confounders including pre-pregnancy and blood pressure. Per 10 μm increment in maternal preconception retinal venules was associated with over two-fold risks in developing notching (Relative risk [RR]: 2.84; 95% confidence interval [CI]: 1.79, 4.81) and ≥95th percentile umbilical artery pulsatility index (2.36; 1.72, 3.23) during mid-to-late pregnancy, respectively. Women with preconception retinal venular widening tended to demonstrate steeper resistance increments in both maternal uterine arteries and fetal umbilical arteries during mid-to-late pregnancy. Clinical finding Pregnancy Science Q Mosammat Nazmun Nahar verfasserin aut Ruochen Du verfasserin aut Jerry Kok Yen Chan verfasserin aut June Vic Khi Tan verfasserin aut Johan G. Eriksson verfasserin aut Tien Yin Wong verfasserin aut Shiao-Yng Chan verfasserin aut Lin Lin Su verfasserin aut Yap Seng Chong verfasserin aut Cuilin Zhang verfasserin aut In iScience Elsevier, 2019 26(2023), 12, Seite 108535- (DE-627)1019532106 25890042 nnns volume:26 year:2023 number:12 pages:108535- https://doi.org/10.1016/j.isci.2023.108535 kostenfrei https://doaj.org/article/2bbfb40d842741f5b0f547fb5044c39e kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004223026123 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 26 2023 12 108535-
spelling	10.1016/j.isci.2023.108535 doi (DE-627)DOAJ099162466 (DE-599)DOAJ2bbfb40d842741f5b0f547fb5044c39e DE-627 ger DE-627 rakwb eng Ling-Jun Li verfasserin aut Preconception maternal retinal venular widening and steeper resistance increments in the utero-fetoplacental circulation in pregnancy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: We investigated the relationship of preconception maternal retinal vasculature and utero-fetoplacental circulation in ensuing pregnancy. Embedded in a hospital-based, prospective preconception cohort, 396 women with a singleton live birth were included for analysis. We assessed retinal vascular caliber during preconception phase and retrieved ultrasonogram results documenting utero-fetoplacental circulatory indices using Doppler ultrasonography and documented them at 18–21 weeks, 24–28 weeks, and 32–34 weeks where available. We performed a modified Poisson regression to estimate the relative risk of utero-fetoplacental abnormalities, adjusting for major confounders including pre-pregnancy and blood pressure. Per 10 μm increment in maternal preconception retinal venules was associated with over two-fold risks in developing notching (Relative risk [RR]: 2.84; 95% confidence interval [CI]: 1.79, 4.81) and ≥95th percentile umbilical artery pulsatility index (2.36; 1.72, 3.23) during mid-to-late pregnancy, respectively. Women with preconception retinal venular widening tended to demonstrate steeper resistance increments in both maternal uterine arteries and fetal umbilical arteries during mid-to-late pregnancy. Clinical finding Pregnancy Science Q Mosammat Nazmun Nahar verfasserin aut Ruochen Du verfasserin aut Jerry Kok Yen Chan verfasserin aut June Vic Khi Tan verfasserin aut Johan G. Eriksson verfasserin aut Tien Yin Wong verfasserin aut Shiao-Yng Chan verfasserin aut Lin Lin Su verfasserin aut Yap Seng Chong verfasserin aut Cuilin Zhang verfasserin aut In iScience Elsevier, 2019 26(2023), 12, Seite 108535- (DE-627)1019532106 25890042 nnns volume:26 year:2023 number:12 pages:108535- https://doi.org/10.1016/j.isci.2023.108535 kostenfrei https://doaj.org/article/2bbfb40d842741f5b0f547fb5044c39e kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004223026123 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 26 2023 12 108535-
allfields_unstemmed	10.1016/j.isci.2023.108535 doi (DE-627)DOAJ099162466 (DE-599)DOAJ2bbfb40d842741f5b0f547fb5044c39e DE-627 ger DE-627 rakwb eng Ling-Jun Li verfasserin aut Preconception maternal retinal venular widening and steeper resistance increments in the utero-fetoplacental circulation in pregnancy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: We investigated the relationship of preconception maternal retinal vasculature and utero-fetoplacental circulation in ensuing pregnancy. Embedded in a hospital-based, prospective preconception cohort, 396 women with a singleton live birth were included for analysis. We assessed retinal vascular caliber during preconception phase and retrieved ultrasonogram results documenting utero-fetoplacental circulatory indices using Doppler ultrasonography and documented them at 18–21 weeks, 24–28 weeks, and 32–34 weeks where available. We performed a modified Poisson regression to estimate the relative risk of utero-fetoplacental abnormalities, adjusting for major confounders including pre-pregnancy and blood pressure. Per 10 μm increment in maternal preconception retinal venules was associated with over two-fold risks in developing notching (Relative risk [RR]: 2.84; 95% confidence interval [CI]: 1.79, 4.81) and ≥95th percentile umbilical artery pulsatility index (2.36; 1.72, 3.23) during mid-to-late pregnancy, respectively. Women with preconception retinal venular widening tended to demonstrate steeper resistance increments in both maternal uterine arteries and fetal umbilical arteries during mid-to-late pregnancy. Clinical finding Pregnancy Science Q Mosammat Nazmun Nahar verfasserin aut Ruochen Du verfasserin aut Jerry Kok Yen Chan verfasserin aut June Vic Khi Tan verfasserin aut Johan G. Eriksson verfasserin aut Tien Yin Wong verfasserin aut Shiao-Yng Chan verfasserin aut Lin Lin Su verfasserin aut Yap Seng Chong verfasserin aut Cuilin Zhang verfasserin aut In iScience Elsevier, 2019 26(2023), 12, Seite 108535- (DE-627)1019532106 25890042 nnns volume:26 year:2023 number:12 pages:108535- https://doi.org/10.1016/j.isci.2023.108535 kostenfrei https://doaj.org/article/2bbfb40d842741f5b0f547fb5044c39e kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004223026123 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 26 2023 12 108535-
allfieldsGer	10.1016/j.isci.2023.108535 doi (DE-627)DOAJ099162466 (DE-599)DOAJ2bbfb40d842741f5b0f547fb5044c39e DE-627 ger DE-627 rakwb eng Ling-Jun Li verfasserin aut Preconception maternal retinal venular widening and steeper resistance increments in the utero-fetoplacental circulation in pregnancy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: We investigated the relationship of preconception maternal retinal vasculature and utero-fetoplacental circulation in ensuing pregnancy. Embedded in a hospital-based, prospective preconception cohort, 396 women with a singleton live birth were included for analysis. We assessed retinal vascular caliber during preconception phase and retrieved ultrasonogram results documenting utero-fetoplacental circulatory indices using Doppler ultrasonography and documented them at 18–21 weeks, 24–28 weeks, and 32–34 weeks where available. We performed a modified Poisson regression to estimate the relative risk of utero-fetoplacental abnormalities, adjusting for major confounders including pre-pregnancy and blood pressure. Per 10 μm increment in maternal preconception retinal venules was associated with over two-fold risks in developing notching (Relative risk [RR]: 2.84; 95% confidence interval [CI]: 1.79, 4.81) and ≥95th percentile umbilical artery pulsatility index (2.36; 1.72, 3.23) during mid-to-late pregnancy, respectively. Women with preconception retinal venular widening tended to demonstrate steeper resistance increments in both maternal uterine arteries and fetal umbilical arteries during mid-to-late pregnancy. Clinical finding Pregnancy Science Q Mosammat Nazmun Nahar verfasserin aut Ruochen Du verfasserin aut Jerry Kok Yen Chan verfasserin aut June Vic Khi Tan verfasserin aut Johan G. Eriksson verfasserin aut Tien Yin Wong verfasserin aut Shiao-Yng Chan verfasserin aut Lin Lin Su verfasserin aut Yap Seng Chong verfasserin aut Cuilin Zhang verfasserin aut In iScience Elsevier, 2019 26(2023), 12, Seite 108535- (DE-627)1019532106 25890042 nnns volume:26 year:2023 number:12 pages:108535- https://doi.org/10.1016/j.isci.2023.108535 kostenfrei https://doaj.org/article/2bbfb40d842741f5b0f547fb5044c39e kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004223026123 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 26 2023 12 108535-
allfieldsSound	10.1016/j.isci.2023.108535 doi (DE-627)DOAJ099162466 (DE-599)DOAJ2bbfb40d842741f5b0f547fb5044c39e DE-627 ger DE-627 rakwb eng Ling-Jun Li verfasserin aut Preconception maternal retinal venular widening and steeper resistance increments in the utero-fetoplacental circulation in pregnancy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: We investigated the relationship of preconception maternal retinal vasculature and utero-fetoplacental circulation in ensuing pregnancy. Embedded in a hospital-based, prospective preconception cohort, 396 women with a singleton live birth were included for analysis. We assessed retinal vascular caliber during preconception phase and retrieved ultrasonogram results documenting utero-fetoplacental circulatory indices using Doppler ultrasonography and documented them at 18–21 weeks, 24–28 weeks, and 32–34 weeks where available. We performed a modified Poisson regression to estimate the relative risk of utero-fetoplacental abnormalities, adjusting for major confounders including pre-pregnancy and blood pressure. Per 10 μm increment in maternal preconception retinal venules was associated with over two-fold risks in developing notching (Relative risk [RR]: 2.84; 95% confidence interval [CI]: 1.79, 4.81) and ≥95th percentile umbilical artery pulsatility index (2.36; 1.72, 3.23) during mid-to-late pregnancy, respectively. Women with preconception retinal venular widening tended to demonstrate steeper resistance increments in both maternal uterine arteries and fetal umbilical arteries during mid-to-late pregnancy. Clinical finding Pregnancy Science Q Mosammat Nazmun Nahar verfasserin aut Ruochen Du verfasserin aut Jerry Kok Yen Chan verfasserin aut June Vic Khi Tan verfasserin aut Johan G. Eriksson verfasserin aut Tien Yin Wong verfasserin aut Shiao-Yng Chan verfasserin aut Lin Lin Su verfasserin aut Yap Seng Chong verfasserin aut Cuilin Zhang verfasserin aut In iScience Elsevier, 2019 26(2023), 12, Seite 108535- (DE-627)1019532106 25890042 nnns volume:26 year:2023 number:12 pages:108535- https://doi.org/10.1016/j.isci.2023.108535 kostenfrei https://doaj.org/article/2bbfb40d842741f5b0f547fb5044c39e kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004223026123 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 26 2023 12 108535-
language	English
source	In iScience 26(2023), 12, Seite 108535- volume:26 year:2023 number:12 pages:108535-
sourceStr	In iScience 26(2023), 12, Seite 108535- volume:26 year:2023 number:12 pages:108535-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Clinical finding Pregnancy Science Q
isfreeaccess_bool	true
container_title	iScience
authorswithroles_txt_mv	Ling-Jun Li @@aut@@ Mosammat Nazmun Nahar @@aut@@ Ruochen Du @@aut@@ Jerry Kok Yen Chan @@aut@@ June Vic Khi Tan @@aut@@ Johan G. Eriksson @@aut@@ Tien Yin Wong @@aut@@ Shiao-Yng Chan @@aut@@ Lin Lin Su @@aut@@ Yap Seng Chong @@aut@@ Cuilin Zhang @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	1019532106
id	DOAJ099162466
language_de	englisch
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author	Ling-Jun Li
spellingShingle	Ling-Jun Li misc Clinical finding misc Pregnancy misc Science misc Q Preconception maternal retinal venular widening and steeper resistance increments in the utero-fetoplacental circulation in pregnancy
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topic_title	Preconception maternal retinal venular widening and steeper resistance increments in the utero-fetoplacental circulation in pregnancy Clinical finding Pregnancy
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title	Preconception maternal retinal venular widening and steeper resistance increments in the utero-fetoplacental circulation in pregnancy
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title_full	Preconception maternal retinal venular widening and steeper resistance increments in the utero-fetoplacental circulation in pregnancy
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author_browse	Ling-Jun Li Mosammat Nazmun Nahar Ruochen Du Jerry Kok Yen Chan June Vic Khi Tan Johan G. Eriksson Tien Yin Wong Shiao-Yng Chan Lin Lin Su Yap Seng Chong Cuilin Zhang
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title_sort	preconception maternal retinal venular widening and steeper resistance increments in the utero-fetoplacental circulation in pregnancy
title_auth	Preconception maternal retinal venular widening and steeper resistance increments in the utero-fetoplacental circulation in pregnancy
abstract	Summary: We investigated the relationship of preconception maternal retinal vasculature and utero-fetoplacental circulation in ensuing pregnancy. Embedded in a hospital-based, prospective preconception cohort, 396 women with a singleton live birth were included for analysis. We assessed retinal vascular caliber during preconception phase and retrieved ultrasonogram results documenting utero-fetoplacental circulatory indices using Doppler ultrasonography and documented them at 18–21 weeks, 24–28 weeks, and 32–34 weeks where available. We performed a modified Poisson regression to estimate the relative risk of utero-fetoplacental abnormalities, adjusting for major confounders including pre-pregnancy and blood pressure. Per 10 μm increment in maternal preconception retinal venules was associated with over two-fold risks in developing notching (Relative risk [RR]: 2.84; 95% confidence interval [CI]: 1.79, 4.81) and ≥95th percentile umbilical artery pulsatility index (2.36; 1.72, 3.23) during mid-to-late pregnancy, respectively. Women with preconception retinal venular widening tended to demonstrate steeper resistance increments in both maternal uterine arteries and fetal umbilical arteries during mid-to-late pregnancy.
abstractGer	Summary: We investigated the relationship of preconception maternal retinal vasculature and utero-fetoplacental circulation in ensuing pregnancy. Embedded in a hospital-based, prospective preconception cohort, 396 women with a singleton live birth were included for analysis. We assessed retinal vascular caliber during preconception phase and retrieved ultrasonogram results documenting utero-fetoplacental circulatory indices using Doppler ultrasonography and documented them at 18–21 weeks, 24–28 weeks, and 32–34 weeks where available. We performed a modified Poisson regression to estimate the relative risk of utero-fetoplacental abnormalities, adjusting for major confounders including pre-pregnancy and blood pressure. Per 10 μm increment in maternal preconception retinal venules was associated with over two-fold risks in developing notching (Relative risk [RR]: 2.84; 95% confidence interval [CI]: 1.79, 4.81) and ≥95th percentile umbilical artery pulsatility index (2.36; 1.72, 3.23) during mid-to-late pregnancy, respectively. Women with preconception retinal venular widening tended to demonstrate steeper resistance increments in both maternal uterine arteries and fetal umbilical arteries during mid-to-late pregnancy.
abstract_unstemmed	Summary: We investigated the relationship of preconception maternal retinal vasculature and utero-fetoplacental circulation in ensuing pregnancy. Embedded in a hospital-based, prospective preconception cohort, 396 women with a singleton live birth were included for analysis. We assessed retinal vascular caliber during preconception phase and retrieved ultrasonogram results documenting utero-fetoplacental circulatory indices using Doppler ultrasonography and documented them at 18–21 weeks, 24–28 weeks, and 32–34 weeks where available. We performed a modified Poisson regression to estimate the relative risk of utero-fetoplacental abnormalities, adjusting for major confounders including pre-pregnancy and blood pressure. Per 10 μm increment in maternal preconception retinal venules was associated with over two-fold risks in developing notching (Relative risk [RR]: 2.84; 95% confidence interval [CI]: 1.79, 4.81) and ≥95th percentile umbilical artery pulsatility index (2.36; 1.72, 3.23) during mid-to-late pregnancy, respectively. Women with preconception retinal venular widening tended to demonstrate steeper resistance increments in both maternal uterine arteries and fetal umbilical arteries during mid-to-late pregnancy.
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title_short	Preconception maternal retinal venular widening and steeper resistance increments in the utero-fetoplacental circulation in pregnancy
url	https://doi.org/10.1016/j.isci.2023.108535 https://doaj.org/article/2bbfb40d842741f5b0f547fb5044c39e http://www.sciencedirect.com/science/article/pii/S2589004223026123 https://doaj.org/toc/2589-0042
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doi_str	10.1016/j.isci.2023.108535
up_date	2024-07-03T21:22:05.254Z
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Preconception maternal retinal venular widening and steeper resistance increments in the utero-fetoplacental circulation in pregnancy

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