A rare association of a high grade glioblastoma, cerebral abscess and acute lymphoblastic leukemia in a child with Noonan syndrome

Noonan syndrome is a genetic disorder frequently caused by PTPN11 mutations. Patients with Noonan syndrome are characterized by facial dysmorphism, short stature and congenital heart defects and they have a reported predisposition to malignancies such as leukemia, and solid and central nervous syste...
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Autor*in:	Wiem Boufrikha [verfasserIn] Rim Rakez [verfasserIn] Inaam Bizid [verfasserIn] M.Maher Hadhri [verfasserIn] Manel Njima [verfasserIn] Sarra Boukhris [verfasserIn] M.Adnene Laatiri [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	Acute lymphoblastic leukemia Brain tumor Case report Cerebral abscess Genetic diseases

Übergeordnetes Werk:	In: Leukemia Research Reports - Elsevier, 2015, 21(2024), Seite 100404-
Übergeordnetes Werk:	volume:21 ; year:2024 ; pages:100404-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.lrr.2023.100404

Katalog-ID:	DOAJ099439972

Internformat


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spelling	10.1016/j.lrr.2023.100404 doi (DE-627)DOAJ099439972 (DE-599)DOAJ2bcbb7ba81dd4e1d8ac154f926637cc3 DE-627 ger DE-627 rakwb eng RC254-282 Wiem Boufrikha verfasserin aut A rare association of a high grade glioblastoma, cerebral abscess and acute lymphoblastic leukemia in a child with Noonan syndrome 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Noonan syndrome is a genetic disorder frequently caused by PTPN11 mutations. Patients with Noonan syndrome are characterized by facial dysmorphism, short stature and congenital heart defects and they have a reported predisposition to malignancies such as leukemia, and solid and central nervous system tumors. Here, we report a case of a 14-year-old boy with Noonan syndrome treated for T-cell acute lymphoblastic leukemia who presented with 2 concomitant abnormalities: cerebral abscess and high grade glioblastoma. This exceptional association exhibits to a poorer prognosis and may sometimes delay the diagnosis and therefore the therapeutic intervention. Acute lymphoblastic leukemia Brain tumor Case report Cerebral abscess Genetic diseases Neoplasms. Tumors. Oncology. Including cancer and carcinogens Rim Rakez verfasserin aut Inaam Bizid verfasserin aut M.Maher Hadhri verfasserin aut Manel Njima verfasserin aut Sarra Boukhris verfasserin aut M.Adnene Laatiri verfasserin aut In Leukemia Research Reports Elsevier, 2015 21(2024), Seite 100404- (DE-627)738404586 (DE-600)2706248-X 22130489 nnns volume:21 year:2024 pages:100404- https://doi.org/10.1016/j.lrr.2023.100404 kostenfrei https://doaj.org/article/2bcbb7ba81dd4e1d8ac154f926637cc3 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213048923000444 kostenfrei https://doaj.org/toc/2213-0489 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 21 2024 100404-
allfields_unstemmed	10.1016/j.lrr.2023.100404 doi (DE-627)DOAJ099439972 (DE-599)DOAJ2bcbb7ba81dd4e1d8ac154f926637cc3 DE-627 ger DE-627 rakwb eng RC254-282 Wiem Boufrikha verfasserin aut A rare association of a high grade glioblastoma, cerebral abscess and acute lymphoblastic leukemia in a child with Noonan syndrome 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Noonan syndrome is a genetic disorder frequently caused by PTPN11 mutations. Patients with Noonan syndrome are characterized by facial dysmorphism, short stature and congenital heart defects and they have a reported predisposition to malignancies such as leukemia, and solid and central nervous system tumors. Here, we report a case of a 14-year-old boy with Noonan syndrome treated for T-cell acute lymphoblastic leukemia who presented with 2 concomitant abnormalities: cerebral abscess and high grade glioblastoma. This exceptional association exhibits to a poorer prognosis and may sometimes delay the diagnosis and therefore the therapeutic intervention. Acute lymphoblastic leukemia Brain tumor Case report Cerebral abscess Genetic diseases Neoplasms. Tumors. Oncology. Including cancer and carcinogens Rim Rakez verfasserin aut Inaam Bizid verfasserin aut M.Maher Hadhri verfasserin aut Manel Njima verfasserin aut Sarra Boukhris verfasserin aut M.Adnene Laatiri verfasserin aut In Leukemia Research Reports Elsevier, 2015 21(2024), Seite 100404- (DE-627)738404586 (DE-600)2706248-X 22130489 nnns volume:21 year:2024 pages:100404- https://doi.org/10.1016/j.lrr.2023.100404 kostenfrei https://doaj.org/article/2bcbb7ba81dd4e1d8ac154f926637cc3 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213048923000444 kostenfrei https://doaj.org/toc/2213-0489 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 21 2024 100404-
allfieldsGer	10.1016/j.lrr.2023.100404 doi (DE-627)DOAJ099439972 (DE-599)DOAJ2bcbb7ba81dd4e1d8ac154f926637cc3 DE-627 ger DE-627 rakwb eng RC254-282 Wiem Boufrikha verfasserin aut A rare association of a high grade glioblastoma, cerebral abscess and acute lymphoblastic leukemia in a child with Noonan syndrome 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Noonan syndrome is a genetic disorder frequently caused by PTPN11 mutations. Patients with Noonan syndrome are characterized by facial dysmorphism, short stature and congenital heart defects and they have a reported predisposition to malignancies such as leukemia, and solid and central nervous system tumors. Here, we report a case of a 14-year-old boy with Noonan syndrome treated for T-cell acute lymphoblastic leukemia who presented with 2 concomitant abnormalities: cerebral abscess and high grade glioblastoma. This exceptional association exhibits to a poorer prognosis and may sometimes delay the diagnosis and therefore the therapeutic intervention. Acute lymphoblastic leukemia Brain tumor Case report Cerebral abscess Genetic diseases Neoplasms. Tumors. Oncology. Including cancer and carcinogens Rim Rakez verfasserin aut Inaam Bizid verfasserin aut M.Maher Hadhri verfasserin aut Manel Njima verfasserin aut Sarra Boukhris verfasserin aut M.Adnene Laatiri verfasserin aut In Leukemia Research Reports Elsevier, 2015 21(2024), Seite 100404- (DE-627)738404586 (DE-600)2706248-X 22130489 nnns volume:21 year:2024 pages:100404- https://doi.org/10.1016/j.lrr.2023.100404 kostenfrei https://doaj.org/article/2bcbb7ba81dd4e1d8ac154f926637cc3 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213048923000444 kostenfrei https://doaj.org/toc/2213-0489 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 21 2024 100404-
allfieldsSound	10.1016/j.lrr.2023.100404 doi (DE-627)DOAJ099439972 (DE-599)DOAJ2bcbb7ba81dd4e1d8ac154f926637cc3 DE-627 ger DE-627 rakwb eng RC254-282 Wiem Boufrikha verfasserin aut A rare association of a high grade glioblastoma, cerebral abscess and acute lymphoblastic leukemia in a child with Noonan syndrome 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Noonan syndrome is a genetic disorder frequently caused by PTPN11 mutations. Patients with Noonan syndrome are characterized by facial dysmorphism, short stature and congenital heart defects and they have a reported predisposition to malignancies such as leukemia, and solid and central nervous system tumors. Here, we report a case of a 14-year-old boy with Noonan syndrome treated for T-cell acute lymphoblastic leukemia who presented with 2 concomitant abnormalities: cerebral abscess and high grade glioblastoma. This exceptional association exhibits to a poorer prognosis and may sometimes delay the diagnosis and therefore the therapeutic intervention. Acute lymphoblastic leukemia Brain tumor Case report Cerebral abscess Genetic diseases Neoplasms. Tumors. Oncology. Including cancer and carcinogens Rim Rakez verfasserin aut Inaam Bizid verfasserin aut M.Maher Hadhri verfasserin aut Manel Njima verfasserin aut Sarra Boukhris verfasserin aut M.Adnene Laatiri verfasserin aut In Leukemia Research Reports Elsevier, 2015 21(2024), Seite 100404- (DE-627)738404586 (DE-600)2706248-X 22130489 nnns volume:21 year:2024 pages:100404- https://doi.org/10.1016/j.lrr.2023.100404 kostenfrei https://doaj.org/article/2bcbb7ba81dd4e1d8ac154f926637cc3 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213048923000444 kostenfrei https://doaj.org/toc/2213-0489 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 21 2024 100404-
language	English
source	In Leukemia Research Reports 21(2024), Seite 100404- volume:21 year:2024 pages:100404-
sourceStr	In Leukemia Research Reports 21(2024), Seite 100404- volume:21 year:2024 pages:100404-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Acute lymphoblastic leukemia Brain tumor Case report Cerebral abscess Genetic diseases Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	Leukemia Research Reports
authorswithroles_txt_mv	Wiem Boufrikha @@aut@@ Rim Rakez @@aut@@ Inaam Bizid @@aut@@ M.Maher Hadhri @@aut@@ Manel Njima @@aut@@ Sarra Boukhris @@aut@@ M.Adnene Laatiri @@aut@@
publishDateDaySort_date	2024-01-01T00:00:00Z
hierarchy_top_id	738404586
id	DOAJ099439972
language_de	englisch
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callnumber-first	R - Medicine
author	Wiem Boufrikha
spellingShingle	Wiem Boufrikha misc RC254-282 misc Acute lymphoblastic leukemia misc Brain tumor misc Case report misc Cerebral abscess misc Genetic diseases misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens A rare association of a high grade glioblastoma, cerebral abscess and acute lymphoblastic leukemia in a child with Noonan syndrome
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topic_title	RC254-282 A rare association of a high grade glioblastoma, cerebral abscess and acute lymphoblastic leukemia in a child with Noonan syndrome Acute lymphoblastic leukemia Brain tumor Case report Cerebral abscess Genetic diseases
topic	misc RC254-282 misc Acute lymphoblastic leukemia misc Brain tumor misc Case report misc Cerebral abscess misc Genetic diseases misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc Acute lymphoblastic leukemia misc Brain tumor misc Case report misc Cerebral abscess misc Genetic diseases misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	A rare association of a high grade glioblastoma, cerebral abscess and acute lymphoblastic leukemia in a child with Noonan syndrome
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title_full	A rare association of a high grade glioblastoma, cerebral abscess and acute lymphoblastic leukemia in a child with Noonan syndrome
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title_sort	rare association of a high grade glioblastoma, cerebral abscess and acute lymphoblastic leukemia in a child with noonan syndrome
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title_auth	A rare association of a high grade glioblastoma, cerebral abscess and acute lymphoblastic leukemia in a child with Noonan syndrome
abstract	Noonan syndrome is a genetic disorder frequently caused by PTPN11 mutations. Patients with Noonan syndrome are characterized by facial dysmorphism, short stature and congenital heart defects and they have a reported predisposition to malignancies such as leukemia, and solid and central nervous system tumors. Here, we report a case of a 14-year-old boy with Noonan syndrome treated for T-cell acute lymphoblastic leukemia who presented with 2 concomitant abnormalities: cerebral abscess and high grade glioblastoma. This exceptional association exhibits to a poorer prognosis and may sometimes delay the diagnosis and therefore the therapeutic intervention.
abstractGer	Noonan syndrome is a genetic disorder frequently caused by PTPN11 mutations. Patients with Noonan syndrome are characterized by facial dysmorphism, short stature and congenital heart defects and they have a reported predisposition to malignancies such as leukemia, and solid and central nervous system tumors. Here, we report a case of a 14-year-old boy with Noonan syndrome treated for T-cell acute lymphoblastic leukemia who presented with 2 concomitant abnormalities: cerebral abscess and high grade glioblastoma. This exceptional association exhibits to a poorer prognosis and may sometimes delay the diagnosis and therefore the therapeutic intervention.
abstract_unstemmed	Noonan syndrome is a genetic disorder frequently caused by PTPN11 mutations. Patients with Noonan syndrome are characterized by facial dysmorphism, short stature and congenital heart defects and they have a reported predisposition to malignancies such as leukemia, and solid and central nervous system tumors. Here, we report a case of a 14-year-old boy with Noonan syndrome treated for T-cell acute lymphoblastic leukemia who presented with 2 concomitant abnormalities: cerebral abscess and high grade glioblastoma. This exceptional association exhibits to a poorer prognosis and may sometimes delay the diagnosis and therefore the therapeutic intervention.
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title_short	A rare association of a high grade glioblastoma, cerebral abscess and acute lymphoblastic leukemia in a child with Noonan syndrome
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A rare association of a high grade glioblastoma, cerebral abscess and acute lymphoblastic leukemia in a child with Noonan syndrome

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