Noninvasive assessment of the presence and size of esophageal varices

Background/Aim. A significant number of patients with liver cirrhosis who underwent screening endoscopy do not have esophageal varices (EVs) or have EVs that do not require prophylactic therapy. Given the invasiveness of the procedure, the need to develop nonendoscopic methods in predicting the presence of EVs is reasonable. The aim of the study was to determine the significance of clinical, biochemical, and ultrasonic parameters in the prediction of EVs. Methods. The study included 59 patients with cirrhosis of the liver, 39 (66.1%) patients with EVs, and 20 (33.9%) patients without EVs. In the group of patients with EVs, 22 (56.4%) patients had small EVs, and 17 (46.3%) had large EVs. Clinical parameters that included Child-Pugh (CP) score, ascites, and splenomegaly were evaluated. In all participants, complete blood count, liver function tests, abdominal ultrasound, and gastroscopy were performed, and a platelet count/spleen diameter (PC/SD) ratio was calculated. Results. Univariate logistic regression analysis showed that in-dependent risk factors for the occurrence of EVs were the following: CP B class [odds ratio (OR) 6.67; p = 0.003] and CP C class (OR 23.33; p = 0.005) relative to class A, ascites (OR 7.78; p = 0.001), spleen size (OR 1.035; p = 0.016), bilirubin (OR 1.065; p = 0.007), albumin (OR 0.794; p = 0.001), prothrombin time (OR 0.912; p < 0.001), international normalized ratio-INR (OR 231.364; p < 0.001), platelet count (OR 0.989; p = 0.023), and PC/SD ratio (OR 0.999; p = 0.034). In a multivariate model, it was shown that a decreased platelet count was a statistically significant risk factor for the presence of EVs (OR 0.983; p = 0.023). Leukopenia and the size of the right liver lobe were found to be statistically significant factors for the occurrence of large EVs. Based on the receiver operating characteristic (ROC) curve for the PC/SD ratio, the cutoff value of the test was obtained at 907 (907.11), with a negative predictive value of 76.4% for large EVs. Conclusion. The cutoff value of PC/SD ratio < 907 has a predictive value for the occurrence of large EVs. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Petrović Gordana [verfasserIn] Nagorni Aleksandar [verfasserIn] Bjelaković Goran [verfasserIn] Benedeto-Stojanov Daniela [verfasserIn] Radovanović-Dinić Biljana [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch ; srp

Erschienen:	2023

Schlagwörter:	esophageal and gastric varices liver cirrhosis platelet count prognosis risk factors spleen

Übergeordnetes Werk:	In: Vojnosanitetski Pregled - Military Health Department, Ministry of Defance, Serbia, 2012, 80(2023), 8, Seite 661-669
Übergeordnetes Werk:	volume:80 ; year:2023 ; number:8 ; pages:661-669

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.2298/VSP220915008P

Katalog-ID:	DOAJ099449900

Internformat


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520			\|a Background/Aim. A significant number of patients with liver cirrhosis who underwent screening endoscopy do not have esophageal varices (EVs) or have EVs that do not require prophylactic therapy. Given the invasiveness of the procedure, the need to develop nonendoscopic methods in predicting the presence of EVs is reasonable. The aim of the study was to determine the significance of clinical, biochemical, and ultrasonic parameters in the prediction of EVs. Methods. The study included 59 patients with cirrhosis of the liver, 39 (66.1%) patients with EVs, and 20 (33.9%) patients without EVs. In the group of patients with EVs, 22 (56.4%) patients had small EVs, and 17 (46.3%) had large EVs. Clinical parameters that included Child-Pugh (CP) score, ascites, and splenomegaly were evaluated. In all participants, complete blood count, liver function tests, abdominal ultrasound, and gastroscopy were performed, and a platelet count/spleen diameter (PC/SD) ratio was calculated. Results. Univariate logistic regression analysis showed that in-dependent risk factors for the occurrence of EVs were the following: CP B class [odds ratio (OR) 6.67; p = 0.003] and CP C class (OR 23.33; p = 0.005) relative to class A, ascites (OR 7.78; p = 0.001), spleen size (OR 1.035; p = 0.016), bilirubin (OR 1.065; p = 0.007), albumin (OR 0.794; p = 0.001), prothrombin time (OR 0.912; p < 0.001), international normalized ratio-INR (OR 231.364; p < 0.001), platelet count (OR 0.989; p = 0.023), and PC/SD ratio (OR 0.999; p = 0.034). In a multivariate model, it was shown that a decreased platelet count was a statistically significant risk factor for the presence of EVs (OR 0.983; p = 0.023). Leukopenia and the size of the right liver lobe were found to be statistically significant factors for the occurrence of large EVs. Based on the receiver operating characteristic (ROC) curve for the PC/SD ratio, the cutoff value of the test was obtained at 907 (907.11), with a negative predictive value of 76.4% for large EVs. Conclusion. The cutoff value of PC/SD ratio < 907 has a predictive value for the occurrence of large EVs.
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allfields	10.2298/VSP220915008P doi (DE-627)DOAJ099449900 (DE-599)DOAJa868b11fe0534b9ab4d959200934a3ab DE-627 ger DE-627 rakwb eng srp R5-920 Petrović Gordana verfasserin aut Noninvasive assessment of the presence and size of esophageal varices 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background/Aim. A significant number of patients with liver cirrhosis who underwent screening endoscopy do not have esophageal varices (EVs) or have EVs that do not require prophylactic therapy. Given the invasiveness of the procedure, the need to develop nonendoscopic methods in predicting the presence of EVs is reasonable. The aim of the study was to determine the significance of clinical, biochemical, and ultrasonic parameters in the prediction of EVs. Methods. The study included 59 patients with cirrhosis of the liver, 39 (66.1%) patients with EVs, and 20 (33.9%) patients without EVs. In the group of patients with EVs, 22 (56.4%) patients had small EVs, and 17 (46.3%) had large EVs. Clinical parameters that included Child-Pugh (CP) score, ascites, and splenomegaly were evaluated. In all participants, complete blood count, liver function tests, abdominal ultrasound, and gastroscopy were performed, and a platelet count/spleen diameter (PC/SD) ratio was calculated. Results. Univariate logistic regression analysis showed that in-dependent risk factors for the occurrence of EVs were the following: CP B class [odds ratio (OR) 6.67; p = 0.003] and CP C class (OR 23.33; p = 0.005) relative to class A, ascites (OR 7.78; p = 0.001), spleen size (OR 1.035; p = 0.016), bilirubin (OR 1.065; p = 0.007), albumin (OR 0.794; p = 0.001), prothrombin time (OR 0.912; p < 0.001), international normalized ratio-INR (OR 231.364; p < 0.001), platelet count (OR 0.989; p = 0.023), and PC/SD ratio (OR 0.999; p = 0.034). In a multivariate model, it was shown that a decreased platelet count was a statistically significant risk factor for the presence of EVs (OR 0.983; p = 0.023). Leukopenia and the size of the right liver lobe were found to be statistically significant factors for the occurrence of large EVs. Based on the receiver operating characteristic (ROC) curve for the PC/SD ratio, the cutoff value of the test was obtained at 907 (907.11), with a negative predictive value of 76.4% for large EVs. Conclusion. The cutoff value of PC/SD ratio < 907 has a predictive value for the occurrence of large EVs. esophageal and gastric varices liver cirrhosis platelet count prognosis risk factors spleen Medicine (General) Nagorni Aleksandar verfasserin aut Bjelaković Goran verfasserin aut Benedeto-Stojanov Daniela verfasserin aut Radovanović-Dinić Biljana verfasserin aut In Vojnosanitetski Pregled Military Health Department, Ministry of Defance, Serbia, 2012 80(2023), 8, Seite 661-669 (DE-627)474382613 (DE-600)2169819-3 24060720 nnns volume:80 year:2023 number:8 pages:661-669 https://doi.org/10.2298/VSP220915008P kostenfrei https://doaj.org/article/a868b11fe0534b9ab4d959200934a3ab kostenfrei https://doiserbia.nb.rs/img/doi/0042-8450/2023/0042-84502300008P.pdf kostenfrei https://doaj.org/toc/0042-8450 Journal toc kostenfrei https://doaj.org/toc/2406-0720 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 80 2023 8 661-669
spelling	10.2298/VSP220915008P doi (DE-627)DOAJ099449900 (DE-599)DOAJa868b11fe0534b9ab4d959200934a3ab DE-627 ger DE-627 rakwb eng srp R5-920 Petrović Gordana verfasserin aut Noninvasive assessment of the presence and size of esophageal varices 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background/Aim. A significant number of patients with liver cirrhosis who underwent screening endoscopy do not have esophageal varices (EVs) or have EVs that do not require prophylactic therapy. Given the invasiveness of the procedure, the need to develop nonendoscopic methods in predicting the presence of EVs is reasonable. The aim of the study was to determine the significance of clinical, biochemical, and ultrasonic parameters in the prediction of EVs. Methods. The study included 59 patients with cirrhosis of the liver, 39 (66.1%) patients with EVs, and 20 (33.9%) patients without EVs. In the group of patients with EVs, 22 (56.4%) patients had small EVs, and 17 (46.3%) had large EVs. Clinical parameters that included Child-Pugh (CP) score, ascites, and splenomegaly were evaluated. In all participants, complete blood count, liver function tests, abdominal ultrasound, and gastroscopy were performed, and a platelet count/spleen diameter (PC/SD) ratio was calculated. Results. Univariate logistic regression analysis showed that in-dependent risk factors for the occurrence of EVs were the following: CP B class [odds ratio (OR) 6.67; p = 0.003] and CP C class (OR 23.33; p = 0.005) relative to class A, ascites (OR 7.78; p = 0.001), spleen size (OR 1.035; p = 0.016), bilirubin (OR 1.065; p = 0.007), albumin (OR 0.794; p = 0.001), prothrombin time (OR 0.912; p < 0.001), international normalized ratio-INR (OR 231.364; p < 0.001), platelet count (OR 0.989; p = 0.023), and PC/SD ratio (OR 0.999; p = 0.034). In a multivariate model, it was shown that a decreased platelet count was a statistically significant risk factor for the presence of EVs (OR 0.983; p = 0.023). Leukopenia and the size of the right liver lobe were found to be statistically significant factors for the occurrence of large EVs. Based on the receiver operating characteristic (ROC) curve for the PC/SD ratio, the cutoff value of the test was obtained at 907 (907.11), with a negative predictive value of 76.4% for large EVs. Conclusion. The cutoff value of PC/SD ratio < 907 has a predictive value for the occurrence of large EVs. esophageal and gastric varices liver cirrhosis platelet count prognosis risk factors spleen Medicine (General) Nagorni Aleksandar verfasserin aut Bjelaković Goran verfasserin aut Benedeto-Stojanov Daniela verfasserin aut Radovanović-Dinić Biljana verfasserin aut In Vojnosanitetski Pregled Military Health Department, Ministry of Defance, Serbia, 2012 80(2023), 8, Seite 661-669 (DE-627)474382613 (DE-600)2169819-3 24060720 nnns volume:80 year:2023 number:8 pages:661-669 https://doi.org/10.2298/VSP220915008P kostenfrei https://doaj.org/article/a868b11fe0534b9ab4d959200934a3ab kostenfrei https://doiserbia.nb.rs/img/doi/0042-8450/2023/0042-84502300008P.pdf kostenfrei https://doaj.org/toc/0042-8450 Journal toc kostenfrei https://doaj.org/toc/2406-0720 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 80 2023 8 661-669
allfields_unstemmed	10.2298/VSP220915008P doi (DE-627)DOAJ099449900 (DE-599)DOAJa868b11fe0534b9ab4d959200934a3ab DE-627 ger DE-627 rakwb eng srp R5-920 Petrović Gordana verfasserin aut Noninvasive assessment of the presence and size of esophageal varices 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background/Aim. A significant number of patients with liver cirrhosis who underwent screening endoscopy do not have esophageal varices (EVs) or have EVs that do not require prophylactic therapy. Given the invasiveness of the procedure, the need to develop nonendoscopic methods in predicting the presence of EVs is reasonable. The aim of the study was to determine the significance of clinical, biochemical, and ultrasonic parameters in the prediction of EVs. Methods. The study included 59 patients with cirrhosis of the liver, 39 (66.1%) patients with EVs, and 20 (33.9%) patients without EVs. In the group of patients with EVs, 22 (56.4%) patients had small EVs, and 17 (46.3%) had large EVs. Clinical parameters that included Child-Pugh (CP) score, ascites, and splenomegaly were evaluated. In all participants, complete blood count, liver function tests, abdominal ultrasound, and gastroscopy were performed, and a platelet count/spleen diameter (PC/SD) ratio was calculated. Results. Univariate logistic regression analysis showed that in-dependent risk factors for the occurrence of EVs were the following: CP B class [odds ratio (OR) 6.67; p = 0.003] and CP C class (OR 23.33; p = 0.005) relative to class A, ascites (OR 7.78; p = 0.001), spleen size (OR 1.035; p = 0.016), bilirubin (OR 1.065; p = 0.007), albumin (OR 0.794; p = 0.001), prothrombin time (OR 0.912; p < 0.001), international normalized ratio-INR (OR 231.364; p < 0.001), platelet count (OR 0.989; p = 0.023), and PC/SD ratio (OR 0.999; p = 0.034). In a multivariate model, it was shown that a decreased platelet count was a statistically significant risk factor for the presence of EVs (OR 0.983; p = 0.023). Leukopenia and the size of the right liver lobe were found to be statistically significant factors for the occurrence of large EVs. Based on the receiver operating characteristic (ROC) curve for the PC/SD ratio, the cutoff value of the test was obtained at 907 (907.11), with a negative predictive value of 76.4% for large EVs. Conclusion. The cutoff value of PC/SD ratio < 907 has a predictive value for the occurrence of large EVs. esophageal and gastric varices liver cirrhosis platelet count prognosis risk factors spleen Medicine (General) Nagorni Aleksandar verfasserin aut Bjelaković Goran verfasserin aut Benedeto-Stojanov Daniela verfasserin aut Radovanović-Dinić Biljana verfasserin aut In Vojnosanitetski Pregled Military Health Department, Ministry of Defance, Serbia, 2012 80(2023), 8, Seite 661-669 (DE-627)474382613 (DE-600)2169819-3 24060720 nnns volume:80 year:2023 number:8 pages:661-669 https://doi.org/10.2298/VSP220915008P kostenfrei https://doaj.org/article/a868b11fe0534b9ab4d959200934a3ab kostenfrei https://doiserbia.nb.rs/img/doi/0042-8450/2023/0042-84502300008P.pdf kostenfrei https://doaj.org/toc/0042-8450 Journal toc kostenfrei https://doaj.org/toc/2406-0720 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 80 2023 8 661-669
allfieldsGer	10.2298/VSP220915008P doi (DE-627)DOAJ099449900 (DE-599)DOAJa868b11fe0534b9ab4d959200934a3ab DE-627 ger DE-627 rakwb eng srp R5-920 Petrović Gordana verfasserin aut Noninvasive assessment of the presence and size of esophageal varices 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background/Aim. A significant number of patients with liver cirrhosis who underwent screening endoscopy do not have esophageal varices (EVs) or have EVs that do not require prophylactic therapy. Given the invasiveness of the procedure, the need to develop nonendoscopic methods in predicting the presence of EVs is reasonable. The aim of the study was to determine the significance of clinical, biochemical, and ultrasonic parameters in the prediction of EVs. Methods. The study included 59 patients with cirrhosis of the liver, 39 (66.1%) patients with EVs, and 20 (33.9%) patients without EVs. In the group of patients with EVs, 22 (56.4%) patients had small EVs, and 17 (46.3%) had large EVs. Clinical parameters that included Child-Pugh (CP) score, ascites, and splenomegaly were evaluated. In all participants, complete blood count, liver function tests, abdominal ultrasound, and gastroscopy were performed, and a platelet count/spleen diameter (PC/SD) ratio was calculated. Results. Univariate logistic regression analysis showed that in-dependent risk factors for the occurrence of EVs were the following: CP B class [odds ratio (OR) 6.67; p = 0.003] and CP C class (OR 23.33; p = 0.005) relative to class A, ascites (OR 7.78; p = 0.001), spleen size (OR 1.035; p = 0.016), bilirubin (OR 1.065; p = 0.007), albumin (OR 0.794; p = 0.001), prothrombin time (OR 0.912; p < 0.001), international normalized ratio-INR (OR 231.364; p < 0.001), platelet count (OR 0.989; p = 0.023), and PC/SD ratio (OR 0.999; p = 0.034). In a multivariate model, it was shown that a decreased platelet count was a statistically significant risk factor for the presence of EVs (OR 0.983; p = 0.023). Leukopenia and the size of the right liver lobe were found to be statistically significant factors for the occurrence of large EVs. Based on the receiver operating characteristic (ROC) curve for the PC/SD ratio, the cutoff value of the test was obtained at 907 (907.11), with a negative predictive value of 76.4% for large EVs. Conclusion. The cutoff value of PC/SD ratio < 907 has a predictive value for the occurrence of large EVs. esophageal and gastric varices liver cirrhosis platelet count prognosis risk factors spleen Medicine (General) Nagorni Aleksandar verfasserin aut Bjelaković Goran verfasserin aut Benedeto-Stojanov Daniela verfasserin aut Radovanović-Dinić Biljana verfasserin aut In Vojnosanitetski Pregled Military Health Department, Ministry of Defance, Serbia, 2012 80(2023), 8, Seite 661-669 (DE-627)474382613 (DE-600)2169819-3 24060720 nnns volume:80 year:2023 number:8 pages:661-669 https://doi.org/10.2298/VSP220915008P kostenfrei https://doaj.org/article/a868b11fe0534b9ab4d959200934a3ab kostenfrei https://doiserbia.nb.rs/img/doi/0042-8450/2023/0042-84502300008P.pdf kostenfrei https://doaj.org/toc/0042-8450 Journal toc kostenfrei https://doaj.org/toc/2406-0720 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 80 2023 8 661-669
allfieldsSound	10.2298/VSP220915008P doi (DE-627)DOAJ099449900 (DE-599)DOAJa868b11fe0534b9ab4d959200934a3ab DE-627 ger DE-627 rakwb eng srp R5-920 Petrović Gordana verfasserin aut Noninvasive assessment of the presence and size of esophageal varices 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background/Aim. A significant number of patients with liver cirrhosis who underwent screening endoscopy do not have esophageal varices (EVs) or have EVs that do not require prophylactic therapy. Given the invasiveness of the procedure, the need to develop nonendoscopic methods in predicting the presence of EVs is reasonable. The aim of the study was to determine the significance of clinical, biochemical, and ultrasonic parameters in the prediction of EVs. Methods. The study included 59 patients with cirrhosis of the liver, 39 (66.1%) patients with EVs, and 20 (33.9%) patients without EVs. In the group of patients with EVs, 22 (56.4%) patients had small EVs, and 17 (46.3%) had large EVs. Clinical parameters that included Child-Pugh (CP) score, ascites, and splenomegaly were evaluated. In all participants, complete blood count, liver function tests, abdominal ultrasound, and gastroscopy were performed, and a platelet count/spleen diameter (PC/SD) ratio was calculated. Results. Univariate logistic regression analysis showed that in-dependent risk factors for the occurrence of EVs were the following: CP B class [odds ratio (OR) 6.67; p = 0.003] and CP C class (OR 23.33; p = 0.005) relative to class A, ascites (OR 7.78; p = 0.001), spleen size (OR 1.035; p = 0.016), bilirubin (OR 1.065; p = 0.007), albumin (OR 0.794; p = 0.001), prothrombin time (OR 0.912; p < 0.001), international normalized ratio-INR (OR 231.364; p < 0.001), platelet count (OR 0.989; p = 0.023), and PC/SD ratio (OR 0.999; p = 0.034). In a multivariate model, it was shown that a decreased platelet count was a statistically significant risk factor for the presence of EVs (OR 0.983; p = 0.023). Leukopenia and the size of the right liver lobe were found to be statistically significant factors for the occurrence of large EVs. Based on the receiver operating characteristic (ROC) curve for the PC/SD ratio, the cutoff value of the test was obtained at 907 (907.11), with a negative predictive value of 76.4% for large EVs. Conclusion. The cutoff value of PC/SD ratio < 907 has a predictive value for the occurrence of large EVs. esophageal and gastric varices liver cirrhosis platelet count prognosis risk factors spleen Medicine (General) Nagorni Aleksandar verfasserin aut Bjelaković Goran verfasserin aut Benedeto-Stojanov Daniela verfasserin aut Radovanović-Dinić Biljana verfasserin aut In Vojnosanitetski Pregled Military Health Department, Ministry of Defance, Serbia, 2012 80(2023), 8, Seite 661-669 (DE-627)474382613 (DE-600)2169819-3 24060720 nnns volume:80 year:2023 number:8 pages:661-669 https://doi.org/10.2298/VSP220915008P kostenfrei https://doaj.org/article/a868b11fe0534b9ab4d959200934a3ab kostenfrei https://doiserbia.nb.rs/img/doi/0042-8450/2023/0042-84502300008P.pdf kostenfrei https://doaj.org/toc/0042-8450 Journal toc kostenfrei https://doaj.org/toc/2406-0720 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 80 2023 8 661-669
language	English
source	In Vojnosanitetski Pregled 80(2023), 8, Seite 661-669 volume:80 year:2023 number:8 pages:661-669
sourceStr	In Vojnosanitetski Pregled 80(2023), 8, Seite 661-669 volume:80 year:2023 number:8 pages:661-669
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	esophageal and gastric varices liver cirrhosis platelet count prognosis risk factors spleen Medicine (General)
isfreeaccess_bool	true
container_title	Vojnosanitetski Pregled
authorswithroles_txt_mv	Petrović Gordana @@aut@@ Nagorni Aleksandar @@aut@@ Bjelaković Goran @@aut@@ Benedeto-Stojanov Daniela @@aut@@ Radovanović-Dinić Biljana @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	474382613
id	DOAJ099449900
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">DOAJ099449900</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240414034104.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">240414s2023 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.2298/VSP220915008P</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ099449900</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJa868b11fe0534b9ab4d959200934a3ab</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield><subfield code="a">srp</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">R5-920</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Petrović Gordana</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Noninvasive assessment of the presence and size of esophageal varices</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2023</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background/Aim. A significant number of patients with liver cirrhosis who underwent screening endoscopy do not have esophageal varices (EVs) or have EVs that do not require prophylactic therapy. Given the invasiveness of the procedure, the need to develop nonendoscopic methods in predicting the presence of EVs is reasonable. The aim of the study was to determine the significance of clinical, biochemical, and ultrasonic parameters in the prediction of EVs. Methods. The study included 59 patients with cirrhosis of the liver, 39 (66.1%) patients with EVs, and 20 (33.9%) patients without EVs. In the group of patients with EVs, 22 (56.4%) patients had small EVs, and 17 (46.3%) had large EVs. Clinical parameters that included Child-Pugh (CP) score, ascites, and splenomegaly were evaluated. In all participants, complete blood count, liver function tests, abdominal ultrasound, and gastroscopy were performed, and a platelet count/spleen diameter (PC/SD) ratio was calculated. Results. Univariate logistic regression analysis showed that in-dependent risk factors for the occurrence of EVs were the following: CP B class [odds ratio (OR) 6.67; p = 0.003] and CP C class (OR 23.33; p = 0.005) relative to class A, ascites (OR 7.78; p = 0.001), spleen size (OR 1.035; p = 0.016), bilirubin (OR 1.065; p = 0.007), albumin (OR 0.794; p = 0.001), prothrombin time (OR 0.912; p < 0.001), international normalized ratio-INR (OR 231.364; p < 0.001), platelet count (OR 0.989; p = 0.023), and PC/SD ratio (OR 0.999; p = 0.034). In a multivariate model, it was shown that a decreased platelet count was a statistically significant risk factor for the presence of EVs (OR 0.983; p = 0.023). Leukopenia and the size of the right liver lobe were found to be statistically significant factors for the occurrence of large EVs. Based on the receiver operating characteristic (ROC) curve for the PC/SD ratio, the cutoff value of the test was obtained at 907 (907.11), with a negative predictive value of 76.4% for large EVs. Conclusion. 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callnumber-first	R - Medicine
author	Petrović Gordana
spellingShingle	Petrović Gordana misc R5-920 misc esophageal and gastric varices misc liver cirrhosis misc platelet count misc prognosis misc risk factors misc spleen misc Medicine (General) Noninvasive assessment of the presence and size of esophageal varices
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topic_title	R5-920 Noninvasive assessment of the presence and size of esophageal varices esophageal and gastric varices liver cirrhosis platelet count prognosis risk factors spleen
topic	misc R5-920 misc esophageal and gastric varices misc liver cirrhosis misc platelet count misc prognosis misc risk factors misc spleen misc Medicine (General)
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title	Noninvasive assessment of the presence and size of esophageal varices
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title_full	Noninvasive assessment of the presence and size of esophageal varices
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author_browse	Petrović Gordana Nagorni Aleksandar Bjelaković Goran Benedeto-Stojanov Daniela Radovanović-Dinić Biljana
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title_sort	noninvasive assessment of the presence and size of esophageal varices
callnumber	R5-920
title_auth	Noninvasive assessment of the presence and size of esophageal varices
abstract	Background/Aim. A significant number of patients with liver cirrhosis who underwent screening endoscopy do not have esophageal varices (EVs) or have EVs that do not require prophylactic therapy. Given the invasiveness of the procedure, the need to develop nonendoscopic methods in predicting the presence of EVs is reasonable. The aim of the study was to determine the significance of clinical, biochemical, and ultrasonic parameters in the prediction of EVs. Methods. The study included 59 patients with cirrhosis of the liver, 39 (66.1%) patients with EVs, and 20 (33.9%) patients without EVs. In the group of patients with EVs, 22 (56.4%) patients had small EVs, and 17 (46.3%) had large EVs. Clinical parameters that included Child-Pugh (CP) score, ascites, and splenomegaly were evaluated. In all participants, complete blood count, liver function tests, abdominal ultrasound, and gastroscopy were performed, and a platelet count/spleen diameter (PC/SD) ratio was calculated. Results. Univariate logistic regression analysis showed that in-dependent risk factors for the occurrence of EVs were the following: CP B class [odds ratio (OR) 6.67; p = 0.003] and CP C class (OR 23.33; p = 0.005) relative to class A, ascites (OR 7.78; p = 0.001), spleen size (OR 1.035; p = 0.016), bilirubin (OR 1.065; p = 0.007), albumin (OR 0.794; p = 0.001), prothrombin time (OR 0.912; p < 0.001), international normalized ratio-INR (OR 231.364; p < 0.001), platelet count (OR 0.989; p = 0.023), and PC/SD ratio (OR 0.999; p = 0.034). In a multivariate model, it was shown that a decreased platelet count was a statistically significant risk factor for the presence of EVs (OR 0.983; p = 0.023). Leukopenia and the size of the right liver lobe were found to be statistically significant factors for the occurrence of large EVs. Based on the receiver operating characteristic (ROC) curve for the PC/SD ratio, the cutoff value of the test was obtained at 907 (907.11), with a negative predictive value of 76.4% for large EVs. Conclusion. The cutoff value of PC/SD ratio < 907 has a predictive value for the occurrence of large EVs.
abstractGer	Background/Aim. A significant number of patients with liver cirrhosis who underwent screening endoscopy do not have esophageal varices (EVs) or have EVs that do not require prophylactic therapy. Given the invasiveness of the procedure, the need to develop nonendoscopic methods in predicting the presence of EVs is reasonable. The aim of the study was to determine the significance of clinical, biochemical, and ultrasonic parameters in the prediction of EVs. Methods. The study included 59 patients with cirrhosis of the liver, 39 (66.1%) patients with EVs, and 20 (33.9%) patients without EVs. In the group of patients with EVs, 22 (56.4%) patients had small EVs, and 17 (46.3%) had large EVs. Clinical parameters that included Child-Pugh (CP) score, ascites, and splenomegaly were evaluated. In all participants, complete blood count, liver function tests, abdominal ultrasound, and gastroscopy were performed, and a platelet count/spleen diameter (PC/SD) ratio was calculated. Results. Univariate logistic regression analysis showed that in-dependent risk factors for the occurrence of EVs were the following: CP B class [odds ratio (OR) 6.67; p = 0.003] and CP C class (OR 23.33; p = 0.005) relative to class A, ascites (OR 7.78; p = 0.001), spleen size (OR 1.035; p = 0.016), bilirubin (OR 1.065; p = 0.007), albumin (OR 0.794; p = 0.001), prothrombin time (OR 0.912; p < 0.001), international normalized ratio-INR (OR 231.364; p < 0.001), platelet count (OR 0.989; p = 0.023), and PC/SD ratio (OR 0.999; p = 0.034). In a multivariate model, it was shown that a decreased platelet count was a statistically significant risk factor for the presence of EVs (OR 0.983; p = 0.023). Leukopenia and the size of the right liver lobe were found to be statistically significant factors for the occurrence of large EVs. Based on the receiver operating characteristic (ROC) curve for the PC/SD ratio, the cutoff value of the test was obtained at 907 (907.11), with a negative predictive value of 76.4% for large EVs. Conclusion. The cutoff value of PC/SD ratio < 907 has a predictive value for the occurrence of large EVs.
abstract_unstemmed	Background/Aim. A significant number of patients with liver cirrhosis who underwent screening endoscopy do not have esophageal varices (EVs) or have EVs that do not require prophylactic therapy. Given the invasiveness of the procedure, the need to develop nonendoscopic methods in predicting the presence of EVs is reasonable. The aim of the study was to determine the significance of clinical, biochemical, and ultrasonic parameters in the prediction of EVs. Methods. The study included 59 patients with cirrhosis of the liver, 39 (66.1%) patients with EVs, and 20 (33.9%) patients without EVs. In the group of patients with EVs, 22 (56.4%) patients had small EVs, and 17 (46.3%) had large EVs. Clinical parameters that included Child-Pugh (CP) score, ascites, and splenomegaly were evaluated. In all participants, complete blood count, liver function tests, abdominal ultrasound, and gastroscopy were performed, and a platelet count/spleen diameter (PC/SD) ratio was calculated. Results. Univariate logistic regression analysis showed that in-dependent risk factors for the occurrence of EVs were the following: CP B class [odds ratio (OR) 6.67; p = 0.003] and CP C class (OR 23.33; p = 0.005) relative to class A, ascites (OR 7.78; p = 0.001), spleen size (OR 1.035; p = 0.016), bilirubin (OR 1.065; p = 0.007), albumin (OR 0.794; p = 0.001), prothrombin time (OR 0.912; p < 0.001), international normalized ratio-INR (OR 231.364; p < 0.001), platelet count (OR 0.989; p = 0.023), and PC/SD ratio (OR 0.999; p = 0.034). In a multivariate model, it was shown that a decreased platelet count was a statistically significant risk factor for the presence of EVs (OR 0.983; p = 0.023). Leukopenia and the size of the right liver lobe were found to be statistically significant factors for the occurrence of large EVs. Based on the receiver operating characteristic (ROC) curve for the PC/SD ratio, the cutoff value of the test was obtained at 907 (907.11), with a negative predictive value of 76.4% for large EVs. Conclusion. The cutoff value of PC/SD ratio < 907 has a predictive value for the occurrence of large EVs.
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title_short	Noninvasive assessment of the presence and size of esophageal varices
url	https://doi.org/10.2298/VSP220915008P https://doaj.org/article/a868b11fe0534b9ab4d959200934a3ab https://doiserbia.nb.rs/img/doi/0042-8450/2023/0042-84502300008P.pdf https://doaj.org/toc/0042-8450 https://doaj.org/toc/2406-0720
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author2	Nagorni Aleksandar Bjelaković Goran Benedeto-Stojanov Daniela Radovanović-Dinić Biljana
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Univariate logistic regression analysis showed that in-dependent risk factors for the occurrence of EVs were the following: CP B class [odds ratio (OR) 6.67; p = 0.003] and CP C class (OR 23.33; p = 0.005) relative to class A, ascites (OR 7.78; p = 0.001), spleen size (OR 1.035; p = 0.016), bilirubin (OR 1.065; p = 0.007), albumin (OR 0.794; p = 0.001), prothrombin time (OR 0.912; p < 0.001), international normalized ratio-INR (OR 231.364; p < 0.001), platelet count (OR 0.989; p = 0.023), and PC/SD ratio (OR 0.999; p = 0.034). In a multivariate model, it was shown that a decreased platelet count was a statistically significant risk factor for the presence of EVs (OR 0.983; p = 0.023). Leukopenia and the size of the right liver lobe were found to be statistically significant factors for the occurrence of large EVs. Based on the receiver operating characteristic (ROC) curve for the PC/SD ratio, the cutoff value of the test was obtained at 907 (907.11), with a negative predictive value of 76.4% for large EVs. Conclusion. 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Noninvasive assessment of the presence and size of esophageal varices

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