Association between CYP3A5 genotypes with hypertension in Chinese Han population: A case-control study

Background: The association of CYP3A5 gene polymorphisms with hypertension in the Chinese population is unknown. We explored the association between the CYP3A5 (rs776746) gene and hypertension in the Chinese Han population. Methods: Using a case-control design, 340 cases and 254 controls were enroll...
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Autor*in:	Zhanzhan Li [verfasserIn] Peng Chen [verfasserIn] Tao Zhou [verfasserIn] Xiaofang Chen [verfasserIn] Lizhang Chen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	case-control cyp3a5 gene gene polymorphism hypertension interaction

Übergeordnetes Werk:	In: Clinical and Experimental Hypertension - Taylor & Francis Group, 2023, 39(2017), 3, Seite 235-240
Übergeordnetes Werk:	volume:39 ; year:2017 ; number:3 ; pages:235-240

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1080/10641963.2016.1246559

Katalog-ID:	DOAJ099482045

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520			\|a Background: The association of CYP3A5 gene polymorphisms with hypertension in the Chinese population is unknown. We explored the association between the CYP3A5 (rs776746) gene and hypertension in the Chinese Han population. Methods: Using a case-control design, 340 cases and 254 controls were enrolled from the Third Affiliated Hospital of South Medical University between July and December of 2015. We used a standardized questionnaire to collect data regarding age, sex, smoking, drinking, family history of hypertension, and physical exercise. Height and weight were measured, and the body mass index (BMI) was calculated by weight/height2. Blood pressure was measured three times after 5 min of rest with at least 15 s between measurements, and the mean was considered the final BP. A Clinical examination was conducted. Results: A total of 594 participants, including 340 cases and 254 controls, were entered into the analyses. The genotype frequencies of the CYP3A5 G<A polymorphism did not deviate from the Hardy-Weinberg equilibrium. The genotype frequencies among the cases were 38.8% (GA, 132 individuals), 42.9% (GG, 146 individuals), and 18.2% (AA, 62 individuals). The differences in genotype between the cases and the controls were statistically significant. The AA genotype was associated with an elevated risk of hypertension after adjusting for potential confounders in Model 2. There was no interaction between smoking and the CYP3A5 genotype, while the interaction between drinking and the CYP3A5 genotype was significant. Conclusion: The CYP3A5 gene may be associated with the risk of hypertension in the Chinese Han population, and this effect may be exacerbated by drinking.
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allfields	10.1080/10641963.2016.1246559 doi (DE-627)DOAJ099482045 (DE-599)DOAJc964da009ae645b4a7364720f4dd6dc4 DE-627 ger DE-627 rakwb eng RC666-701 Zhanzhan Li verfasserin aut Association between CYP3A5 genotypes with hypertension in Chinese Han population: A case-control study 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The association of CYP3A5 gene polymorphisms with hypertension in the Chinese population is unknown. We explored the association between the CYP3A5 (rs776746) gene and hypertension in the Chinese Han population. Methods: Using a case-control design, 340 cases and 254 controls were enrolled from the Third Affiliated Hospital of South Medical University between July and December of 2015. We used a standardized questionnaire to collect data regarding age, sex, smoking, drinking, family history of hypertension, and physical exercise. Height and weight were measured, and the body mass index (BMI) was calculated by weight/height2. Blood pressure was measured three times after 5 min of rest with at least 15 s between measurements, and the mean was considered the final BP. A Clinical examination was conducted. Results: A total of 594 participants, including 340 cases and 254 controls, were entered into the analyses. The genotype frequencies of the CYP3A5 G<A polymorphism did not deviate from the Hardy-Weinberg equilibrium. The genotype frequencies among the cases were 38.8% (GA, 132 individuals), 42.9% (GG, 146 individuals), and 18.2% (AA, 62 individuals). The differences in genotype between the cases and the controls were statistically significant. The AA genotype was associated with an elevated risk of hypertension after adjusting for potential confounders in Model 2. There was no interaction between smoking and the CYP3A5 genotype, while the interaction between drinking and the CYP3A5 genotype was significant. Conclusion: The CYP3A5 gene may be associated with the risk of hypertension in the Chinese Han population, and this effect may be exacerbated by drinking. case-control cyp3a5 gene gene polymorphism hypertension interaction Diseases of the circulatory (Cardiovascular) system Peng Chen verfasserin aut Tao Zhou verfasserin aut Xiaofang Chen verfasserin aut Lizhang Chen verfasserin aut In Clinical and Experimental Hypertension Taylor & Francis Group, 2023 39(2017), 3, Seite 235-240 (DE-627)323606504 (DE-600)2026245-0 15256006 nnns volume:39 year:2017 number:3 pages:235-240 https://doi.org/10.1080/10641963.2016.1246559 kostenfrei https://doaj.org/article/c964da009ae645b4a7364720f4dd6dc4 kostenfrei http://dx.doi.org/10.1080/10641963.2016.1246559 kostenfrei https://doaj.org/toc/1064-1963 Journal toc kostenfrei https://doaj.org/toc/1525-6006 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_206 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4305 GBV_ILN_4338 AR 39 2017 3 235-240
spelling	10.1080/10641963.2016.1246559 doi (DE-627)DOAJ099482045 (DE-599)DOAJc964da009ae645b4a7364720f4dd6dc4 DE-627 ger DE-627 rakwb eng RC666-701 Zhanzhan Li verfasserin aut Association between CYP3A5 genotypes with hypertension in Chinese Han population: A case-control study 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The association of CYP3A5 gene polymorphisms with hypertension in the Chinese population is unknown. We explored the association between the CYP3A5 (rs776746) gene and hypertension in the Chinese Han population. Methods: Using a case-control design, 340 cases and 254 controls were enrolled from the Third Affiliated Hospital of South Medical University between July and December of 2015. We used a standardized questionnaire to collect data regarding age, sex, smoking, drinking, family history of hypertension, and physical exercise. Height and weight were measured, and the body mass index (BMI) was calculated by weight/height2. Blood pressure was measured three times after 5 min of rest with at least 15 s between measurements, and the mean was considered the final BP. A Clinical examination was conducted. Results: A total of 594 participants, including 340 cases and 254 controls, were entered into the analyses. The genotype frequencies of the CYP3A5 G<A polymorphism did not deviate from the Hardy-Weinberg equilibrium. The genotype frequencies among the cases were 38.8% (GA, 132 individuals), 42.9% (GG, 146 individuals), and 18.2% (AA, 62 individuals). The differences in genotype between the cases and the controls were statistically significant. The AA genotype was associated with an elevated risk of hypertension after adjusting for potential confounders in Model 2. There was no interaction between smoking and the CYP3A5 genotype, while the interaction between drinking and the CYP3A5 genotype was significant. Conclusion: The CYP3A5 gene may be associated with the risk of hypertension in the Chinese Han population, and this effect may be exacerbated by drinking. case-control cyp3a5 gene gene polymorphism hypertension interaction Diseases of the circulatory (Cardiovascular) system Peng Chen verfasserin aut Tao Zhou verfasserin aut Xiaofang Chen verfasserin aut Lizhang Chen verfasserin aut In Clinical and Experimental Hypertension Taylor & Francis Group, 2023 39(2017), 3, Seite 235-240 (DE-627)323606504 (DE-600)2026245-0 15256006 nnns volume:39 year:2017 number:3 pages:235-240 https://doi.org/10.1080/10641963.2016.1246559 kostenfrei https://doaj.org/article/c964da009ae645b4a7364720f4dd6dc4 kostenfrei http://dx.doi.org/10.1080/10641963.2016.1246559 kostenfrei https://doaj.org/toc/1064-1963 Journal toc kostenfrei https://doaj.org/toc/1525-6006 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_206 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4305 GBV_ILN_4338 AR 39 2017 3 235-240
allfields_unstemmed	10.1080/10641963.2016.1246559 doi (DE-627)DOAJ099482045 (DE-599)DOAJc964da009ae645b4a7364720f4dd6dc4 DE-627 ger DE-627 rakwb eng RC666-701 Zhanzhan Li verfasserin aut Association between CYP3A5 genotypes with hypertension in Chinese Han population: A case-control study 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The association of CYP3A5 gene polymorphisms with hypertension in the Chinese population is unknown. We explored the association between the CYP3A5 (rs776746) gene and hypertension in the Chinese Han population. Methods: Using a case-control design, 340 cases and 254 controls were enrolled from the Third Affiliated Hospital of South Medical University between July and December of 2015. We used a standardized questionnaire to collect data regarding age, sex, smoking, drinking, family history of hypertension, and physical exercise. Height and weight were measured, and the body mass index (BMI) was calculated by weight/height2. Blood pressure was measured three times after 5 min of rest with at least 15 s between measurements, and the mean was considered the final BP. A Clinical examination was conducted. Results: A total of 594 participants, including 340 cases and 254 controls, were entered into the analyses. The genotype frequencies of the CYP3A5 G<A polymorphism did not deviate from the Hardy-Weinberg equilibrium. The genotype frequencies among the cases were 38.8% (GA, 132 individuals), 42.9% (GG, 146 individuals), and 18.2% (AA, 62 individuals). The differences in genotype between the cases and the controls were statistically significant. The AA genotype was associated with an elevated risk of hypertension after adjusting for potential confounders in Model 2. There was no interaction between smoking and the CYP3A5 genotype, while the interaction between drinking and the CYP3A5 genotype was significant. Conclusion: The CYP3A5 gene may be associated with the risk of hypertension in the Chinese Han population, and this effect may be exacerbated by drinking. case-control cyp3a5 gene gene polymorphism hypertension interaction Diseases of the circulatory (Cardiovascular) system Peng Chen verfasserin aut Tao Zhou verfasserin aut Xiaofang Chen verfasserin aut Lizhang Chen verfasserin aut In Clinical and Experimental Hypertension Taylor & Francis Group, 2023 39(2017), 3, Seite 235-240 (DE-627)323606504 (DE-600)2026245-0 15256006 nnns volume:39 year:2017 number:3 pages:235-240 https://doi.org/10.1080/10641963.2016.1246559 kostenfrei https://doaj.org/article/c964da009ae645b4a7364720f4dd6dc4 kostenfrei http://dx.doi.org/10.1080/10641963.2016.1246559 kostenfrei https://doaj.org/toc/1064-1963 Journal toc kostenfrei https://doaj.org/toc/1525-6006 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_206 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4305 GBV_ILN_4338 AR 39 2017 3 235-240
allfieldsGer	10.1080/10641963.2016.1246559 doi (DE-627)DOAJ099482045 (DE-599)DOAJc964da009ae645b4a7364720f4dd6dc4 DE-627 ger DE-627 rakwb eng RC666-701 Zhanzhan Li verfasserin aut Association between CYP3A5 genotypes with hypertension in Chinese Han population: A case-control study 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The association of CYP3A5 gene polymorphisms with hypertension in the Chinese population is unknown. We explored the association between the CYP3A5 (rs776746) gene and hypertension in the Chinese Han population. Methods: Using a case-control design, 340 cases and 254 controls were enrolled from the Third Affiliated Hospital of South Medical University between July and December of 2015. We used a standardized questionnaire to collect data regarding age, sex, smoking, drinking, family history of hypertension, and physical exercise. Height and weight were measured, and the body mass index (BMI) was calculated by weight/height2. Blood pressure was measured three times after 5 min of rest with at least 15 s between measurements, and the mean was considered the final BP. A Clinical examination was conducted. Results: A total of 594 participants, including 340 cases and 254 controls, were entered into the analyses. The genotype frequencies of the CYP3A5 G<A polymorphism did not deviate from the Hardy-Weinberg equilibrium. The genotype frequencies among the cases were 38.8% (GA, 132 individuals), 42.9% (GG, 146 individuals), and 18.2% (AA, 62 individuals). The differences in genotype between the cases and the controls were statistically significant. The AA genotype was associated with an elevated risk of hypertension after adjusting for potential confounders in Model 2. There was no interaction between smoking and the CYP3A5 genotype, while the interaction between drinking and the CYP3A5 genotype was significant. Conclusion: The CYP3A5 gene may be associated with the risk of hypertension in the Chinese Han population, and this effect may be exacerbated by drinking. case-control cyp3a5 gene gene polymorphism hypertension interaction Diseases of the circulatory (Cardiovascular) system Peng Chen verfasserin aut Tao Zhou verfasserin aut Xiaofang Chen verfasserin aut Lizhang Chen verfasserin aut In Clinical and Experimental Hypertension Taylor & Francis Group, 2023 39(2017), 3, Seite 235-240 (DE-627)323606504 (DE-600)2026245-0 15256006 nnns volume:39 year:2017 number:3 pages:235-240 https://doi.org/10.1080/10641963.2016.1246559 kostenfrei https://doaj.org/article/c964da009ae645b4a7364720f4dd6dc4 kostenfrei http://dx.doi.org/10.1080/10641963.2016.1246559 kostenfrei https://doaj.org/toc/1064-1963 Journal toc kostenfrei https://doaj.org/toc/1525-6006 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_206 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4305 GBV_ILN_4338 AR 39 2017 3 235-240
allfieldsSound	10.1080/10641963.2016.1246559 doi (DE-627)DOAJ099482045 (DE-599)DOAJc964da009ae645b4a7364720f4dd6dc4 DE-627 ger DE-627 rakwb eng RC666-701 Zhanzhan Li verfasserin aut Association between CYP3A5 genotypes with hypertension in Chinese Han population: A case-control study 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The association of CYP3A5 gene polymorphisms with hypertension in the Chinese population is unknown. We explored the association between the CYP3A5 (rs776746) gene and hypertension in the Chinese Han population. Methods: Using a case-control design, 340 cases and 254 controls were enrolled from the Third Affiliated Hospital of South Medical University between July and December of 2015. We used a standardized questionnaire to collect data regarding age, sex, smoking, drinking, family history of hypertension, and physical exercise. Height and weight were measured, and the body mass index (BMI) was calculated by weight/height2. Blood pressure was measured three times after 5 min of rest with at least 15 s between measurements, and the mean was considered the final BP. A Clinical examination was conducted. Results: A total of 594 participants, including 340 cases and 254 controls, were entered into the analyses. The genotype frequencies of the CYP3A5 G<A polymorphism did not deviate from the Hardy-Weinberg equilibrium. The genotype frequencies among the cases were 38.8% (GA, 132 individuals), 42.9% (GG, 146 individuals), and 18.2% (AA, 62 individuals). The differences in genotype between the cases and the controls were statistically significant. The AA genotype was associated with an elevated risk of hypertension after adjusting for potential confounders in Model 2. There was no interaction between smoking and the CYP3A5 genotype, while the interaction between drinking and the CYP3A5 genotype was significant. Conclusion: The CYP3A5 gene may be associated with the risk of hypertension in the Chinese Han population, and this effect may be exacerbated by drinking. case-control cyp3a5 gene gene polymorphism hypertension interaction Diseases of the circulatory (Cardiovascular) system Peng Chen verfasserin aut Tao Zhou verfasserin aut Xiaofang Chen verfasserin aut Lizhang Chen verfasserin aut In Clinical and Experimental Hypertension Taylor & Francis Group, 2023 39(2017), 3, Seite 235-240 (DE-627)323606504 (DE-600)2026245-0 15256006 nnns volume:39 year:2017 number:3 pages:235-240 https://doi.org/10.1080/10641963.2016.1246559 kostenfrei https://doaj.org/article/c964da009ae645b4a7364720f4dd6dc4 kostenfrei http://dx.doi.org/10.1080/10641963.2016.1246559 kostenfrei https://doaj.org/toc/1064-1963 Journal toc kostenfrei https://doaj.org/toc/1525-6006 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_206 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4305 GBV_ILN_4338 AR 39 2017 3 235-240
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We explored the association between the CYP3A5 (rs776746) gene and hypertension in the Chinese Han population. Methods: Using a case-control design, 340 cases and 254 controls were enrolled from the Third Affiliated Hospital of South Medical University between July and December of 2015. We used a standardized questionnaire to collect data regarding age, sex, smoking, drinking, family history of hypertension, and physical exercise. Height and weight were measured, and the body mass index (BMI) was calculated by weight/height2. Blood pressure was measured three times after 5 min of rest with at least 15 s between measurements, and the mean was considered the final BP. A Clinical examination was conducted. Results: A total of 594 participants, including 340 cases and 254 controls, were entered into the analyses. The genotype frequencies of the CYP3A5 G<A polymorphism did not deviate from the Hardy-Weinberg equilibrium. The genotype frequencies among the cases were 38.8% (GA, 132 individuals), 42.9% (GG, 146 individuals), and 18.2% (AA, 62 individuals). The differences in genotype between the cases and the controls were statistically significant. The AA genotype was associated with an elevated risk of hypertension after adjusting for potential confounders in Model 2. There was no interaction between smoking and the CYP3A5 genotype, while the interaction between drinking and the CYP3A5 genotype was significant. 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callnumber-first	R - Medicine
author	Zhanzhan Li
spellingShingle	Zhanzhan Li misc RC666-701 misc case-control misc cyp3a5 gene misc gene polymorphism misc hypertension misc interaction misc Diseases of the circulatory (Cardiovascular) system Association between CYP3A5 genotypes with hypertension in Chinese Han population: A case-control study
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topic_title	RC666-701 Association between CYP3A5 genotypes with hypertension in Chinese Han population: A case-control study case-control cyp3a5 gene gene polymorphism hypertension interaction
topic	misc RC666-701 misc case-control misc cyp3a5 gene misc gene polymorphism misc hypertension misc interaction misc Diseases of the circulatory (Cardiovascular) system
topic_unstemmed	misc RC666-701 misc case-control misc cyp3a5 gene misc gene polymorphism misc hypertension misc interaction misc Diseases of the circulatory (Cardiovascular) system
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title	Association between CYP3A5 genotypes with hypertension in Chinese Han population: A case-control study
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title_full	Association between CYP3A5 genotypes with hypertension in Chinese Han population: A case-control study
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title_sort	association between cyp3a5 genotypes with hypertension in chinese han population: a case-control study
callnumber	RC666-701
title_auth	Association between CYP3A5 genotypes with hypertension in Chinese Han population: A case-control study
abstract	Background: The association of CYP3A5 gene polymorphisms with hypertension in the Chinese population is unknown. We explored the association between the CYP3A5 (rs776746) gene and hypertension in the Chinese Han population. Methods: Using a case-control design, 340 cases and 254 controls were enrolled from the Third Affiliated Hospital of South Medical University between July and December of 2015. We used a standardized questionnaire to collect data regarding age, sex, smoking, drinking, family history of hypertension, and physical exercise. Height and weight were measured, and the body mass index (BMI) was calculated by weight/height2. Blood pressure was measured three times after 5 min of rest with at least 15 s between measurements, and the mean was considered the final BP. A Clinical examination was conducted. Results: A total of 594 participants, including 340 cases and 254 controls, were entered into the analyses. The genotype frequencies of the CYP3A5 G<A polymorphism did not deviate from the Hardy-Weinberg equilibrium. The genotype frequencies among the cases were 38.8% (GA, 132 individuals), 42.9% (GG, 146 individuals), and 18.2% (AA, 62 individuals). The differences in genotype between the cases and the controls were statistically significant. The AA genotype was associated with an elevated risk of hypertension after adjusting for potential confounders in Model 2. There was no interaction between smoking and the CYP3A5 genotype, while the interaction between drinking and the CYP3A5 genotype was significant. Conclusion: The CYP3A5 gene may be associated with the risk of hypertension in the Chinese Han population, and this effect may be exacerbated by drinking.
abstractGer	Background: The association of CYP3A5 gene polymorphisms with hypertension in the Chinese population is unknown. We explored the association between the CYP3A5 (rs776746) gene and hypertension in the Chinese Han population. Methods: Using a case-control design, 340 cases and 254 controls were enrolled from the Third Affiliated Hospital of South Medical University between July and December of 2015. We used a standardized questionnaire to collect data regarding age, sex, smoking, drinking, family history of hypertension, and physical exercise. Height and weight were measured, and the body mass index (BMI) was calculated by weight/height2. Blood pressure was measured three times after 5 min of rest with at least 15 s between measurements, and the mean was considered the final BP. A Clinical examination was conducted. Results: A total of 594 participants, including 340 cases and 254 controls, were entered into the analyses. The genotype frequencies of the CYP3A5 G<A polymorphism did not deviate from the Hardy-Weinberg equilibrium. The genotype frequencies among the cases were 38.8% (GA, 132 individuals), 42.9% (GG, 146 individuals), and 18.2% (AA, 62 individuals). The differences in genotype between the cases and the controls were statistically significant. The AA genotype was associated with an elevated risk of hypertension after adjusting for potential confounders in Model 2. There was no interaction between smoking and the CYP3A5 genotype, while the interaction between drinking and the CYP3A5 genotype was significant. Conclusion: The CYP3A5 gene may be associated with the risk of hypertension in the Chinese Han population, and this effect may be exacerbated by drinking.
abstract_unstemmed	Background: The association of CYP3A5 gene polymorphisms with hypertension in the Chinese population is unknown. We explored the association between the CYP3A5 (rs776746) gene and hypertension in the Chinese Han population. Methods: Using a case-control design, 340 cases and 254 controls were enrolled from the Third Affiliated Hospital of South Medical University between July and December of 2015. We used a standardized questionnaire to collect data regarding age, sex, smoking, drinking, family history of hypertension, and physical exercise. Height and weight were measured, and the body mass index (BMI) was calculated by weight/height2. Blood pressure was measured three times after 5 min of rest with at least 15 s between measurements, and the mean was considered the final BP. A Clinical examination was conducted. Results: A total of 594 participants, including 340 cases and 254 controls, were entered into the analyses. The genotype frequencies of the CYP3A5 G<A polymorphism did not deviate from the Hardy-Weinberg equilibrium. The genotype frequencies among the cases were 38.8% (GA, 132 individuals), 42.9% (GG, 146 individuals), and 18.2% (AA, 62 individuals). The differences in genotype between the cases and the controls were statistically significant. The AA genotype was associated with an elevated risk of hypertension after adjusting for potential confounders in Model 2. There was no interaction between smoking and the CYP3A5 genotype, while the interaction between drinking and the CYP3A5 genotype was significant. Conclusion: The CYP3A5 gene may be associated with the risk of hypertension in the Chinese Han population, and this effect may be exacerbated by drinking.
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title_short	Association between CYP3A5 genotypes with hypertension in Chinese Han population: A case-control study
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Association between CYP3A5 genotypes with hypertension in Chinese Han population: A case-control study

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