MST1/2 in inflammation and immunity
ABSTRACTThe mammalian Sterile 20-like kinase 1/2 (MST1/2) belongs to the serine/threonine (GC) protein kinase superfamily. Collective studies confirm the vital role MST1/2 in inflammation and immunity. MST1/2 is closely related to the progress of inflammation. Generally, MST1/2 aggravates the inflam...
Ausführliche Beschreibung
Autor*in: |
Tongfen Li [verfasserIn] Yiqiong Wen [verfasserIn] Qiongfen Lu [verfasserIn] Shu Hua [verfasserIn] Yunjiao Hou [verfasserIn] Xiaohua Du [verfasserIn] Yuanyuan Zheng [verfasserIn] Shibo Sun [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2023 |
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Schlagwörter: |
the mammalian Sterile 20-like 1 |
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Übergeordnetes Werk: |
In: Cell Adhesion & Migration - Taylor & Francis Group, 2019, 17(2023), 1, Seite 15 |
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Übergeordnetes Werk: |
volume:17 ; year:2023 ; number:1 ; pages:15 |
Links: |
Link aufrufen |
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DOI / URN: |
10.1080/19336918.2023.2276616 |
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Katalog-ID: |
DOAJ099595826 |
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10.1080/19336918.2023.2276616 doi (DE-627)DOAJ099595826 (DE-599)DOAJ60ed6821aa174f899ecaf860697c2adb DE-627 ger DE-627 rakwb eng QH573-671 Tongfen Li verfasserin aut MST1/2 in inflammation and immunity 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACTThe mammalian Sterile 20-like kinase 1/2 (MST1/2) belongs to the serine/threonine (GC) protein kinase superfamily. Collective studies confirm the vital role MST1/2 in inflammation and immunity. MST1/2 is closely related to the progress of inflammation. Generally, MST1/2 aggravates the inflammatory injury through MST1-JNK, MST1-mROS, MST1-Foxo3, and NF-κB pathways, as well as several regulatory factors such as tumor necrosis factor-α (TNF-α), mitochondrial extension factor 1 (MIEF1), and lipopolysaccharide (LPS). Moreover, MST1/2 is also involved in the regulation of immunity to balance immune activation and tolerance by regulating MST1/2-Rac, MST1-Akt1/c-myc, MST1-Foxos, MST1-STAT, Btk pathways, and lymphocyte function-related antigen 1 (LFA-1), which subsequently prevents immunodeficiency syndrome and autoimmune diseases. This article reviews the effects of MST1/2 on inflammation and immunity. Immunity inflammation the mammalian Sterile 20-like 1 the mammalian Sterile 20-like 2 pathways Cytology Yiqiong Wen verfasserin aut Qiongfen Lu verfasserin aut Shu Hua verfasserin aut Yunjiao Hou verfasserin aut Xiaohua Du verfasserin aut Yuanyuan Zheng verfasserin aut Shibo Sun verfasserin aut In Cell Adhesion & Migration Taylor & Francis Group, 2019 17(2023), 1, Seite 15 (DE-627)523859813 (DE-600)2268518-2 19336926 nnns volume:17 year:2023 number:1 pages:15 https://doi.org/10.1080/19336918.2023.2276616 kostenfrei https://doaj.org/article/60ed6821aa174f899ecaf860697c2adb kostenfrei https://www.tandfonline.com/doi/10.1080/19336918.2023.2276616 kostenfrei https://doaj.org/toc/1933-6918 Journal toc kostenfrei https://doaj.org/toc/1933-6926 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2014 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2023 1 15 |
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10.1080/19336918.2023.2276616 doi (DE-627)DOAJ099595826 (DE-599)DOAJ60ed6821aa174f899ecaf860697c2adb DE-627 ger DE-627 rakwb eng QH573-671 Tongfen Li verfasserin aut MST1/2 in inflammation and immunity 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACTThe mammalian Sterile 20-like kinase 1/2 (MST1/2) belongs to the serine/threonine (GC) protein kinase superfamily. Collective studies confirm the vital role MST1/2 in inflammation and immunity. MST1/2 is closely related to the progress of inflammation. Generally, MST1/2 aggravates the inflammatory injury through MST1-JNK, MST1-mROS, MST1-Foxo3, and NF-κB pathways, as well as several regulatory factors such as tumor necrosis factor-α (TNF-α), mitochondrial extension factor 1 (MIEF1), and lipopolysaccharide (LPS). Moreover, MST1/2 is also involved in the regulation of immunity to balance immune activation and tolerance by regulating MST1/2-Rac, MST1-Akt1/c-myc, MST1-Foxos, MST1-STAT, Btk pathways, and lymphocyte function-related antigen 1 (LFA-1), which subsequently prevents immunodeficiency syndrome and autoimmune diseases. This article reviews the effects of MST1/2 on inflammation and immunity. Immunity inflammation the mammalian Sterile 20-like 1 the mammalian Sterile 20-like 2 pathways Cytology Yiqiong Wen verfasserin aut Qiongfen Lu verfasserin aut Shu Hua verfasserin aut Yunjiao Hou verfasserin aut Xiaohua Du verfasserin aut Yuanyuan Zheng verfasserin aut Shibo Sun verfasserin aut In Cell Adhesion & Migration Taylor & Francis Group, 2019 17(2023), 1, Seite 15 (DE-627)523859813 (DE-600)2268518-2 19336926 nnns volume:17 year:2023 number:1 pages:15 https://doi.org/10.1080/19336918.2023.2276616 kostenfrei https://doaj.org/article/60ed6821aa174f899ecaf860697c2adb kostenfrei https://www.tandfonline.com/doi/10.1080/19336918.2023.2276616 kostenfrei https://doaj.org/toc/1933-6918 Journal toc kostenfrei https://doaj.org/toc/1933-6926 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2014 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2023 1 15 |
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10.1080/19336918.2023.2276616 doi (DE-627)DOAJ099595826 (DE-599)DOAJ60ed6821aa174f899ecaf860697c2adb DE-627 ger DE-627 rakwb eng QH573-671 Tongfen Li verfasserin aut MST1/2 in inflammation and immunity 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACTThe mammalian Sterile 20-like kinase 1/2 (MST1/2) belongs to the serine/threonine (GC) protein kinase superfamily. Collective studies confirm the vital role MST1/2 in inflammation and immunity. MST1/2 is closely related to the progress of inflammation. Generally, MST1/2 aggravates the inflammatory injury through MST1-JNK, MST1-mROS, MST1-Foxo3, and NF-κB pathways, as well as several regulatory factors such as tumor necrosis factor-α (TNF-α), mitochondrial extension factor 1 (MIEF1), and lipopolysaccharide (LPS). Moreover, MST1/2 is also involved in the regulation of immunity to balance immune activation and tolerance by regulating MST1/2-Rac, MST1-Akt1/c-myc, MST1-Foxos, MST1-STAT, Btk pathways, and lymphocyte function-related antigen 1 (LFA-1), which subsequently prevents immunodeficiency syndrome and autoimmune diseases. This article reviews the effects of MST1/2 on inflammation and immunity. Immunity inflammation the mammalian Sterile 20-like 1 the mammalian Sterile 20-like 2 pathways Cytology Yiqiong Wen verfasserin aut Qiongfen Lu verfasserin aut Shu Hua verfasserin aut Yunjiao Hou verfasserin aut Xiaohua Du verfasserin aut Yuanyuan Zheng verfasserin aut Shibo Sun verfasserin aut In Cell Adhesion & Migration Taylor & Francis Group, 2019 17(2023), 1, Seite 15 (DE-627)523859813 (DE-600)2268518-2 19336926 nnns volume:17 year:2023 number:1 pages:15 https://doi.org/10.1080/19336918.2023.2276616 kostenfrei https://doaj.org/article/60ed6821aa174f899ecaf860697c2adb kostenfrei https://www.tandfonline.com/doi/10.1080/19336918.2023.2276616 kostenfrei https://doaj.org/toc/1933-6918 Journal toc kostenfrei https://doaj.org/toc/1933-6926 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2014 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2023 1 15 |
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10.1080/19336918.2023.2276616 doi (DE-627)DOAJ099595826 (DE-599)DOAJ60ed6821aa174f899ecaf860697c2adb DE-627 ger DE-627 rakwb eng QH573-671 Tongfen Li verfasserin aut MST1/2 in inflammation and immunity 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACTThe mammalian Sterile 20-like kinase 1/2 (MST1/2) belongs to the serine/threonine (GC) protein kinase superfamily. Collective studies confirm the vital role MST1/2 in inflammation and immunity. MST1/2 is closely related to the progress of inflammation. Generally, MST1/2 aggravates the inflammatory injury through MST1-JNK, MST1-mROS, MST1-Foxo3, and NF-κB pathways, as well as several regulatory factors such as tumor necrosis factor-α (TNF-α), mitochondrial extension factor 1 (MIEF1), and lipopolysaccharide (LPS). Moreover, MST1/2 is also involved in the regulation of immunity to balance immune activation and tolerance by regulating MST1/2-Rac, MST1-Akt1/c-myc, MST1-Foxos, MST1-STAT, Btk pathways, and lymphocyte function-related antigen 1 (LFA-1), which subsequently prevents immunodeficiency syndrome and autoimmune diseases. This article reviews the effects of MST1/2 on inflammation and immunity. Immunity inflammation the mammalian Sterile 20-like 1 the mammalian Sterile 20-like 2 pathways Cytology Yiqiong Wen verfasserin aut Qiongfen Lu verfasserin aut Shu Hua verfasserin aut Yunjiao Hou verfasserin aut Xiaohua Du verfasserin aut Yuanyuan Zheng verfasserin aut Shibo Sun verfasserin aut In Cell Adhesion & Migration Taylor & Francis Group, 2019 17(2023), 1, Seite 15 (DE-627)523859813 (DE-600)2268518-2 19336926 nnns volume:17 year:2023 number:1 pages:15 https://doi.org/10.1080/19336918.2023.2276616 kostenfrei https://doaj.org/article/60ed6821aa174f899ecaf860697c2adb kostenfrei https://www.tandfonline.com/doi/10.1080/19336918.2023.2276616 kostenfrei https://doaj.org/toc/1933-6918 Journal toc kostenfrei https://doaj.org/toc/1933-6926 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2014 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2023 1 15 |
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10.1080/19336918.2023.2276616 doi (DE-627)DOAJ099595826 (DE-599)DOAJ60ed6821aa174f899ecaf860697c2adb DE-627 ger DE-627 rakwb eng QH573-671 Tongfen Li verfasserin aut MST1/2 in inflammation and immunity 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACTThe mammalian Sterile 20-like kinase 1/2 (MST1/2) belongs to the serine/threonine (GC) protein kinase superfamily. Collective studies confirm the vital role MST1/2 in inflammation and immunity. MST1/2 is closely related to the progress of inflammation. Generally, MST1/2 aggravates the inflammatory injury through MST1-JNK, MST1-mROS, MST1-Foxo3, and NF-κB pathways, as well as several regulatory factors such as tumor necrosis factor-α (TNF-α), mitochondrial extension factor 1 (MIEF1), and lipopolysaccharide (LPS). Moreover, MST1/2 is also involved in the regulation of immunity to balance immune activation and tolerance by regulating MST1/2-Rac, MST1-Akt1/c-myc, MST1-Foxos, MST1-STAT, Btk pathways, and lymphocyte function-related antigen 1 (LFA-1), which subsequently prevents immunodeficiency syndrome and autoimmune diseases. This article reviews the effects of MST1/2 on inflammation and immunity. Immunity inflammation the mammalian Sterile 20-like 1 the mammalian Sterile 20-like 2 pathways Cytology Yiqiong Wen verfasserin aut Qiongfen Lu verfasserin aut Shu Hua verfasserin aut Yunjiao Hou verfasserin aut Xiaohua Du verfasserin aut Yuanyuan Zheng verfasserin aut Shibo Sun verfasserin aut In Cell Adhesion & Migration Taylor & Francis Group, 2019 17(2023), 1, Seite 15 (DE-627)523859813 (DE-600)2268518-2 19336926 nnns volume:17 year:2023 number:1 pages:15 https://doi.org/10.1080/19336918.2023.2276616 kostenfrei https://doaj.org/article/60ed6821aa174f899ecaf860697c2adb kostenfrei https://www.tandfonline.com/doi/10.1080/19336918.2023.2276616 kostenfrei https://doaj.org/toc/1933-6918 Journal toc kostenfrei https://doaj.org/toc/1933-6926 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2014 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2023 1 15 |
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ABSTRACTThe mammalian Sterile 20-like kinase 1/2 (MST1/2) belongs to the serine/threonine (GC) protein kinase superfamily. Collective studies confirm the vital role MST1/2 in inflammation and immunity. MST1/2 is closely related to the progress of inflammation. Generally, MST1/2 aggravates the inflammatory injury through MST1-JNK, MST1-mROS, MST1-Foxo3, and NF-κB pathways, as well as several regulatory factors such as tumor necrosis factor-α (TNF-α), mitochondrial extension factor 1 (MIEF1), and lipopolysaccharide (LPS). Moreover, MST1/2 is also involved in the regulation of immunity to balance immune activation and tolerance by regulating MST1/2-Rac, MST1-Akt1/c-myc, MST1-Foxos, MST1-STAT, Btk pathways, and lymphocyte function-related antigen 1 (LFA-1), which subsequently prevents immunodeficiency syndrome and autoimmune diseases. This article reviews the effects of MST1/2 on inflammation and immunity. |
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ABSTRACTThe mammalian Sterile 20-like kinase 1/2 (MST1/2) belongs to the serine/threonine (GC) protein kinase superfamily. Collective studies confirm the vital role MST1/2 in inflammation and immunity. MST1/2 is closely related to the progress of inflammation. Generally, MST1/2 aggravates the inflammatory injury through MST1-JNK, MST1-mROS, MST1-Foxo3, and NF-κB pathways, as well as several regulatory factors such as tumor necrosis factor-α (TNF-α), mitochondrial extension factor 1 (MIEF1), and lipopolysaccharide (LPS). Moreover, MST1/2 is also involved in the regulation of immunity to balance immune activation and tolerance by regulating MST1/2-Rac, MST1-Akt1/c-myc, MST1-Foxos, MST1-STAT, Btk pathways, and lymphocyte function-related antigen 1 (LFA-1), which subsequently prevents immunodeficiency syndrome and autoimmune diseases. This article reviews the effects of MST1/2 on inflammation and immunity. |
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ABSTRACTThe mammalian Sterile 20-like kinase 1/2 (MST1/2) belongs to the serine/threonine (GC) protein kinase superfamily. Collective studies confirm the vital role MST1/2 in inflammation and immunity. MST1/2 is closely related to the progress of inflammation. Generally, MST1/2 aggravates the inflammatory injury through MST1-JNK, MST1-mROS, MST1-Foxo3, and NF-κB pathways, as well as several regulatory factors such as tumor necrosis factor-α (TNF-α), mitochondrial extension factor 1 (MIEF1), and lipopolysaccharide (LPS). Moreover, MST1/2 is also involved in the regulation of immunity to balance immune activation and tolerance by regulating MST1/2-Rac, MST1-Akt1/c-myc, MST1-Foxos, MST1-STAT, Btk pathways, and lymphocyte function-related antigen 1 (LFA-1), which subsequently prevents immunodeficiency syndrome and autoimmune diseases. This article reviews the effects of MST1/2 on inflammation and immunity. |
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