Lipid-Lowering and Antioxidant Effects of Self-Assembled Astaxanthin–Anthocyanin Nanoparticles on High-Fat <i<Caenorhabditis elegans</i<

Obesity has become a serious global public health risk threatening millions of people. In this study, the astaxanthin–anthocyanin nanoparticles (AXT-ACN NPs) were used to investigate their effects on the lipid accumulation and antioxidative capacity of the high-sugar-diet-induced high-fat <i<C...
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Gespeichert in:

Autor*in:	Deyang Yu [verfasserIn] Meng Guo [verfasserIn] Mingqian Tan [verfasserIn] Wentao Su [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	astaxanthin anthocyanin high-fat diet antioxidant lipid-lowering

Übergeordnetes Werk:	In: Foods - MDPI AG, 2013, 13(2024), 4, p 514
Übergeordnetes Werk:	volume:13 ; year:2024 ; number:4, p 514

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/foods13040514

Katalog-ID:	DOAJ099645408

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allfields	10.3390/foods13040514 doi (DE-627)DOAJ099645408 (DE-599)DOAJa346ffa866d64832a811d111cc867fec DE-627 ger DE-627 rakwb eng TP1-1185 Deyang Yu verfasserin aut Lipid-Lowering and Antioxidant Effects of Self-Assembled Astaxanthin–Anthocyanin Nanoparticles on High-Fat <i<Caenorhabditis elegans</i< 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Obesity has become a serious global public health risk threatening millions of people. In this study, the astaxanthin–anthocyanin nanoparticles (AXT-ACN NPs) were used to investigate their effects on the lipid accumulation and antioxidative capacity of the high-sugar-diet-induced high-fat <i<Caenorhabditis elegans</i< (<i<C. elegans</i<). It can be found that the lifespan, motility, and reproductive capacity of the high-fat <i<C. elegans</i< were significantly decreased compared to the normal nematodes in the control group. However, treatment of high-fat <i<C. elegans</i< with AXT-ACN NPs resulted in a prolonged lifespan of 35 days, improved motility, and a 22.06% increase in total spawn production of the nematodes. Furthermore, AXT-ACN NPs were found to effectively extend the lifespan of high-fat <i<C. elegans</i< under heat and oxidative stress conditions. Oil-red O staining results also demonstrated that AXT-ACN NPs have a remarkable effect on reducing the fat accumulation in nematodes, compared with pure astaxanthin and anthocyanin nanoparticles. Additionally, AXT-ACN NPs can significantly decrease the accumulation of lipofuscin and the level of reactive oxygen species (ROS). The activities of antioxidant-related enzymes in nematodes were further measured, which revealed that the AXT-ACN NPs could increase the activities of catalase (CAT), superoxidase dismutase (SOD), and glutathione peroxidase (GSH-Px), and decrease the malondialdehyde (MDA) content. The astaxanthin and anthocyanin in AXT-ACN NPs showed sound synergistic antioxidation and lipid-lowering effects, making them potential components in functional foods. astaxanthin anthocyanin <i<Caenorhabditis elegans</i< high-fat diet antioxidant lipid-lowering Chemical technology Meng Guo verfasserin aut Mingqian Tan verfasserin aut Wentao Su verfasserin aut In Foods MDPI AG, 2013 13(2024), 4, p 514 (DE-627)737287632 (DE-600)2704223-6 23048158 nnns volume:13 year:2024 number:4, p 514 https://doi.org/10.3390/foods13040514 kostenfrei https://doaj.org/article/a346ffa866d64832a811d111cc867fec kostenfrei https://www.mdpi.com/2304-8158/13/4/514 kostenfrei https://doaj.org/toc/2304-8158 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2024 4, p 514
spelling	10.3390/foods13040514 doi (DE-627)DOAJ099645408 (DE-599)DOAJa346ffa866d64832a811d111cc867fec DE-627 ger DE-627 rakwb eng TP1-1185 Deyang Yu verfasserin aut Lipid-Lowering and Antioxidant Effects of Self-Assembled Astaxanthin–Anthocyanin Nanoparticles on High-Fat <i<Caenorhabditis elegans</i< 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Obesity has become a serious global public health risk threatening millions of people. In this study, the astaxanthin–anthocyanin nanoparticles (AXT-ACN NPs) were used to investigate their effects on the lipid accumulation and antioxidative capacity of the high-sugar-diet-induced high-fat <i<Caenorhabditis elegans</i< (<i<C. elegans</i<). It can be found that the lifespan, motility, and reproductive capacity of the high-fat <i<C. elegans</i< were significantly decreased compared to the normal nematodes in the control group. However, treatment of high-fat <i<C. elegans</i< with AXT-ACN NPs resulted in a prolonged lifespan of 35 days, improved motility, and a 22.06% increase in total spawn production of the nematodes. Furthermore, AXT-ACN NPs were found to effectively extend the lifespan of high-fat <i<C. elegans</i< under heat and oxidative stress conditions. Oil-red O staining results also demonstrated that AXT-ACN NPs have a remarkable effect on reducing the fat accumulation in nematodes, compared with pure astaxanthin and anthocyanin nanoparticles. Additionally, AXT-ACN NPs can significantly decrease the accumulation of lipofuscin and the level of reactive oxygen species (ROS). The activities of antioxidant-related enzymes in nematodes were further measured, which revealed that the AXT-ACN NPs could increase the activities of catalase (CAT), superoxidase dismutase (SOD), and glutathione peroxidase (GSH-Px), and decrease the malondialdehyde (MDA) content. The astaxanthin and anthocyanin in AXT-ACN NPs showed sound synergistic antioxidation and lipid-lowering effects, making them potential components in functional foods. astaxanthin anthocyanin <i<Caenorhabditis elegans</i< high-fat diet antioxidant lipid-lowering Chemical technology Meng Guo verfasserin aut Mingqian Tan verfasserin aut Wentao Su verfasserin aut In Foods MDPI AG, 2013 13(2024), 4, p 514 (DE-627)737287632 (DE-600)2704223-6 23048158 nnns volume:13 year:2024 number:4, p 514 https://doi.org/10.3390/foods13040514 kostenfrei https://doaj.org/article/a346ffa866d64832a811d111cc867fec kostenfrei https://www.mdpi.com/2304-8158/13/4/514 kostenfrei https://doaj.org/toc/2304-8158 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2024 4, p 514
allfields_unstemmed	10.3390/foods13040514 doi (DE-627)DOAJ099645408 (DE-599)DOAJa346ffa866d64832a811d111cc867fec DE-627 ger DE-627 rakwb eng TP1-1185 Deyang Yu verfasserin aut Lipid-Lowering and Antioxidant Effects of Self-Assembled Astaxanthin–Anthocyanin Nanoparticles on High-Fat <i<Caenorhabditis elegans</i< 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Obesity has become a serious global public health risk threatening millions of people. In this study, the astaxanthin–anthocyanin nanoparticles (AXT-ACN NPs) were used to investigate their effects on the lipid accumulation and antioxidative capacity of the high-sugar-diet-induced high-fat <i<Caenorhabditis elegans</i< (<i<C. elegans</i<). It can be found that the lifespan, motility, and reproductive capacity of the high-fat <i<C. elegans</i< were significantly decreased compared to the normal nematodes in the control group. However, treatment of high-fat <i<C. elegans</i< with AXT-ACN NPs resulted in a prolonged lifespan of 35 days, improved motility, and a 22.06% increase in total spawn production of the nematodes. Furthermore, AXT-ACN NPs were found to effectively extend the lifespan of high-fat <i<C. elegans</i< under heat and oxidative stress conditions. Oil-red O staining results also demonstrated that AXT-ACN NPs have a remarkable effect on reducing the fat accumulation in nematodes, compared with pure astaxanthin and anthocyanin nanoparticles. Additionally, AXT-ACN NPs can significantly decrease the accumulation of lipofuscin and the level of reactive oxygen species (ROS). The activities of antioxidant-related enzymes in nematodes were further measured, which revealed that the AXT-ACN NPs could increase the activities of catalase (CAT), superoxidase dismutase (SOD), and glutathione peroxidase (GSH-Px), and decrease the malondialdehyde (MDA) content. The astaxanthin and anthocyanin in AXT-ACN NPs showed sound synergistic antioxidation and lipid-lowering effects, making them potential components in functional foods. astaxanthin anthocyanin <i<Caenorhabditis elegans</i< high-fat diet antioxidant lipid-lowering Chemical technology Meng Guo verfasserin aut Mingqian Tan verfasserin aut Wentao Su verfasserin aut In Foods MDPI AG, 2013 13(2024), 4, p 514 (DE-627)737287632 (DE-600)2704223-6 23048158 nnns volume:13 year:2024 number:4, p 514 https://doi.org/10.3390/foods13040514 kostenfrei https://doaj.org/article/a346ffa866d64832a811d111cc867fec kostenfrei https://www.mdpi.com/2304-8158/13/4/514 kostenfrei https://doaj.org/toc/2304-8158 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2024 4, p 514
allfieldsGer	10.3390/foods13040514 doi (DE-627)DOAJ099645408 (DE-599)DOAJa346ffa866d64832a811d111cc867fec DE-627 ger DE-627 rakwb eng TP1-1185 Deyang Yu verfasserin aut Lipid-Lowering and Antioxidant Effects of Self-Assembled Astaxanthin–Anthocyanin Nanoparticles on High-Fat <i<Caenorhabditis elegans</i< 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Obesity has become a serious global public health risk threatening millions of people. In this study, the astaxanthin–anthocyanin nanoparticles (AXT-ACN NPs) were used to investigate their effects on the lipid accumulation and antioxidative capacity of the high-sugar-diet-induced high-fat <i<Caenorhabditis elegans</i< (<i<C. elegans</i<). It can be found that the lifespan, motility, and reproductive capacity of the high-fat <i<C. elegans</i< were significantly decreased compared to the normal nematodes in the control group. However, treatment of high-fat <i<C. elegans</i< with AXT-ACN NPs resulted in a prolonged lifespan of 35 days, improved motility, and a 22.06% increase in total spawn production of the nematodes. Furthermore, AXT-ACN NPs were found to effectively extend the lifespan of high-fat <i<C. elegans</i< under heat and oxidative stress conditions. Oil-red O staining results also demonstrated that AXT-ACN NPs have a remarkable effect on reducing the fat accumulation in nematodes, compared with pure astaxanthin and anthocyanin nanoparticles. Additionally, AXT-ACN NPs can significantly decrease the accumulation of lipofuscin and the level of reactive oxygen species (ROS). The activities of antioxidant-related enzymes in nematodes were further measured, which revealed that the AXT-ACN NPs could increase the activities of catalase (CAT), superoxidase dismutase (SOD), and glutathione peroxidase (GSH-Px), and decrease the malondialdehyde (MDA) content. The astaxanthin and anthocyanin in AXT-ACN NPs showed sound synergistic antioxidation and lipid-lowering effects, making them potential components in functional foods. astaxanthin anthocyanin <i<Caenorhabditis elegans</i< high-fat diet antioxidant lipid-lowering Chemical technology Meng Guo verfasserin aut Mingqian Tan verfasserin aut Wentao Su verfasserin aut In Foods MDPI AG, 2013 13(2024), 4, p 514 (DE-627)737287632 (DE-600)2704223-6 23048158 nnns volume:13 year:2024 number:4, p 514 https://doi.org/10.3390/foods13040514 kostenfrei https://doaj.org/article/a346ffa866d64832a811d111cc867fec kostenfrei https://www.mdpi.com/2304-8158/13/4/514 kostenfrei https://doaj.org/toc/2304-8158 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2024 4, p 514
allfieldsSound	10.3390/foods13040514 doi (DE-627)DOAJ099645408 (DE-599)DOAJa346ffa866d64832a811d111cc867fec DE-627 ger DE-627 rakwb eng TP1-1185 Deyang Yu verfasserin aut Lipid-Lowering and Antioxidant Effects of Self-Assembled Astaxanthin–Anthocyanin Nanoparticles on High-Fat <i<Caenorhabditis elegans</i< 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Obesity has become a serious global public health risk threatening millions of people. In this study, the astaxanthin–anthocyanin nanoparticles (AXT-ACN NPs) were used to investigate their effects on the lipid accumulation and antioxidative capacity of the high-sugar-diet-induced high-fat <i<Caenorhabditis elegans</i< (<i<C. elegans</i<). It can be found that the lifespan, motility, and reproductive capacity of the high-fat <i<C. elegans</i< were significantly decreased compared to the normal nematodes in the control group. However, treatment of high-fat <i<C. elegans</i< with AXT-ACN NPs resulted in a prolonged lifespan of 35 days, improved motility, and a 22.06% increase in total spawn production of the nematodes. Furthermore, AXT-ACN NPs were found to effectively extend the lifespan of high-fat <i<C. elegans</i< under heat and oxidative stress conditions. Oil-red O staining results also demonstrated that AXT-ACN NPs have a remarkable effect on reducing the fat accumulation in nematodes, compared with pure astaxanthin and anthocyanin nanoparticles. Additionally, AXT-ACN NPs can significantly decrease the accumulation of lipofuscin and the level of reactive oxygen species (ROS). The activities of antioxidant-related enzymes in nematodes were further measured, which revealed that the AXT-ACN NPs could increase the activities of catalase (CAT), superoxidase dismutase (SOD), and glutathione peroxidase (GSH-Px), and decrease the malondialdehyde (MDA) content. The astaxanthin and anthocyanin in AXT-ACN NPs showed sound synergistic antioxidation and lipid-lowering effects, making them potential components in functional foods. astaxanthin anthocyanin <i<Caenorhabditis elegans</i< high-fat diet antioxidant lipid-lowering Chemical technology Meng Guo verfasserin aut Mingqian Tan verfasserin aut Wentao Su verfasserin aut In Foods MDPI AG, 2013 13(2024), 4, p 514 (DE-627)737287632 (DE-600)2704223-6 23048158 nnns volume:13 year:2024 number:4, p 514 https://doi.org/10.3390/foods13040514 kostenfrei https://doaj.org/article/a346ffa866d64832a811d111cc867fec kostenfrei https://www.mdpi.com/2304-8158/13/4/514 kostenfrei https://doaj.org/toc/2304-8158 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2024 4, p 514
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callnumber-first	T - Technology
author	Deyang Yu
spellingShingle	Deyang Yu misc TP1-1185 misc astaxanthin misc anthocyanin misc <i<Caenorhabditis elegans</i< misc high-fat diet misc antioxidant misc lipid-lowering misc Chemical technology Lipid-Lowering and Antioxidant Effects of Self-Assembled Astaxanthin–Anthocyanin Nanoparticles on High-Fat <i<Caenorhabditis elegans</i<
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topic_title	TP1-1185 Lipid-Lowering and Antioxidant Effects of Self-Assembled Astaxanthin–Anthocyanin Nanoparticles on High-Fat <i<Caenorhabditis elegans</i< astaxanthin anthocyanin <i<Caenorhabditis elegans</i< high-fat diet antioxidant lipid-lowering
topic	misc TP1-1185 misc astaxanthin misc anthocyanin misc <i<Caenorhabditis elegans</i< misc high-fat diet misc antioxidant misc lipid-lowering misc Chemical technology
topic_unstemmed	misc TP1-1185 misc astaxanthin misc anthocyanin misc <i<Caenorhabditis elegans</i< misc high-fat diet misc antioxidant misc lipid-lowering misc Chemical technology
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title	Lipid-Lowering and Antioxidant Effects of Self-Assembled Astaxanthin–Anthocyanin Nanoparticles on High-Fat <i<Caenorhabditis elegans</i<
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title_full	Lipid-Lowering and Antioxidant Effects of Self-Assembled Astaxanthin–Anthocyanin Nanoparticles on High-Fat <i<Caenorhabditis elegans</i<
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author_browse	Deyang Yu Meng Guo Mingqian Tan Wentao Su
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doi_str_mv	10.3390/foods13040514
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title_sort	lipid-lowering and antioxidant effects of self-assembled astaxanthin–anthocyanin nanoparticles on high-fat <i<caenorhabditis elegans</i<
callnumber	TP1-1185
title_auth	Lipid-Lowering and Antioxidant Effects of Self-Assembled Astaxanthin–Anthocyanin Nanoparticles on High-Fat <i<Caenorhabditis elegans</i<
abstract	Obesity has become a serious global public health risk threatening millions of people. In this study, the astaxanthin–anthocyanin nanoparticles (AXT-ACN NPs) were used to investigate their effects on the lipid accumulation and antioxidative capacity of the high-sugar-diet-induced high-fat <i<Caenorhabditis elegans</i< (<i<C. elegans</i<). It can be found that the lifespan, motility, and reproductive capacity of the high-fat <i<C. elegans</i< were significantly decreased compared to the normal nematodes in the control group. However, treatment of high-fat <i<C. elegans</i< with AXT-ACN NPs resulted in a prolonged lifespan of 35 days, improved motility, and a 22.06% increase in total spawn production of the nematodes. Furthermore, AXT-ACN NPs were found to effectively extend the lifespan of high-fat <i<C. elegans</i< under heat and oxidative stress conditions. Oil-red O staining results also demonstrated that AXT-ACN NPs have a remarkable effect on reducing the fat accumulation in nematodes, compared with pure astaxanthin and anthocyanin nanoparticles. Additionally, AXT-ACN NPs can significantly decrease the accumulation of lipofuscin and the level of reactive oxygen species (ROS). The activities of antioxidant-related enzymes in nematodes were further measured, which revealed that the AXT-ACN NPs could increase the activities of catalase (CAT), superoxidase dismutase (SOD), and glutathione peroxidase (GSH-Px), and decrease the malondialdehyde (MDA) content. The astaxanthin and anthocyanin in AXT-ACN NPs showed sound synergistic antioxidation and lipid-lowering effects, making them potential components in functional foods.
abstractGer	Obesity has become a serious global public health risk threatening millions of people. In this study, the astaxanthin–anthocyanin nanoparticles (AXT-ACN NPs) were used to investigate their effects on the lipid accumulation and antioxidative capacity of the high-sugar-diet-induced high-fat <i<Caenorhabditis elegans</i< (<i<C. elegans</i<). It can be found that the lifespan, motility, and reproductive capacity of the high-fat <i<C. elegans</i< were significantly decreased compared to the normal nematodes in the control group. However, treatment of high-fat <i<C. elegans</i< with AXT-ACN NPs resulted in a prolonged lifespan of 35 days, improved motility, and a 22.06% increase in total spawn production of the nematodes. Furthermore, AXT-ACN NPs were found to effectively extend the lifespan of high-fat <i<C. elegans</i< under heat and oxidative stress conditions. Oil-red O staining results also demonstrated that AXT-ACN NPs have a remarkable effect on reducing the fat accumulation in nematodes, compared with pure astaxanthin and anthocyanin nanoparticles. Additionally, AXT-ACN NPs can significantly decrease the accumulation of lipofuscin and the level of reactive oxygen species (ROS). The activities of antioxidant-related enzymes in nematodes were further measured, which revealed that the AXT-ACN NPs could increase the activities of catalase (CAT), superoxidase dismutase (SOD), and glutathione peroxidase (GSH-Px), and decrease the malondialdehyde (MDA) content. The astaxanthin and anthocyanin in AXT-ACN NPs showed sound synergistic antioxidation and lipid-lowering effects, making them potential components in functional foods.
abstract_unstemmed	Obesity has become a serious global public health risk threatening millions of people. In this study, the astaxanthin–anthocyanin nanoparticles (AXT-ACN NPs) were used to investigate their effects on the lipid accumulation and antioxidative capacity of the high-sugar-diet-induced high-fat <i<Caenorhabditis elegans</i< (<i<C. elegans</i<). It can be found that the lifespan, motility, and reproductive capacity of the high-fat <i<C. elegans</i< were significantly decreased compared to the normal nematodes in the control group. However, treatment of high-fat <i<C. elegans</i< with AXT-ACN NPs resulted in a prolonged lifespan of 35 days, improved motility, and a 22.06% increase in total spawn production of the nematodes. Furthermore, AXT-ACN NPs were found to effectively extend the lifespan of high-fat <i<C. elegans</i< under heat and oxidative stress conditions. Oil-red O staining results also demonstrated that AXT-ACN NPs have a remarkable effect on reducing the fat accumulation in nematodes, compared with pure astaxanthin and anthocyanin nanoparticles. Additionally, AXT-ACN NPs can significantly decrease the accumulation of lipofuscin and the level of reactive oxygen species (ROS). The activities of antioxidant-related enzymes in nematodes were further measured, which revealed that the AXT-ACN NPs could increase the activities of catalase (CAT), superoxidase dismutase (SOD), and glutathione peroxidase (GSH-Px), and decrease the malondialdehyde (MDA) content. The astaxanthin and anthocyanin in AXT-ACN NPs showed sound synergistic antioxidation and lipid-lowering effects, making them potential components in functional foods.
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container_issue	4, p 514
title_short	Lipid-Lowering and Antioxidant Effects of Self-Assembled Astaxanthin–Anthocyanin Nanoparticles on High-Fat <i<Caenorhabditis elegans</i<
url	https://doi.org/10.3390/foods13040514 https://doaj.org/article/a346ffa866d64832a811d111cc867fec https://www.mdpi.com/2304-8158/13/4/514 https://doaj.org/toc/2304-8158
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up_date	2024-07-03T23:45:17.353Z
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Lipid-Lowering and Antioxidant Effects of Self-Assembled Astaxanthin–Anthocyanin Nanoparticles on High-Fat <i<Caenorhabditis elegans</i<

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