Diagnostic and Therapeutic Management of Primary Orbital Neuroendocrine Tumors (NETs): Systematic Literature Review and Clinical Case Presentation

Background: The ocular involvement of neuroendocrine neoplasms (NENs) is uncommon and mainly represented by metastases from gastrointestinal and lung neuroendocrine tumors. Primary orbital NENs are even less common and their diagnostic and therapeutic management is a challenge. Methods: A systematic...
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Autor*in:	Giulia Arrivi [verfasserIn] Monia Specchia [verfasserIn] Emanuela Pilozzi [verfasserIn] Maria Rinzivillo [verfasserIn] Damiano Caruso [verfasserIn] Curzio Santangeli [verfasserIn] Daniela Prosperi [verfasserIn] Anna Maria Ascolese [verfasserIn] Francesco Panzuto [verfasserIn] Federica Mazzuca [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	primary orbital orbit neuroendocrine tumor NETs multidisciplinary team diagnosis

Übergeordnetes Werk:	In: Biomedicines - MDPI AG, 2014, 12(2024), 2, p 379
Übergeordnetes Werk:	volume:12 ; year:2024 ; number:2, p 379

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/biomedicines12020379

Katalog-ID:	DOAJ099669854

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allfieldsGer	10.3390/biomedicines12020379 doi (DE-627)DOAJ099669854 (DE-599)DOAJ17d74d9df05f4a2d8fc5f4df0cfa42c8 DE-627 ger DE-627 rakwb eng QH301-705.5 Giulia Arrivi verfasserin aut Diagnostic and Therapeutic Management of Primary Orbital Neuroendocrine Tumors (NETs): Systematic Literature Review and Clinical Case Presentation 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The ocular involvement of neuroendocrine neoplasms (NENs) is uncommon and mainly represented by metastases from gastrointestinal and lung neuroendocrine tumors. Primary orbital NENs are even less common and their diagnostic and therapeutic management is a challenge. Methods: A systematic review of the literature was conducted from 1966 to September 2023 on PubMed to identify articles on orbital NENs and to summarize their clinical–pathological features, diagnosis and therapeutic management. Furthermore, we presented a case of a locally advanced retro-orbital primary neuroendocrine tumor that was referred to the certified Center of Excellence of Sant’Andrea Hospital, La Sapienza University of Rome, Italy. Results: The final analysis included 63 records on orbital NENs and 11 records focused on primary orbital NENs. The localization was mostly unilateral and in the right orbit; proptosis or exophthalmos represented the initial symptoms. The diagnostic work-up and therapeutic management was discussed and a diagnostic algorithm for the suspicion of primary orbital NENs was proposed. Conclusions: A multidisciplinary approach is required for the management of primary orbital NENs, emphasizing the importance of early referral to dedicated centers for prompt differential diagnosis, tailored treatment, and an improved quality of life and survival. primary orbital orbit neuroendocrine tumor NETs multidisciplinary team diagnosis Biology (General) Monia Specchia verfasserin aut Emanuela Pilozzi verfasserin aut Maria Rinzivillo verfasserin aut Damiano Caruso verfasserin aut Curzio Santangeli verfasserin aut Daniela Prosperi verfasserin aut Anna Maria Ascolese verfasserin aut Francesco Panzuto verfasserin aut Federica Mazzuca verfasserin aut In Biomedicines MDPI AG, 2014 12(2024), 2, p 379 (DE-627)750370483 (DE-600)2720867-9 22279059 nnns volume:12 year:2024 number:2, p 379 https://doi.org/10.3390/biomedicines12020379 kostenfrei https://doaj.org/article/17d74d9df05f4a2d8fc5f4df0cfa42c8 kostenfrei https://www.mdpi.com/2227-9059/12/2/379 kostenfrei https://doaj.org/toc/2227-9059 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2024 2, p 379
allfieldsSound	10.3390/biomedicines12020379 doi (DE-627)DOAJ099669854 (DE-599)DOAJ17d74d9df05f4a2d8fc5f4df0cfa42c8 DE-627 ger DE-627 rakwb eng QH301-705.5 Giulia Arrivi verfasserin aut Diagnostic and Therapeutic Management of Primary Orbital Neuroendocrine Tumors (NETs): Systematic Literature Review and Clinical Case Presentation 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The ocular involvement of neuroendocrine neoplasms (NENs) is uncommon and mainly represented by metastases from gastrointestinal and lung neuroendocrine tumors. Primary orbital NENs are even less common and their diagnostic and therapeutic management is a challenge. Methods: A systematic review of the literature was conducted from 1966 to September 2023 on PubMed to identify articles on orbital NENs and to summarize their clinical–pathological features, diagnosis and therapeutic management. Furthermore, we presented a case of a locally advanced retro-orbital primary neuroendocrine tumor that was referred to the certified Center of Excellence of Sant’Andrea Hospital, La Sapienza University of Rome, Italy. Results: The final analysis included 63 records on orbital NENs and 11 records focused on primary orbital NENs. The localization was mostly unilateral and in the right orbit; proptosis or exophthalmos represented the initial symptoms. The diagnostic work-up and therapeutic management was discussed and a diagnostic algorithm for the suspicion of primary orbital NENs was proposed. Conclusions: A multidisciplinary approach is required for the management of primary orbital NENs, emphasizing the importance of early referral to dedicated centers for prompt differential diagnosis, tailored treatment, and an improved quality of life and survival. primary orbital orbit neuroendocrine tumor NETs multidisciplinary team diagnosis Biology (General) Monia Specchia verfasserin aut Emanuela Pilozzi verfasserin aut Maria Rinzivillo verfasserin aut Damiano Caruso verfasserin aut Curzio Santangeli verfasserin aut Daniela Prosperi verfasserin aut Anna Maria Ascolese verfasserin aut Francesco Panzuto verfasserin aut Federica Mazzuca verfasserin aut In Biomedicines MDPI AG, 2014 12(2024), 2, p 379 (DE-627)750370483 (DE-600)2720867-9 22279059 nnns volume:12 year:2024 number:2, p 379 https://doi.org/10.3390/biomedicines12020379 kostenfrei https://doaj.org/article/17d74d9df05f4a2d8fc5f4df0cfa42c8 kostenfrei https://www.mdpi.com/2227-9059/12/2/379 kostenfrei https://doaj.org/toc/2227-9059 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2024 2, p 379
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authorswithroles_txt_mv	Giulia Arrivi @@aut@@ Monia Specchia @@aut@@ Emanuela Pilozzi @@aut@@ Maria Rinzivillo @@aut@@ Damiano Caruso @@aut@@ Curzio Santangeli @@aut@@ Daniela Prosperi @@aut@@ Anna Maria Ascolese @@aut@@ Francesco Panzuto @@aut@@ Federica Mazzuca @@aut@@
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callnumber-first	Q - Science
author	Giulia Arrivi
spellingShingle	Giulia Arrivi misc QH301-705.5 misc primary orbital misc orbit misc neuroendocrine tumor misc NETs misc multidisciplinary team misc diagnosis misc Biology (General) Diagnostic and Therapeutic Management of Primary Orbital Neuroendocrine Tumors (NETs): Systematic Literature Review and Clinical Case Presentation
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topic_title	QH301-705.5 Diagnostic and Therapeutic Management of Primary Orbital Neuroendocrine Tumors (NETs): Systematic Literature Review and Clinical Case Presentation primary orbital orbit neuroendocrine tumor NETs multidisciplinary team diagnosis
topic	misc QH301-705.5 misc primary orbital misc orbit misc neuroendocrine tumor misc NETs misc multidisciplinary team misc diagnosis misc Biology (General)
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title	Diagnostic and Therapeutic Management of Primary Orbital Neuroendocrine Tumors (NETs): Systematic Literature Review and Clinical Case Presentation
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author_browse	Giulia Arrivi Monia Specchia Emanuela Pilozzi Maria Rinzivillo Damiano Caruso Curzio Santangeli Daniela Prosperi Anna Maria Ascolese Francesco Panzuto Federica Mazzuca
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title_sort	diagnostic and therapeutic management of primary orbital neuroendocrine tumors (nets): systematic literature review and clinical case presentation
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title_auth	Diagnostic and Therapeutic Management of Primary Orbital Neuroendocrine Tumors (NETs): Systematic Literature Review and Clinical Case Presentation
abstract	Background: The ocular involvement of neuroendocrine neoplasms (NENs) is uncommon and mainly represented by metastases from gastrointestinal and lung neuroendocrine tumors. Primary orbital NENs are even less common and their diagnostic and therapeutic management is a challenge. Methods: A systematic review of the literature was conducted from 1966 to September 2023 on PubMed to identify articles on orbital NENs and to summarize their clinical–pathological features, diagnosis and therapeutic management. Furthermore, we presented a case of a locally advanced retro-orbital primary neuroendocrine tumor that was referred to the certified Center of Excellence of Sant’Andrea Hospital, La Sapienza University of Rome, Italy. Results: The final analysis included 63 records on orbital NENs and 11 records focused on primary orbital NENs. The localization was mostly unilateral and in the right orbit; proptosis or exophthalmos represented the initial symptoms. The diagnostic work-up and therapeutic management was discussed and a diagnostic algorithm for the suspicion of primary orbital NENs was proposed. Conclusions: A multidisciplinary approach is required for the management of primary orbital NENs, emphasizing the importance of early referral to dedicated centers for prompt differential diagnosis, tailored treatment, and an improved quality of life and survival.
abstractGer	Background: The ocular involvement of neuroendocrine neoplasms (NENs) is uncommon and mainly represented by metastases from gastrointestinal and lung neuroendocrine tumors. Primary orbital NENs are even less common and their diagnostic and therapeutic management is a challenge. Methods: A systematic review of the literature was conducted from 1966 to September 2023 on PubMed to identify articles on orbital NENs and to summarize their clinical–pathological features, diagnosis and therapeutic management. Furthermore, we presented a case of a locally advanced retro-orbital primary neuroendocrine tumor that was referred to the certified Center of Excellence of Sant’Andrea Hospital, La Sapienza University of Rome, Italy. Results: The final analysis included 63 records on orbital NENs and 11 records focused on primary orbital NENs. The localization was mostly unilateral and in the right orbit; proptosis or exophthalmos represented the initial symptoms. The diagnostic work-up and therapeutic management was discussed and a diagnostic algorithm for the suspicion of primary orbital NENs was proposed. Conclusions: A multidisciplinary approach is required for the management of primary orbital NENs, emphasizing the importance of early referral to dedicated centers for prompt differential diagnosis, tailored treatment, and an improved quality of life and survival.
abstract_unstemmed	Background: The ocular involvement of neuroendocrine neoplasms (NENs) is uncommon and mainly represented by metastases from gastrointestinal and lung neuroendocrine tumors. Primary orbital NENs are even less common and their diagnostic and therapeutic management is a challenge. Methods: A systematic review of the literature was conducted from 1966 to September 2023 on PubMed to identify articles on orbital NENs and to summarize their clinical–pathological features, diagnosis and therapeutic management. Furthermore, we presented a case of a locally advanced retro-orbital primary neuroendocrine tumor that was referred to the certified Center of Excellence of Sant’Andrea Hospital, La Sapienza University of Rome, Italy. Results: The final analysis included 63 records on orbital NENs and 11 records focused on primary orbital NENs. The localization was mostly unilateral and in the right orbit; proptosis or exophthalmos represented the initial symptoms. The diagnostic work-up and therapeutic management was discussed and a diagnostic algorithm for the suspicion of primary orbital NENs was proposed. Conclusions: A multidisciplinary approach is required for the management of primary orbital NENs, emphasizing the importance of early referral to dedicated centers for prompt differential diagnosis, tailored treatment, and an improved quality of life and survival.
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title_short	Diagnostic and Therapeutic Management of Primary Orbital Neuroendocrine Tumors (NETs): Systematic Literature Review and Clinical Case Presentation
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Diagnostic and Therapeutic Management of Primary Orbital Neuroendocrine Tumors (NETs): Systematic Literature Review and Clinical Case Presentation

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