Oxidative Damage and Telomere Length as Markers of Lung Cancer Development among Chronic Obstructive Pulmonary Disease (COPD) Smokers

Lung cancer (LC) constitutes an important cause of death among patients with Chronic Obstructive Pulmonary Disease (COPD). Both diseases may share pathobiological mechanisms related to oxidative damage and cellular senescence. In this study, the potential value of leucocyte telomere length, a hallma...
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Autor*in:	Elizabeth Córdoba-Lanús [verfasserIn] Luis M. Montuenga [verfasserIn] Angélica Domínguez-de-Barros [verfasserIn] Alexis Oliva [verfasserIn] Delia Mayato [verfasserIn] Ana Remírez-Sanz [verfasserIn] Francisca Gonzalvo [verfasserIn] Bartolomé Celli [verfasserIn] Javier J. Zulueta [verfasserIn] Ciro Casanova [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	lung cancer COPD telomeres oxidative stress 8-OHdG biomarkers

Übergeordnetes Werk:	In: Antioxidants - MDPI AG, 2013, 13(2024), 2, p 156
Übergeordnetes Werk:	volume:13 ; year:2024 ; number:2, p 156

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/antiox13020156

Katalog-ID:	DOAJ099680998

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source	In Antioxidants 13(2024), 2, p 156 volume:13 year:2024 number:2, p 156
sourceStr	In Antioxidants 13(2024), 2, p 156 volume:13 year:2024 number:2, p 156
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authorswithroles_txt_mv	Elizabeth Córdoba-Lanús @@aut@@ Luis M. Montuenga @@aut@@ Angélica Domínguez-de-Barros @@aut@@ Alexis Oliva @@aut@@ Delia Mayato @@aut@@ Ana Remírez-Sanz @@aut@@ Francisca Gonzalvo @@aut@@ Bartolomé Celli @@aut@@ Javier J. Zulueta @@aut@@ Ciro Casanova @@aut@@
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callnumber-first	R - Medicine
author	Elizabeth Córdoba-Lanús
spellingShingle	Elizabeth Córdoba-Lanús misc RM1-950 misc lung cancer misc COPD misc telomeres misc oxidative stress misc 8-OHdG misc biomarkers misc Therapeutics. Pharmacology Oxidative Damage and Telomere Length as Markers of Lung Cancer Development among Chronic Obstructive Pulmonary Disease (COPD) Smokers
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topic_title	RM1-950 Oxidative Damage and Telomere Length as Markers of Lung Cancer Development among Chronic Obstructive Pulmonary Disease (COPD) Smokers lung cancer COPD telomeres oxidative stress 8-OHdG biomarkers
topic	misc RM1-950 misc lung cancer misc COPD misc telomeres misc oxidative stress misc 8-OHdG misc biomarkers misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc lung cancer misc COPD misc telomeres misc oxidative stress misc 8-OHdG misc biomarkers misc Therapeutics. Pharmacology
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title	Oxidative Damage and Telomere Length as Markers of Lung Cancer Development among Chronic Obstructive Pulmonary Disease (COPD) Smokers
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title_full	Oxidative Damage and Telomere Length as Markers of Lung Cancer Development among Chronic Obstructive Pulmonary Disease (COPD) Smokers
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author_browse	Elizabeth Córdoba-Lanús Luis M. Montuenga Angélica Domínguez-de-Barros Alexis Oliva Delia Mayato Ana Remírez-Sanz Francisca Gonzalvo Bartolomé Celli Javier J. Zulueta Ciro Casanova
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title_sort	oxidative damage and telomere length as markers of lung cancer development among chronic obstructive pulmonary disease (copd) smokers
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title_auth	Oxidative Damage and Telomere Length as Markers of Lung Cancer Development among Chronic Obstructive Pulmonary Disease (COPD) Smokers
abstract	Lung cancer (LC) constitutes an important cause of death among patients with Chronic Obstructive Pulmonary Disease (COPD). Both diseases may share pathobiological mechanisms related to oxidative damage and cellular senescence. In this study, the potential value of leucocyte telomere length, a hallmark of aging, and 8-OHdG concentrations, indicative of oxidative DNA damage, as risk biomarkers of LC was evaluated in COPD patients three years prior to LC diagnosis. Relative telomere length measured using qPCR and serum levels of 8-OHdG were determined at the baseline in 99 COPD smokers (33 with LC and 66 age-matched COPD without LC as controls). Of these, 21 COPD with LC and 42 controls had the biomarkers measured 3 years before. Single nucleotide variants (SNVs) in TERT, RTEL, and NAF1 genes were also determined. COPD cases were evaluated, which showed greater telomere length (<i<p</i< < 0.001) and increased serum 8-OHdG levels (<i<p</i< = 0.004) three years prior to LC diagnosis compared to the controls. This relationship was confirmed at the time of LC diagnosis. No significant association was found between the studied SNVs in cases vs. controls. In conclusion, this preliminary study shows that longer leucocyte telomere length and increased 8-OHdG serum levels can be useful as early biomarkers of the risk for future lung cancer development among COPD patients.
abstractGer	Lung cancer (LC) constitutes an important cause of death among patients with Chronic Obstructive Pulmonary Disease (COPD). Both diseases may share pathobiological mechanisms related to oxidative damage and cellular senescence. In this study, the potential value of leucocyte telomere length, a hallmark of aging, and 8-OHdG concentrations, indicative of oxidative DNA damage, as risk biomarkers of LC was evaluated in COPD patients three years prior to LC diagnosis. Relative telomere length measured using qPCR and serum levels of 8-OHdG were determined at the baseline in 99 COPD smokers (33 with LC and 66 age-matched COPD without LC as controls). Of these, 21 COPD with LC and 42 controls had the biomarkers measured 3 years before. Single nucleotide variants (SNVs) in TERT, RTEL, and NAF1 genes were also determined. COPD cases were evaluated, which showed greater telomere length (<i<p</i< < 0.001) and increased serum 8-OHdG levels (<i<p</i< = 0.004) three years prior to LC diagnosis compared to the controls. This relationship was confirmed at the time of LC diagnosis. No significant association was found between the studied SNVs in cases vs. controls. In conclusion, this preliminary study shows that longer leucocyte telomere length and increased 8-OHdG serum levels can be useful as early biomarkers of the risk for future lung cancer development among COPD patients.
abstract_unstemmed	Lung cancer (LC) constitutes an important cause of death among patients with Chronic Obstructive Pulmonary Disease (COPD). Both diseases may share pathobiological mechanisms related to oxidative damage and cellular senescence. In this study, the potential value of leucocyte telomere length, a hallmark of aging, and 8-OHdG concentrations, indicative of oxidative DNA damage, as risk biomarkers of LC was evaluated in COPD patients three years prior to LC diagnosis. Relative telomere length measured using qPCR and serum levels of 8-OHdG were determined at the baseline in 99 COPD smokers (33 with LC and 66 age-matched COPD without LC as controls). Of these, 21 COPD with LC and 42 controls had the biomarkers measured 3 years before. Single nucleotide variants (SNVs) in TERT, RTEL, and NAF1 genes were also determined. COPD cases were evaluated, which showed greater telomere length (<i<p</i< < 0.001) and increased serum 8-OHdG levels (<i<p</i< = 0.004) three years prior to LC diagnosis compared to the controls. This relationship was confirmed at the time of LC diagnosis. No significant association was found between the studied SNVs in cases vs. controls. In conclusion, this preliminary study shows that longer leucocyte telomere length and increased 8-OHdG serum levels can be useful as early biomarkers of the risk for future lung cancer development among COPD patients.
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title_short	Oxidative Damage and Telomere Length as Markers of Lung Cancer Development among Chronic Obstructive Pulmonary Disease (COPD) Smokers
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up_date	2024-07-03T23:54:55.622Z
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Oxidative Damage and Telomere Length as Markers of Lung Cancer Development among Chronic Obstructive Pulmonary Disease (COPD) Smokers

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