Fabrication of a novel sensor for lactate screening in saliva samples before and after exercise in athletes

In this research, a chronoamperometric biosensor based on zinc oxide (ZnO)-graphene oxide (GO) nanocomposite material was designed and employed for lactate determination. The ZnO-GO hybrid proved to be a suitable substrate for the immobilization of lactate oxidase (LOD). The presence of ZnO and GO c...
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Gespeichert in:

Autor*in:	Jiang Han [verfasserIn] Jia Shaohui [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	Lactate sensor Nanocomposite Graphene Saliva sample Lactate oxidase

Übergeordnetes Werk:	In: Alexandria Engineering Journal - Elsevier, 2016, 92(2024), Seite 171-175
Übergeordnetes Werk:	volume:92 ; year:2024 ; pages:171-175

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.aej.2024.02.040

Katalog-ID:	DOAJ099731401

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allfields	10.1016/j.aej.2024.02.040 doi (DE-627)DOAJ099731401 (DE-599)DOAJ6f1b553eb432464aa0cf6ae03f319aa9 DE-627 ger DE-627 rakwb eng TA1-2040 Jiang Han verfasserin aut Fabrication of a novel sensor for lactate screening in saliva samples before and after exercise in athletes 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this research, a chronoamperometric biosensor based on zinc oxide (ZnO)-graphene oxide (GO) nanocomposite material was designed and employed for lactate determination. The ZnO-GO hybrid proved to be a suitable substrate for the immobilization of lactate oxidase (LOD). The presence of ZnO and GO components in hybrid material led to synergistic effects and facilitates the LOD loading and electron transfer between the receptor and screen printed carbon electrode (SPCE) surface. The LOD-GO-ZnO modified SCPE exhibits excellent lactate sensing capabilities thanks to the uniform dispersion of ultrafine ZnO nanoparticles and enhanced mass-transfer kinetics. In phosphate buffer solution (pH=7.4), this novel electrochemical lactate biosensor demonstrates a linear response to lactate within the concentration range of 0.015–1.25 mM. Limit of detection (based on S/N=3) of the assay was estimated to be 9 µM. More importantly, the presence method is a highly selective device for the analysis of lactate in biological fluids. The lactate level in saliva samples was successfully measured before and after exercise of athletes using the suggested biosensor. This method offers a simple, cost-effective, fast, and effective platform for lactate determination in typical diagnostic applications. Lactate sensor Nanocomposite Graphene Saliva sample Lactate oxidase Engineering (General). Civil engineering (General) Jia Shaohui verfasserin aut In Alexandria Engineering Journal Elsevier, 2016 92(2024), Seite 171-175 (DE-627)669887609 (DE-600)2631413-7 20902670 nnns volume:92 year:2024 pages:171-175 https://doi.org/10.1016/j.aej.2024.02.040 kostenfrei https://doaj.org/article/6f1b553eb432464aa0cf6ae03f319aa9 kostenfrei http://www.sciencedirect.com/science/article/pii/S1110016824001789 kostenfrei https://doaj.org/toc/1110-0168 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 92 2024 171-175
spelling	10.1016/j.aej.2024.02.040 doi (DE-627)DOAJ099731401 (DE-599)DOAJ6f1b553eb432464aa0cf6ae03f319aa9 DE-627 ger DE-627 rakwb eng TA1-2040 Jiang Han verfasserin aut Fabrication of a novel sensor for lactate screening in saliva samples before and after exercise in athletes 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this research, a chronoamperometric biosensor based on zinc oxide (ZnO)-graphene oxide (GO) nanocomposite material was designed and employed for lactate determination. The ZnO-GO hybrid proved to be a suitable substrate for the immobilization of lactate oxidase (LOD). The presence of ZnO and GO components in hybrid material led to synergistic effects and facilitates the LOD loading and electron transfer between the receptor and screen printed carbon electrode (SPCE) surface. The LOD-GO-ZnO modified SCPE exhibits excellent lactate sensing capabilities thanks to the uniform dispersion of ultrafine ZnO nanoparticles and enhanced mass-transfer kinetics. In phosphate buffer solution (pH=7.4), this novel electrochemical lactate biosensor demonstrates a linear response to lactate within the concentration range of 0.015–1.25 mM. Limit of detection (based on S/N=3) of the assay was estimated to be 9 µM. More importantly, the presence method is a highly selective device for the analysis of lactate in biological fluids. The lactate level in saliva samples was successfully measured before and after exercise of athletes using the suggested biosensor. This method offers a simple, cost-effective, fast, and effective platform for lactate determination in typical diagnostic applications. Lactate sensor Nanocomposite Graphene Saliva sample Lactate oxidase Engineering (General). Civil engineering (General) Jia Shaohui verfasserin aut In Alexandria Engineering Journal Elsevier, 2016 92(2024), Seite 171-175 (DE-627)669887609 (DE-600)2631413-7 20902670 nnns volume:92 year:2024 pages:171-175 https://doi.org/10.1016/j.aej.2024.02.040 kostenfrei https://doaj.org/article/6f1b553eb432464aa0cf6ae03f319aa9 kostenfrei http://www.sciencedirect.com/science/article/pii/S1110016824001789 kostenfrei https://doaj.org/toc/1110-0168 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 92 2024 171-175
allfields_unstemmed	10.1016/j.aej.2024.02.040 doi (DE-627)DOAJ099731401 (DE-599)DOAJ6f1b553eb432464aa0cf6ae03f319aa9 DE-627 ger DE-627 rakwb eng TA1-2040 Jiang Han verfasserin aut Fabrication of a novel sensor for lactate screening in saliva samples before and after exercise in athletes 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this research, a chronoamperometric biosensor based on zinc oxide (ZnO)-graphene oxide (GO) nanocomposite material was designed and employed for lactate determination. The ZnO-GO hybrid proved to be a suitable substrate for the immobilization of lactate oxidase (LOD). The presence of ZnO and GO components in hybrid material led to synergistic effects and facilitates the LOD loading and electron transfer between the receptor and screen printed carbon electrode (SPCE) surface. The LOD-GO-ZnO modified SCPE exhibits excellent lactate sensing capabilities thanks to the uniform dispersion of ultrafine ZnO nanoparticles and enhanced mass-transfer kinetics. In phosphate buffer solution (pH=7.4), this novel electrochemical lactate biosensor demonstrates a linear response to lactate within the concentration range of 0.015–1.25 mM. Limit of detection (based on S/N=3) of the assay was estimated to be 9 µM. More importantly, the presence method is a highly selective device for the analysis of lactate in biological fluids. The lactate level in saliva samples was successfully measured before and after exercise of athletes using the suggested biosensor. This method offers a simple, cost-effective, fast, and effective platform for lactate determination in typical diagnostic applications. Lactate sensor Nanocomposite Graphene Saliva sample Lactate oxidase Engineering (General). Civil engineering (General) Jia Shaohui verfasserin aut In Alexandria Engineering Journal Elsevier, 2016 92(2024), Seite 171-175 (DE-627)669887609 (DE-600)2631413-7 20902670 nnns volume:92 year:2024 pages:171-175 https://doi.org/10.1016/j.aej.2024.02.040 kostenfrei https://doaj.org/article/6f1b553eb432464aa0cf6ae03f319aa9 kostenfrei http://www.sciencedirect.com/science/article/pii/S1110016824001789 kostenfrei https://doaj.org/toc/1110-0168 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 92 2024 171-175
allfieldsGer	10.1016/j.aej.2024.02.040 doi (DE-627)DOAJ099731401 (DE-599)DOAJ6f1b553eb432464aa0cf6ae03f319aa9 DE-627 ger DE-627 rakwb eng TA1-2040 Jiang Han verfasserin aut Fabrication of a novel sensor for lactate screening in saliva samples before and after exercise in athletes 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this research, a chronoamperometric biosensor based on zinc oxide (ZnO)-graphene oxide (GO) nanocomposite material was designed and employed for lactate determination. The ZnO-GO hybrid proved to be a suitable substrate for the immobilization of lactate oxidase (LOD). The presence of ZnO and GO components in hybrid material led to synergistic effects and facilitates the LOD loading and electron transfer between the receptor and screen printed carbon electrode (SPCE) surface. The LOD-GO-ZnO modified SCPE exhibits excellent lactate sensing capabilities thanks to the uniform dispersion of ultrafine ZnO nanoparticles and enhanced mass-transfer kinetics. In phosphate buffer solution (pH=7.4), this novel electrochemical lactate biosensor demonstrates a linear response to lactate within the concentration range of 0.015–1.25 mM. Limit of detection (based on S/N=3) of the assay was estimated to be 9 µM. More importantly, the presence method is a highly selective device for the analysis of lactate in biological fluids. The lactate level in saliva samples was successfully measured before and after exercise of athletes using the suggested biosensor. This method offers a simple, cost-effective, fast, and effective platform for lactate determination in typical diagnostic applications. Lactate sensor Nanocomposite Graphene Saliva sample Lactate oxidase Engineering (General). Civil engineering (General) Jia Shaohui verfasserin aut In Alexandria Engineering Journal Elsevier, 2016 92(2024), Seite 171-175 (DE-627)669887609 (DE-600)2631413-7 20902670 nnns volume:92 year:2024 pages:171-175 https://doi.org/10.1016/j.aej.2024.02.040 kostenfrei https://doaj.org/article/6f1b553eb432464aa0cf6ae03f319aa9 kostenfrei http://www.sciencedirect.com/science/article/pii/S1110016824001789 kostenfrei https://doaj.org/toc/1110-0168 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 92 2024 171-175
allfieldsSound	10.1016/j.aej.2024.02.040 doi (DE-627)DOAJ099731401 (DE-599)DOAJ6f1b553eb432464aa0cf6ae03f319aa9 DE-627 ger DE-627 rakwb eng TA1-2040 Jiang Han verfasserin aut Fabrication of a novel sensor for lactate screening in saliva samples before and after exercise in athletes 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this research, a chronoamperometric biosensor based on zinc oxide (ZnO)-graphene oxide (GO) nanocomposite material was designed and employed for lactate determination. The ZnO-GO hybrid proved to be a suitable substrate for the immobilization of lactate oxidase (LOD). The presence of ZnO and GO components in hybrid material led to synergistic effects and facilitates the LOD loading and electron transfer between the receptor and screen printed carbon electrode (SPCE) surface. The LOD-GO-ZnO modified SCPE exhibits excellent lactate sensing capabilities thanks to the uniform dispersion of ultrafine ZnO nanoparticles and enhanced mass-transfer kinetics. In phosphate buffer solution (pH=7.4), this novel electrochemical lactate biosensor demonstrates a linear response to lactate within the concentration range of 0.015–1.25 mM. Limit of detection (based on S/N=3) of the assay was estimated to be 9 µM. More importantly, the presence method is a highly selective device for the analysis of lactate in biological fluids. The lactate level in saliva samples was successfully measured before and after exercise of athletes using the suggested biosensor. This method offers a simple, cost-effective, fast, and effective platform for lactate determination in typical diagnostic applications. Lactate sensor Nanocomposite Graphene Saliva sample Lactate oxidase Engineering (General). Civil engineering (General) Jia Shaohui verfasserin aut In Alexandria Engineering Journal Elsevier, 2016 92(2024), Seite 171-175 (DE-627)669887609 (DE-600)2631413-7 20902670 nnns volume:92 year:2024 pages:171-175 https://doi.org/10.1016/j.aej.2024.02.040 kostenfrei https://doaj.org/article/6f1b553eb432464aa0cf6ae03f319aa9 kostenfrei http://www.sciencedirect.com/science/article/pii/S1110016824001789 kostenfrei https://doaj.org/toc/1110-0168 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 92 2024 171-175
language	English
source	In Alexandria Engineering Journal 92(2024), Seite 171-175 volume:92 year:2024 pages:171-175
sourceStr	In Alexandria Engineering Journal 92(2024), Seite 171-175 volume:92 year:2024 pages:171-175
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Lactate sensor Nanocomposite Graphene Saliva sample Lactate oxidase Engineering (General). Civil engineering (General)
isfreeaccess_bool	true
container_title	Alexandria Engineering Journal
authorswithroles_txt_mv	Jiang Han @@aut@@ Jia Shaohui @@aut@@
publishDateDaySort_date	2024-01-01T00:00:00Z
hierarchy_top_id	669887609
id	DOAJ099731401
language_de	englisch
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callnumber-first	T - Technology
author	Jiang Han
spellingShingle	Jiang Han misc TA1-2040 misc Lactate sensor misc Nanocomposite misc Graphene misc Saliva sample misc Lactate oxidase misc Engineering (General). Civil engineering (General) Fabrication of a novel sensor for lactate screening in saliva samples before and after exercise in athletes
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topic_title	TA1-2040 Fabrication of a novel sensor for lactate screening in saliva samples before and after exercise in athletes Lactate sensor Nanocomposite Graphene Saliva sample Lactate oxidase
topic	misc TA1-2040 misc Lactate sensor misc Nanocomposite misc Graphene misc Saliva sample misc Lactate oxidase misc Engineering (General). Civil engineering (General)
topic_unstemmed	misc TA1-2040 misc Lactate sensor misc Nanocomposite misc Graphene misc Saliva sample misc Lactate oxidase misc Engineering (General). Civil engineering (General)
topic_browse	misc TA1-2040 misc Lactate sensor misc Nanocomposite misc Graphene misc Saliva sample misc Lactate oxidase misc Engineering (General). Civil engineering (General)
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title	Fabrication of a novel sensor for lactate screening in saliva samples before and after exercise in athletes
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title_full	Fabrication of a novel sensor for lactate screening in saliva samples before and after exercise in athletes
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title_sort	fabrication of a novel sensor for lactate screening in saliva samples before and after exercise in athletes
callnumber	TA1-2040
title_auth	Fabrication of a novel sensor for lactate screening in saliva samples before and after exercise in athletes
abstract	In this research, a chronoamperometric biosensor based on zinc oxide (ZnO)-graphene oxide (GO) nanocomposite material was designed and employed for lactate determination. The ZnO-GO hybrid proved to be a suitable substrate for the immobilization of lactate oxidase (LOD). The presence of ZnO and GO components in hybrid material led to synergistic effects and facilitates the LOD loading and electron transfer between the receptor and screen printed carbon electrode (SPCE) surface. The LOD-GO-ZnO modified SCPE exhibits excellent lactate sensing capabilities thanks to the uniform dispersion of ultrafine ZnO nanoparticles and enhanced mass-transfer kinetics. In phosphate buffer solution (pH=7.4), this novel electrochemical lactate biosensor demonstrates a linear response to lactate within the concentration range of 0.015–1.25 mM. Limit of detection (based on S/N=3) of the assay was estimated to be 9 µM. More importantly, the presence method is a highly selective device for the analysis of lactate in biological fluids. The lactate level in saliva samples was successfully measured before and after exercise of athletes using the suggested biosensor. This method offers a simple, cost-effective, fast, and effective platform for lactate determination in typical diagnostic applications.
abstractGer	In this research, a chronoamperometric biosensor based on zinc oxide (ZnO)-graphene oxide (GO) nanocomposite material was designed and employed for lactate determination. The ZnO-GO hybrid proved to be a suitable substrate for the immobilization of lactate oxidase (LOD). The presence of ZnO and GO components in hybrid material led to synergistic effects and facilitates the LOD loading and electron transfer between the receptor and screen printed carbon electrode (SPCE) surface. The LOD-GO-ZnO modified SCPE exhibits excellent lactate sensing capabilities thanks to the uniform dispersion of ultrafine ZnO nanoparticles and enhanced mass-transfer kinetics. In phosphate buffer solution (pH=7.4), this novel electrochemical lactate biosensor demonstrates a linear response to lactate within the concentration range of 0.015–1.25 mM. Limit of detection (based on S/N=3) of the assay was estimated to be 9 µM. More importantly, the presence method is a highly selective device for the analysis of lactate in biological fluids. The lactate level in saliva samples was successfully measured before and after exercise of athletes using the suggested biosensor. This method offers a simple, cost-effective, fast, and effective platform for lactate determination in typical diagnostic applications.
abstract_unstemmed	In this research, a chronoamperometric biosensor based on zinc oxide (ZnO)-graphene oxide (GO) nanocomposite material was designed and employed for lactate determination. The ZnO-GO hybrid proved to be a suitable substrate for the immobilization of lactate oxidase (LOD). The presence of ZnO and GO components in hybrid material led to synergistic effects and facilitates the LOD loading and electron transfer between the receptor and screen printed carbon electrode (SPCE) surface. The LOD-GO-ZnO modified SCPE exhibits excellent lactate sensing capabilities thanks to the uniform dispersion of ultrafine ZnO nanoparticles and enhanced mass-transfer kinetics. In phosphate buffer solution (pH=7.4), this novel electrochemical lactate biosensor demonstrates a linear response to lactate within the concentration range of 0.015–1.25 mM. Limit of detection (based on S/N=3) of the assay was estimated to be 9 µM. More importantly, the presence method is a highly selective device for the analysis of lactate in biological fluids. The lactate level in saliva samples was successfully measured before and after exercise of athletes using the suggested biosensor. This method offers a simple, cost-effective, fast, and effective platform for lactate determination in typical diagnostic applications.
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title_short	Fabrication of a novel sensor for lactate screening in saliva samples before and after exercise in athletes
url	https://doi.org/10.1016/j.aej.2024.02.040 https://doaj.org/article/6f1b553eb432464aa0cf6ae03f319aa9 http://www.sciencedirect.com/science/article/pii/S1110016824001789 https://doaj.org/toc/1110-0168
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up_date	2024-07-04T00:06:29.403Z
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Fabrication of a novel sensor for lactate screening in saliva samples before and after exercise in athletes

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