Long-term outcomes of survivors with influenza A H1N1 virus-induced severe pneumonia and ARDS: a single-center prospective cohort study

IntroductionSystematic evaluation of long-term outcomes in survivors of H1N1 is still lacking. This study aimed to characterize long-term outcomes of severe H1N1-induced pneumonia and acute respiratory distress syndrome (ARDS).MethodThis was a single-center, prospective, cohort study. Survivors were...
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Autor*in:	Xiao Tang [verfasserIn] Xiao-Li Xu [verfasserIn] Na Wan [verfasserIn] Yu Zhao [verfasserIn] Rui Wang [verfasserIn] Xu-Yan Li [verfasserIn] Ying Li [verfasserIn] Li Wang [verfasserIn] Hai-Chao Li [verfasserIn] Yue Gu [verfasserIn] Chun-Yan Zhang [verfasserIn] Qi Yang [verfasserIn] Zhao-Hui Tong [verfasserIn] Bing Sun [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	influenza A (H1N1) virus severe community-acquired pneumonia (SCAP) acute respiratory distress syndrome (ARDS) pulmonary fibrosis pulmonary function

Übergeordnetes Werk:	In: Frontiers in Cellular and Infection Microbiology - Frontiers Media S.A., 2016, 14(2024)
Übergeordnetes Werk:	volume:14 ; year:2024

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fcimb.2024.1378379

Katalog-ID:	DOAJ099784890

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520			\|a IntroductionSystematic evaluation of long-term outcomes in survivors of H1N1 is still lacking. This study aimed to characterize long-term outcomes of severe H1N1-induced pneumonia and acute respiratory distress syndrome (ARDS).MethodThis was a single-center, prospective, cohort study. Survivors were followed up for four times after discharge from intensive care unit (ICU) by lung high-resolution computed tomography (HRCT), pulmonary function assessment, 6-minute walk test (6MWT), and SF-36 instrument.ResultA total of 60 survivors of H1N1-induced pneumonia and ARDS were followed up for four times. The carbon monoxide at single breath (DLCO) of predicted values and the 6MWT results didn’t continue improving after 3 months. Health-related quality of life didn’t change during the 12 months after ICU discharge. Reticulation or interlobular septal thickening on HRCT did not begin to improve significantly until the 12-month follow-up. The DLCO of predicted values showed negative correlation with the severity degree of primary disease and reticulation or interlobular septal thickening, and a positive correlation with physical functioning. The DLCO of predicted values and reticulation or interlobular septal thickening both correlated with the highest tidal volume during mechanical ventilation. Levels of fibrogenic cytokines had a positive correlation with reticulation or interlobular septal thickening.ConclusionThe improvements in pulmonary function and exercise capacity, imaging, and health-related quality of life had different time phase and impact on each other during 12 months of follow-up. Long-term outcomes of pulmonary fibrosis might be related to the lung injury and excessive lung fibroproliferation at the early stage during ICU admission.
650		4	\|a influenza A (H1N1) virus
650		4	\|a severe community-acquired pneumonia (SCAP)
650		4	\|a acute respiratory distress syndrome (ARDS)
650		4	\|a pulmonary fibrosis
650		4	\|a pulmonary function
653		0	\|a Microbiology
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700	0		\|a Qi Yang \|e verfasserin \|4 aut
700	0		\|a Zhao-Hui Tong \|e verfasserin \|4 aut
700	0		\|a Bing Sun \|e verfasserin \|4 aut
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allfields	10.3389/fcimb.2024.1378379 doi (DE-627)DOAJ099784890 (DE-599)DOAJ90492af2776141bc84544f00ea41b00f DE-627 ger DE-627 rakwb eng QR1-502 Xiao Tang verfasserin aut Long-term outcomes of survivors with influenza A H1N1 virus-induced severe pneumonia and ARDS: a single-center prospective cohort study 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionSystematic evaluation of long-term outcomes in survivors of H1N1 is still lacking. This study aimed to characterize long-term outcomes of severe H1N1-induced pneumonia and acute respiratory distress syndrome (ARDS).MethodThis was a single-center, prospective, cohort study. Survivors were followed up for four times after discharge from intensive care unit (ICU) by lung high-resolution computed tomography (HRCT), pulmonary function assessment, 6-minute walk test (6MWT), and SF-36 instrument.ResultA total of 60 survivors of H1N1-induced pneumonia and ARDS were followed up for four times. The carbon monoxide at single breath (DLCO) of predicted values and the 6MWT results didn’t continue improving after 3 months. Health-related quality of life didn’t change during the 12 months after ICU discharge. Reticulation or interlobular septal thickening on HRCT did not begin to improve significantly until the 12-month follow-up. The DLCO of predicted values showed negative correlation with the severity degree of primary disease and reticulation or interlobular septal thickening, and a positive correlation with physical functioning. The DLCO of predicted values and reticulation or interlobular septal thickening both correlated with the highest tidal volume during mechanical ventilation. Levels of fibrogenic cytokines had a positive correlation with reticulation or interlobular septal thickening.ConclusionThe improvements in pulmonary function and exercise capacity, imaging, and health-related quality of life had different time phase and impact on each other during 12 months of follow-up. Long-term outcomes of pulmonary fibrosis might be related to the lung injury and excessive lung fibroproliferation at the early stage during ICU admission. influenza A (H1N1) virus severe community-acquired pneumonia (SCAP) acute respiratory distress syndrome (ARDS) pulmonary fibrosis pulmonary function Microbiology Xiao-Li Xu verfasserin aut Na Wan verfasserin aut Yu Zhao verfasserin aut Rui Wang verfasserin aut Xu-Yan Li verfasserin aut Ying Li verfasserin aut Li Wang verfasserin aut Hai-Chao Li verfasserin aut Yue Gu verfasserin aut Chun-Yan Zhang verfasserin aut Qi Yang verfasserin aut Zhao-Hui Tong verfasserin aut Bing Sun verfasserin aut In Frontiers in Cellular and Infection Microbiology Frontiers Media S.A., 2016 14(2024) (DE-627)664968554 (DE-600)2619676-1 22352988 nnns volume:14 year:2024 https://doi.org/10.3389/fcimb.2024.1378379 kostenfrei https://doaj.org/article/90492af2776141bc84544f00ea41b00f kostenfrei https://www.frontiersin.org/articles/10.3389/fcimb.2024.1378379/full kostenfrei https://doaj.org/toc/2235-2988 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024
spelling	10.3389/fcimb.2024.1378379 doi (DE-627)DOAJ099784890 (DE-599)DOAJ90492af2776141bc84544f00ea41b00f DE-627 ger DE-627 rakwb eng QR1-502 Xiao Tang verfasserin aut Long-term outcomes of survivors with influenza A H1N1 virus-induced severe pneumonia and ARDS: a single-center prospective cohort study 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionSystematic evaluation of long-term outcomes in survivors of H1N1 is still lacking. This study aimed to characterize long-term outcomes of severe H1N1-induced pneumonia and acute respiratory distress syndrome (ARDS).MethodThis was a single-center, prospective, cohort study. Survivors were followed up for four times after discharge from intensive care unit (ICU) by lung high-resolution computed tomography (HRCT), pulmonary function assessment, 6-minute walk test (6MWT), and SF-36 instrument.ResultA total of 60 survivors of H1N1-induced pneumonia and ARDS were followed up for four times. The carbon monoxide at single breath (DLCO) of predicted values and the 6MWT results didn’t continue improving after 3 months. Health-related quality of life didn’t change during the 12 months after ICU discharge. Reticulation or interlobular septal thickening on HRCT did not begin to improve significantly until the 12-month follow-up. The DLCO of predicted values showed negative correlation with the severity degree of primary disease and reticulation or interlobular septal thickening, and a positive correlation with physical functioning. The DLCO of predicted values and reticulation or interlobular septal thickening both correlated with the highest tidal volume during mechanical ventilation. Levels of fibrogenic cytokines had a positive correlation with reticulation or interlobular septal thickening.ConclusionThe improvements in pulmonary function and exercise capacity, imaging, and health-related quality of life had different time phase and impact on each other during 12 months of follow-up. Long-term outcomes of pulmonary fibrosis might be related to the lung injury and excessive lung fibroproliferation at the early stage during ICU admission. influenza A (H1N1) virus severe community-acquired pneumonia (SCAP) acute respiratory distress syndrome (ARDS) pulmonary fibrosis pulmonary function Microbiology Xiao-Li Xu verfasserin aut Na Wan verfasserin aut Yu Zhao verfasserin aut Rui Wang verfasserin aut Xu-Yan Li verfasserin aut Ying Li verfasserin aut Li Wang verfasserin aut Hai-Chao Li verfasserin aut Yue Gu verfasserin aut Chun-Yan Zhang verfasserin aut Qi Yang verfasserin aut Zhao-Hui Tong verfasserin aut Bing Sun verfasserin aut In Frontiers in Cellular and Infection Microbiology Frontiers Media S.A., 2016 14(2024) (DE-627)664968554 (DE-600)2619676-1 22352988 nnns volume:14 year:2024 https://doi.org/10.3389/fcimb.2024.1378379 kostenfrei https://doaj.org/article/90492af2776141bc84544f00ea41b00f kostenfrei https://www.frontiersin.org/articles/10.3389/fcimb.2024.1378379/full kostenfrei https://doaj.org/toc/2235-2988 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024
allfields_unstemmed	10.3389/fcimb.2024.1378379 doi (DE-627)DOAJ099784890 (DE-599)DOAJ90492af2776141bc84544f00ea41b00f DE-627 ger DE-627 rakwb eng QR1-502 Xiao Tang verfasserin aut Long-term outcomes of survivors with influenza A H1N1 virus-induced severe pneumonia and ARDS: a single-center prospective cohort study 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionSystematic evaluation of long-term outcomes in survivors of H1N1 is still lacking. This study aimed to characterize long-term outcomes of severe H1N1-induced pneumonia and acute respiratory distress syndrome (ARDS).MethodThis was a single-center, prospective, cohort study. Survivors were followed up for four times after discharge from intensive care unit (ICU) by lung high-resolution computed tomography (HRCT), pulmonary function assessment, 6-minute walk test (6MWT), and SF-36 instrument.ResultA total of 60 survivors of H1N1-induced pneumonia and ARDS were followed up for four times. The carbon monoxide at single breath (DLCO) of predicted values and the 6MWT results didn’t continue improving after 3 months. Health-related quality of life didn’t change during the 12 months after ICU discharge. Reticulation or interlobular septal thickening on HRCT did not begin to improve significantly until the 12-month follow-up. The DLCO of predicted values showed negative correlation with the severity degree of primary disease and reticulation or interlobular septal thickening, and a positive correlation with physical functioning. The DLCO of predicted values and reticulation or interlobular septal thickening both correlated with the highest tidal volume during mechanical ventilation. Levels of fibrogenic cytokines had a positive correlation with reticulation or interlobular septal thickening.ConclusionThe improvements in pulmonary function and exercise capacity, imaging, and health-related quality of life had different time phase and impact on each other during 12 months of follow-up. Long-term outcomes of pulmonary fibrosis might be related to the lung injury and excessive lung fibroproliferation at the early stage during ICU admission. influenza A (H1N1) virus severe community-acquired pneumonia (SCAP) acute respiratory distress syndrome (ARDS) pulmonary fibrosis pulmonary function Microbiology Xiao-Li Xu verfasserin aut Na Wan verfasserin aut Yu Zhao verfasserin aut Rui Wang verfasserin aut Xu-Yan Li verfasserin aut Ying Li verfasserin aut Li Wang verfasserin aut Hai-Chao Li verfasserin aut Yue Gu verfasserin aut Chun-Yan Zhang verfasserin aut Qi Yang verfasserin aut Zhao-Hui Tong verfasserin aut Bing Sun verfasserin aut In Frontiers in Cellular and Infection Microbiology Frontiers Media S.A., 2016 14(2024) (DE-627)664968554 (DE-600)2619676-1 22352988 nnns volume:14 year:2024 https://doi.org/10.3389/fcimb.2024.1378379 kostenfrei https://doaj.org/article/90492af2776141bc84544f00ea41b00f kostenfrei https://www.frontiersin.org/articles/10.3389/fcimb.2024.1378379/full kostenfrei https://doaj.org/toc/2235-2988 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024
allfieldsGer	10.3389/fcimb.2024.1378379 doi (DE-627)DOAJ099784890 (DE-599)DOAJ90492af2776141bc84544f00ea41b00f DE-627 ger DE-627 rakwb eng QR1-502 Xiao Tang verfasserin aut Long-term outcomes of survivors with influenza A H1N1 virus-induced severe pneumonia and ARDS: a single-center prospective cohort study 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionSystematic evaluation of long-term outcomes in survivors of H1N1 is still lacking. This study aimed to characterize long-term outcomes of severe H1N1-induced pneumonia and acute respiratory distress syndrome (ARDS).MethodThis was a single-center, prospective, cohort study. Survivors were followed up for four times after discharge from intensive care unit (ICU) by lung high-resolution computed tomography (HRCT), pulmonary function assessment, 6-minute walk test (6MWT), and SF-36 instrument.ResultA total of 60 survivors of H1N1-induced pneumonia and ARDS were followed up for four times. The carbon monoxide at single breath (DLCO) of predicted values and the 6MWT results didn’t continue improving after 3 months. Health-related quality of life didn’t change during the 12 months after ICU discharge. Reticulation or interlobular septal thickening on HRCT did not begin to improve significantly until the 12-month follow-up. The DLCO of predicted values showed negative correlation with the severity degree of primary disease and reticulation or interlobular septal thickening, and a positive correlation with physical functioning. The DLCO of predicted values and reticulation or interlobular septal thickening both correlated with the highest tidal volume during mechanical ventilation. Levels of fibrogenic cytokines had a positive correlation with reticulation or interlobular septal thickening.ConclusionThe improvements in pulmonary function and exercise capacity, imaging, and health-related quality of life had different time phase and impact on each other during 12 months of follow-up. Long-term outcomes of pulmonary fibrosis might be related to the lung injury and excessive lung fibroproliferation at the early stage during ICU admission. influenza A (H1N1) virus severe community-acquired pneumonia (SCAP) acute respiratory distress syndrome (ARDS) pulmonary fibrosis pulmonary function Microbiology Xiao-Li Xu verfasserin aut Na Wan verfasserin aut Yu Zhao verfasserin aut Rui Wang verfasserin aut Xu-Yan Li verfasserin aut Ying Li verfasserin aut Li Wang verfasserin aut Hai-Chao Li verfasserin aut Yue Gu verfasserin aut Chun-Yan Zhang verfasserin aut Qi Yang verfasserin aut Zhao-Hui Tong verfasserin aut Bing Sun verfasserin aut In Frontiers in Cellular and Infection Microbiology Frontiers Media S.A., 2016 14(2024) (DE-627)664968554 (DE-600)2619676-1 22352988 nnns volume:14 year:2024 https://doi.org/10.3389/fcimb.2024.1378379 kostenfrei https://doaj.org/article/90492af2776141bc84544f00ea41b00f kostenfrei https://www.frontiersin.org/articles/10.3389/fcimb.2024.1378379/full kostenfrei https://doaj.org/toc/2235-2988 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024
allfieldsSound	10.3389/fcimb.2024.1378379 doi (DE-627)DOAJ099784890 (DE-599)DOAJ90492af2776141bc84544f00ea41b00f DE-627 ger DE-627 rakwb eng QR1-502 Xiao Tang verfasserin aut Long-term outcomes of survivors with influenza A H1N1 virus-induced severe pneumonia and ARDS: a single-center prospective cohort study 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionSystematic evaluation of long-term outcomes in survivors of H1N1 is still lacking. This study aimed to characterize long-term outcomes of severe H1N1-induced pneumonia and acute respiratory distress syndrome (ARDS).MethodThis was a single-center, prospective, cohort study. Survivors were followed up for four times after discharge from intensive care unit (ICU) by lung high-resolution computed tomography (HRCT), pulmonary function assessment, 6-minute walk test (6MWT), and SF-36 instrument.ResultA total of 60 survivors of H1N1-induced pneumonia and ARDS were followed up for four times. The carbon monoxide at single breath (DLCO) of predicted values and the 6MWT results didn’t continue improving after 3 months. Health-related quality of life didn’t change during the 12 months after ICU discharge. Reticulation or interlobular septal thickening on HRCT did not begin to improve significantly until the 12-month follow-up. The DLCO of predicted values showed negative correlation with the severity degree of primary disease and reticulation or interlobular septal thickening, and a positive correlation with physical functioning. The DLCO of predicted values and reticulation or interlobular septal thickening both correlated with the highest tidal volume during mechanical ventilation. Levels of fibrogenic cytokines had a positive correlation with reticulation or interlobular septal thickening.ConclusionThe improvements in pulmonary function and exercise capacity, imaging, and health-related quality of life had different time phase and impact on each other during 12 months of follow-up. Long-term outcomes of pulmonary fibrosis might be related to the lung injury and excessive lung fibroproliferation at the early stage during ICU admission. influenza A (H1N1) virus severe community-acquired pneumonia (SCAP) acute respiratory distress syndrome (ARDS) pulmonary fibrosis pulmonary function Microbiology Xiao-Li Xu verfasserin aut Na Wan verfasserin aut Yu Zhao verfasserin aut Rui Wang verfasserin aut Xu-Yan Li verfasserin aut Ying Li verfasserin aut Li Wang verfasserin aut Hai-Chao Li verfasserin aut Yue Gu verfasserin aut Chun-Yan Zhang verfasserin aut Qi Yang verfasserin aut Zhao-Hui Tong verfasserin aut Bing Sun verfasserin aut In Frontiers in Cellular and Infection Microbiology Frontiers Media S.A., 2016 14(2024) (DE-627)664968554 (DE-600)2619676-1 22352988 nnns volume:14 year:2024 https://doi.org/10.3389/fcimb.2024.1378379 kostenfrei https://doaj.org/article/90492af2776141bc84544f00ea41b00f kostenfrei https://www.frontiersin.org/articles/10.3389/fcimb.2024.1378379/full kostenfrei https://doaj.org/toc/2235-2988 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024
language	English
source	In Frontiers in Cellular and Infection Microbiology 14(2024) volume:14 year:2024
sourceStr	In Frontiers in Cellular and Infection Microbiology 14(2024) volume:14 year:2024
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	influenza A (H1N1) virus severe community-acquired pneumonia (SCAP) acute respiratory distress syndrome (ARDS) pulmonary fibrosis pulmonary function Microbiology
isfreeaccess_bool	true
container_title	Frontiers in Cellular and Infection Microbiology
authorswithroles_txt_mv	Xiao Tang @@aut@@ Xiao-Li Xu @@aut@@ Na Wan @@aut@@ Yu Zhao @@aut@@ Rui Wang @@aut@@ Xu-Yan Li @@aut@@ Ying Li @@aut@@ Li Wang @@aut@@ Hai-Chao Li @@aut@@ Yue Gu @@aut@@ Chun-Yan Zhang @@aut@@ Qi Yang @@aut@@ Zhao-Hui Tong @@aut@@ Bing Sun @@aut@@
publishDateDaySort_date	2024-01-01T00:00:00Z
hierarchy_top_id	664968554
id	DOAJ099784890
language_de	englisch
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callnumber-first	Q - Science
author	Xiao Tang
spellingShingle	Xiao Tang misc QR1-502 misc influenza A (H1N1) virus misc severe community-acquired pneumonia (SCAP) misc acute respiratory distress syndrome (ARDS) misc pulmonary fibrosis misc pulmonary function misc Microbiology Long-term outcomes of survivors with influenza A H1N1 virus-induced severe pneumonia and ARDS: a single-center prospective cohort study
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topic_title	QR1-502 Long-term outcomes of survivors with influenza A H1N1 virus-induced severe pneumonia and ARDS: a single-center prospective cohort study influenza A (H1N1) virus severe community-acquired pneumonia (SCAP) acute respiratory distress syndrome (ARDS) pulmonary fibrosis pulmonary function
topic	misc QR1-502 misc influenza A (H1N1) virus misc severe community-acquired pneumonia (SCAP) misc acute respiratory distress syndrome (ARDS) misc pulmonary fibrosis misc pulmonary function misc Microbiology
topic_unstemmed	misc QR1-502 misc influenza A (H1N1) virus misc severe community-acquired pneumonia (SCAP) misc acute respiratory distress syndrome (ARDS) misc pulmonary fibrosis misc pulmonary function misc Microbiology
topic_browse	misc QR1-502 misc influenza A (H1N1) virus misc severe community-acquired pneumonia (SCAP) misc acute respiratory distress syndrome (ARDS) misc pulmonary fibrosis misc pulmonary function misc Microbiology
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title	Long-term outcomes of survivors with influenza A H1N1 virus-induced severe pneumonia and ARDS: a single-center prospective cohort study
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title_full	Long-term outcomes of survivors with influenza A H1N1 virus-induced severe pneumonia and ARDS: a single-center prospective cohort study
author_sort	Xiao Tang
journal	Frontiers in Cellular and Infection Microbiology
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author_browse	Xiao Tang Xiao-Li Xu Na Wan Yu Zhao Rui Wang Xu-Yan Li Ying Li Li Wang Hai-Chao Li Yue Gu Chun-Yan Zhang Qi Yang Zhao-Hui Tong Bing Sun
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doi_str_mv	10.3389/fcimb.2024.1378379
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title_sort	long-term outcomes of survivors with influenza a h1n1 virus-induced severe pneumonia and ards: a single-center prospective cohort study
callnumber	QR1-502
title_auth	Long-term outcomes of survivors with influenza A H1N1 virus-induced severe pneumonia and ARDS: a single-center prospective cohort study
abstract	IntroductionSystematic evaluation of long-term outcomes in survivors of H1N1 is still lacking. This study aimed to characterize long-term outcomes of severe H1N1-induced pneumonia and acute respiratory distress syndrome (ARDS).MethodThis was a single-center, prospective, cohort study. Survivors were followed up for four times after discharge from intensive care unit (ICU) by lung high-resolution computed tomography (HRCT), pulmonary function assessment, 6-minute walk test (6MWT), and SF-36 instrument.ResultA total of 60 survivors of H1N1-induced pneumonia and ARDS were followed up for four times. The carbon monoxide at single breath (DLCO) of predicted values and the 6MWT results didn’t continue improving after 3 months. Health-related quality of life didn’t change during the 12 months after ICU discharge. Reticulation or interlobular septal thickening on HRCT did not begin to improve significantly until the 12-month follow-up. The DLCO of predicted values showed negative correlation with the severity degree of primary disease and reticulation or interlobular septal thickening, and a positive correlation with physical functioning. The DLCO of predicted values and reticulation or interlobular septal thickening both correlated with the highest tidal volume during mechanical ventilation. Levels of fibrogenic cytokines had a positive correlation with reticulation or interlobular septal thickening.ConclusionThe improvements in pulmonary function and exercise capacity, imaging, and health-related quality of life had different time phase and impact on each other during 12 months of follow-up. Long-term outcomes of pulmonary fibrosis might be related to the lung injury and excessive lung fibroproliferation at the early stage during ICU admission.
abstractGer	IntroductionSystematic evaluation of long-term outcomes in survivors of H1N1 is still lacking. This study aimed to characterize long-term outcomes of severe H1N1-induced pneumonia and acute respiratory distress syndrome (ARDS).MethodThis was a single-center, prospective, cohort study. Survivors were followed up for four times after discharge from intensive care unit (ICU) by lung high-resolution computed tomography (HRCT), pulmonary function assessment, 6-minute walk test (6MWT), and SF-36 instrument.ResultA total of 60 survivors of H1N1-induced pneumonia and ARDS were followed up for four times. The carbon monoxide at single breath (DLCO) of predicted values and the 6MWT results didn’t continue improving after 3 months. Health-related quality of life didn’t change during the 12 months after ICU discharge. Reticulation or interlobular septal thickening on HRCT did not begin to improve significantly until the 12-month follow-up. The DLCO of predicted values showed negative correlation with the severity degree of primary disease and reticulation or interlobular septal thickening, and a positive correlation with physical functioning. The DLCO of predicted values and reticulation or interlobular septal thickening both correlated with the highest tidal volume during mechanical ventilation. Levels of fibrogenic cytokines had a positive correlation with reticulation or interlobular septal thickening.ConclusionThe improvements in pulmonary function and exercise capacity, imaging, and health-related quality of life had different time phase and impact on each other during 12 months of follow-up. Long-term outcomes of pulmonary fibrosis might be related to the lung injury and excessive lung fibroproliferation at the early stage during ICU admission.
abstract_unstemmed	IntroductionSystematic evaluation of long-term outcomes in survivors of H1N1 is still lacking. This study aimed to characterize long-term outcomes of severe H1N1-induced pneumonia and acute respiratory distress syndrome (ARDS).MethodThis was a single-center, prospective, cohort study. Survivors were followed up for four times after discharge from intensive care unit (ICU) by lung high-resolution computed tomography (HRCT), pulmonary function assessment, 6-minute walk test (6MWT), and SF-36 instrument.ResultA total of 60 survivors of H1N1-induced pneumonia and ARDS were followed up for four times. The carbon monoxide at single breath (DLCO) of predicted values and the 6MWT results didn’t continue improving after 3 months. Health-related quality of life didn’t change during the 12 months after ICU discharge. Reticulation or interlobular septal thickening on HRCT did not begin to improve significantly until the 12-month follow-up. The DLCO of predicted values showed negative correlation with the severity degree of primary disease and reticulation or interlobular septal thickening, and a positive correlation with physical functioning. The DLCO of predicted values and reticulation or interlobular septal thickening both correlated with the highest tidal volume during mechanical ventilation. Levels of fibrogenic cytokines had a positive correlation with reticulation or interlobular septal thickening.ConclusionThe improvements in pulmonary function and exercise capacity, imaging, and health-related quality of life had different time phase and impact on each other during 12 months of follow-up. Long-term outcomes of pulmonary fibrosis might be related to the lung injury and excessive lung fibroproliferation at the early stage during ICU admission.
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title_short	Long-term outcomes of survivors with influenza A H1N1 virus-induced severe pneumonia and ARDS: a single-center prospective cohort study
url	https://doi.org/10.3389/fcimb.2024.1378379 https://doaj.org/article/90492af2776141bc84544f00ea41b00f https://www.frontiersin.org/articles/10.3389/fcimb.2024.1378379/full https://doaj.org/toc/2235-2988
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author2	Xiao-Li Xu Na Wan Yu Zhao Rui Wang Xu-Yan Li Ying Li Li Wang Hai-Chao Li Yue Gu Chun-Yan Zhang Qi Yang Zhao-Hui Tong Bing Sun
author2Str	Xiao-Li Xu Na Wan Yu Zhao Rui Wang Xu-Yan Li Ying Li Li Wang Hai-Chao Li Yue Gu Chun-Yan Zhang Qi Yang Zhao-Hui Tong Bing Sun
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doi_str	10.3389/fcimb.2024.1378379
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up_date	2024-07-04T00:19:49.161Z
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