Regulation of Autophagosome–Lysosome Fusion by Human Viral Infections

Autophagy plays a fundamental role in maintaining cellular homeostasis by eliminating intracellular components via lysosomes. Successful degradation through autophagy relies on the fusion of autophagosomes to lysosomes, which leads to the formation of autolysosomes containing acidic proteases that d...
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Autor*in:	Po-Yuan Ke [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	autophagy virus autophagosome lysosome autophagosome–lysosome fusion

Übergeordnetes Werk:	In: Pathogens - MDPI AG, 2012, 13(2024), 3, p 266
Übergeordnetes Werk:	volume:13 ; year:2024 ; number:3, p 266

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DOI / URN:	10.3390/pathogens13030266

Katalog-ID:	DOAJ099831422

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allfields	10.3390/pathogens13030266 doi (DE-627)DOAJ099831422 (DE-599)DOAJc2357872e42e487ab6da85a4da9e8916 DE-627 ger DE-627 rakwb eng Po-Yuan Ke verfasserin aut Regulation of Autophagosome–Lysosome Fusion by Human Viral Infections 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Autophagy plays a fundamental role in maintaining cellular homeostasis by eliminating intracellular components via lysosomes. Successful degradation through autophagy relies on the fusion of autophagosomes to lysosomes, which leads to the formation of autolysosomes containing acidic proteases that degrade the sequestered materials. Viral infections can exploit autophagy in infected cells to balance virus–host cell interactions by degrading the invading virus or promoting viral growth. In recent years, cumulative studies have indicated that viral infections may interfere with the fusion of autophagosomes and lysosomes, thus benefiting viral replication and associated pathogenesis. In this review, I provide an overview of the current understanding of the molecular mechanism by which human viral infections deregulate autophagosome–lysosome fusion and summarize the physiological significance in the virus life cycle and host cell damage. autophagy virus autophagosome lysosome autophagosome–lysosome fusion Medicine R In Pathogens MDPI AG, 2012 13(2024), 3, p 266 (DE-627)732627885 (DE-600)2695572-6 20760817 nnns volume:13 year:2024 number:3, p 266 https://doi.org/10.3390/pathogens13030266 kostenfrei https://doaj.org/article/c2357872e42e487ab6da85a4da9e8916 kostenfrei https://www.mdpi.com/2076-0817/13/3/266 kostenfrei https://doaj.org/toc/2076-0817 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2024 3, p 266
spelling	10.3390/pathogens13030266 doi (DE-627)DOAJ099831422 (DE-599)DOAJc2357872e42e487ab6da85a4da9e8916 DE-627 ger DE-627 rakwb eng Po-Yuan Ke verfasserin aut Regulation of Autophagosome–Lysosome Fusion by Human Viral Infections 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Autophagy plays a fundamental role in maintaining cellular homeostasis by eliminating intracellular components via lysosomes. Successful degradation through autophagy relies on the fusion of autophagosomes to lysosomes, which leads to the formation of autolysosomes containing acidic proteases that degrade the sequestered materials. Viral infections can exploit autophagy in infected cells to balance virus–host cell interactions by degrading the invading virus or promoting viral growth. In recent years, cumulative studies have indicated that viral infections may interfere with the fusion of autophagosomes and lysosomes, thus benefiting viral replication and associated pathogenesis. In this review, I provide an overview of the current understanding of the molecular mechanism by which human viral infections deregulate autophagosome–lysosome fusion and summarize the physiological significance in the virus life cycle and host cell damage. autophagy virus autophagosome lysosome autophagosome–lysosome fusion Medicine R In Pathogens MDPI AG, 2012 13(2024), 3, p 266 (DE-627)732627885 (DE-600)2695572-6 20760817 nnns volume:13 year:2024 number:3, p 266 https://doi.org/10.3390/pathogens13030266 kostenfrei https://doaj.org/article/c2357872e42e487ab6da85a4da9e8916 kostenfrei https://www.mdpi.com/2076-0817/13/3/266 kostenfrei https://doaj.org/toc/2076-0817 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2024 3, p 266
allfields_unstemmed	10.3390/pathogens13030266 doi (DE-627)DOAJ099831422 (DE-599)DOAJc2357872e42e487ab6da85a4da9e8916 DE-627 ger DE-627 rakwb eng Po-Yuan Ke verfasserin aut Regulation of Autophagosome–Lysosome Fusion by Human Viral Infections 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Autophagy plays a fundamental role in maintaining cellular homeostasis by eliminating intracellular components via lysosomes. Successful degradation through autophagy relies on the fusion of autophagosomes to lysosomes, which leads to the formation of autolysosomes containing acidic proteases that degrade the sequestered materials. Viral infections can exploit autophagy in infected cells to balance virus–host cell interactions by degrading the invading virus or promoting viral growth. In recent years, cumulative studies have indicated that viral infections may interfere with the fusion of autophagosomes and lysosomes, thus benefiting viral replication and associated pathogenesis. In this review, I provide an overview of the current understanding of the molecular mechanism by which human viral infections deregulate autophagosome–lysosome fusion and summarize the physiological significance in the virus life cycle and host cell damage. autophagy virus autophagosome lysosome autophagosome–lysosome fusion Medicine R In Pathogens MDPI AG, 2012 13(2024), 3, p 266 (DE-627)732627885 (DE-600)2695572-6 20760817 nnns volume:13 year:2024 number:3, p 266 https://doi.org/10.3390/pathogens13030266 kostenfrei https://doaj.org/article/c2357872e42e487ab6da85a4da9e8916 kostenfrei https://www.mdpi.com/2076-0817/13/3/266 kostenfrei https://doaj.org/toc/2076-0817 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2024 3, p 266
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language	English
source	In Pathogens 13(2024), 3, p 266 volume:13 year:2024 number:3, p 266
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author	Po-Yuan Ke
spellingShingle	Po-Yuan Ke misc autophagy misc virus misc autophagosome misc lysosome misc autophagosome–lysosome fusion misc Medicine misc R Regulation of Autophagosome–Lysosome Fusion by Human Viral Infections
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topic_title	Regulation of Autophagosome–Lysosome Fusion by Human Viral Infections autophagy virus autophagosome lysosome autophagosome–lysosome fusion
topic	misc autophagy misc virus misc autophagosome misc lysosome misc autophagosome–lysosome fusion misc Medicine misc R
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title	Regulation of Autophagosome–Lysosome Fusion by Human Viral Infections
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title_full	Regulation of Autophagosome–Lysosome Fusion by Human Viral Infections
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title_sort	regulation of autophagosome–lysosome fusion by human viral infections
title_auth	Regulation of Autophagosome–Lysosome Fusion by Human Viral Infections
abstract	Autophagy plays a fundamental role in maintaining cellular homeostasis by eliminating intracellular components via lysosomes. Successful degradation through autophagy relies on the fusion of autophagosomes to lysosomes, which leads to the formation of autolysosomes containing acidic proteases that degrade the sequestered materials. Viral infections can exploit autophagy in infected cells to balance virus–host cell interactions by degrading the invading virus or promoting viral growth. In recent years, cumulative studies have indicated that viral infections may interfere with the fusion of autophagosomes and lysosomes, thus benefiting viral replication and associated pathogenesis. In this review, I provide an overview of the current understanding of the molecular mechanism by which human viral infections deregulate autophagosome–lysosome fusion and summarize the physiological significance in the virus life cycle and host cell damage.
abstractGer	Autophagy plays a fundamental role in maintaining cellular homeostasis by eliminating intracellular components via lysosomes. Successful degradation through autophagy relies on the fusion of autophagosomes to lysosomes, which leads to the formation of autolysosomes containing acidic proteases that degrade the sequestered materials. Viral infections can exploit autophagy in infected cells to balance virus–host cell interactions by degrading the invading virus or promoting viral growth. In recent years, cumulative studies have indicated that viral infections may interfere with the fusion of autophagosomes and lysosomes, thus benefiting viral replication and associated pathogenesis. In this review, I provide an overview of the current understanding of the molecular mechanism by which human viral infections deregulate autophagosome–lysosome fusion and summarize the physiological significance in the virus life cycle and host cell damage.
abstract_unstemmed	Autophagy plays a fundamental role in maintaining cellular homeostasis by eliminating intracellular components via lysosomes. Successful degradation through autophagy relies on the fusion of autophagosomes to lysosomes, which leads to the formation of autolysosomes containing acidic proteases that degrade the sequestered materials. Viral infections can exploit autophagy in infected cells to balance virus–host cell interactions by degrading the invading virus or promoting viral growth. In recent years, cumulative studies have indicated that viral infections may interfere with the fusion of autophagosomes and lysosomes, thus benefiting viral replication and associated pathogenesis. In this review, I provide an overview of the current understanding of the molecular mechanism by which human viral infections deregulate autophagosome–lysosome fusion and summarize the physiological significance in the virus life cycle and host cell damage.
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container_issue	3, p 266
title_short	Regulation of Autophagosome–Lysosome Fusion by Human Viral Infections
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up_date	2024-07-04T00:31:30.411Z
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