Development and characterization of a bacteriophage cocktail with high lytic efficacy against field-isolated Salmonella enterica
ABSTRACT: Salmonella spp. is a prevalent pathogen that causes great public health concern worldwide. Bacteriophage-based cocktails have arisen as an alternative to antibiotics to inhibit the growth of Salmonella. However, the bactericidal effect of bacteriophage cocktails in vivo largely differs fro...
Ausführliche Beschreibung
Autor*in: |
Matías Aguilera [verfasserIn] Eduardo Tobar-Calfucoy [verfasserIn] Victoria Rojas-Martínez [verfasserIn] Rodrigo Norambuena [verfasserIn] María Jesús Serrano [verfasserIn] Onix Cifuentes [verfasserIn] María Sofía Zamudio [verfasserIn] Daniel San Martín [verfasserIn] Pabla Lara [verfasserIn] Andrea Sabag [verfasserIn] Marcela Zabner [verfasserIn] Daniel Tichy [verfasserIn] Pamela Camejo [verfasserIn] Luis León [verfasserIn] Michael Pino [verfasserIn] Soledad Ulloa [verfasserIn] Felipe Rojas [verfasserIn] Christian Pieringer [verfasserIn] Cecilia Muster [verfasserIn] Daniel Castillo [verfasserIn] Nicolás Ferreira [verfasserIn] Camilo Avendaño [verfasserIn] Mauro Canaval [verfasserIn] Hans Pieringer [verfasserIn] Pablo Cifuentes [verfasserIn] Nicolás Cifuentes Muñoz [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2023 |
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Übergeordnetes Werk: |
In: Poultry Science - Elsevier, 2020, 102(2023), 12, Seite 103125- |
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Übergeordnetes Werk: |
volume:102 ; year:2023 ; number:12 ; pages:103125- |
Links: |
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DOI / URN: |
10.1016/j.psj.2023.103125 |
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Katalog-ID: |
DOAJ100036155 |
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520 | |a ABSTRACT: Salmonella spp. is a prevalent pathogen that causes great public health concern worldwide. Bacteriophage-based cocktails have arisen as an alternative to antibiotics to inhibit the growth of Salmonella. However, the bactericidal effect of bacteriophage cocktails in vivo largely differs from their observed effect in vitro. This is partly because in vitro developments of cocktails do not always consider the bacterial diversity nor the environmental conditions where bacteriophages will have to replicate. Here, we isolated and sequenced 47 bacteriophages that showed variable degrees of lytic activity against 258 Salmonella isolates from a commercial broiler company in Brazil. Three of these bacteriophages were characterized and selected to assemble a cocktail. In vitro quantitative assays determined the cocktail to be highly effective against multiple serovars of Salmonella, including Minnesota and Heidelberg. Remarkably, the in vitro lytic activity of the cocktail was retained or improved in conditions that more closely resembled the chicken gut, such as anaerobiosis, 42°C, and Salmonella mono-strain biofilms. Analysis of bacterial cross-resistance between the 3 bacteriophages composing the cocktail revealed limited or no generation of cross-resistance. Our results highlight the relevance of an optimized flux of work to develop bacteriophage cocktails against Salmonella with high lytic efficacy and strong potential to be applied in vivo in commercial broiler farms. | ||
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10.1016/j.psj.2023.103125 doi (DE-627)DOAJ100036155 (DE-599)DOAJ4c0ff8466c1d4e1e819af6b72f7e5ed9 DE-627 ger DE-627 rakwb eng SF1-1100 Matías Aguilera verfasserin aut Development and characterization of a bacteriophage cocktail with high lytic efficacy against field-isolated Salmonella enterica 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT: Salmonella spp. is a prevalent pathogen that causes great public health concern worldwide. Bacteriophage-based cocktails have arisen as an alternative to antibiotics to inhibit the growth of Salmonella. However, the bactericidal effect of bacteriophage cocktails in vivo largely differs from their observed effect in vitro. This is partly because in vitro developments of cocktails do not always consider the bacterial diversity nor the environmental conditions where bacteriophages will have to replicate. Here, we isolated and sequenced 47 bacteriophages that showed variable degrees of lytic activity against 258 Salmonella isolates from a commercial broiler company in Brazil. Three of these bacteriophages were characterized and selected to assemble a cocktail. In vitro quantitative assays determined the cocktail to be highly effective against multiple serovars of Salmonella, including Minnesota and Heidelberg. Remarkably, the in vitro lytic activity of the cocktail was retained or improved in conditions that more closely resembled the chicken gut, such as anaerobiosis, 42°C, and Salmonella mono-strain biofilms. Analysis of bacterial cross-resistance between the 3 bacteriophages composing the cocktail revealed limited or no generation of cross-resistance. Our results highlight the relevance of an optimized flux of work to develop bacteriophage cocktails against Salmonella with high lytic efficacy and strong potential to be applied in vivo in commercial broiler farms. Salmonella bacteriophage cocktail poultry Animal culture Eduardo Tobar-Calfucoy verfasserin aut Victoria Rojas-Martínez verfasserin aut Rodrigo Norambuena verfasserin aut María Jesús Serrano verfasserin aut Onix Cifuentes verfasserin aut María Sofía Zamudio verfasserin aut Daniel San Martín verfasserin aut Pabla Lara verfasserin aut Andrea Sabag verfasserin aut Marcela Zabner verfasserin aut Daniel Tichy verfasserin aut Pamela Camejo verfasserin aut Luis León verfasserin aut Michael Pino verfasserin aut Soledad Ulloa verfasserin aut Felipe Rojas verfasserin aut Christian Pieringer verfasserin aut Cecilia Muster verfasserin aut Daniel Castillo verfasserin aut Nicolás Ferreira verfasserin aut Camilo Avendaño verfasserin aut Mauro Canaval verfasserin aut Hans Pieringer verfasserin aut Pablo Cifuentes verfasserin aut Nicolás Cifuentes Muñoz verfasserin aut In Poultry Science Elsevier, 2020 102(2023), 12, Seite 103125- (DE-627)320569535 (DE-600)2016331-9 15253171 nnns volume:102 year:2023 number:12 pages:103125- https://doi.org/10.1016/j.psj.2023.103125 kostenfrei https://doaj.org/article/4c0ff8466c1d4e1e819af6b72f7e5ed9 kostenfrei http://www.sciencedirect.com/science/article/pii/S0032579123006442 kostenfrei https://doaj.org/toc/0032-5791 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 102 2023 12 103125- |
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10.1016/j.psj.2023.103125 doi (DE-627)DOAJ100036155 (DE-599)DOAJ4c0ff8466c1d4e1e819af6b72f7e5ed9 DE-627 ger DE-627 rakwb eng SF1-1100 Matías Aguilera verfasserin aut Development and characterization of a bacteriophage cocktail with high lytic efficacy against field-isolated Salmonella enterica 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT: Salmonella spp. is a prevalent pathogen that causes great public health concern worldwide. Bacteriophage-based cocktails have arisen as an alternative to antibiotics to inhibit the growth of Salmonella. However, the bactericidal effect of bacteriophage cocktails in vivo largely differs from their observed effect in vitro. This is partly because in vitro developments of cocktails do not always consider the bacterial diversity nor the environmental conditions where bacteriophages will have to replicate. Here, we isolated and sequenced 47 bacteriophages that showed variable degrees of lytic activity against 258 Salmonella isolates from a commercial broiler company in Brazil. Three of these bacteriophages were characterized and selected to assemble a cocktail. In vitro quantitative assays determined the cocktail to be highly effective against multiple serovars of Salmonella, including Minnesota and Heidelberg. Remarkably, the in vitro lytic activity of the cocktail was retained or improved in conditions that more closely resembled the chicken gut, such as anaerobiosis, 42°C, and Salmonella mono-strain biofilms. Analysis of bacterial cross-resistance between the 3 bacteriophages composing the cocktail revealed limited or no generation of cross-resistance. Our results highlight the relevance of an optimized flux of work to develop bacteriophage cocktails against Salmonella with high lytic efficacy and strong potential to be applied in vivo in commercial broiler farms. Salmonella bacteriophage cocktail poultry Animal culture Eduardo Tobar-Calfucoy verfasserin aut Victoria Rojas-Martínez verfasserin aut Rodrigo Norambuena verfasserin aut María Jesús Serrano verfasserin aut Onix Cifuentes verfasserin aut María Sofía Zamudio verfasserin aut Daniel San Martín verfasserin aut Pabla Lara verfasserin aut Andrea Sabag verfasserin aut Marcela Zabner verfasserin aut Daniel Tichy verfasserin aut Pamela Camejo verfasserin aut Luis León verfasserin aut Michael Pino verfasserin aut Soledad Ulloa verfasserin aut Felipe Rojas verfasserin aut Christian Pieringer verfasserin aut Cecilia Muster verfasserin aut Daniel Castillo verfasserin aut Nicolás Ferreira verfasserin aut Camilo Avendaño verfasserin aut Mauro Canaval verfasserin aut Hans Pieringer verfasserin aut Pablo Cifuentes verfasserin aut Nicolás Cifuentes Muñoz verfasserin aut In Poultry Science Elsevier, 2020 102(2023), 12, Seite 103125- (DE-627)320569535 (DE-600)2016331-9 15253171 nnns volume:102 year:2023 number:12 pages:103125- https://doi.org/10.1016/j.psj.2023.103125 kostenfrei https://doaj.org/article/4c0ff8466c1d4e1e819af6b72f7e5ed9 kostenfrei http://www.sciencedirect.com/science/article/pii/S0032579123006442 kostenfrei https://doaj.org/toc/0032-5791 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 102 2023 12 103125- |
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10.1016/j.psj.2023.103125 doi (DE-627)DOAJ100036155 (DE-599)DOAJ4c0ff8466c1d4e1e819af6b72f7e5ed9 DE-627 ger DE-627 rakwb eng SF1-1100 Matías Aguilera verfasserin aut Development and characterization of a bacteriophage cocktail with high lytic efficacy against field-isolated Salmonella enterica 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT: Salmonella spp. is a prevalent pathogen that causes great public health concern worldwide. Bacteriophage-based cocktails have arisen as an alternative to antibiotics to inhibit the growth of Salmonella. However, the bactericidal effect of bacteriophage cocktails in vivo largely differs from their observed effect in vitro. This is partly because in vitro developments of cocktails do not always consider the bacterial diversity nor the environmental conditions where bacteriophages will have to replicate. Here, we isolated and sequenced 47 bacteriophages that showed variable degrees of lytic activity against 258 Salmonella isolates from a commercial broiler company in Brazil. Three of these bacteriophages were characterized and selected to assemble a cocktail. In vitro quantitative assays determined the cocktail to be highly effective against multiple serovars of Salmonella, including Minnesota and Heidelberg. Remarkably, the in vitro lytic activity of the cocktail was retained or improved in conditions that more closely resembled the chicken gut, such as anaerobiosis, 42°C, and Salmonella mono-strain biofilms. Analysis of bacterial cross-resistance between the 3 bacteriophages composing the cocktail revealed limited or no generation of cross-resistance. Our results highlight the relevance of an optimized flux of work to develop bacteriophage cocktails against Salmonella with high lytic efficacy and strong potential to be applied in vivo in commercial broiler farms. Salmonella bacteriophage cocktail poultry Animal culture Eduardo Tobar-Calfucoy verfasserin aut Victoria Rojas-Martínez verfasserin aut Rodrigo Norambuena verfasserin aut María Jesús Serrano verfasserin aut Onix Cifuentes verfasserin aut María Sofía Zamudio verfasserin aut Daniel San Martín verfasserin aut Pabla Lara verfasserin aut Andrea Sabag verfasserin aut Marcela Zabner verfasserin aut Daniel Tichy verfasserin aut Pamela Camejo verfasserin aut Luis León verfasserin aut Michael Pino verfasserin aut Soledad Ulloa verfasserin aut Felipe Rojas verfasserin aut Christian Pieringer verfasserin aut Cecilia Muster verfasserin aut Daniel Castillo verfasserin aut Nicolás Ferreira verfasserin aut Camilo Avendaño verfasserin aut Mauro Canaval verfasserin aut Hans Pieringer verfasserin aut Pablo Cifuentes verfasserin aut Nicolás Cifuentes Muñoz verfasserin aut In Poultry Science Elsevier, 2020 102(2023), 12, Seite 103125- (DE-627)320569535 (DE-600)2016331-9 15253171 nnns volume:102 year:2023 number:12 pages:103125- https://doi.org/10.1016/j.psj.2023.103125 kostenfrei https://doaj.org/article/4c0ff8466c1d4e1e819af6b72f7e5ed9 kostenfrei http://www.sciencedirect.com/science/article/pii/S0032579123006442 kostenfrei https://doaj.org/toc/0032-5791 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 102 2023 12 103125- |
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10.1016/j.psj.2023.103125 doi (DE-627)DOAJ100036155 (DE-599)DOAJ4c0ff8466c1d4e1e819af6b72f7e5ed9 DE-627 ger DE-627 rakwb eng SF1-1100 Matías Aguilera verfasserin aut Development and characterization of a bacteriophage cocktail with high lytic efficacy against field-isolated Salmonella enterica 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT: Salmonella spp. is a prevalent pathogen that causes great public health concern worldwide. Bacteriophage-based cocktails have arisen as an alternative to antibiotics to inhibit the growth of Salmonella. However, the bactericidal effect of bacteriophage cocktails in vivo largely differs from their observed effect in vitro. This is partly because in vitro developments of cocktails do not always consider the bacterial diversity nor the environmental conditions where bacteriophages will have to replicate. Here, we isolated and sequenced 47 bacteriophages that showed variable degrees of lytic activity against 258 Salmonella isolates from a commercial broiler company in Brazil. Three of these bacteriophages were characterized and selected to assemble a cocktail. In vitro quantitative assays determined the cocktail to be highly effective against multiple serovars of Salmonella, including Minnesota and Heidelberg. Remarkably, the in vitro lytic activity of the cocktail was retained or improved in conditions that more closely resembled the chicken gut, such as anaerobiosis, 42°C, and Salmonella mono-strain biofilms. Analysis of bacterial cross-resistance between the 3 bacteriophages composing the cocktail revealed limited or no generation of cross-resistance. Our results highlight the relevance of an optimized flux of work to develop bacteriophage cocktails against Salmonella with high lytic efficacy and strong potential to be applied in vivo in commercial broiler farms. Salmonella bacteriophage cocktail poultry Animal culture Eduardo Tobar-Calfucoy verfasserin aut Victoria Rojas-Martínez verfasserin aut Rodrigo Norambuena verfasserin aut María Jesús Serrano verfasserin aut Onix Cifuentes verfasserin aut María Sofía Zamudio verfasserin aut Daniel San Martín verfasserin aut Pabla Lara verfasserin aut Andrea Sabag verfasserin aut Marcela Zabner verfasserin aut Daniel Tichy verfasserin aut Pamela Camejo verfasserin aut Luis León verfasserin aut Michael Pino verfasserin aut Soledad Ulloa verfasserin aut Felipe Rojas verfasserin aut Christian Pieringer verfasserin aut Cecilia Muster verfasserin aut Daniel Castillo verfasserin aut Nicolás Ferreira verfasserin aut Camilo Avendaño verfasserin aut Mauro Canaval verfasserin aut Hans Pieringer verfasserin aut Pablo Cifuentes verfasserin aut Nicolás Cifuentes Muñoz verfasserin aut In Poultry Science Elsevier, 2020 102(2023), 12, Seite 103125- (DE-627)320569535 (DE-600)2016331-9 15253171 nnns volume:102 year:2023 number:12 pages:103125- https://doi.org/10.1016/j.psj.2023.103125 kostenfrei https://doaj.org/article/4c0ff8466c1d4e1e819af6b72f7e5ed9 kostenfrei http://www.sciencedirect.com/science/article/pii/S0032579123006442 kostenfrei https://doaj.org/toc/0032-5791 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 102 2023 12 103125- |
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10.1016/j.psj.2023.103125 doi (DE-627)DOAJ100036155 (DE-599)DOAJ4c0ff8466c1d4e1e819af6b72f7e5ed9 DE-627 ger DE-627 rakwb eng SF1-1100 Matías Aguilera verfasserin aut Development and characterization of a bacteriophage cocktail with high lytic efficacy against field-isolated Salmonella enterica 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT: Salmonella spp. is a prevalent pathogen that causes great public health concern worldwide. Bacteriophage-based cocktails have arisen as an alternative to antibiotics to inhibit the growth of Salmonella. However, the bactericidal effect of bacteriophage cocktails in vivo largely differs from their observed effect in vitro. This is partly because in vitro developments of cocktails do not always consider the bacterial diversity nor the environmental conditions where bacteriophages will have to replicate. Here, we isolated and sequenced 47 bacteriophages that showed variable degrees of lytic activity against 258 Salmonella isolates from a commercial broiler company in Brazil. Three of these bacteriophages were characterized and selected to assemble a cocktail. In vitro quantitative assays determined the cocktail to be highly effective against multiple serovars of Salmonella, including Minnesota and Heidelberg. Remarkably, the in vitro lytic activity of the cocktail was retained or improved in conditions that more closely resembled the chicken gut, such as anaerobiosis, 42°C, and Salmonella mono-strain biofilms. Analysis of bacterial cross-resistance between the 3 bacteriophages composing the cocktail revealed limited or no generation of cross-resistance. Our results highlight the relevance of an optimized flux of work to develop bacteriophage cocktails against Salmonella with high lytic efficacy and strong potential to be applied in vivo in commercial broiler farms. Salmonella bacteriophage cocktail poultry Animal culture Eduardo Tobar-Calfucoy verfasserin aut Victoria Rojas-Martínez verfasserin aut Rodrigo Norambuena verfasserin aut María Jesús Serrano verfasserin aut Onix Cifuentes verfasserin aut María Sofía Zamudio verfasserin aut Daniel San Martín verfasserin aut Pabla Lara verfasserin aut Andrea Sabag verfasserin aut Marcela Zabner verfasserin aut Daniel Tichy verfasserin aut Pamela Camejo verfasserin aut Luis León verfasserin aut Michael Pino verfasserin aut Soledad Ulloa verfasserin aut Felipe Rojas verfasserin aut Christian Pieringer verfasserin aut Cecilia Muster verfasserin aut Daniel Castillo verfasserin aut Nicolás Ferreira verfasserin aut Camilo Avendaño verfasserin aut Mauro Canaval verfasserin aut Hans Pieringer verfasserin aut Pablo Cifuentes verfasserin aut Nicolás Cifuentes Muñoz verfasserin aut In Poultry Science Elsevier, 2020 102(2023), 12, Seite 103125- (DE-627)320569535 (DE-600)2016331-9 15253171 nnns volume:102 year:2023 number:12 pages:103125- https://doi.org/10.1016/j.psj.2023.103125 kostenfrei https://doaj.org/article/4c0ff8466c1d4e1e819af6b72f7e5ed9 kostenfrei http://www.sciencedirect.com/science/article/pii/S0032579123006442 kostenfrei https://doaj.org/toc/0032-5791 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 102 2023 12 103125- |
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Matías Aguilera @@aut@@ Eduardo Tobar-Calfucoy @@aut@@ Victoria Rojas-Martínez @@aut@@ Rodrigo Norambuena @@aut@@ María Jesús Serrano @@aut@@ Onix Cifuentes @@aut@@ María Sofía Zamudio @@aut@@ Daniel San Martín @@aut@@ Pabla Lara @@aut@@ Andrea Sabag @@aut@@ Marcela Zabner @@aut@@ Daniel Tichy @@aut@@ Pamela Camejo @@aut@@ Luis León @@aut@@ Michael Pino @@aut@@ Soledad Ulloa @@aut@@ Felipe Rojas @@aut@@ Christian Pieringer @@aut@@ Cecilia Muster @@aut@@ Daniel Castillo @@aut@@ Nicolás Ferreira @@aut@@ Camilo Avendaño @@aut@@ Mauro Canaval @@aut@@ Hans Pieringer @@aut@@ Pablo Cifuentes @@aut@@ Nicolás Cifuentes Muñoz @@aut@@ |
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S - Agriculture |
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Matías Aguilera |
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Matías Aguilera misc SF1-1100 misc Salmonella misc bacteriophage misc cocktail misc poultry misc Animal culture Development and characterization of a bacteriophage cocktail with high lytic efficacy against field-isolated Salmonella enterica |
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SF1-1100 Development and characterization of a bacteriophage cocktail with high lytic efficacy against field-isolated Salmonella enterica Salmonella bacteriophage cocktail poultry |
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Development and characterization of a bacteriophage cocktail with high lytic efficacy against field-isolated Salmonella enterica |
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Development and characterization of a bacteriophage cocktail with high lytic efficacy against field-isolated Salmonella enterica |
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Matías Aguilera |
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Matías Aguilera Eduardo Tobar-Calfucoy Victoria Rojas-Martínez Rodrigo Norambuena María Jesús Serrano Onix Cifuentes María Sofía Zamudio Daniel San Martín Pabla Lara Andrea Sabag Marcela Zabner Daniel Tichy Pamela Camejo Luis León Michael Pino Soledad Ulloa Felipe Rojas Christian Pieringer Cecilia Muster Daniel Castillo Nicolás Ferreira Camilo Avendaño Mauro Canaval Hans Pieringer Pablo Cifuentes Nicolás Cifuentes Muñoz |
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development and characterization of a bacteriophage cocktail with high lytic efficacy against field-isolated salmonella enterica |
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SF1-1100 |
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Development and characterization of a bacteriophage cocktail with high lytic efficacy against field-isolated Salmonella enterica |
abstract |
ABSTRACT: Salmonella spp. is a prevalent pathogen that causes great public health concern worldwide. Bacteriophage-based cocktails have arisen as an alternative to antibiotics to inhibit the growth of Salmonella. However, the bactericidal effect of bacteriophage cocktails in vivo largely differs from their observed effect in vitro. This is partly because in vitro developments of cocktails do not always consider the bacterial diversity nor the environmental conditions where bacteriophages will have to replicate. Here, we isolated and sequenced 47 bacteriophages that showed variable degrees of lytic activity against 258 Salmonella isolates from a commercial broiler company in Brazil. Three of these bacteriophages were characterized and selected to assemble a cocktail. In vitro quantitative assays determined the cocktail to be highly effective against multiple serovars of Salmonella, including Minnesota and Heidelberg. Remarkably, the in vitro lytic activity of the cocktail was retained or improved in conditions that more closely resembled the chicken gut, such as anaerobiosis, 42°C, and Salmonella mono-strain biofilms. Analysis of bacterial cross-resistance between the 3 bacteriophages composing the cocktail revealed limited or no generation of cross-resistance. Our results highlight the relevance of an optimized flux of work to develop bacteriophage cocktails against Salmonella with high lytic efficacy and strong potential to be applied in vivo in commercial broiler farms. |
abstractGer |
ABSTRACT: Salmonella spp. is a prevalent pathogen that causes great public health concern worldwide. Bacteriophage-based cocktails have arisen as an alternative to antibiotics to inhibit the growth of Salmonella. However, the bactericidal effect of bacteriophage cocktails in vivo largely differs from their observed effect in vitro. This is partly because in vitro developments of cocktails do not always consider the bacterial diversity nor the environmental conditions where bacteriophages will have to replicate. Here, we isolated and sequenced 47 bacteriophages that showed variable degrees of lytic activity against 258 Salmonella isolates from a commercial broiler company in Brazil. Three of these bacteriophages were characterized and selected to assemble a cocktail. In vitro quantitative assays determined the cocktail to be highly effective against multiple serovars of Salmonella, including Minnesota and Heidelberg. Remarkably, the in vitro lytic activity of the cocktail was retained or improved in conditions that more closely resembled the chicken gut, such as anaerobiosis, 42°C, and Salmonella mono-strain biofilms. Analysis of bacterial cross-resistance between the 3 bacteriophages composing the cocktail revealed limited or no generation of cross-resistance. Our results highlight the relevance of an optimized flux of work to develop bacteriophage cocktails against Salmonella with high lytic efficacy and strong potential to be applied in vivo in commercial broiler farms. |
abstract_unstemmed |
ABSTRACT: Salmonella spp. is a prevalent pathogen that causes great public health concern worldwide. Bacteriophage-based cocktails have arisen as an alternative to antibiotics to inhibit the growth of Salmonella. However, the bactericidal effect of bacteriophage cocktails in vivo largely differs from their observed effect in vitro. This is partly because in vitro developments of cocktails do not always consider the bacterial diversity nor the environmental conditions where bacteriophages will have to replicate. Here, we isolated and sequenced 47 bacteriophages that showed variable degrees of lytic activity against 258 Salmonella isolates from a commercial broiler company in Brazil. Three of these bacteriophages were characterized and selected to assemble a cocktail. In vitro quantitative assays determined the cocktail to be highly effective against multiple serovars of Salmonella, including Minnesota and Heidelberg. Remarkably, the in vitro lytic activity of the cocktail was retained or improved in conditions that more closely resembled the chicken gut, such as anaerobiosis, 42°C, and Salmonella mono-strain biofilms. Analysis of bacterial cross-resistance between the 3 bacteriophages composing the cocktail revealed limited or no generation of cross-resistance. Our results highlight the relevance of an optimized flux of work to develop bacteriophage cocktails against Salmonella with high lytic efficacy and strong potential to be applied in vivo in commercial broiler farms. |
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title_short |
Development and characterization of a bacteriophage cocktail with high lytic efficacy against field-isolated Salmonella enterica |
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https://doi.org/10.1016/j.psj.2023.103125 https://doaj.org/article/4c0ff8466c1d4e1e819af6b72f7e5ed9 http://www.sciencedirect.com/science/article/pii/S0032579123006442 https://doaj.org/toc/0032-5791 |
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Eduardo Tobar-Calfucoy Victoria Rojas-Martínez Rodrigo Norambuena María Jesús Serrano Onix Cifuentes María Sofía Zamudio Daniel San Martín Pabla Lara Andrea Sabag Marcela Zabner Daniel Tichy Pamela Camejo Luis León Michael Pino Soledad Ulloa Felipe Rojas Christian Pieringer Cecilia Muster Daniel Castillo Nicolás Ferreira Camilo Avendaño Mauro Canaval Hans Pieringer Pablo Cifuentes Nicolás Cifuentes Muñoz |
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Eduardo Tobar-Calfucoy Victoria Rojas-Martínez Rodrigo Norambuena María Jesús Serrano Onix Cifuentes María Sofía Zamudio Daniel San Martín Pabla Lara Andrea Sabag Marcela Zabner Daniel Tichy Pamela Camejo Luis León Michael Pino Soledad Ulloa Felipe Rojas Christian Pieringer Cecilia Muster Daniel Castillo Nicolás Ferreira Camilo Avendaño Mauro Canaval Hans Pieringer Pablo Cifuentes Nicolás Cifuentes Muñoz |
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10.1016/j.psj.2023.103125 |
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2024-07-04T01:21:52.878Z |
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score |
7.3985567 |