Effects of Physical Exercise on Inflammatory Biomarkers in patients with Chronic Kidney Disease: A Meta-Analysis

Chronic Kidney Disease (CKD) is found to be associated with systemic inflammation with increased levels of inflammatory biomarkers which increases the risk of cardiovascular events in these patients. This systematic review and meta-analysis was done to assess the effects of exercise on inflammatory...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Sonia Sonia [verfasserIn] Sheetal Kalra [verfasserIn] Minaxi Saini [verfasserIn] Puneeta Ajmera [verfasserIn] Anuradha Saini [verfasserIn] Richa Rai [verfasserIn] Sajjan Pal [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Aerobic Exercise Biomarkers Chronic Renal Insufficiency Exercise Inflammation Resistance

Übergeordnetes Werk:	In: Journal of the Dow University of Health Sciences - Dow University of Health Sciences, 2020, 17(2023), 3
Übergeordnetes Werk:	volume:17 ; year:2023 ; number:3

Links:	Link aufrufen Link aufrufen Journal toc Journal toc

Katalog-ID:	DOAJ100037798

Internformat


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520			\|a Chronic Kidney Disease (CKD) is found to be associated with systemic inflammation with increased levels of inflammatory biomarkers which increases the risk of cardiovascular events in these patients. This systematic review and meta-analysis was done to assess the effects of exercise on inflammatory biomarkers in patients with CKD. PubMed, Google Scholar, Scopus and PEDro databases were systematically searched. All published articles till March 2023 were included in this review. Of the articles retrieved 15 were included in qualitative analysis and among them 9 were quantitatively analysed. Included studies were of fair and good quality on PEDro rating scale. Cochrane Collaboration tool of risk of bias was used to assess the risk of bias. Results of the analysis suggested that exercise is effective in lowering the level of inflammatory C-reactive protein (CRP) level. The result was statistically significant (mean difference = -1.51, 95% CI: -2.23 to -0.79, I2= 71%, p-value 0.004). For tumour necrosis factor (TNF- α) the differences were found statistically significant (mean difference = -0.67, 95 % CI: -1.31 to -0.03, I2= 81%, p-value <0.001). For Interleukins (IL) -6 the result was statistically significant (mean difference = -0.68, 95% CI: -1.74 to 0.37, I2= 61%, p-value <0.001). For IL-10 the result was statistically significant (mean difference = 1.80, 95% CI: 0.18, 3.42, I2= 95%, p-value <0.001). It is concluded that various exercises like aerobic training, resistance training and inspiratory muscle training balance training have a significant effect on reducing the inflammation in patient with CKD thereby helps reducing cardiac.
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allfields	(DE-627)DOAJ100037798 (DE-599)DOAJ357e24c3c3224c7f99383eb58d6b6104 DE-627 ger DE-627 rakwb eng Sonia Sonia verfasserin aut Effects of Physical Exercise on Inflammatory Biomarkers in patients with Chronic Kidney Disease: A Meta-Analysis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Chronic Kidney Disease (CKD) is found to be associated with systemic inflammation with increased levels of inflammatory biomarkers which increases the risk of cardiovascular events in these patients. This systematic review and meta-analysis was done to assess the effects of exercise on inflammatory biomarkers in patients with CKD. PubMed, Google Scholar, Scopus and PEDro databases were systematically searched. All published articles till March 2023 were included in this review. Of the articles retrieved 15 were included in qualitative analysis and among them 9 were quantitatively analysed. Included studies were of fair and good quality on PEDro rating scale. Cochrane Collaboration tool of risk of bias was used to assess the risk of bias. Results of the analysis suggested that exercise is effective in lowering the level of inflammatory C-reactive protein (CRP) level. The result was statistically significant (mean difference = -1.51, 95% CI: -2.23 to -0.79, I2= 71%, p-value 0.004). For tumour necrosis factor (TNF- α) the differences were found statistically significant (mean difference = -0.67, 95 % CI: -1.31 to -0.03, I2= 81%, p-value <0.001). For Interleukins (IL) -6 the result was statistically significant (mean difference = -0.68, 95% CI: -1.74 to 0.37, I2= 61%, p-value <0.001). For IL-10 the result was statistically significant (mean difference = 1.80, 95% CI: 0.18, 3.42, I2= 95%, p-value <0.001). It is concluded that various exercises like aerobic training, resistance training and inspiratory muscle training balance training have a significant effect on reducing the inflammation in patient with CKD thereby helps reducing cardiac. Aerobic Exercise Biomarkers Chronic Renal Insufficiency Exercise Inflammation Resistance Medicine R Sheetal Kalra verfasserin aut Minaxi Saini verfasserin aut Puneeta Ajmera verfasserin aut Anuradha Saini verfasserin aut Richa Rai verfasserin aut Sajjan Pal verfasserin aut In Journal of the Dow University of Health Sciences Dow University of Health Sciences, 2020 17(2023), 3 (DE-627)1734609230 24102180 nnns volume:17 year:2023 number:3 https://doaj.org/article/357e24c3c3224c7f99383eb58d6b6104 kostenfrei https://jduhs.com/index.php/jduhs/article/view/1831 kostenfrei https://doaj.org/toc/1995-2198 Journal toc kostenfrei https://doaj.org/toc/2410-2180 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2023 3
spelling	(DE-627)DOAJ100037798 (DE-599)DOAJ357e24c3c3224c7f99383eb58d6b6104 DE-627 ger DE-627 rakwb eng Sonia Sonia verfasserin aut Effects of Physical Exercise on Inflammatory Biomarkers in patients with Chronic Kidney Disease: A Meta-Analysis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Chronic Kidney Disease (CKD) is found to be associated with systemic inflammation with increased levels of inflammatory biomarkers which increases the risk of cardiovascular events in these patients. This systematic review and meta-analysis was done to assess the effects of exercise on inflammatory biomarkers in patients with CKD. PubMed, Google Scholar, Scopus and PEDro databases were systematically searched. All published articles till March 2023 were included in this review. Of the articles retrieved 15 were included in qualitative analysis and among them 9 were quantitatively analysed. Included studies were of fair and good quality on PEDro rating scale. Cochrane Collaboration tool of risk of bias was used to assess the risk of bias. Results of the analysis suggested that exercise is effective in lowering the level of inflammatory C-reactive protein (CRP) level. The result was statistically significant (mean difference = -1.51, 95% CI: -2.23 to -0.79, I2= 71%, p-value 0.004). For tumour necrosis factor (TNF- α) the differences were found statistically significant (mean difference = -0.67, 95 % CI: -1.31 to -0.03, I2= 81%, p-value <0.001). For Interleukins (IL) -6 the result was statistically significant (mean difference = -0.68, 95% CI: -1.74 to 0.37, I2= 61%, p-value <0.001). For IL-10 the result was statistically significant (mean difference = 1.80, 95% CI: 0.18, 3.42, I2= 95%, p-value <0.001). It is concluded that various exercises like aerobic training, resistance training and inspiratory muscle training balance training have a significant effect on reducing the inflammation in patient with CKD thereby helps reducing cardiac. Aerobic Exercise Biomarkers Chronic Renal Insufficiency Exercise Inflammation Resistance Medicine R Sheetal Kalra verfasserin aut Minaxi Saini verfasserin aut Puneeta Ajmera verfasserin aut Anuradha Saini verfasserin aut Richa Rai verfasserin aut Sajjan Pal verfasserin aut In Journal of the Dow University of Health Sciences Dow University of Health Sciences, 2020 17(2023), 3 (DE-627)1734609230 24102180 nnns volume:17 year:2023 number:3 https://doaj.org/article/357e24c3c3224c7f99383eb58d6b6104 kostenfrei https://jduhs.com/index.php/jduhs/article/view/1831 kostenfrei https://doaj.org/toc/1995-2198 Journal toc kostenfrei https://doaj.org/toc/2410-2180 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2023 3
allfields_unstemmed	(DE-627)DOAJ100037798 (DE-599)DOAJ357e24c3c3224c7f99383eb58d6b6104 DE-627 ger DE-627 rakwb eng Sonia Sonia verfasserin aut Effects of Physical Exercise on Inflammatory Biomarkers in patients with Chronic Kidney Disease: A Meta-Analysis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Chronic Kidney Disease (CKD) is found to be associated with systemic inflammation with increased levels of inflammatory biomarkers which increases the risk of cardiovascular events in these patients. This systematic review and meta-analysis was done to assess the effects of exercise on inflammatory biomarkers in patients with CKD. PubMed, Google Scholar, Scopus and PEDro databases were systematically searched. All published articles till March 2023 were included in this review. Of the articles retrieved 15 were included in qualitative analysis and among them 9 were quantitatively analysed. Included studies were of fair and good quality on PEDro rating scale. Cochrane Collaboration tool of risk of bias was used to assess the risk of bias. Results of the analysis suggested that exercise is effective in lowering the level of inflammatory C-reactive protein (CRP) level. The result was statistically significant (mean difference = -1.51, 95% CI: -2.23 to -0.79, I2= 71%, p-value 0.004). For tumour necrosis factor (TNF- α) the differences were found statistically significant (mean difference = -0.67, 95 % CI: -1.31 to -0.03, I2= 81%, p-value <0.001). For Interleukins (IL) -6 the result was statistically significant (mean difference = -0.68, 95% CI: -1.74 to 0.37, I2= 61%, p-value <0.001). For IL-10 the result was statistically significant (mean difference = 1.80, 95% CI: 0.18, 3.42, I2= 95%, p-value <0.001). It is concluded that various exercises like aerobic training, resistance training and inspiratory muscle training balance training have a significant effect on reducing the inflammation in patient with CKD thereby helps reducing cardiac. Aerobic Exercise Biomarkers Chronic Renal Insufficiency Exercise Inflammation Resistance Medicine R Sheetal Kalra verfasserin aut Minaxi Saini verfasserin aut Puneeta Ajmera verfasserin aut Anuradha Saini verfasserin aut Richa Rai verfasserin aut Sajjan Pal verfasserin aut In Journal of the Dow University of Health Sciences Dow University of Health Sciences, 2020 17(2023), 3 (DE-627)1734609230 24102180 nnns volume:17 year:2023 number:3 https://doaj.org/article/357e24c3c3224c7f99383eb58d6b6104 kostenfrei https://jduhs.com/index.php/jduhs/article/view/1831 kostenfrei https://doaj.org/toc/1995-2198 Journal toc kostenfrei https://doaj.org/toc/2410-2180 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2023 3
allfieldsGer	(DE-627)DOAJ100037798 (DE-599)DOAJ357e24c3c3224c7f99383eb58d6b6104 DE-627 ger DE-627 rakwb eng Sonia Sonia verfasserin aut Effects of Physical Exercise on Inflammatory Biomarkers in patients with Chronic Kidney Disease: A Meta-Analysis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Chronic Kidney Disease (CKD) is found to be associated with systemic inflammation with increased levels of inflammatory biomarkers which increases the risk of cardiovascular events in these patients. This systematic review and meta-analysis was done to assess the effects of exercise on inflammatory biomarkers in patients with CKD. PubMed, Google Scholar, Scopus and PEDro databases were systematically searched. All published articles till March 2023 were included in this review. Of the articles retrieved 15 were included in qualitative analysis and among them 9 were quantitatively analysed. Included studies were of fair and good quality on PEDro rating scale. Cochrane Collaboration tool of risk of bias was used to assess the risk of bias. Results of the analysis suggested that exercise is effective in lowering the level of inflammatory C-reactive protein (CRP) level. The result was statistically significant (mean difference = -1.51, 95% CI: -2.23 to -0.79, I2= 71%, p-value 0.004). For tumour necrosis factor (TNF- α) the differences were found statistically significant (mean difference = -0.67, 95 % CI: -1.31 to -0.03, I2= 81%, p-value <0.001). For Interleukins (IL) -6 the result was statistically significant (mean difference = -0.68, 95% CI: -1.74 to 0.37, I2= 61%, p-value <0.001). For IL-10 the result was statistically significant (mean difference = 1.80, 95% CI: 0.18, 3.42, I2= 95%, p-value <0.001). It is concluded that various exercises like aerobic training, resistance training and inspiratory muscle training balance training have a significant effect on reducing the inflammation in patient with CKD thereby helps reducing cardiac. Aerobic Exercise Biomarkers Chronic Renal Insufficiency Exercise Inflammation Resistance Medicine R Sheetal Kalra verfasserin aut Minaxi Saini verfasserin aut Puneeta Ajmera verfasserin aut Anuradha Saini verfasserin aut Richa Rai verfasserin aut Sajjan Pal verfasserin aut In Journal of the Dow University of Health Sciences Dow University of Health Sciences, 2020 17(2023), 3 (DE-627)1734609230 24102180 nnns volume:17 year:2023 number:3 https://doaj.org/article/357e24c3c3224c7f99383eb58d6b6104 kostenfrei https://jduhs.com/index.php/jduhs/article/view/1831 kostenfrei https://doaj.org/toc/1995-2198 Journal toc kostenfrei https://doaj.org/toc/2410-2180 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2023 3
allfieldsSound	(DE-627)DOAJ100037798 (DE-599)DOAJ357e24c3c3224c7f99383eb58d6b6104 DE-627 ger DE-627 rakwb eng Sonia Sonia verfasserin aut Effects of Physical Exercise on Inflammatory Biomarkers in patients with Chronic Kidney Disease: A Meta-Analysis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Chronic Kidney Disease (CKD) is found to be associated with systemic inflammation with increased levels of inflammatory biomarkers which increases the risk of cardiovascular events in these patients. This systematic review and meta-analysis was done to assess the effects of exercise on inflammatory biomarkers in patients with CKD. PubMed, Google Scholar, Scopus and PEDro databases were systematically searched. All published articles till March 2023 were included in this review. Of the articles retrieved 15 were included in qualitative analysis and among them 9 were quantitatively analysed. Included studies were of fair and good quality on PEDro rating scale. Cochrane Collaboration tool of risk of bias was used to assess the risk of bias. Results of the analysis suggested that exercise is effective in lowering the level of inflammatory C-reactive protein (CRP) level. The result was statistically significant (mean difference = -1.51, 95% CI: -2.23 to -0.79, I2= 71%, p-value 0.004). For tumour necrosis factor (TNF- α) the differences were found statistically significant (mean difference = -0.67, 95 % CI: -1.31 to -0.03, I2= 81%, p-value <0.001). For Interleukins (IL) -6 the result was statistically significant (mean difference = -0.68, 95% CI: -1.74 to 0.37, I2= 61%, p-value <0.001). For IL-10 the result was statistically significant (mean difference = 1.80, 95% CI: 0.18, 3.42, I2= 95%, p-value <0.001). It is concluded that various exercises like aerobic training, resistance training and inspiratory muscle training balance training have a significant effect on reducing the inflammation in patient with CKD thereby helps reducing cardiac. Aerobic Exercise Biomarkers Chronic Renal Insufficiency Exercise Inflammation Resistance Medicine R Sheetal Kalra verfasserin aut Minaxi Saini verfasserin aut Puneeta Ajmera verfasserin aut Anuradha Saini verfasserin aut Richa Rai verfasserin aut Sajjan Pal verfasserin aut In Journal of the Dow University of Health Sciences Dow University of Health Sciences, 2020 17(2023), 3 (DE-627)1734609230 24102180 nnns volume:17 year:2023 number:3 https://doaj.org/article/357e24c3c3224c7f99383eb58d6b6104 kostenfrei https://jduhs.com/index.php/jduhs/article/view/1831 kostenfrei https://doaj.org/toc/1995-2198 Journal toc kostenfrei https://doaj.org/toc/2410-2180 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2023 3
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author	Sonia Sonia
spellingShingle	Sonia Sonia misc Aerobic Exercise misc Biomarkers misc Chronic Renal Insufficiency misc Exercise misc Inflammation misc Resistance misc Medicine misc R Effects of Physical Exercise on Inflammatory Biomarkers in patients with Chronic Kidney Disease: A Meta-Analysis
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topic_title	Effects of Physical Exercise on Inflammatory Biomarkers in patients with Chronic Kidney Disease: A Meta-Analysis Aerobic Exercise Biomarkers Chronic Renal Insufficiency Exercise Inflammation Resistance
topic	misc Aerobic Exercise misc Biomarkers misc Chronic Renal Insufficiency misc Exercise misc Inflammation misc Resistance misc Medicine misc R
topic_unstemmed	misc Aerobic Exercise misc Biomarkers misc Chronic Renal Insufficiency misc Exercise misc Inflammation misc Resistance misc Medicine misc R
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title	Effects of Physical Exercise on Inflammatory Biomarkers in patients with Chronic Kidney Disease: A Meta-Analysis
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title_full	Effects of Physical Exercise on Inflammatory Biomarkers in patients with Chronic Kidney Disease: A Meta-Analysis
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author_browse	Sonia Sonia Sheetal Kalra Minaxi Saini Puneeta Ajmera Anuradha Saini Richa Rai Sajjan Pal
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title_sort	effects of physical exercise on inflammatory biomarkers in patients with chronic kidney disease: a meta-analysis
title_auth	Effects of Physical Exercise on Inflammatory Biomarkers in patients with Chronic Kidney Disease: A Meta-Analysis
abstract	Chronic Kidney Disease (CKD) is found to be associated with systemic inflammation with increased levels of inflammatory biomarkers which increases the risk of cardiovascular events in these patients. This systematic review and meta-analysis was done to assess the effects of exercise on inflammatory biomarkers in patients with CKD. PubMed, Google Scholar, Scopus and PEDro databases were systematically searched. All published articles till March 2023 were included in this review. Of the articles retrieved 15 were included in qualitative analysis and among them 9 were quantitatively analysed. Included studies were of fair and good quality on PEDro rating scale. Cochrane Collaboration tool of risk of bias was used to assess the risk of bias. Results of the analysis suggested that exercise is effective in lowering the level of inflammatory C-reactive protein (CRP) level. The result was statistically significant (mean difference = -1.51, 95% CI: -2.23 to -0.79, I2= 71%, p-value 0.004). For tumour necrosis factor (TNF- α) the differences were found statistically significant (mean difference = -0.67, 95 % CI: -1.31 to -0.03, I2= 81%, p-value <0.001). For Interleukins (IL) -6 the result was statistically significant (mean difference = -0.68, 95% CI: -1.74 to 0.37, I2= 61%, p-value <0.001). For IL-10 the result was statistically significant (mean difference = 1.80, 95% CI: 0.18, 3.42, I2= 95%, p-value <0.001). It is concluded that various exercises like aerobic training, resistance training and inspiratory muscle training balance training have a significant effect on reducing the inflammation in patient with CKD thereby helps reducing cardiac.
abstractGer	Chronic Kidney Disease (CKD) is found to be associated with systemic inflammation with increased levels of inflammatory biomarkers which increases the risk of cardiovascular events in these patients. This systematic review and meta-analysis was done to assess the effects of exercise on inflammatory biomarkers in patients with CKD. PubMed, Google Scholar, Scopus and PEDro databases were systematically searched. All published articles till March 2023 were included in this review. Of the articles retrieved 15 were included in qualitative analysis and among them 9 were quantitatively analysed. Included studies were of fair and good quality on PEDro rating scale. Cochrane Collaboration tool of risk of bias was used to assess the risk of bias. Results of the analysis suggested that exercise is effective in lowering the level of inflammatory C-reactive protein (CRP) level. The result was statistically significant (mean difference = -1.51, 95% CI: -2.23 to -0.79, I2= 71%, p-value 0.004). For tumour necrosis factor (TNF- α) the differences were found statistically significant (mean difference = -0.67, 95 % CI: -1.31 to -0.03, I2= 81%, p-value <0.001). For Interleukins (IL) -6 the result was statistically significant (mean difference = -0.68, 95% CI: -1.74 to 0.37, I2= 61%, p-value <0.001). For IL-10 the result was statistically significant (mean difference = 1.80, 95% CI: 0.18, 3.42, I2= 95%, p-value <0.001). It is concluded that various exercises like aerobic training, resistance training and inspiratory muscle training balance training have a significant effect on reducing the inflammation in patient with CKD thereby helps reducing cardiac.
abstract_unstemmed	Chronic Kidney Disease (CKD) is found to be associated with systemic inflammation with increased levels of inflammatory biomarkers which increases the risk of cardiovascular events in these patients. This systematic review and meta-analysis was done to assess the effects of exercise on inflammatory biomarkers in patients with CKD. PubMed, Google Scholar, Scopus and PEDro databases were systematically searched. All published articles till March 2023 were included in this review. Of the articles retrieved 15 were included in qualitative analysis and among them 9 were quantitatively analysed. Included studies were of fair and good quality on PEDro rating scale. Cochrane Collaboration tool of risk of bias was used to assess the risk of bias. Results of the analysis suggested that exercise is effective in lowering the level of inflammatory C-reactive protein (CRP) level. The result was statistically significant (mean difference = -1.51, 95% CI: -2.23 to -0.79, I2= 71%, p-value 0.004). For tumour necrosis factor (TNF- α) the differences were found statistically significant (mean difference = -0.67, 95 % CI: -1.31 to -0.03, I2= 81%, p-value <0.001). For Interleukins (IL) -6 the result was statistically significant (mean difference = -0.68, 95% CI: -1.74 to 0.37, I2= 61%, p-value <0.001). For IL-10 the result was statistically significant (mean difference = 1.80, 95% CI: 0.18, 3.42, I2= 95%, p-value <0.001). It is concluded that various exercises like aerobic training, resistance training and inspiratory muscle training balance training have a significant effect on reducing the inflammation in patient with CKD thereby helps reducing cardiac.
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title_short	Effects of Physical Exercise on Inflammatory Biomarkers in patients with Chronic Kidney Disease: A Meta-Analysis
url	https://doaj.org/article/357e24c3c3224c7f99383eb58d6b6104 https://jduhs.com/index.php/jduhs/article/view/1831 https://doaj.org/toc/1995-2198 https://doaj.org/toc/2410-2180
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Effects of Physical Exercise on Inflammatory Biomarkers in patients with Chronic Kidney Disease: A Meta-Analysis

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