Expressions of vascular endothelial growth factor A, mucin-1, colony-stimulating factor-1, heparin-binding epidermal growth factor-like growth factor, and fibroblast growth factor 2 genes in the female reproductive tracts of women with ectopic pregnancy: A case-control study

Abstract Background: Ectopic pregnancy (EP) is defined as embryo implantation in a location other than the uterine cavity. Objective: We aimed to evaluate the expression of several genes, which may play a role in EP, in the ampulla region of fallopian tubes and endometrial tissue of women with EP. M...
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Autor*in:	Sima Golkar [verfasserIn] Zahra Chekini [verfasserIn] Fatemehsadat Amjadi [verfasserIn] Parvaneh Afsharian [verfasserIn] Aida Najafian [verfasserIn] Firouzeh Ghaffari [verfasserIn] Reza Aflatoonian [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	ectopic pregnancy, gene expression, vascular endothelial growth factor a, mucin-1, colony-stimulating factor-1, heparin-binding epidermal growth factor-like growth factor, fibroblast growth factor 2.

Übergeordnetes Werk:	In: International Journal of Reproductive BioMedicine - Shahid Sadoughi University of Medical Sciences, 2017, 21(2023), 10, Seite 801-808
Übergeordnetes Werk:	volume:21 ; year:2023 ; number:10 ; pages:801-808

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.18502/ijrm.v21i10.14535

Katalog-ID:	DOAJ100092675

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520			\|a Abstract Background: Ectopic pregnancy (EP) is defined as embryo implantation in a location other than the uterine cavity. Objective: We aimed to evaluate the expression of several genes, which may play a role in EP, in the ampulla region of fallopian tubes and endometrial tissue of women with EP. Materials and Methods: In this case-control study, 5 women who underwent salpingectomy due to EP, comprised the 5 pseudo-pregnant women as a control group. These participants referred to the Royan Institute, Shariati, and Arash hospital, Tehran, Iran during 2019-2021. We evaluated the expressions of vascular endothelial growth factor A, mucin-1, colony-stimulating factor-1, heparin-binding epidermal growth factor-like growth factor (HBEGF), and fibroblast growth factor 2 genes in the fallopian tube and endometrium of EP cases by real-time polymerase chain reaction using specific primers. Results: The vascular endothelial growth factor expression was significantly higher in the ampulla region of the controls. However, no significant differences were observed in endometrial tissue. Assessments of colony-stimulating factor-1 and fibroblast growth factor 2 showed no significant differences between the case and control groups. HBEGF showed significantly higher expression in the ampulla region of EP cases, but no significant difference was observed in HBEGF expression in the endometrial tissues of the study groups. Mucin-1expression was significantly higher in both study regions of the EP cases. Conclusion: Our results have strongly suggested that these genes play important roles in proper implantation, and disruptions in their expression patterns could lead to EP. However, more studies are needed to confirm the current findings.
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allfields	10.18502/ijrm.v21i10.14535 doi (DE-627)DOAJ100092675 (DE-599)DOAJ3415539baa8b4c1d97f9eb63ee5b7558 DE-627 ger DE-627 rakwb eng RG1-991 QH471-489 Sima Golkar verfasserin aut Expressions of vascular endothelial growth factor A, mucin-1, colony-stimulating factor-1, heparin-binding epidermal growth factor-like growth factor, and fibroblast growth factor 2 genes in the female reproductive tracts of women with ectopic pregnancy: A case-control study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: Ectopic pregnancy (EP) is defined as embryo implantation in a location other than the uterine cavity. Objective: We aimed to evaluate the expression of several genes, which may play a role in EP, in the ampulla region of fallopian tubes and endometrial tissue of women with EP. Materials and Methods: In this case-control study, 5 women who underwent salpingectomy due to EP, comprised the 5 pseudo-pregnant women as a control group. These participants referred to the Royan Institute, Shariati, and Arash hospital, Tehran, Iran during 2019-2021. We evaluated the expressions of vascular endothelial growth factor A, mucin-1, colony-stimulating factor-1, heparin-binding epidermal growth factor-like growth factor (HBEGF), and fibroblast growth factor 2 genes in the fallopian tube and endometrium of EP cases by real-time polymerase chain reaction using specific primers. Results: The vascular endothelial growth factor expression was significantly higher in the ampulla region of the controls. However, no significant differences were observed in endometrial tissue. Assessments of colony-stimulating factor-1 and fibroblast growth factor 2 showed no significant differences between the case and control groups. HBEGF showed significantly higher expression in the ampulla region of EP cases, but no significant difference was observed in HBEGF expression in the endometrial tissues of the study groups. Mucin-1expression was significantly higher in both study regions of the EP cases. Conclusion: Our results have strongly suggested that these genes play important roles in proper implantation, and disruptions in their expression patterns could lead to EP. However, more studies are needed to confirm the current findings. ectopic pregnancy, gene expression, vascular endothelial growth factor a, mucin-1, colony-stimulating factor-1, heparin-binding epidermal growth factor-like growth factor, fibroblast growth factor 2. Gynecology and obstetrics Reproduction Zahra Chekini verfasserin aut Fatemehsadat Amjadi verfasserin aut Parvaneh Afsharian verfasserin aut Aida Najafian verfasserin aut Firouzeh Ghaffari verfasserin aut Reza Aflatoonian verfasserin aut In International Journal of Reproductive BioMedicine Shahid Sadoughi University of Medical Sciences, 2017 21(2023), 10, Seite 801-808 (DE-627)891087931 (DE-600)2898387-7 24763772 nnns volume:21 year:2023 number:10 pages:801-808 https://doi.org/10.18502/ijrm.v21i10.14535 kostenfrei https://doaj.org/article/3415539baa8b4c1d97f9eb63ee5b7558 kostenfrei https://doi.org/10.18502/ijrm.v21i10.14535 kostenfrei https://doaj.org/toc/2476-4108 Journal toc kostenfrei https://doaj.org/toc/2476-3772 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2023 10 801-808
spelling	10.18502/ijrm.v21i10.14535 doi (DE-627)DOAJ100092675 (DE-599)DOAJ3415539baa8b4c1d97f9eb63ee5b7558 DE-627 ger DE-627 rakwb eng RG1-991 QH471-489 Sima Golkar verfasserin aut Expressions of vascular endothelial growth factor A, mucin-1, colony-stimulating factor-1, heparin-binding epidermal growth factor-like growth factor, and fibroblast growth factor 2 genes in the female reproductive tracts of women with ectopic pregnancy: A case-control study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: Ectopic pregnancy (EP) is defined as embryo implantation in a location other than the uterine cavity. Objective: We aimed to evaluate the expression of several genes, which may play a role in EP, in the ampulla region of fallopian tubes and endometrial tissue of women with EP. Materials and Methods: In this case-control study, 5 women who underwent salpingectomy due to EP, comprised the 5 pseudo-pregnant women as a control group. These participants referred to the Royan Institute, Shariati, and Arash hospital, Tehran, Iran during 2019-2021. We evaluated the expressions of vascular endothelial growth factor A, mucin-1, colony-stimulating factor-1, heparin-binding epidermal growth factor-like growth factor (HBEGF), and fibroblast growth factor 2 genes in the fallopian tube and endometrium of EP cases by real-time polymerase chain reaction using specific primers. Results: The vascular endothelial growth factor expression was significantly higher in the ampulla region of the controls. However, no significant differences were observed in endometrial tissue. Assessments of colony-stimulating factor-1 and fibroblast growth factor 2 showed no significant differences between the case and control groups. HBEGF showed significantly higher expression in the ampulla region of EP cases, but no significant difference was observed in HBEGF expression in the endometrial tissues of the study groups. Mucin-1expression was significantly higher in both study regions of the EP cases. Conclusion: Our results have strongly suggested that these genes play important roles in proper implantation, and disruptions in their expression patterns could lead to EP. However, more studies are needed to confirm the current findings. ectopic pregnancy, gene expression, vascular endothelial growth factor a, mucin-1, colony-stimulating factor-1, heparin-binding epidermal growth factor-like growth factor, fibroblast growth factor 2. Gynecology and obstetrics Reproduction Zahra Chekini verfasserin aut Fatemehsadat Amjadi verfasserin aut Parvaneh Afsharian verfasserin aut Aida Najafian verfasserin aut Firouzeh Ghaffari verfasserin aut Reza Aflatoonian verfasserin aut In International Journal of Reproductive BioMedicine Shahid Sadoughi University of Medical Sciences, 2017 21(2023), 10, Seite 801-808 (DE-627)891087931 (DE-600)2898387-7 24763772 nnns volume:21 year:2023 number:10 pages:801-808 https://doi.org/10.18502/ijrm.v21i10.14535 kostenfrei https://doaj.org/article/3415539baa8b4c1d97f9eb63ee5b7558 kostenfrei https://doi.org/10.18502/ijrm.v21i10.14535 kostenfrei https://doaj.org/toc/2476-4108 Journal toc kostenfrei https://doaj.org/toc/2476-3772 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2023 10 801-808
allfields_unstemmed	10.18502/ijrm.v21i10.14535 doi (DE-627)DOAJ100092675 (DE-599)DOAJ3415539baa8b4c1d97f9eb63ee5b7558 DE-627 ger DE-627 rakwb eng RG1-991 QH471-489 Sima Golkar verfasserin aut Expressions of vascular endothelial growth factor A, mucin-1, colony-stimulating factor-1, heparin-binding epidermal growth factor-like growth factor, and fibroblast growth factor 2 genes in the female reproductive tracts of women with ectopic pregnancy: A case-control study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: Ectopic pregnancy (EP) is defined as embryo implantation in a location other than the uterine cavity. Objective: We aimed to evaluate the expression of several genes, which may play a role in EP, in the ampulla region of fallopian tubes and endometrial tissue of women with EP. Materials and Methods: In this case-control study, 5 women who underwent salpingectomy due to EP, comprised the 5 pseudo-pregnant women as a control group. These participants referred to the Royan Institute, Shariati, and Arash hospital, Tehran, Iran during 2019-2021. We evaluated the expressions of vascular endothelial growth factor A, mucin-1, colony-stimulating factor-1, heparin-binding epidermal growth factor-like growth factor (HBEGF), and fibroblast growth factor 2 genes in the fallopian tube and endometrium of EP cases by real-time polymerase chain reaction using specific primers. Results: The vascular endothelial growth factor expression was significantly higher in the ampulla region of the controls. However, no significant differences were observed in endometrial tissue. Assessments of colony-stimulating factor-1 and fibroblast growth factor 2 showed no significant differences between the case and control groups. HBEGF showed significantly higher expression in the ampulla region of EP cases, but no significant difference was observed in HBEGF expression in the endometrial tissues of the study groups. Mucin-1expression was significantly higher in both study regions of the EP cases. Conclusion: Our results have strongly suggested that these genes play important roles in proper implantation, and disruptions in their expression patterns could lead to EP. However, more studies are needed to confirm the current findings. ectopic pregnancy, gene expression, vascular endothelial growth factor a, mucin-1, colony-stimulating factor-1, heparin-binding epidermal growth factor-like growth factor, fibroblast growth factor 2. Gynecology and obstetrics Reproduction Zahra Chekini verfasserin aut Fatemehsadat Amjadi verfasserin aut Parvaneh Afsharian verfasserin aut Aida Najafian verfasserin aut Firouzeh Ghaffari verfasserin aut Reza Aflatoonian verfasserin aut In International Journal of Reproductive BioMedicine Shahid Sadoughi University of Medical Sciences, 2017 21(2023), 10, Seite 801-808 (DE-627)891087931 (DE-600)2898387-7 24763772 nnns volume:21 year:2023 number:10 pages:801-808 https://doi.org/10.18502/ijrm.v21i10.14535 kostenfrei https://doaj.org/article/3415539baa8b4c1d97f9eb63ee5b7558 kostenfrei https://doi.org/10.18502/ijrm.v21i10.14535 kostenfrei https://doaj.org/toc/2476-4108 Journal toc kostenfrei https://doaj.org/toc/2476-3772 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2023 10 801-808
allfieldsGer	10.18502/ijrm.v21i10.14535 doi (DE-627)DOAJ100092675 (DE-599)DOAJ3415539baa8b4c1d97f9eb63ee5b7558 DE-627 ger DE-627 rakwb eng RG1-991 QH471-489 Sima Golkar verfasserin aut Expressions of vascular endothelial growth factor A, mucin-1, colony-stimulating factor-1, heparin-binding epidermal growth factor-like growth factor, and fibroblast growth factor 2 genes in the female reproductive tracts of women with ectopic pregnancy: A case-control study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: Ectopic pregnancy (EP) is defined as embryo implantation in a location other than the uterine cavity. Objective: We aimed to evaluate the expression of several genes, which may play a role in EP, in the ampulla region of fallopian tubes and endometrial tissue of women with EP. Materials and Methods: In this case-control study, 5 women who underwent salpingectomy due to EP, comprised the 5 pseudo-pregnant women as a control group. These participants referred to the Royan Institute, Shariati, and Arash hospital, Tehran, Iran during 2019-2021. We evaluated the expressions of vascular endothelial growth factor A, mucin-1, colony-stimulating factor-1, heparin-binding epidermal growth factor-like growth factor (HBEGF), and fibroblast growth factor 2 genes in the fallopian tube and endometrium of EP cases by real-time polymerase chain reaction using specific primers. Results: The vascular endothelial growth factor expression was significantly higher in the ampulla region of the controls. However, no significant differences were observed in endometrial tissue. Assessments of colony-stimulating factor-1 and fibroblast growth factor 2 showed no significant differences between the case and control groups. HBEGF showed significantly higher expression in the ampulla region of EP cases, but no significant difference was observed in HBEGF expression in the endometrial tissues of the study groups. Mucin-1expression was significantly higher in both study regions of the EP cases. Conclusion: Our results have strongly suggested that these genes play important roles in proper implantation, and disruptions in their expression patterns could lead to EP. However, more studies are needed to confirm the current findings. ectopic pregnancy, gene expression, vascular endothelial growth factor a, mucin-1, colony-stimulating factor-1, heparin-binding epidermal growth factor-like growth factor, fibroblast growth factor 2. Gynecology and obstetrics Reproduction Zahra Chekini verfasserin aut Fatemehsadat Amjadi verfasserin aut Parvaneh Afsharian verfasserin aut Aida Najafian verfasserin aut Firouzeh Ghaffari verfasserin aut Reza Aflatoonian verfasserin aut In International Journal of Reproductive BioMedicine Shahid Sadoughi University of Medical Sciences, 2017 21(2023), 10, Seite 801-808 (DE-627)891087931 (DE-600)2898387-7 24763772 nnns volume:21 year:2023 number:10 pages:801-808 https://doi.org/10.18502/ijrm.v21i10.14535 kostenfrei https://doaj.org/article/3415539baa8b4c1d97f9eb63ee5b7558 kostenfrei https://doi.org/10.18502/ijrm.v21i10.14535 kostenfrei https://doaj.org/toc/2476-4108 Journal toc kostenfrei https://doaj.org/toc/2476-3772 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2023 10 801-808
allfieldsSound	10.18502/ijrm.v21i10.14535 doi (DE-627)DOAJ100092675 (DE-599)DOAJ3415539baa8b4c1d97f9eb63ee5b7558 DE-627 ger DE-627 rakwb eng RG1-991 QH471-489 Sima Golkar verfasserin aut Expressions of vascular endothelial growth factor A, mucin-1, colony-stimulating factor-1, heparin-binding epidermal growth factor-like growth factor, and fibroblast growth factor 2 genes in the female reproductive tracts of women with ectopic pregnancy: A case-control study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: Ectopic pregnancy (EP) is defined as embryo implantation in a location other than the uterine cavity. Objective: We aimed to evaluate the expression of several genes, which may play a role in EP, in the ampulla region of fallopian tubes and endometrial tissue of women with EP. Materials and Methods: In this case-control study, 5 women who underwent salpingectomy due to EP, comprised the 5 pseudo-pregnant women as a control group. These participants referred to the Royan Institute, Shariati, and Arash hospital, Tehran, Iran during 2019-2021. We evaluated the expressions of vascular endothelial growth factor A, mucin-1, colony-stimulating factor-1, heparin-binding epidermal growth factor-like growth factor (HBEGF), and fibroblast growth factor 2 genes in the fallopian tube and endometrium of EP cases by real-time polymerase chain reaction using specific primers. Results: The vascular endothelial growth factor expression was significantly higher in the ampulla region of the controls. However, no significant differences were observed in endometrial tissue. Assessments of colony-stimulating factor-1 and fibroblast growth factor 2 showed no significant differences between the case and control groups. HBEGF showed significantly higher expression in the ampulla region of EP cases, but no significant difference was observed in HBEGF expression in the endometrial tissues of the study groups. Mucin-1expression was significantly higher in both study regions of the EP cases. Conclusion: Our results have strongly suggested that these genes play important roles in proper implantation, and disruptions in their expression patterns could lead to EP. However, more studies are needed to confirm the current findings. ectopic pregnancy, gene expression, vascular endothelial growth factor a, mucin-1, colony-stimulating factor-1, heparin-binding epidermal growth factor-like growth factor, fibroblast growth factor 2. Gynecology and obstetrics Reproduction Zahra Chekini verfasserin aut Fatemehsadat Amjadi verfasserin aut Parvaneh Afsharian verfasserin aut Aida Najafian verfasserin aut Firouzeh Ghaffari verfasserin aut Reza Aflatoonian verfasserin aut In International Journal of Reproductive BioMedicine Shahid Sadoughi University of Medical Sciences, 2017 21(2023), 10, Seite 801-808 (DE-627)891087931 (DE-600)2898387-7 24763772 nnns volume:21 year:2023 number:10 pages:801-808 https://doi.org/10.18502/ijrm.v21i10.14535 kostenfrei https://doaj.org/article/3415539baa8b4c1d97f9eb63ee5b7558 kostenfrei https://doi.org/10.18502/ijrm.v21i10.14535 kostenfrei https://doaj.org/toc/2476-4108 Journal toc kostenfrei https://doaj.org/toc/2476-3772 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2023 10 801-808
language	English
source	In International Journal of Reproductive BioMedicine 21(2023), 10, Seite 801-808 volume:21 year:2023 number:10 pages:801-808
sourceStr	In International Journal of Reproductive BioMedicine 21(2023), 10, Seite 801-808 volume:21 year:2023 number:10 pages:801-808
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	ectopic pregnancy, gene expression, vascular endothelial growth factor a, mucin-1, colony-stimulating factor-1, heparin-binding epidermal growth factor-like growth factor, fibroblast growth factor 2. Gynecology and obstetrics Reproduction
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container_title	International Journal of Reproductive BioMedicine
authorswithroles_txt_mv	Sima Golkar @@aut@@ Zahra Chekini @@aut@@ Fatemehsadat Amjadi @@aut@@ Parvaneh Afsharian @@aut@@ Aida Najafian @@aut@@ Firouzeh Ghaffari @@aut@@ Reza Aflatoonian @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	891087931
id	DOAJ100092675
language_de	englisch
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Objective: We aimed to evaluate the expression of several genes, which may play a role in EP, in the ampulla region of fallopian tubes and endometrial tissue of women with EP. Materials and Methods: In this case-control study, 5 women who underwent salpingectomy due to EP, comprised the 5 pseudo-pregnant women as a control group. These participants referred to the Royan Institute, Shariati, and Arash hospital, Tehran, Iran during 2019-2021. We evaluated the expressions of vascular endothelial growth factor A, mucin-1, colony-stimulating factor-1, heparin-binding epidermal growth factor-like growth factor (HBEGF), and fibroblast growth factor 2 genes in the fallopian tube and endometrium of EP cases by real-time polymerase chain reaction using specific primers. Results: The vascular endothelial growth factor expression was significantly higher in the ampulla region of the controls. However, no significant differences were observed in endometrial tissue. Assessments of colony-stimulating factor-1 and fibroblast growth factor 2 showed no significant differences between the case and control groups. HBEGF showed significantly higher expression in the ampulla region of EP cases, but no significant difference was observed in HBEGF expression in the endometrial tissues of the study groups. Mucin-1expression was significantly higher in both study regions of the EP cases. Conclusion: Our results have strongly suggested that these genes play important roles in proper implantation, and disruptions in their expression patterns could lead to EP. 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callnumber-first	R - Medicine
author	Sima Golkar
spellingShingle	Sima Golkar misc RG1-991 misc QH471-489 misc ectopic pregnancy, gene expression, vascular endothelial growth factor a, mucin-1, colony-stimulating factor-1, heparin-binding epidermal growth factor-like growth factor, fibroblast growth factor 2. misc Gynecology and obstetrics misc Reproduction Expressions of vascular endothelial growth factor A, mucin-1, colony-stimulating factor-1, heparin-binding epidermal growth factor-like growth factor, and fibroblast growth factor 2 genes in the female reproductive tracts of women with ectopic pregnancy: A case-control study
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topic_title	RG1-991 QH471-489 Expressions of vascular endothelial growth factor A, mucin-1, colony-stimulating factor-1, heparin-binding epidermal growth factor-like growth factor, and fibroblast growth factor 2 genes in the female reproductive tracts of women with ectopic pregnancy: A case-control study ectopic pregnancy, gene expression, vascular endothelial growth factor a, mucin-1, colony-stimulating factor-1, heparin-binding epidermal growth factor-like growth factor, fibroblast growth factor 2.
topic	misc RG1-991 misc QH471-489 misc ectopic pregnancy, gene expression, vascular endothelial growth factor a, mucin-1, colony-stimulating factor-1, heparin-binding epidermal growth factor-like growth factor, fibroblast growth factor 2. misc Gynecology and obstetrics misc Reproduction
topic_unstemmed	misc RG1-991 misc QH471-489 misc ectopic pregnancy, gene expression, vascular endothelial growth factor a, mucin-1, colony-stimulating factor-1, heparin-binding epidermal growth factor-like growth factor, fibroblast growth factor 2. misc Gynecology and obstetrics misc Reproduction
topic_browse	misc RG1-991 misc QH471-489 misc ectopic pregnancy, gene expression, vascular endothelial growth factor a, mucin-1, colony-stimulating factor-1, heparin-binding epidermal growth factor-like growth factor, fibroblast growth factor 2. misc Gynecology and obstetrics misc Reproduction
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hierarchy_parent_title	International Journal of Reproductive BioMedicine
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hierarchy_top_title	International Journal of Reproductive BioMedicine
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title	Expressions of vascular endothelial growth factor A, mucin-1, colony-stimulating factor-1, heparin-binding epidermal growth factor-like growth factor, and fibroblast growth factor 2 genes in the female reproductive tracts of women with ectopic pregnancy: A case-control study
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title_full	Expressions of vascular endothelial growth factor A, mucin-1, colony-stimulating factor-1, heparin-binding epidermal growth factor-like growth factor, and fibroblast growth factor 2 genes in the female reproductive tracts of women with ectopic pregnancy: A case-control study
author_sort	Sima Golkar
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author_browse	Sima Golkar Zahra Chekini Fatemehsadat Amjadi Parvaneh Afsharian Aida Najafian Firouzeh Ghaffari Reza Aflatoonian
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class	RG1-991 QH471-489
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author-letter	Sima Golkar
doi_str_mv	10.18502/ijrm.v21i10.14535
author2-role	verfasserin
title_sort	expressions of vascular endothelial growth factor a, mucin-1, colony-stimulating factor-1, heparin-binding epidermal growth factor-like growth factor, and fibroblast growth factor 2 genes in the female reproductive tracts of women with ectopic pregnancy: a case-control study
callnumber	RG1-991
title_auth	Expressions of vascular endothelial growth factor A, mucin-1, colony-stimulating factor-1, heparin-binding epidermal growth factor-like growth factor, and fibroblast growth factor 2 genes in the female reproductive tracts of women with ectopic pregnancy: A case-control study
abstract	Abstract Background: Ectopic pregnancy (EP) is defined as embryo implantation in a location other than the uterine cavity. Objective: We aimed to evaluate the expression of several genes, which may play a role in EP, in the ampulla region of fallopian tubes and endometrial tissue of women with EP. Materials and Methods: In this case-control study, 5 women who underwent salpingectomy due to EP, comprised the 5 pseudo-pregnant women as a control group. These participants referred to the Royan Institute, Shariati, and Arash hospital, Tehran, Iran during 2019-2021. We evaluated the expressions of vascular endothelial growth factor A, mucin-1, colony-stimulating factor-1, heparin-binding epidermal growth factor-like growth factor (HBEGF), and fibroblast growth factor 2 genes in the fallopian tube and endometrium of EP cases by real-time polymerase chain reaction using specific primers. Results: The vascular endothelial growth factor expression was significantly higher in the ampulla region of the controls. However, no significant differences were observed in endometrial tissue. Assessments of colony-stimulating factor-1 and fibroblast growth factor 2 showed no significant differences between the case and control groups. HBEGF showed significantly higher expression in the ampulla region of EP cases, but no significant difference was observed in HBEGF expression in the endometrial tissues of the study groups. Mucin-1expression was significantly higher in both study regions of the EP cases. Conclusion: Our results have strongly suggested that these genes play important roles in proper implantation, and disruptions in their expression patterns could lead to EP. However, more studies are needed to confirm the current findings.
abstractGer	Abstract Background: Ectopic pregnancy (EP) is defined as embryo implantation in a location other than the uterine cavity. Objective: We aimed to evaluate the expression of several genes, which may play a role in EP, in the ampulla region of fallopian tubes and endometrial tissue of women with EP. Materials and Methods: In this case-control study, 5 women who underwent salpingectomy due to EP, comprised the 5 pseudo-pregnant women as a control group. These participants referred to the Royan Institute, Shariati, and Arash hospital, Tehran, Iran during 2019-2021. We evaluated the expressions of vascular endothelial growth factor A, mucin-1, colony-stimulating factor-1, heparin-binding epidermal growth factor-like growth factor (HBEGF), and fibroblast growth factor 2 genes in the fallopian tube and endometrium of EP cases by real-time polymerase chain reaction using specific primers. Results: The vascular endothelial growth factor expression was significantly higher in the ampulla region of the controls. However, no significant differences were observed in endometrial tissue. Assessments of colony-stimulating factor-1 and fibroblast growth factor 2 showed no significant differences between the case and control groups. HBEGF showed significantly higher expression in the ampulla region of EP cases, but no significant difference was observed in HBEGF expression in the endometrial tissues of the study groups. Mucin-1expression was significantly higher in both study regions of the EP cases. Conclusion: Our results have strongly suggested that these genes play important roles in proper implantation, and disruptions in their expression patterns could lead to EP. However, more studies are needed to confirm the current findings.
abstract_unstemmed	Abstract Background: Ectopic pregnancy (EP) is defined as embryo implantation in a location other than the uterine cavity. Objective: We aimed to evaluate the expression of several genes, which may play a role in EP, in the ampulla region of fallopian tubes and endometrial tissue of women with EP. Materials and Methods: In this case-control study, 5 women who underwent salpingectomy due to EP, comprised the 5 pseudo-pregnant women as a control group. These participants referred to the Royan Institute, Shariati, and Arash hospital, Tehran, Iran during 2019-2021. We evaluated the expressions of vascular endothelial growth factor A, mucin-1, colony-stimulating factor-1, heparin-binding epidermal growth factor-like growth factor (HBEGF), and fibroblast growth factor 2 genes in the fallopian tube and endometrium of EP cases by real-time polymerase chain reaction using specific primers. Results: The vascular endothelial growth factor expression was significantly higher in the ampulla region of the controls. However, no significant differences were observed in endometrial tissue. Assessments of colony-stimulating factor-1 and fibroblast growth factor 2 showed no significant differences between the case and control groups. HBEGF showed significantly higher expression in the ampulla region of EP cases, but no significant difference was observed in HBEGF expression in the endometrial tissues of the study groups. Mucin-1expression was significantly higher in both study regions of the EP cases. Conclusion: Our results have strongly suggested that these genes play important roles in proper implantation, and disruptions in their expression patterns could lead to EP. However, more studies are needed to confirm the current findings.
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title_short	Expressions of vascular endothelial growth factor A, mucin-1, colony-stimulating factor-1, heparin-binding epidermal growth factor-like growth factor, and fibroblast growth factor 2 genes in the female reproductive tracts of women with ectopic pregnancy: A case-control study
url	https://doi.org/10.18502/ijrm.v21i10.14535 https://doaj.org/article/3415539baa8b4c1d97f9eb63ee5b7558 https://doaj.org/toc/2476-4108 https://doaj.org/toc/2476-3772
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Expressions of vascular endothelial growth factor A, mucin-1, colony-stimulating factor-1, heparin-binding epidermal growth factor-like growth factor, and fibroblast growth factor 2 genes in the female reproductive tracts of women with ectopic pregnancy: A case-control study

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