Cancer stem cells and their niche in cancer progression and therapy

Abstract High recurrence and metastasis rates and poor prognoses are the major challenges of current cancer therapy. Mounting evidence suggests that cancer stem cells (CSCs) play an important role in cancer development, chemoradiotherapy resistance, recurrence, and metastasis. Therefore, targeted CS...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Qiuping Liu [verfasserIn] Zongliang Guo [verfasserIn] Guoyin Li [verfasserIn] Yunxia Zhang [verfasserIn] Xiaomeng Liu [verfasserIn] Bing Li [verfasserIn] Jinping Wang [verfasserIn] Xiaoyan Li [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	cancer stem cells CSC niche Cellular components Extracellular matrix Therapeutic strategies

Übergeordnetes Werk:	In: Cancer Cell International - BMC, 2003, 23(2023), 1, Seite 12
Übergeordnetes Werk:	volume:23 ; year:2023 ; number:1 ; pages:12

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12935-023-03130-2

Katalog-ID:	DOAJ10019866X

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520			\|a Abstract High recurrence and metastasis rates and poor prognoses are the major challenges of current cancer therapy. Mounting evidence suggests that cancer stem cells (CSCs) play an important role in cancer development, chemoradiotherapy resistance, recurrence, and metastasis. Therefore, targeted CSC therapy has become a new strategy for solving the problems of cancer metastasis and recurrence. Since the properties of CSCs are regulated by the specific tumour microenvironment, the so-called CSC niche, which targets crosstalk between CSCs and their niches, is vital in our pursuit of new therapeutic opportunities to prevent cancer from recurring. In this review, we aim to highlight the factors within the CSC niche that have important roles in regulating CSC properties, including the extracellular matrix (ECM), stromal cells (e.g., associated macrophages (TAMs), cancer-associated fibroblasts (CAFs), and mesenchymal stem cells (MSCs)), and physiological changes (e.g., inflammation, hypoxia, and angiogenesis). We also discuss recent progress regarding therapies targeting CSCs and their niche to elucidate developments of more effective therapeutic strategies to eliminate cancer.
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spelling	10.1186/s12935-023-03130-2 doi (DE-627)DOAJ10019866X (DE-599)DOAJ076f8d6e9c0d47c2876336390d88daf9 DE-627 ger DE-627 rakwb eng RC254-282 QH573-671 Qiuping Liu verfasserin aut Cancer stem cells and their niche in cancer progression and therapy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract High recurrence and metastasis rates and poor prognoses are the major challenges of current cancer therapy. Mounting evidence suggests that cancer stem cells (CSCs) play an important role in cancer development, chemoradiotherapy resistance, recurrence, and metastasis. Therefore, targeted CSC therapy has become a new strategy for solving the problems of cancer metastasis and recurrence. Since the properties of CSCs are regulated by the specific tumour microenvironment, the so-called CSC niche, which targets crosstalk between CSCs and their niches, is vital in our pursuit of new therapeutic opportunities to prevent cancer from recurring. In this review, we aim to highlight the factors within the CSC niche that have important roles in regulating CSC properties, including the extracellular matrix (ECM), stromal cells (e.g., associated macrophages (TAMs), cancer-associated fibroblasts (CAFs), and mesenchymal stem cells (MSCs)), and physiological changes (e.g., inflammation, hypoxia, and angiogenesis). We also discuss recent progress regarding therapies targeting CSCs and their niche to elucidate developments of more effective therapeutic strategies to eliminate cancer. cancer stem cells CSC niche Cellular components Extracellular matrix Therapeutic strategies Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cytology Zongliang Guo verfasserin aut Guoyin Li verfasserin aut Yunxia Zhang verfasserin aut Xiaomeng Liu verfasserin aut Bing Li verfasserin aut Jinping Wang verfasserin aut Xiaoyan Li verfasserin aut In Cancer Cell International BMC, 2003 23(2023), 1, Seite 12 (DE-627)355989204 (DE-600)2091573-1 14752867 nnns volume:23 year:2023 number:1 pages:12 https://doi.org/10.1186/s12935-023-03130-2 kostenfrei https://doaj.org/article/076f8d6e9c0d47c2876336390d88daf9 kostenfrei https://doi.org/10.1186/s12935-023-03130-2 kostenfrei https://doaj.org/toc/1475-2867 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 12
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allfieldsSound	10.1186/s12935-023-03130-2 doi (DE-627)DOAJ10019866X (DE-599)DOAJ076f8d6e9c0d47c2876336390d88daf9 DE-627 ger DE-627 rakwb eng RC254-282 QH573-671 Qiuping Liu verfasserin aut Cancer stem cells and their niche in cancer progression and therapy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract High recurrence and metastasis rates and poor prognoses are the major challenges of current cancer therapy. Mounting evidence suggests that cancer stem cells (CSCs) play an important role in cancer development, chemoradiotherapy resistance, recurrence, and metastasis. Therefore, targeted CSC therapy has become a new strategy for solving the problems of cancer metastasis and recurrence. Since the properties of CSCs are regulated by the specific tumour microenvironment, the so-called CSC niche, which targets crosstalk between CSCs and their niches, is vital in our pursuit of new therapeutic opportunities to prevent cancer from recurring. In this review, we aim to highlight the factors within the CSC niche that have important roles in regulating CSC properties, including the extracellular matrix (ECM), stromal cells (e.g., associated macrophages (TAMs), cancer-associated fibroblasts (CAFs), and mesenchymal stem cells (MSCs)), and physiological changes (e.g., inflammation, hypoxia, and angiogenesis). We also discuss recent progress regarding therapies targeting CSCs and their niche to elucidate developments of more effective therapeutic strategies to eliminate cancer. cancer stem cells CSC niche Cellular components Extracellular matrix Therapeutic strategies Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cytology Zongliang Guo verfasserin aut Guoyin Li verfasserin aut Yunxia Zhang verfasserin aut Xiaomeng Liu verfasserin aut Bing Li verfasserin aut Jinping Wang verfasserin aut Xiaoyan Li verfasserin aut In Cancer Cell International BMC, 2003 23(2023), 1, Seite 12 (DE-627)355989204 (DE-600)2091573-1 14752867 nnns volume:23 year:2023 number:1 pages:12 https://doi.org/10.1186/s12935-023-03130-2 kostenfrei https://doaj.org/article/076f8d6e9c0d47c2876336390d88daf9 kostenfrei https://doi.org/10.1186/s12935-023-03130-2 kostenfrei https://doaj.org/toc/1475-2867 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 12
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authorswithroles_txt_mv	Qiuping Liu @@aut@@ Zongliang Guo @@aut@@ Guoyin Li @@aut@@ Yunxia Zhang @@aut@@ Xiaomeng Liu @@aut@@ Bing Li @@aut@@ Jinping Wang @@aut@@ Xiaoyan Li @@aut@@
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callnumber-first	R - Medicine
author	Qiuping Liu
spellingShingle	Qiuping Liu misc RC254-282 misc QH573-671 misc cancer stem cells misc CSC niche misc Cellular components misc Extracellular matrix misc Therapeutic strategies misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens misc Cytology Cancer stem cells and their niche in cancer progression and therapy
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topic_title	RC254-282 QH573-671 Cancer stem cells and their niche in cancer progression and therapy cancer stem cells CSC niche Cellular components Extracellular matrix Therapeutic strategies
topic	misc RC254-282 misc QH573-671 misc cancer stem cells misc CSC niche misc Cellular components misc Extracellular matrix misc Therapeutic strategies misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens misc Cytology
topic_unstemmed	misc RC254-282 misc QH573-671 misc cancer stem cells misc CSC niche misc Cellular components misc Extracellular matrix misc Therapeutic strategies misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens misc Cytology
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title	Cancer stem cells and their niche in cancer progression and therapy
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title_full	Cancer stem cells and their niche in cancer progression and therapy
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title_sort	cancer stem cells and their niche in cancer progression and therapy
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title_auth	Cancer stem cells and their niche in cancer progression and therapy
abstract	Abstract High recurrence and metastasis rates and poor prognoses are the major challenges of current cancer therapy. Mounting evidence suggests that cancer stem cells (CSCs) play an important role in cancer development, chemoradiotherapy resistance, recurrence, and metastasis. Therefore, targeted CSC therapy has become a new strategy for solving the problems of cancer metastasis and recurrence. Since the properties of CSCs are regulated by the specific tumour microenvironment, the so-called CSC niche, which targets crosstalk between CSCs and their niches, is vital in our pursuit of new therapeutic opportunities to prevent cancer from recurring. In this review, we aim to highlight the factors within the CSC niche that have important roles in regulating CSC properties, including the extracellular matrix (ECM), stromal cells (e.g., associated macrophages (TAMs), cancer-associated fibroblasts (CAFs), and mesenchymal stem cells (MSCs)), and physiological changes (e.g., inflammation, hypoxia, and angiogenesis). We also discuss recent progress regarding therapies targeting CSCs and their niche to elucidate developments of more effective therapeutic strategies to eliminate cancer.
abstractGer	Abstract High recurrence and metastasis rates and poor prognoses are the major challenges of current cancer therapy. Mounting evidence suggests that cancer stem cells (CSCs) play an important role in cancer development, chemoradiotherapy resistance, recurrence, and metastasis. Therefore, targeted CSC therapy has become a new strategy for solving the problems of cancer metastasis and recurrence. Since the properties of CSCs are regulated by the specific tumour microenvironment, the so-called CSC niche, which targets crosstalk between CSCs and their niches, is vital in our pursuit of new therapeutic opportunities to prevent cancer from recurring. In this review, we aim to highlight the factors within the CSC niche that have important roles in regulating CSC properties, including the extracellular matrix (ECM), stromal cells (e.g., associated macrophages (TAMs), cancer-associated fibroblasts (CAFs), and mesenchymal stem cells (MSCs)), and physiological changes (e.g., inflammation, hypoxia, and angiogenesis). We also discuss recent progress regarding therapies targeting CSCs and their niche to elucidate developments of more effective therapeutic strategies to eliminate cancer.
abstract_unstemmed	Abstract High recurrence and metastasis rates and poor prognoses are the major challenges of current cancer therapy. Mounting evidence suggests that cancer stem cells (CSCs) play an important role in cancer development, chemoradiotherapy resistance, recurrence, and metastasis. Therefore, targeted CSC therapy has become a new strategy for solving the problems of cancer metastasis and recurrence. Since the properties of CSCs are regulated by the specific tumour microenvironment, the so-called CSC niche, which targets crosstalk between CSCs and their niches, is vital in our pursuit of new therapeutic opportunities to prevent cancer from recurring. In this review, we aim to highlight the factors within the CSC niche that have important roles in regulating CSC properties, including the extracellular matrix (ECM), stromal cells (e.g., associated macrophages (TAMs), cancer-associated fibroblasts (CAFs), and mesenchymal stem cells (MSCs)), and physiological changes (e.g., inflammation, hypoxia, and angiogenesis). We also discuss recent progress regarding therapies targeting CSCs and their niche to elucidate developments of more effective therapeutic strategies to eliminate cancer.
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title_short	Cancer stem cells and their niche in cancer progression and therapy
url	https://doi.org/10.1186/s12935-023-03130-2 https://doaj.org/article/076f8d6e9c0d47c2876336390d88daf9 https://doaj.org/toc/1475-2867
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Cancer stem cells and their niche in cancer progression and therapy

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