Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease

Abstract Background Alterations in progranulin (PGRN) expression are associated with multiple neurodegenerative diseases (NDs), including frontotemporal dementia (FTD), Alzheimer’s disease (AD), Parkinson’s disease (PD), and lysosomal storage disorders (LSDs). Recently, the loss of PGRN was shown to...
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Gespeichert in:

Autor*in:	Drew A. Gillett [verfasserIn] Rebecca L. Wallings [verfasserIn] Oihane Uriarte Huarte [verfasserIn] Malú Gámez Tansey [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Progranulin GPNMB Endo-lysosomal system Immune system Neurodegenerative diseases

Übergeordnetes Werk:	In: Journal of Neuroinflammation - BMC, 2004, 20(2023), 1, Seite 22
Übergeordnetes Werk:	volume:20 ; year:2023 ; number:1 ; pages:22

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12974-023-02965-w

Katalog-ID:	DOAJ100203361

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520			\|a Abstract Background Alterations in progranulin (PGRN) expression are associated with multiple neurodegenerative diseases (NDs), including frontotemporal dementia (FTD), Alzheimer’s disease (AD), Parkinson’s disease (PD), and lysosomal storage disorders (LSDs). Recently, the loss of PGRN was shown to result in endo-lysosomal system dysfunction and an age-dependent increase in the expression of another protein associated with NDs, glycoprotein non-metastatic B (GPNMB). Main body It is unclear what role GPNMB plays in the context of PGRN insufficiency and how they interact and contribute to the development or progression of NDs. This review focuses on the interplay between these two critical proteins within the context of endo-lysosomal health, immune function, and inflammation in their contribution to NDs. Short conclusion PGRN and GPNMB are interrelated proteins that regulate disease-relevant processes and may have value as therapeutic targets to delay disease progression or extend therapeutic windows.
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allfields	10.1186/s12974-023-02965-w doi (DE-627)DOAJ100203361 (DE-599)DOAJ4ea2394ac7fa4eb59e18243bad63c6a7 DE-627 ger DE-627 rakwb eng RC346-429 Drew A. Gillett verfasserin aut Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Alterations in progranulin (PGRN) expression are associated with multiple neurodegenerative diseases (NDs), including frontotemporal dementia (FTD), Alzheimer’s disease (AD), Parkinson’s disease (PD), and lysosomal storage disorders (LSDs). Recently, the loss of PGRN was shown to result in endo-lysosomal system dysfunction and an age-dependent increase in the expression of another protein associated with NDs, glycoprotein non-metastatic B (GPNMB). Main body It is unclear what role GPNMB plays in the context of PGRN insufficiency and how they interact and contribute to the development or progression of NDs. This review focuses on the interplay between these two critical proteins within the context of endo-lysosomal health, immune function, and inflammation in their contribution to NDs. Short conclusion PGRN and GPNMB are interrelated proteins that regulate disease-relevant processes and may have value as therapeutic targets to delay disease progression or extend therapeutic windows. Progranulin GPNMB Endo-lysosomal system Immune system Neurodegenerative diseases Neurology. Diseases of the nervous system Rebecca L. Wallings verfasserin aut Oihane Uriarte Huarte verfasserin aut Malú Gámez Tansey verfasserin aut In Journal of Neuroinflammation BMC, 2004 20(2023), 1, Seite 22 (DE-627)391784781 (DE-600)2156455-3 17422094 nnns volume:20 year:2023 number:1 pages:22 https://doi.org/10.1186/s12974-023-02965-w kostenfrei https://doaj.org/article/4ea2394ac7fa4eb59e18243bad63c6a7 kostenfrei https://doi.org/10.1186/s12974-023-02965-w kostenfrei https://doaj.org/toc/1742-2094 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2023 1 22
spelling	10.1186/s12974-023-02965-w doi (DE-627)DOAJ100203361 (DE-599)DOAJ4ea2394ac7fa4eb59e18243bad63c6a7 DE-627 ger DE-627 rakwb eng RC346-429 Drew A. Gillett verfasserin aut Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Alterations in progranulin (PGRN) expression are associated with multiple neurodegenerative diseases (NDs), including frontotemporal dementia (FTD), Alzheimer’s disease (AD), Parkinson’s disease (PD), and lysosomal storage disorders (LSDs). Recently, the loss of PGRN was shown to result in endo-lysosomal system dysfunction and an age-dependent increase in the expression of another protein associated with NDs, glycoprotein non-metastatic B (GPNMB). Main body It is unclear what role GPNMB plays in the context of PGRN insufficiency and how they interact and contribute to the development or progression of NDs. This review focuses on the interplay between these two critical proteins within the context of endo-lysosomal health, immune function, and inflammation in their contribution to NDs. Short conclusion PGRN and GPNMB are interrelated proteins that regulate disease-relevant processes and may have value as therapeutic targets to delay disease progression or extend therapeutic windows. Progranulin GPNMB Endo-lysosomal system Immune system Neurodegenerative diseases Neurology. Diseases of the nervous system Rebecca L. Wallings verfasserin aut Oihane Uriarte Huarte verfasserin aut Malú Gámez Tansey verfasserin aut In Journal of Neuroinflammation BMC, 2004 20(2023), 1, Seite 22 (DE-627)391784781 (DE-600)2156455-3 17422094 nnns volume:20 year:2023 number:1 pages:22 https://doi.org/10.1186/s12974-023-02965-w kostenfrei https://doaj.org/article/4ea2394ac7fa4eb59e18243bad63c6a7 kostenfrei https://doi.org/10.1186/s12974-023-02965-w kostenfrei https://doaj.org/toc/1742-2094 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2023 1 22
allfields_unstemmed	10.1186/s12974-023-02965-w doi (DE-627)DOAJ100203361 (DE-599)DOAJ4ea2394ac7fa4eb59e18243bad63c6a7 DE-627 ger DE-627 rakwb eng RC346-429 Drew A. Gillett verfasserin aut Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Alterations in progranulin (PGRN) expression are associated with multiple neurodegenerative diseases (NDs), including frontotemporal dementia (FTD), Alzheimer’s disease (AD), Parkinson’s disease (PD), and lysosomal storage disorders (LSDs). Recently, the loss of PGRN was shown to result in endo-lysosomal system dysfunction and an age-dependent increase in the expression of another protein associated with NDs, glycoprotein non-metastatic B (GPNMB). Main body It is unclear what role GPNMB plays in the context of PGRN insufficiency and how they interact and contribute to the development or progression of NDs. This review focuses on the interplay between these two critical proteins within the context of endo-lysosomal health, immune function, and inflammation in their contribution to NDs. Short conclusion PGRN and GPNMB are interrelated proteins that regulate disease-relevant processes and may have value as therapeutic targets to delay disease progression or extend therapeutic windows. Progranulin GPNMB Endo-lysosomal system Immune system Neurodegenerative diseases Neurology. Diseases of the nervous system Rebecca L. Wallings verfasserin aut Oihane Uriarte Huarte verfasserin aut Malú Gámez Tansey verfasserin aut In Journal of Neuroinflammation BMC, 2004 20(2023), 1, Seite 22 (DE-627)391784781 (DE-600)2156455-3 17422094 nnns volume:20 year:2023 number:1 pages:22 https://doi.org/10.1186/s12974-023-02965-w kostenfrei https://doaj.org/article/4ea2394ac7fa4eb59e18243bad63c6a7 kostenfrei https://doi.org/10.1186/s12974-023-02965-w kostenfrei https://doaj.org/toc/1742-2094 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2023 1 22
allfieldsGer	10.1186/s12974-023-02965-w doi (DE-627)DOAJ100203361 (DE-599)DOAJ4ea2394ac7fa4eb59e18243bad63c6a7 DE-627 ger DE-627 rakwb eng RC346-429 Drew A. Gillett verfasserin aut Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Alterations in progranulin (PGRN) expression are associated with multiple neurodegenerative diseases (NDs), including frontotemporal dementia (FTD), Alzheimer’s disease (AD), Parkinson’s disease (PD), and lysosomal storage disorders (LSDs). Recently, the loss of PGRN was shown to result in endo-lysosomal system dysfunction and an age-dependent increase in the expression of another protein associated with NDs, glycoprotein non-metastatic B (GPNMB). Main body It is unclear what role GPNMB plays in the context of PGRN insufficiency and how they interact and contribute to the development or progression of NDs. This review focuses on the interplay between these two critical proteins within the context of endo-lysosomal health, immune function, and inflammation in their contribution to NDs. Short conclusion PGRN and GPNMB are interrelated proteins that regulate disease-relevant processes and may have value as therapeutic targets to delay disease progression or extend therapeutic windows. Progranulin GPNMB Endo-lysosomal system Immune system Neurodegenerative diseases Neurology. Diseases of the nervous system Rebecca L. Wallings verfasserin aut Oihane Uriarte Huarte verfasserin aut Malú Gámez Tansey verfasserin aut In Journal of Neuroinflammation BMC, 2004 20(2023), 1, Seite 22 (DE-627)391784781 (DE-600)2156455-3 17422094 nnns volume:20 year:2023 number:1 pages:22 https://doi.org/10.1186/s12974-023-02965-w kostenfrei https://doaj.org/article/4ea2394ac7fa4eb59e18243bad63c6a7 kostenfrei https://doi.org/10.1186/s12974-023-02965-w kostenfrei https://doaj.org/toc/1742-2094 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2023 1 22
allfieldsSound	10.1186/s12974-023-02965-w doi (DE-627)DOAJ100203361 (DE-599)DOAJ4ea2394ac7fa4eb59e18243bad63c6a7 DE-627 ger DE-627 rakwb eng RC346-429 Drew A. Gillett verfasserin aut Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Alterations in progranulin (PGRN) expression are associated with multiple neurodegenerative diseases (NDs), including frontotemporal dementia (FTD), Alzheimer’s disease (AD), Parkinson’s disease (PD), and lysosomal storage disorders (LSDs). Recently, the loss of PGRN was shown to result in endo-lysosomal system dysfunction and an age-dependent increase in the expression of another protein associated with NDs, glycoprotein non-metastatic B (GPNMB). Main body It is unclear what role GPNMB plays in the context of PGRN insufficiency and how they interact and contribute to the development or progression of NDs. This review focuses on the interplay between these two critical proteins within the context of endo-lysosomal health, immune function, and inflammation in their contribution to NDs. Short conclusion PGRN and GPNMB are interrelated proteins that regulate disease-relevant processes and may have value as therapeutic targets to delay disease progression or extend therapeutic windows. Progranulin GPNMB Endo-lysosomal system Immune system Neurodegenerative diseases Neurology. Diseases of the nervous system Rebecca L. Wallings verfasserin aut Oihane Uriarte Huarte verfasserin aut Malú Gámez Tansey verfasserin aut In Journal of Neuroinflammation BMC, 2004 20(2023), 1, Seite 22 (DE-627)391784781 (DE-600)2156455-3 17422094 nnns volume:20 year:2023 number:1 pages:22 https://doi.org/10.1186/s12974-023-02965-w kostenfrei https://doaj.org/article/4ea2394ac7fa4eb59e18243bad63c6a7 kostenfrei https://doi.org/10.1186/s12974-023-02965-w kostenfrei https://doaj.org/toc/1742-2094 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2023 1 22
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Gillett</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2023</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Background Alterations in progranulin (PGRN) expression are associated with multiple neurodegenerative diseases (NDs), including frontotemporal dementia (FTD), Alzheimer’s disease (AD), Parkinson’s disease (PD), and lysosomal storage disorders (LSDs). Recently, the loss of PGRN was shown to result in endo-lysosomal system dysfunction and an age-dependent increase in the expression of another protein associated with NDs, glycoprotein non-metastatic B (GPNMB). Main body It is unclear what role GPNMB plays in the context of PGRN insufficiency and how they interact and contribute to the development or progression of NDs. This review focuses on the interplay between these two critical proteins within the context of endo-lysosomal health, immune function, and inflammation in their contribution to NDs. 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callnumber-first	R - Medicine
author	Drew A. Gillett
spellingShingle	Drew A. Gillett misc RC346-429 misc Progranulin misc GPNMB misc Endo-lysosomal system misc Immune system misc Neurodegenerative diseases misc Neurology. Diseases of the nervous system Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease
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topic_title	RC346-429 Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease Progranulin GPNMB Endo-lysosomal system Immune system Neurodegenerative diseases
topic	misc RC346-429 misc Progranulin misc GPNMB misc Endo-lysosomal system misc Immune system misc Neurodegenerative diseases misc Neurology. Diseases of the nervous system
topic_unstemmed	misc RC346-429 misc Progranulin misc GPNMB misc Endo-lysosomal system misc Immune system misc Neurodegenerative diseases misc Neurology. Diseases of the nervous system
topic_browse	misc RC346-429 misc Progranulin misc GPNMB misc Endo-lysosomal system misc Immune system misc Neurodegenerative diseases misc Neurology. Diseases of the nervous system
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title	Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease
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title_full	Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease
author_sort	Drew A. Gillett
journal	Journal of Neuroinflammation
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author_browse	Drew A. Gillett Rebecca L. Wallings Oihane Uriarte Huarte Malú Gámez Tansey
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title_sort	progranulin and gpnmb: interactions in endo-lysosome function and inflammation in neurodegenerative disease
callnumber	RC346-429
title_auth	Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease
abstract	Abstract Background Alterations in progranulin (PGRN) expression are associated with multiple neurodegenerative diseases (NDs), including frontotemporal dementia (FTD), Alzheimer’s disease (AD), Parkinson’s disease (PD), and lysosomal storage disorders (LSDs). Recently, the loss of PGRN was shown to result in endo-lysosomal system dysfunction and an age-dependent increase in the expression of another protein associated with NDs, glycoprotein non-metastatic B (GPNMB). Main body It is unclear what role GPNMB plays in the context of PGRN insufficiency and how they interact and contribute to the development or progression of NDs. This review focuses on the interplay between these two critical proteins within the context of endo-lysosomal health, immune function, and inflammation in their contribution to NDs. Short conclusion PGRN and GPNMB are interrelated proteins that regulate disease-relevant processes and may have value as therapeutic targets to delay disease progression or extend therapeutic windows.
abstractGer	Abstract Background Alterations in progranulin (PGRN) expression are associated with multiple neurodegenerative diseases (NDs), including frontotemporal dementia (FTD), Alzheimer’s disease (AD), Parkinson’s disease (PD), and lysosomal storage disorders (LSDs). Recently, the loss of PGRN was shown to result in endo-lysosomal system dysfunction and an age-dependent increase in the expression of another protein associated with NDs, glycoprotein non-metastatic B (GPNMB). Main body It is unclear what role GPNMB plays in the context of PGRN insufficiency and how they interact and contribute to the development or progression of NDs. This review focuses on the interplay between these two critical proteins within the context of endo-lysosomal health, immune function, and inflammation in their contribution to NDs. Short conclusion PGRN and GPNMB are interrelated proteins that regulate disease-relevant processes and may have value as therapeutic targets to delay disease progression or extend therapeutic windows.
abstract_unstemmed	Abstract Background Alterations in progranulin (PGRN) expression are associated with multiple neurodegenerative diseases (NDs), including frontotemporal dementia (FTD), Alzheimer’s disease (AD), Parkinson’s disease (PD), and lysosomal storage disorders (LSDs). Recently, the loss of PGRN was shown to result in endo-lysosomal system dysfunction and an age-dependent increase in the expression of another protein associated with NDs, glycoprotein non-metastatic B (GPNMB). Main body It is unclear what role GPNMB plays in the context of PGRN insufficiency and how they interact and contribute to the development or progression of NDs. This review focuses on the interplay between these two critical proteins within the context of endo-lysosomal health, immune function, and inflammation in their contribution to NDs. Short conclusion PGRN and GPNMB are interrelated proteins that regulate disease-relevant processes and may have value as therapeutic targets to delay disease progression or extend therapeutic windows.
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title_short	Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease
url	https://doi.org/10.1186/s12974-023-02965-w https://doaj.org/article/4ea2394ac7fa4eb59e18243bad63c6a7 https://doaj.org/toc/1742-2094
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