Meta-analysis of the role of neutrophil to lymphocyte ratio in neonatal sepsis
Abstract Introduction The neutrophil to lymphocyte ratio (NLR), an inflammatory biomarker, measures innate-adaptive immune system balance. In this systematic review and meta-analysis, we aim to analyze the current literature to evaluate the diagnostic role of NLR in neonatal sepsis. Methods PubMed,...
Ausführliche Beschreibung
Autor*in: |
Jingyang Chen [verfasserIn] Sanaz Yasrebinia [verfasserIn] Arshin Ghaedi [verfasserIn] Monireh Khanzadeh [verfasserIn] Stephan Quintin [verfasserIn] Abeer Dagra [verfasserIn] Rodeania Peart [verfasserIn] Brandon Lucke-Wold [verfasserIn] Shokoufeh Khanzadeh [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2023 |
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Übergeordnetes Werk: |
In: BMC Infectious Diseases - BMC, 2003, 23(2023), 1, Seite 13 |
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Übergeordnetes Werk: |
volume:23 ; year:2023 ; number:1 ; pages:13 |
Links: |
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DOI / URN: |
10.1186/s12879-023-08800-0 |
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Katalog-ID: |
DOAJ10022007X |
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520 | |a Abstract Introduction The neutrophil to lymphocyte ratio (NLR), an inflammatory biomarker, measures innate-adaptive immune system balance. In this systematic review and meta-analysis, we aim to analyze the current literature to evaluate the diagnostic role of NLR in neonatal sepsis. Methods PubMed, Web of Science, and Scopus were used to conduct a systematic search for relevant publications published before May 14, 2022. Results Thirty studies, including 2328 neonates with sepsis and 1800 neonates in the control group, were included in our meta-analysis. The results indicated that NLR is higher in neonates with sepsis compared to healthy controls (SMD = 1.81, 95% CI = 1.14–2.48, P-value < 0.001) in either prospective (SMD = 2.38, 95% CI = 1.40–3.35, P-value < 0.001) or retrospective studies (SMD = 0.87, 95% CI = 0.63–1.12, P-value < 0.001) with a pooled sensitivity of 79% (95% CI = 62–90%), and a pooled specificity of 91% (95% CI = 73–97%). Also, we found that NLR is higher in neonates with sepsis compared to those who were suspected of sepsis but eventually had negative blood cultures (SMD =1.99, 95% CI = 0.76–3.22, P-value = 0.002) with a pooled sensitivity of 0.79% (95% CI = 0.69–0.86%), and a pooled specificity of 73% (95% CI = 54–85%). In addition, neonates with sepsis had elevated levels of NLR compared to other ICU admitted neonates (SMD = 0.73, 95% CI = 0.63–0.84, P < 0.001). The pooled sensitivity was 0.65 (95% CI, 0.55–0.80), and the pooled specificity was 0.80 (95% CI, 0.68–0.88). Conclusion Our findings support NLR as a promising biomarker that can be readily integrated into clinical settings to aid in diagnosing neonatal sepsis. As evidenced by our results, restoring balance to the innate and adaptive immune system may serve as attractive therapeutic targets. Theoretically, a reduction in NLR values could be used to measure therapeutic efficacy, reflecting the restoration of balance within these systems. | ||
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10.1186/s12879-023-08800-0 doi (DE-627)DOAJ10022007X (DE-599)DOAJa6d5ce6e08604cef83aea1c78c63fadb DE-627 ger DE-627 rakwb eng RC109-216 Jingyang Chen verfasserin aut Meta-analysis of the role of neutrophil to lymphocyte ratio in neonatal sepsis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Introduction The neutrophil to lymphocyte ratio (NLR), an inflammatory biomarker, measures innate-adaptive immune system balance. In this systematic review and meta-analysis, we aim to analyze the current literature to evaluate the diagnostic role of NLR in neonatal sepsis. Methods PubMed, Web of Science, and Scopus were used to conduct a systematic search for relevant publications published before May 14, 2022. Results Thirty studies, including 2328 neonates with sepsis and 1800 neonates in the control group, were included in our meta-analysis. The results indicated that NLR is higher in neonates with sepsis compared to healthy controls (SMD = 1.81, 95% CI = 1.14–2.48, P-value < 0.001) in either prospective (SMD = 2.38, 95% CI = 1.40–3.35, P-value < 0.001) or retrospective studies (SMD = 0.87, 95% CI = 0.63–1.12, P-value < 0.001) with a pooled sensitivity of 79% (95% CI = 62–90%), and a pooled specificity of 91% (95% CI = 73–97%). Also, we found that NLR is higher in neonates with sepsis compared to those who were suspected of sepsis but eventually had negative blood cultures (SMD =1.99, 95% CI = 0.76–3.22, P-value = 0.002) with a pooled sensitivity of 0.79% (95% CI = 0.69–0.86%), and a pooled specificity of 73% (95% CI = 54–85%). In addition, neonates with sepsis had elevated levels of NLR compared to other ICU admitted neonates (SMD = 0.73, 95% CI = 0.63–0.84, P < 0.001). The pooled sensitivity was 0.65 (95% CI, 0.55–0.80), and the pooled specificity was 0.80 (95% CI, 0.68–0.88). Conclusion Our findings support NLR as a promising biomarker that can be readily integrated into clinical settings to aid in diagnosing neonatal sepsis. As evidenced by our results, restoring balance to the innate and adaptive immune system may serve as attractive therapeutic targets. Theoretically, a reduction in NLR values could be used to measure therapeutic efficacy, reflecting the restoration of balance within these systems. Neutrophil to lymphocyte ratio Neonatal sepsis Systematic review Meta-analysis Infectious and parasitic diseases Sanaz Yasrebinia verfasserin aut Arshin Ghaedi verfasserin aut Monireh Khanzadeh verfasserin aut Stephan Quintin verfasserin aut Abeer Dagra verfasserin aut Rodeania Peart verfasserin aut Brandon Lucke-Wold verfasserin aut Shokoufeh Khanzadeh verfasserin aut In BMC Infectious Diseases BMC, 2003 23(2023), 1, Seite 13 (DE-627)326645381 (DE-600)2041550-3 14712334 nnns volume:23 year:2023 number:1 pages:13 https://doi.org/10.1186/s12879-023-08800-0 kostenfrei https://doaj.org/article/a6d5ce6e08604cef83aea1c78c63fadb kostenfrei https://doi.org/10.1186/s12879-023-08800-0 kostenfrei https://doaj.org/toc/1471-2334 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 13 |
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10.1186/s12879-023-08800-0 doi (DE-627)DOAJ10022007X (DE-599)DOAJa6d5ce6e08604cef83aea1c78c63fadb DE-627 ger DE-627 rakwb eng RC109-216 Jingyang Chen verfasserin aut Meta-analysis of the role of neutrophil to lymphocyte ratio in neonatal sepsis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Introduction The neutrophil to lymphocyte ratio (NLR), an inflammatory biomarker, measures innate-adaptive immune system balance. In this systematic review and meta-analysis, we aim to analyze the current literature to evaluate the diagnostic role of NLR in neonatal sepsis. Methods PubMed, Web of Science, and Scopus were used to conduct a systematic search for relevant publications published before May 14, 2022. Results Thirty studies, including 2328 neonates with sepsis and 1800 neonates in the control group, were included in our meta-analysis. The results indicated that NLR is higher in neonates with sepsis compared to healthy controls (SMD = 1.81, 95% CI = 1.14–2.48, P-value < 0.001) in either prospective (SMD = 2.38, 95% CI = 1.40–3.35, P-value < 0.001) or retrospective studies (SMD = 0.87, 95% CI = 0.63–1.12, P-value < 0.001) with a pooled sensitivity of 79% (95% CI = 62–90%), and a pooled specificity of 91% (95% CI = 73–97%). Also, we found that NLR is higher in neonates with sepsis compared to those who were suspected of sepsis but eventually had negative blood cultures (SMD =1.99, 95% CI = 0.76–3.22, P-value = 0.002) with a pooled sensitivity of 0.79% (95% CI = 0.69–0.86%), and a pooled specificity of 73% (95% CI = 54–85%). In addition, neonates with sepsis had elevated levels of NLR compared to other ICU admitted neonates (SMD = 0.73, 95% CI = 0.63–0.84, P < 0.001). The pooled sensitivity was 0.65 (95% CI, 0.55–0.80), and the pooled specificity was 0.80 (95% CI, 0.68–0.88). Conclusion Our findings support NLR as a promising biomarker that can be readily integrated into clinical settings to aid in diagnosing neonatal sepsis. As evidenced by our results, restoring balance to the innate and adaptive immune system may serve as attractive therapeutic targets. Theoretically, a reduction in NLR values could be used to measure therapeutic efficacy, reflecting the restoration of balance within these systems. Neutrophil to lymphocyte ratio Neonatal sepsis Systematic review Meta-analysis Infectious and parasitic diseases Sanaz Yasrebinia verfasserin aut Arshin Ghaedi verfasserin aut Monireh Khanzadeh verfasserin aut Stephan Quintin verfasserin aut Abeer Dagra verfasserin aut Rodeania Peart verfasserin aut Brandon Lucke-Wold verfasserin aut Shokoufeh Khanzadeh verfasserin aut In BMC Infectious Diseases BMC, 2003 23(2023), 1, Seite 13 (DE-627)326645381 (DE-600)2041550-3 14712334 nnns volume:23 year:2023 number:1 pages:13 https://doi.org/10.1186/s12879-023-08800-0 kostenfrei https://doaj.org/article/a6d5ce6e08604cef83aea1c78c63fadb kostenfrei https://doi.org/10.1186/s12879-023-08800-0 kostenfrei https://doaj.org/toc/1471-2334 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 13 |
allfields_unstemmed |
10.1186/s12879-023-08800-0 doi (DE-627)DOAJ10022007X (DE-599)DOAJa6d5ce6e08604cef83aea1c78c63fadb DE-627 ger DE-627 rakwb eng RC109-216 Jingyang Chen verfasserin aut Meta-analysis of the role of neutrophil to lymphocyte ratio in neonatal sepsis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Introduction The neutrophil to lymphocyte ratio (NLR), an inflammatory biomarker, measures innate-adaptive immune system balance. In this systematic review and meta-analysis, we aim to analyze the current literature to evaluate the diagnostic role of NLR in neonatal sepsis. Methods PubMed, Web of Science, and Scopus were used to conduct a systematic search for relevant publications published before May 14, 2022. Results Thirty studies, including 2328 neonates with sepsis and 1800 neonates in the control group, were included in our meta-analysis. The results indicated that NLR is higher in neonates with sepsis compared to healthy controls (SMD = 1.81, 95% CI = 1.14–2.48, P-value < 0.001) in either prospective (SMD = 2.38, 95% CI = 1.40–3.35, P-value < 0.001) or retrospective studies (SMD = 0.87, 95% CI = 0.63–1.12, P-value < 0.001) with a pooled sensitivity of 79% (95% CI = 62–90%), and a pooled specificity of 91% (95% CI = 73–97%). Also, we found that NLR is higher in neonates with sepsis compared to those who were suspected of sepsis but eventually had negative blood cultures (SMD =1.99, 95% CI = 0.76–3.22, P-value = 0.002) with a pooled sensitivity of 0.79% (95% CI = 0.69–0.86%), and a pooled specificity of 73% (95% CI = 54–85%). In addition, neonates with sepsis had elevated levels of NLR compared to other ICU admitted neonates (SMD = 0.73, 95% CI = 0.63–0.84, P < 0.001). The pooled sensitivity was 0.65 (95% CI, 0.55–0.80), and the pooled specificity was 0.80 (95% CI, 0.68–0.88). Conclusion Our findings support NLR as a promising biomarker that can be readily integrated into clinical settings to aid in diagnosing neonatal sepsis. As evidenced by our results, restoring balance to the innate and adaptive immune system may serve as attractive therapeutic targets. Theoretically, a reduction in NLR values could be used to measure therapeutic efficacy, reflecting the restoration of balance within these systems. Neutrophil to lymphocyte ratio Neonatal sepsis Systematic review Meta-analysis Infectious and parasitic diseases Sanaz Yasrebinia verfasserin aut Arshin Ghaedi verfasserin aut Monireh Khanzadeh verfasserin aut Stephan Quintin verfasserin aut Abeer Dagra verfasserin aut Rodeania Peart verfasserin aut Brandon Lucke-Wold verfasserin aut Shokoufeh Khanzadeh verfasserin aut In BMC Infectious Diseases BMC, 2003 23(2023), 1, Seite 13 (DE-627)326645381 (DE-600)2041550-3 14712334 nnns volume:23 year:2023 number:1 pages:13 https://doi.org/10.1186/s12879-023-08800-0 kostenfrei https://doaj.org/article/a6d5ce6e08604cef83aea1c78c63fadb kostenfrei https://doi.org/10.1186/s12879-023-08800-0 kostenfrei https://doaj.org/toc/1471-2334 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 13 |
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10.1186/s12879-023-08800-0 doi (DE-627)DOAJ10022007X (DE-599)DOAJa6d5ce6e08604cef83aea1c78c63fadb DE-627 ger DE-627 rakwb eng RC109-216 Jingyang Chen verfasserin aut Meta-analysis of the role of neutrophil to lymphocyte ratio in neonatal sepsis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Introduction The neutrophil to lymphocyte ratio (NLR), an inflammatory biomarker, measures innate-adaptive immune system balance. In this systematic review and meta-analysis, we aim to analyze the current literature to evaluate the diagnostic role of NLR in neonatal sepsis. Methods PubMed, Web of Science, and Scopus were used to conduct a systematic search for relevant publications published before May 14, 2022. Results Thirty studies, including 2328 neonates with sepsis and 1800 neonates in the control group, were included in our meta-analysis. The results indicated that NLR is higher in neonates with sepsis compared to healthy controls (SMD = 1.81, 95% CI = 1.14–2.48, P-value < 0.001) in either prospective (SMD = 2.38, 95% CI = 1.40–3.35, P-value < 0.001) or retrospective studies (SMD = 0.87, 95% CI = 0.63–1.12, P-value < 0.001) with a pooled sensitivity of 79% (95% CI = 62–90%), and a pooled specificity of 91% (95% CI = 73–97%). Also, we found that NLR is higher in neonates with sepsis compared to those who were suspected of sepsis but eventually had negative blood cultures (SMD =1.99, 95% CI = 0.76–3.22, P-value = 0.002) with a pooled sensitivity of 0.79% (95% CI = 0.69–0.86%), and a pooled specificity of 73% (95% CI = 54–85%). In addition, neonates with sepsis had elevated levels of NLR compared to other ICU admitted neonates (SMD = 0.73, 95% CI = 0.63–0.84, P < 0.001). The pooled sensitivity was 0.65 (95% CI, 0.55–0.80), and the pooled specificity was 0.80 (95% CI, 0.68–0.88). Conclusion Our findings support NLR as a promising biomarker that can be readily integrated into clinical settings to aid in diagnosing neonatal sepsis. As evidenced by our results, restoring balance to the innate and adaptive immune system may serve as attractive therapeutic targets. Theoretically, a reduction in NLR values could be used to measure therapeutic efficacy, reflecting the restoration of balance within these systems. Neutrophil to lymphocyte ratio Neonatal sepsis Systematic review Meta-analysis Infectious and parasitic diseases Sanaz Yasrebinia verfasserin aut Arshin Ghaedi verfasserin aut Monireh Khanzadeh verfasserin aut Stephan Quintin verfasserin aut Abeer Dagra verfasserin aut Rodeania Peart verfasserin aut Brandon Lucke-Wold verfasserin aut Shokoufeh Khanzadeh verfasserin aut In BMC Infectious Diseases BMC, 2003 23(2023), 1, Seite 13 (DE-627)326645381 (DE-600)2041550-3 14712334 nnns volume:23 year:2023 number:1 pages:13 https://doi.org/10.1186/s12879-023-08800-0 kostenfrei https://doaj.org/article/a6d5ce6e08604cef83aea1c78c63fadb kostenfrei https://doi.org/10.1186/s12879-023-08800-0 kostenfrei https://doaj.org/toc/1471-2334 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 13 |
allfieldsSound |
10.1186/s12879-023-08800-0 doi (DE-627)DOAJ10022007X (DE-599)DOAJa6d5ce6e08604cef83aea1c78c63fadb DE-627 ger DE-627 rakwb eng RC109-216 Jingyang Chen verfasserin aut Meta-analysis of the role of neutrophil to lymphocyte ratio in neonatal sepsis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Introduction The neutrophil to lymphocyte ratio (NLR), an inflammatory biomarker, measures innate-adaptive immune system balance. In this systematic review and meta-analysis, we aim to analyze the current literature to evaluate the diagnostic role of NLR in neonatal sepsis. Methods PubMed, Web of Science, and Scopus were used to conduct a systematic search for relevant publications published before May 14, 2022. Results Thirty studies, including 2328 neonates with sepsis and 1800 neonates in the control group, were included in our meta-analysis. The results indicated that NLR is higher in neonates with sepsis compared to healthy controls (SMD = 1.81, 95% CI = 1.14–2.48, P-value < 0.001) in either prospective (SMD = 2.38, 95% CI = 1.40–3.35, P-value < 0.001) or retrospective studies (SMD = 0.87, 95% CI = 0.63–1.12, P-value < 0.001) with a pooled sensitivity of 79% (95% CI = 62–90%), and a pooled specificity of 91% (95% CI = 73–97%). Also, we found that NLR is higher in neonates with sepsis compared to those who were suspected of sepsis but eventually had negative blood cultures (SMD =1.99, 95% CI = 0.76–3.22, P-value = 0.002) with a pooled sensitivity of 0.79% (95% CI = 0.69–0.86%), and a pooled specificity of 73% (95% CI = 54–85%). In addition, neonates with sepsis had elevated levels of NLR compared to other ICU admitted neonates (SMD = 0.73, 95% CI = 0.63–0.84, P < 0.001). The pooled sensitivity was 0.65 (95% CI, 0.55–0.80), and the pooled specificity was 0.80 (95% CI, 0.68–0.88). Conclusion Our findings support NLR as a promising biomarker that can be readily integrated into clinical settings to aid in diagnosing neonatal sepsis. As evidenced by our results, restoring balance to the innate and adaptive immune system may serve as attractive therapeutic targets. Theoretically, a reduction in NLR values could be used to measure therapeutic efficacy, reflecting the restoration of balance within these systems. Neutrophil to lymphocyte ratio Neonatal sepsis Systematic review Meta-analysis Infectious and parasitic diseases Sanaz Yasrebinia verfasserin aut Arshin Ghaedi verfasserin aut Monireh Khanzadeh verfasserin aut Stephan Quintin verfasserin aut Abeer Dagra verfasserin aut Rodeania Peart verfasserin aut Brandon Lucke-Wold verfasserin aut Shokoufeh Khanzadeh verfasserin aut In BMC Infectious Diseases BMC, 2003 23(2023), 1, Seite 13 (DE-627)326645381 (DE-600)2041550-3 14712334 nnns volume:23 year:2023 number:1 pages:13 https://doi.org/10.1186/s12879-023-08800-0 kostenfrei https://doaj.org/article/a6d5ce6e08604cef83aea1c78c63fadb kostenfrei https://doi.org/10.1186/s12879-023-08800-0 kostenfrei https://doaj.org/toc/1471-2334 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 13 |
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Jingyang Chen Sanaz Yasrebinia Arshin Ghaedi Monireh Khanzadeh Stephan Quintin Abeer Dagra Rodeania Peart Brandon Lucke-Wold Shokoufeh Khanzadeh |
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meta-analysis of the role of neutrophil to lymphocyte ratio in neonatal sepsis |
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Meta-analysis of the role of neutrophil to lymphocyte ratio in neonatal sepsis |
abstract |
Abstract Introduction The neutrophil to lymphocyte ratio (NLR), an inflammatory biomarker, measures innate-adaptive immune system balance. In this systematic review and meta-analysis, we aim to analyze the current literature to evaluate the diagnostic role of NLR in neonatal sepsis. Methods PubMed, Web of Science, and Scopus were used to conduct a systematic search for relevant publications published before May 14, 2022. Results Thirty studies, including 2328 neonates with sepsis and 1800 neonates in the control group, were included in our meta-analysis. The results indicated that NLR is higher in neonates with sepsis compared to healthy controls (SMD = 1.81, 95% CI = 1.14–2.48, P-value < 0.001) in either prospective (SMD = 2.38, 95% CI = 1.40–3.35, P-value < 0.001) or retrospective studies (SMD = 0.87, 95% CI = 0.63–1.12, P-value < 0.001) with a pooled sensitivity of 79% (95% CI = 62–90%), and a pooled specificity of 91% (95% CI = 73–97%). Also, we found that NLR is higher in neonates with sepsis compared to those who were suspected of sepsis but eventually had negative blood cultures (SMD =1.99, 95% CI = 0.76–3.22, P-value = 0.002) with a pooled sensitivity of 0.79% (95% CI = 0.69–0.86%), and a pooled specificity of 73% (95% CI = 54–85%). In addition, neonates with sepsis had elevated levels of NLR compared to other ICU admitted neonates (SMD = 0.73, 95% CI = 0.63–0.84, P < 0.001). The pooled sensitivity was 0.65 (95% CI, 0.55–0.80), and the pooled specificity was 0.80 (95% CI, 0.68–0.88). Conclusion Our findings support NLR as a promising biomarker that can be readily integrated into clinical settings to aid in diagnosing neonatal sepsis. As evidenced by our results, restoring balance to the innate and adaptive immune system may serve as attractive therapeutic targets. Theoretically, a reduction in NLR values could be used to measure therapeutic efficacy, reflecting the restoration of balance within these systems. |
abstractGer |
Abstract Introduction The neutrophil to lymphocyte ratio (NLR), an inflammatory biomarker, measures innate-adaptive immune system balance. In this systematic review and meta-analysis, we aim to analyze the current literature to evaluate the diagnostic role of NLR in neonatal sepsis. Methods PubMed, Web of Science, and Scopus were used to conduct a systematic search for relevant publications published before May 14, 2022. Results Thirty studies, including 2328 neonates with sepsis and 1800 neonates in the control group, were included in our meta-analysis. The results indicated that NLR is higher in neonates with sepsis compared to healthy controls (SMD = 1.81, 95% CI = 1.14–2.48, P-value < 0.001) in either prospective (SMD = 2.38, 95% CI = 1.40–3.35, P-value < 0.001) or retrospective studies (SMD = 0.87, 95% CI = 0.63–1.12, P-value < 0.001) with a pooled sensitivity of 79% (95% CI = 62–90%), and a pooled specificity of 91% (95% CI = 73–97%). Also, we found that NLR is higher in neonates with sepsis compared to those who were suspected of sepsis but eventually had negative blood cultures (SMD =1.99, 95% CI = 0.76–3.22, P-value = 0.002) with a pooled sensitivity of 0.79% (95% CI = 0.69–0.86%), and a pooled specificity of 73% (95% CI = 54–85%). In addition, neonates with sepsis had elevated levels of NLR compared to other ICU admitted neonates (SMD = 0.73, 95% CI = 0.63–0.84, P < 0.001). The pooled sensitivity was 0.65 (95% CI, 0.55–0.80), and the pooled specificity was 0.80 (95% CI, 0.68–0.88). Conclusion Our findings support NLR as a promising biomarker that can be readily integrated into clinical settings to aid in diagnosing neonatal sepsis. As evidenced by our results, restoring balance to the innate and adaptive immune system may serve as attractive therapeutic targets. Theoretically, a reduction in NLR values could be used to measure therapeutic efficacy, reflecting the restoration of balance within these systems. |
abstract_unstemmed |
Abstract Introduction The neutrophil to lymphocyte ratio (NLR), an inflammatory biomarker, measures innate-adaptive immune system balance. In this systematic review and meta-analysis, we aim to analyze the current literature to evaluate the diagnostic role of NLR in neonatal sepsis. Methods PubMed, Web of Science, and Scopus were used to conduct a systematic search for relevant publications published before May 14, 2022. Results Thirty studies, including 2328 neonates with sepsis and 1800 neonates in the control group, were included in our meta-analysis. The results indicated that NLR is higher in neonates with sepsis compared to healthy controls (SMD = 1.81, 95% CI = 1.14–2.48, P-value < 0.001) in either prospective (SMD = 2.38, 95% CI = 1.40–3.35, P-value < 0.001) or retrospective studies (SMD = 0.87, 95% CI = 0.63–1.12, P-value < 0.001) with a pooled sensitivity of 79% (95% CI = 62–90%), and a pooled specificity of 91% (95% CI = 73–97%). Also, we found that NLR is higher in neonates with sepsis compared to those who were suspected of sepsis but eventually had negative blood cultures (SMD =1.99, 95% CI = 0.76–3.22, P-value = 0.002) with a pooled sensitivity of 0.79% (95% CI = 0.69–0.86%), and a pooled specificity of 73% (95% CI = 54–85%). In addition, neonates with sepsis had elevated levels of NLR compared to other ICU admitted neonates (SMD = 0.73, 95% CI = 0.63–0.84, P < 0.001). The pooled sensitivity was 0.65 (95% CI, 0.55–0.80), and the pooled specificity was 0.80 (95% CI, 0.68–0.88). Conclusion Our findings support NLR as a promising biomarker that can be readily integrated into clinical settings to aid in diagnosing neonatal sepsis. As evidenced by our results, restoring balance to the innate and adaptive immune system may serve as attractive therapeutic targets. Theoretically, a reduction in NLR values could be used to measure therapeutic efficacy, reflecting the restoration of balance within these systems. |
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Meta-analysis of the role of neutrophil to lymphocyte ratio in neonatal sepsis |
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