Cell-in-cell structure in cancer: evading strategies from anti-cancer therapies

One of the regulated forms of cell death is the cell-in-cell (CIC) structure, in which a surviving cell is engulfed by another cell, a mechanism that causes the death of the engulfed cell by an adjacent cell. Several investigators have previously shown that the presence of CICs is an independent ris...
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Autor*in:	Kohei Okuyama [verfasserIn] Hiromasa Fukushima [verfasserIn] Tomofumi Naruse [verfasserIn] Souichi Yanamoto [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	cell-in-cell structure entosis phagocytosis chemotherapy targeted therapy radiotherapy

Übergeordnetes Werk:	In: Frontiers in Oncology - Frontiers Media S.A., 2012, 13(2023)
Übergeordnetes Werk:	volume:13 ; year:2023

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fonc.2023.1248097

Katalog-ID:	DOAJ100241875

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allfieldsSound	10.3389/fonc.2023.1248097 doi (DE-627)DOAJ100241875 (DE-599)DOAJfeef16d5e80746caac23054c6fef60a3 DE-627 ger DE-627 rakwb eng RC254-282 Kohei Okuyama verfasserin aut Cell-in-cell structure in cancer: evading strategies from anti-cancer therapies 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier One of the regulated forms of cell death is the cell-in-cell (CIC) structure, in which a surviving cell is engulfed by another cell, a mechanism that causes the death of the engulfed cell by an adjacent cell. Several investigators have previously shown that the presence of CICs is an independent risk factor significantly associated with decreased survival in patients with various types of cancer. In this review, we summarize the role of CIC in the tumor microenvironment (TME), including changes and crosstalk of molecules and proteins in the surrounding CIC, and the role of these factors in contributing to therapeutic resistance acquisition. Moreover, CIC structure formation is influenced by the modulation of TME, which may lead to changes in cellular properties. Future use of CIC as a clinical diagnostic tool will require a better understanding of the effects of chemotherapy on CIC, biomarkers for each CIC formation process, and the development of automated CIC detection methods in tissue sections of tumor specimens. cell-in-cell structure entosis phagocytosis chemotherapy targeted therapy radiotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Kohei Okuyama verfasserin aut Kohei Okuyama verfasserin aut Hiromasa Fukushima verfasserin aut Tomofumi Naruse verfasserin aut Souichi Yanamoto verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 13(2023) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:13 year:2023 https://doi.org/10.3389/fonc.2023.1248097 kostenfrei https://doaj.org/article/feef16d5e80746caac23054c6fef60a3 kostenfrei https://www.frontiersin.org/articles/10.3389/fonc.2023.1248097/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023
language	English
source	In Frontiers in Oncology 13(2023) volume:13 year:2023
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container_title	Frontiers in Oncology
authorswithroles_txt_mv	Kohei Okuyama @@aut@@ Hiromasa Fukushima @@aut@@ Tomofumi Naruse @@aut@@ Souichi Yanamoto @@aut@@
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callnumber-first	R - Medicine
author	Kohei Okuyama
spellingShingle	Kohei Okuyama misc RC254-282 misc cell-in-cell structure misc entosis misc phagocytosis misc chemotherapy misc targeted therapy misc radiotherapy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cell-in-cell structure in cancer: evading strategies from anti-cancer therapies
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topic_title	RC254-282 Cell-in-cell structure in cancer: evading strategies from anti-cancer therapies cell-in-cell structure entosis phagocytosis chemotherapy targeted therapy radiotherapy
topic	misc RC254-282 misc cell-in-cell structure misc entosis misc phagocytosis misc chemotherapy misc targeted therapy misc radiotherapy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc cell-in-cell structure misc entosis misc phagocytosis misc chemotherapy misc targeted therapy misc radiotherapy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Cell-in-cell structure in cancer: evading strategies from anti-cancer therapies
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title_sort	cell-in-cell structure in cancer: evading strategies from anti-cancer therapies
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title_auth	Cell-in-cell structure in cancer: evading strategies from anti-cancer therapies
abstract	One of the regulated forms of cell death is the cell-in-cell (CIC) structure, in which a surviving cell is engulfed by another cell, a mechanism that causes the death of the engulfed cell by an adjacent cell. Several investigators have previously shown that the presence of CICs is an independent risk factor significantly associated with decreased survival in patients with various types of cancer. In this review, we summarize the role of CIC in the tumor microenvironment (TME), including changes and crosstalk of molecules and proteins in the surrounding CIC, and the role of these factors in contributing to therapeutic resistance acquisition. Moreover, CIC structure formation is influenced by the modulation of TME, which may lead to changes in cellular properties. Future use of CIC as a clinical diagnostic tool will require a better understanding of the effects of chemotherapy on CIC, biomarkers for each CIC formation process, and the development of automated CIC detection methods in tissue sections of tumor specimens.
abstractGer	One of the regulated forms of cell death is the cell-in-cell (CIC) structure, in which a surviving cell is engulfed by another cell, a mechanism that causes the death of the engulfed cell by an adjacent cell. Several investigators have previously shown that the presence of CICs is an independent risk factor significantly associated with decreased survival in patients with various types of cancer. In this review, we summarize the role of CIC in the tumor microenvironment (TME), including changes and crosstalk of molecules and proteins in the surrounding CIC, and the role of these factors in contributing to therapeutic resistance acquisition. Moreover, CIC structure formation is influenced by the modulation of TME, which may lead to changes in cellular properties. Future use of CIC as a clinical diagnostic tool will require a better understanding of the effects of chemotherapy on CIC, biomarkers for each CIC formation process, and the development of automated CIC detection methods in tissue sections of tumor specimens.
abstract_unstemmed	One of the regulated forms of cell death is the cell-in-cell (CIC) structure, in which a surviving cell is engulfed by another cell, a mechanism that causes the death of the engulfed cell by an adjacent cell. Several investigators have previously shown that the presence of CICs is an independent risk factor significantly associated with decreased survival in patients with various types of cancer. In this review, we summarize the role of CIC in the tumor microenvironment (TME), including changes and crosstalk of molecules and proteins in the surrounding CIC, and the role of these factors in contributing to therapeutic resistance acquisition. Moreover, CIC structure formation is influenced by the modulation of TME, which may lead to changes in cellular properties. Future use of CIC as a clinical diagnostic tool will require a better understanding of the effects of chemotherapy on CIC, biomarkers for each CIC formation process, and the development of automated CIC detection methods in tissue sections of tumor specimens.
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title_short	Cell-in-cell structure in cancer: evading strategies from anti-cancer therapies
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