STING in tumors: a focus on non-innate immune pathways

Cyclic GMP-AMP synthase (cGAS) and downstream stimulator of interferon genes (STING) are involved in mediating innate immunity by promoting the release of interferon and other inflammatory factors. Mitochondrial DNA (mtDNA) with a double-stranded structure has greater efficiency and sensitivity in b...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Jiaying Yang [verfasserIn] Mei Yang [verfasserIn] Yingtong Wang [verfasserIn] Jicheng Sun [verfasserIn] Yiran Liu [verfasserIn] Ling Zhang [verfasserIn] Baofeng Guo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	mtDNA cGAS-STING PD-L1 TME extracellular vesicles

Übergeordnetes Werk:	In: Frontiers in Cell and Developmental Biology - Frontiers Media S.A., 2014, 11(2023)
Übergeordnetes Werk:	volume:11 ; year:2023

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fcell.2023.1278461

Katalog-ID:	DOAJ100275141

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allfieldsSound	10.3389/fcell.2023.1278461 doi (DE-627)DOAJ100275141 (DE-599)DOAJ414e52227e5c41d5a13456d6ab8753b5 DE-627 ger DE-627 rakwb eng QH301-705.5 Jiaying Yang verfasserin aut STING in tumors: a focus on non-innate immune pathways 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cyclic GMP-AMP synthase (cGAS) and downstream stimulator of interferon genes (STING) are involved in mediating innate immunity by promoting the release of interferon and other inflammatory factors. Mitochondrial DNA (mtDNA) with a double-stranded structure has greater efficiency and sensitivity in being detected by DNA sensors and thus has an important role in the activation of the cGAS-STING pathway. Many previous findings suggest that the cGAS-STING pathway-mediated innate immune regulation is the most important aspect affecting tumor survival, not only in its anti-tumor role but also in shaping the immunosuppressive tumor microenvironment (TME) through a variety of pathways. However, recent studies have shown that STING regulation of non-immune pathways is equally profound and also involved in tumor cell progression. In this paper, we will focus on the non-innate immune system pathways, in which the cGAS-STING pathway also plays an important role in cancer. mtDNA cGAS-STING PD-L1 TME extracellular vesicles Biology (General) Jiaying Yang verfasserin aut Mei Yang verfasserin aut Yingtong Wang verfasserin aut Jicheng Sun verfasserin aut Yiran Liu verfasserin aut Ling Zhang verfasserin aut Baofeng Guo verfasserin aut In Frontiers in Cell and Developmental Biology Frontiers Media S.A., 2014 11(2023) (DE-627)770398138 (DE-600)2737824-X 2296634X nnns volume:11 year:2023 https://doi.org/10.3389/fcell.2023.1278461 kostenfrei https://doaj.org/article/414e52227e5c41d5a13456d6ab8753b5 kostenfrei https://www.frontiersin.org/articles/10.3389/fcell.2023.1278461/full kostenfrei https://doaj.org/toc/2296-634X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2023
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authorswithroles_txt_mv	Jiaying Yang @@aut@@ Mei Yang @@aut@@ Yingtong Wang @@aut@@ Jicheng Sun @@aut@@ Yiran Liu @@aut@@ Ling Zhang @@aut@@ Baofeng Guo @@aut@@
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author	Jiaying Yang
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title	STING in tumors: a focus on non-innate immune pathways
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title_full	STING in tumors: a focus on non-innate immune pathways
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title_sort	sting in tumors: a focus on non-innate immune pathways
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title_auth	STING in tumors: a focus on non-innate immune pathways
abstract	Cyclic GMP-AMP synthase (cGAS) and downstream stimulator of interferon genes (STING) are involved in mediating innate immunity by promoting the release of interferon and other inflammatory factors. Mitochondrial DNA (mtDNA) with a double-stranded structure has greater efficiency and sensitivity in being detected by DNA sensors and thus has an important role in the activation of the cGAS-STING pathway. Many previous findings suggest that the cGAS-STING pathway-mediated innate immune regulation is the most important aspect affecting tumor survival, not only in its anti-tumor role but also in shaping the immunosuppressive tumor microenvironment (TME) through a variety of pathways. However, recent studies have shown that STING regulation of non-immune pathways is equally profound and also involved in tumor cell progression. In this paper, we will focus on the non-innate immune system pathways, in which the cGAS-STING pathway also plays an important role in cancer.
abstractGer	Cyclic GMP-AMP synthase (cGAS) and downstream stimulator of interferon genes (STING) are involved in mediating innate immunity by promoting the release of interferon and other inflammatory factors. Mitochondrial DNA (mtDNA) with a double-stranded structure has greater efficiency and sensitivity in being detected by DNA sensors and thus has an important role in the activation of the cGAS-STING pathway. Many previous findings suggest that the cGAS-STING pathway-mediated innate immune regulation is the most important aspect affecting tumor survival, not only in its anti-tumor role but also in shaping the immunosuppressive tumor microenvironment (TME) through a variety of pathways. However, recent studies have shown that STING regulation of non-immune pathways is equally profound and also involved in tumor cell progression. In this paper, we will focus on the non-innate immune system pathways, in which the cGAS-STING pathway also plays an important role in cancer.
abstract_unstemmed	Cyclic GMP-AMP synthase (cGAS) and downstream stimulator of interferon genes (STING) are involved in mediating innate immunity by promoting the release of interferon and other inflammatory factors. Mitochondrial DNA (mtDNA) with a double-stranded structure has greater efficiency and sensitivity in being detected by DNA sensors and thus has an important role in the activation of the cGAS-STING pathway. Many previous findings suggest that the cGAS-STING pathway-mediated innate immune regulation is the most important aspect affecting tumor survival, not only in its anti-tumor role but also in shaping the immunosuppressive tumor microenvironment (TME) through a variety of pathways. However, recent studies have shown that STING regulation of non-immune pathways is equally profound and also involved in tumor cell progression. In this paper, we will focus on the non-innate immune system pathways, in which the cGAS-STING pathway also plays an important role in cancer.
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title_short	STING in tumors: a focus on non-innate immune pathways
url	https://doi.org/10.3389/fcell.2023.1278461 https://doaj.org/article/414e52227e5c41d5a13456d6ab8753b5 https://www.frontiersin.org/articles/10.3389/fcell.2023.1278461/full https://doaj.org/toc/2296-634X
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