Deer antler extract-nanoparticles exhibit co-nanozyme activity and targeting of prostate cancer cells
Deer antler extract contains chemical compounds and peptides which have been shown to exert many pharmacological functions. However, the extract may also exhibits potential particle characteristics at nanoscale thereby acting as intrinsic nanozyme upon processing. We aim to test the nanoscale effect...
Ausführliche Beschreibung
Autor*in: |
Guldan Nazarbek [verfasserIn] Chenglin Mu [verfasserIn] Ainur Shaimoldina [verfasserIn] Zhuldyz Omarova [verfasserIn] Nurlan Toktarov [verfasserIn] Lian-xiang Wang [verfasserIn] Ashfaq Ahmad [verfasserIn] Didar Zeitkaziyeva [verfasserIn] Haiyan Fan [verfasserIn] Lei Shi [verfasserIn] Zhenbang Chen [verfasserIn] Yingqiu Xie [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2024 |
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Übergeordnetes Werk: |
In: Journal of Functional Foods - Elsevier, 2021, 115(2024), Seite 106089- |
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Übergeordnetes Werk: |
volume:115 ; year:2024 ; pages:106089- |
Links: |
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DOI / URN: |
10.1016/j.jff.2024.106089 |
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Katalog-ID: |
DOAJ100441645 |
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10.1016/j.jff.2024.106089 doi (DE-627)DOAJ100441645 (DE-599)DOAJ7e2750b31ee746e09d59466c0eb8d37a DE-627 ger DE-627 rakwb eng TX341-641 Guldan Nazarbek verfasserin aut Deer antler extract-nanoparticles exhibit co-nanozyme activity and targeting of prostate cancer cells 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Deer antler extract contains chemical compounds and peptides which have been shown to exert many pharmacological functions. However, the extract may also exhibits potential particle characteristics at nanoscale thereby acting as intrinsic nanozyme upon processing. We aim to test the nanoscale effect on cancer cells. We found that the water extract contains nanoscale particles characterized by SEM, TEM, AFM, zeta potential, and exhibits nanozyme or co-nanozyme activities of phosphatase, catalase which has crosstalk associated with anti-prostate cancer cells viability, especially with combined inhibitor of MET kinase by co-targeting phosphorylation. Network pharmacology analysis also showed immune mechanisms. Docking analysis shows the potent antler extract compound mediated inhibition of MET kinase. Nanoscale particles and compounds from antler extract at least in part, contribute to anticancer mechanisms which would be a promising combination agent in anti-cancer via nanotechnology. Nanoparticles Nanozyme Co-nanozyme Antler extract Nutrition. Foods and food supply Chenglin Mu verfasserin aut Ainur Shaimoldina verfasserin aut Zhuldyz Omarova verfasserin aut Nurlan Toktarov verfasserin aut Lian-xiang Wang verfasserin aut Ashfaq Ahmad verfasserin aut Didar Zeitkaziyeva verfasserin aut Haiyan Fan verfasserin aut Lei Shi verfasserin aut Zhenbang Chen verfasserin aut Yingqiu Xie verfasserin aut In Journal of Functional Foods Elsevier, 2021 115(2024), Seite 106089- (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:115 year:2024 pages:106089- https://doi.org/10.1016/j.jff.2024.106089 kostenfrei https://doaj.org/article/7e2750b31ee746e09d59466c0eb8d37a kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464624000914 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 115 2024 106089- |
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10.1016/j.jff.2024.106089 doi (DE-627)DOAJ100441645 (DE-599)DOAJ7e2750b31ee746e09d59466c0eb8d37a DE-627 ger DE-627 rakwb eng TX341-641 Guldan Nazarbek verfasserin aut Deer antler extract-nanoparticles exhibit co-nanozyme activity and targeting of prostate cancer cells 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Deer antler extract contains chemical compounds and peptides which have been shown to exert many pharmacological functions. However, the extract may also exhibits potential particle characteristics at nanoscale thereby acting as intrinsic nanozyme upon processing. We aim to test the nanoscale effect on cancer cells. We found that the water extract contains nanoscale particles characterized by SEM, TEM, AFM, zeta potential, and exhibits nanozyme or co-nanozyme activities of phosphatase, catalase which has crosstalk associated with anti-prostate cancer cells viability, especially with combined inhibitor of MET kinase by co-targeting phosphorylation. Network pharmacology analysis also showed immune mechanisms. Docking analysis shows the potent antler extract compound mediated inhibition of MET kinase. Nanoscale particles and compounds from antler extract at least in part, contribute to anticancer mechanisms which would be a promising combination agent in anti-cancer via nanotechnology. Nanoparticles Nanozyme Co-nanozyme Antler extract Nutrition. Foods and food supply Chenglin Mu verfasserin aut Ainur Shaimoldina verfasserin aut Zhuldyz Omarova verfasserin aut Nurlan Toktarov verfasserin aut Lian-xiang Wang verfasserin aut Ashfaq Ahmad verfasserin aut Didar Zeitkaziyeva verfasserin aut Haiyan Fan verfasserin aut Lei Shi verfasserin aut Zhenbang Chen verfasserin aut Yingqiu Xie verfasserin aut In Journal of Functional Foods Elsevier, 2021 115(2024), Seite 106089- (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:115 year:2024 pages:106089- https://doi.org/10.1016/j.jff.2024.106089 kostenfrei https://doaj.org/article/7e2750b31ee746e09d59466c0eb8d37a kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464624000914 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 115 2024 106089- |
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10.1016/j.jff.2024.106089 doi (DE-627)DOAJ100441645 (DE-599)DOAJ7e2750b31ee746e09d59466c0eb8d37a DE-627 ger DE-627 rakwb eng TX341-641 Guldan Nazarbek verfasserin aut Deer antler extract-nanoparticles exhibit co-nanozyme activity and targeting of prostate cancer cells 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Deer antler extract contains chemical compounds and peptides which have been shown to exert many pharmacological functions. However, the extract may also exhibits potential particle characteristics at nanoscale thereby acting as intrinsic nanozyme upon processing. We aim to test the nanoscale effect on cancer cells. We found that the water extract contains nanoscale particles characterized by SEM, TEM, AFM, zeta potential, and exhibits nanozyme or co-nanozyme activities of phosphatase, catalase which has crosstalk associated with anti-prostate cancer cells viability, especially with combined inhibitor of MET kinase by co-targeting phosphorylation. Network pharmacology analysis also showed immune mechanisms. Docking analysis shows the potent antler extract compound mediated inhibition of MET kinase. Nanoscale particles and compounds from antler extract at least in part, contribute to anticancer mechanisms which would be a promising combination agent in anti-cancer via nanotechnology. Nanoparticles Nanozyme Co-nanozyme Antler extract Nutrition. Foods and food supply Chenglin Mu verfasserin aut Ainur Shaimoldina verfasserin aut Zhuldyz Omarova verfasserin aut Nurlan Toktarov verfasserin aut Lian-xiang Wang verfasserin aut Ashfaq Ahmad verfasserin aut Didar Zeitkaziyeva verfasserin aut Haiyan Fan verfasserin aut Lei Shi verfasserin aut Zhenbang Chen verfasserin aut Yingqiu Xie verfasserin aut In Journal of Functional Foods Elsevier, 2021 115(2024), Seite 106089- (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:115 year:2024 pages:106089- https://doi.org/10.1016/j.jff.2024.106089 kostenfrei https://doaj.org/article/7e2750b31ee746e09d59466c0eb8d37a kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464624000914 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 115 2024 106089- |
allfieldsGer |
10.1016/j.jff.2024.106089 doi (DE-627)DOAJ100441645 (DE-599)DOAJ7e2750b31ee746e09d59466c0eb8d37a DE-627 ger DE-627 rakwb eng TX341-641 Guldan Nazarbek verfasserin aut Deer antler extract-nanoparticles exhibit co-nanozyme activity and targeting of prostate cancer cells 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Deer antler extract contains chemical compounds and peptides which have been shown to exert many pharmacological functions. However, the extract may also exhibits potential particle characteristics at nanoscale thereby acting as intrinsic nanozyme upon processing. We aim to test the nanoscale effect on cancer cells. We found that the water extract contains nanoscale particles characterized by SEM, TEM, AFM, zeta potential, and exhibits nanozyme or co-nanozyme activities of phosphatase, catalase which has crosstalk associated with anti-prostate cancer cells viability, especially with combined inhibitor of MET kinase by co-targeting phosphorylation. Network pharmacology analysis also showed immune mechanisms. Docking analysis shows the potent antler extract compound mediated inhibition of MET kinase. Nanoscale particles and compounds from antler extract at least in part, contribute to anticancer mechanisms which would be a promising combination agent in anti-cancer via nanotechnology. Nanoparticles Nanozyme Co-nanozyme Antler extract Nutrition. Foods and food supply Chenglin Mu verfasserin aut Ainur Shaimoldina verfasserin aut Zhuldyz Omarova verfasserin aut Nurlan Toktarov verfasserin aut Lian-xiang Wang verfasserin aut Ashfaq Ahmad verfasserin aut Didar Zeitkaziyeva verfasserin aut Haiyan Fan verfasserin aut Lei Shi verfasserin aut Zhenbang Chen verfasserin aut Yingqiu Xie verfasserin aut In Journal of Functional Foods Elsevier, 2021 115(2024), Seite 106089- (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:115 year:2024 pages:106089- https://doi.org/10.1016/j.jff.2024.106089 kostenfrei https://doaj.org/article/7e2750b31ee746e09d59466c0eb8d37a kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464624000914 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 115 2024 106089- |
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deer antler extract-nanoparticles exhibit co-nanozyme activity and targeting of prostate cancer cells |
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TX341-641 |
title_auth |
Deer antler extract-nanoparticles exhibit co-nanozyme activity and targeting of prostate cancer cells |
abstract |
Deer antler extract contains chemical compounds and peptides which have been shown to exert many pharmacological functions. However, the extract may also exhibits potential particle characteristics at nanoscale thereby acting as intrinsic nanozyme upon processing. We aim to test the nanoscale effect on cancer cells. We found that the water extract contains nanoscale particles characterized by SEM, TEM, AFM, zeta potential, and exhibits nanozyme or co-nanozyme activities of phosphatase, catalase which has crosstalk associated with anti-prostate cancer cells viability, especially with combined inhibitor of MET kinase by co-targeting phosphorylation. Network pharmacology analysis also showed immune mechanisms. Docking analysis shows the potent antler extract compound mediated inhibition of MET kinase. Nanoscale particles and compounds from antler extract at least in part, contribute to anticancer mechanisms which would be a promising combination agent in anti-cancer via nanotechnology. |
abstractGer |
Deer antler extract contains chemical compounds and peptides which have been shown to exert many pharmacological functions. However, the extract may also exhibits potential particle characteristics at nanoscale thereby acting as intrinsic nanozyme upon processing. We aim to test the nanoscale effect on cancer cells. We found that the water extract contains nanoscale particles characterized by SEM, TEM, AFM, zeta potential, and exhibits nanozyme or co-nanozyme activities of phosphatase, catalase which has crosstalk associated with anti-prostate cancer cells viability, especially with combined inhibitor of MET kinase by co-targeting phosphorylation. Network pharmacology analysis also showed immune mechanisms. Docking analysis shows the potent antler extract compound mediated inhibition of MET kinase. Nanoscale particles and compounds from antler extract at least in part, contribute to anticancer mechanisms which would be a promising combination agent in anti-cancer via nanotechnology. |
abstract_unstemmed |
Deer antler extract contains chemical compounds and peptides which have been shown to exert many pharmacological functions. However, the extract may also exhibits potential particle characteristics at nanoscale thereby acting as intrinsic nanozyme upon processing. We aim to test the nanoscale effect on cancer cells. We found that the water extract contains nanoscale particles characterized by SEM, TEM, AFM, zeta potential, and exhibits nanozyme or co-nanozyme activities of phosphatase, catalase which has crosstalk associated with anti-prostate cancer cells viability, especially with combined inhibitor of MET kinase by co-targeting phosphorylation. Network pharmacology analysis also showed immune mechanisms. Docking analysis shows the potent antler extract compound mediated inhibition of MET kinase. Nanoscale particles and compounds from antler extract at least in part, contribute to anticancer mechanisms which would be a promising combination agent in anti-cancer via nanotechnology. |
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title_short |
Deer antler extract-nanoparticles exhibit co-nanozyme activity and targeting of prostate cancer cells |
url |
https://doi.org/10.1016/j.jff.2024.106089 https://doaj.org/article/7e2750b31ee746e09d59466c0eb8d37a http://www.sciencedirect.com/science/article/pii/S1756464624000914 https://doaj.org/toc/1756-4646 |
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author2 |
Chenglin Mu Ainur Shaimoldina Zhuldyz Omarova Nurlan Toktarov Lian-xiang Wang Ashfaq Ahmad Didar Zeitkaziyeva Haiyan Fan Lei Shi Zhenbang Chen Yingqiu Xie |
author2Str |
Chenglin Mu Ainur Shaimoldina Zhuldyz Omarova Nurlan Toktarov Lian-xiang Wang Ashfaq Ahmad Didar Zeitkaziyeva Haiyan Fan Lei Shi Zhenbang Chen Yingqiu Xie |
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TX - Home Economics |
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doi_str |
10.1016/j.jff.2024.106089 |
callnumber-a |
TX341-641 |
up_date |
2024-07-03T14:40:50.635Z |
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