A comprehensive analysis of the prognostic characteristics of microRNAs in breast cancer

Both overall survival (OS) and disease-specific survival (DSS) are significant when determining a patient’s prognosis for breast cancer (BC). The effect of DSS-related microRNAs on BC susrvival, however, is not well understood. Here, we spotted differentially expressed miRNAs (DEMs) in the TCGA data...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Lingying Wang [verfasserIn] Gui Wang [verfasserIn] Jiahong Song [verfasserIn] Di Yao [verfasserIn] Yong Wang [verfasserIn] Tianyou Chen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	breast cancer overall survival disease specific survival microRNA-551b cancer progression

Übergeordnetes Werk:	In: Frontiers in Genetics - Frontiers Media S.A., 2011, 15(2024)
Übergeordnetes Werk:	volume:15 ; year:2024

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fgene.2024.1293824

Katalog-ID:	DOAJ100446205

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allfieldsSound	10.3389/fgene.2024.1293824 doi (DE-627)DOAJ100446205 (DE-599)DOAJ62df1b65698d4c7590f2f13b026f06df DE-627 ger DE-627 rakwb eng QH426-470 Lingying Wang verfasserin aut A comprehensive analysis of the prognostic characteristics of microRNAs in breast cancer 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Both overall survival (OS) and disease-specific survival (DSS) are significant when determining a patient’s prognosis for breast cancer (BC). The effect of DSS-related microRNAs on BC susrvival, however, is not well understood. Here, we spotted differentially expressed miRNAs (DEMs) in the TCGA database of BC DSS, identified eight DSS-related miRNAs, and constructed a risk model. AUC values at 1, 3, and 5 years were 0.852, 0.861, and 0.868, respectively, indicating a risk model’s excellent prognostic prediction ability. Then, we validated miRNA roles in BC OS and finally defined miR-551b as an independently prognostic miRNA in BC. According to function analysis, miR-551b is strongly linked with the emergence and spread of cancer, including protein ubiquitination, intracellular protein transport, metabolic pathways, and cancer pathways. Moreover, we confirmed the low expression of miR-551b in BC tissue and cells. After miR-551b inhibition or overexpression, cell function was either dramatically increased or diminished, respectively, indicating that miR-551b could regulate BC proliferation, invasion, and migration. In conclusion, we thoroughly clarified BC-related miRNAs on DSS and OS and verified miR-551b as a crucial regulator in the development and prognosis of cancer. These results can offer fresh ideas for BC therapy. breast cancer overall survival disease specific survival microRNA-551b cancer progression Genetics Gui Wang verfasserin aut Jiahong Song verfasserin aut Di Yao verfasserin aut Yong Wang verfasserin aut Tianyou Chen verfasserin aut In Frontiers in Genetics Frontiers Media S.A., 2011 15(2024) (DE-627)65799829X (DE-600)2606823-0 16648021 nnns volume:15 year:2024 https://doi.org/10.3389/fgene.2024.1293824 kostenfrei https://doaj.org/article/62df1b65698d4c7590f2f13b026f06df kostenfrei https://www.frontiersin.org/articles/10.3389/fgene.2024.1293824/full kostenfrei https://doaj.org/toc/1664-8021 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2024
language	English
source	In Frontiers in Genetics 15(2024) volume:15 year:2024
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topic_facet	breast cancer overall survival disease specific survival microRNA-551b cancer progression Genetics
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container_title	Frontiers in Genetics
authorswithroles_txt_mv	Lingying Wang @@aut@@ Gui Wang @@aut@@ Jiahong Song @@aut@@ Di Yao @@aut@@ Yong Wang @@aut@@ Tianyou Chen @@aut@@
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callnumber-first	Q - Science
author	Lingying Wang
spellingShingle	Lingying Wang misc QH426-470 misc breast cancer misc overall survival misc disease specific survival misc microRNA-551b misc cancer progression misc Genetics A comprehensive analysis of the prognostic characteristics of microRNAs in breast cancer
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topic_title	QH426-470 A comprehensive analysis of the prognostic characteristics of microRNAs in breast cancer breast cancer overall survival disease specific survival microRNA-551b cancer progression
topic	misc QH426-470 misc breast cancer misc overall survival misc disease specific survival misc microRNA-551b misc cancer progression misc Genetics
topic_unstemmed	misc QH426-470 misc breast cancer misc overall survival misc disease specific survival misc microRNA-551b misc cancer progression misc Genetics
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title	A comprehensive analysis of the prognostic characteristics of microRNAs in breast cancer
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title_full	A comprehensive analysis of the prognostic characteristics of microRNAs in breast cancer
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author_browse	Lingying Wang Gui Wang Jiahong Song Di Yao Yong Wang Tianyou Chen
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title_sort	comprehensive analysis of the prognostic characteristics of micrornas in breast cancer
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title_auth	A comprehensive analysis of the prognostic characteristics of microRNAs in breast cancer
abstract	Both overall survival (OS) and disease-specific survival (DSS) are significant when determining a patient’s prognosis for breast cancer (BC). The effect of DSS-related microRNAs on BC susrvival, however, is not well understood. Here, we spotted differentially expressed miRNAs (DEMs) in the TCGA database of BC DSS, identified eight DSS-related miRNAs, and constructed a risk model. AUC values at 1, 3, and 5 years were 0.852, 0.861, and 0.868, respectively, indicating a risk model’s excellent prognostic prediction ability. Then, we validated miRNA roles in BC OS and finally defined miR-551b as an independently prognostic miRNA in BC. According to function analysis, miR-551b is strongly linked with the emergence and spread of cancer, including protein ubiquitination, intracellular protein transport, metabolic pathways, and cancer pathways. Moreover, we confirmed the low expression of miR-551b in BC tissue and cells. After miR-551b inhibition or overexpression, cell function was either dramatically increased or diminished, respectively, indicating that miR-551b could regulate BC proliferation, invasion, and migration. In conclusion, we thoroughly clarified BC-related miRNAs on DSS and OS and verified miR-551b as a crucial regulator in the development and prognosis of cancer. These results can offer fresh ideas for BC therapy.
abstractGer	Both overall survival (OS) and disease-specific survival (DSS) are significant when determining a patient’s prognosis for breast cancer (BC). The effect of DSS-related microRNAs on BC susrvival, however, is not well understood. Here, we spotted differentially expressed miRNAs (DEMs) in the TCGA database of BC DSS, identified eight DSS-related miRNAs, and constructed a risk model. AUC values at 1, 3, and 5 years were 0.852, 0.861, and 0.868, respectively, indicating a risk model’s excellent prognostic prediction ability. Then, we validated miRNA roles in BC OS and finally defined miR-551b as an independently prognostic miRNA in BC. According to function analysis, miR-551b is strongly linked with the emergence and spread of cancer, including protein ubiquitination, intracellular protein transport, metabolic pathways, and cancer pathways. Moreover, we confirmed the low expression of miR-551b in BC tissue and cells. After miR-551b inhibition or overexpression, cell function was either dramatically increased or diminished, respectively, indicating that miR-551b could regulate BC proliferation, invasion, and migration. In conclusion, we thoroughly clarified BC-related miRNAs on DSS and OS and verified miR-551b as a crucial regulator in the development and prognosis of cancer. These results can offer fresh ideas for BC therapy.
abstract_unstemmed	Both overall survival (OS) and disease-specific survival (DSS) are significant when determining a patient’s prognosis for breast cancer (BC). The effect of DSS-related microRNAs on BC susrvival, however, is not well understood. Here, we spotted differentially expressed miRNAs (DEMs) in the TCGA database of BC DSS, identified eight DSS-related miRNAs, and constructed a risk model. AUC values at 1, 3, and 5 years were 0.852, 0.861, and 0.868, respectively, indicating a risk model’s excellent prognostic prediction ability. Then, we validated miRNA roles in BC OS and finally defined miR-551b as an independently prognostic miRNA in BC. According to function analysis, miR-551b is strongly linked with the emergence and spread of cancer, including protein ubiquitination, intracellular protein transport, metabolic pathways, and cancer pathways. Moreover, we confirmed the low expression of miR-551b in BC tissue and cells. After miR-551b inhibition or overexpression, cell function was either dramatically increased or diminished, respectively, indicating that miR-551b could regulate BC proliferation, invasion, and migration. In conclusion, we thoroughly clarified BC-related miRNAs on DSS and OS and verified miR-551b as a crucial regulator in the development and prognosis of cancer. These results can offer fresh ideas for BC therapy.
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title_short	A comprehensive analysis of the prognostic characteristics of microRNAs in breast cancer
url	https://doi.org/10.3389/fgene.2024.1293824 https://doaj.org/article/62df1b65698d4c7590f2f13b026f06df https://www.frontiersin.org/articles/10.3389/fgene.2024.1293824/full https://doaj.org/toc/1664-8021
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up_date	2024-07-03T14:42:43.924Z
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