Extra-Anogenital Giant Cutaneous Squamous Cell Carcinomas

Extra-anogenital giant cSCCs are rare but have worse outcomes compared to smaller tumors. Prompted by limited data, the authors conducted a retrospective study to gather more information about giant cSCCs to optimize clinical care. We identified seven cases of giant cSCCs from a review of cSCC cases...
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Autor*in:	Mateusz K. Mateuszczyk [verfasserIn] Iwona Chlebicka [verfasserIn] Magdalena Łyko [verfasserIn] Joanna Maj [verfasserIn] Jacek C. Szepietowski [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	giant cutaneous squamous cell carcinoma cutaneous squamous cell carcinoma squamous cell carcinoma

Übergeordnetes Werk:	In: Life - MDPI AG, 2012, 14(2024), 3, p 421
Übergeordnetes Werk:	volume:14 ; year:2024 ; number:3, p 421

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/life14030421

Katalog-ID:	DOAJ100474608

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spelling	10.3390/life14030421 doi (DE-627)DOAJ100474608 (DE-599)DOAJeadadb2686624bfdae95bc990fc35325 DE-627 ger DE-627 rakwb eng Mateusz K. Mateuszczyk verfasserin aut Extra-Anogenital Giant Cutaneous Squamous Cell Carcinomas 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Extra-anogenital giant cSCCs are rare but have worse outcomes compared to smaller tumors. Prompted by limited data, the authors conducted a retrospective study to gather more information about giant cSCCs to optimize clinical care. We identified seven cases of giant cSCCs from a review of cSCC cases treated in the Unit of Dermatosurgery between 2016 and 2022. Most patients were male (85.71%) with a mean age of 80.29 ± 12.22 years. UV radiation was the most common risk factor (five cases) followed by smoking (three cases) and hidradenitis suppurativa (one case). Most giant cases were located in the head area (71.4%) and the diameter of lesions ranged from 6 to 18 cm. All patients corresponded to tumor stage T3, and 42.86% of patients had lymph node metastases. Surgical excision was the treatment of choice in most cases (85.71%), while a combination of cemiplimab and RP1 was used in some cases due to the ineffectiveness of treatment or contraindications to other therapies. The authors emphasize the importance of early detection and prevention of modifiable risk factors, such as UV radiation, and a multidisciplinary approach to treatment. Other therapies, including immunotherapy, may become increasingly important. giant cutaneous squamous cell carcinoma cutaneous squamous cell carcinoma squamous cell carcinoma Science Q Iwona Chlebicka verfasserin aut Magdalena Łyko verfasserin aut Joanna Maj verfasserin aut Jacek C. Szepietowski verfasserin aut In Life MDPI AG, 2012 14(2024), 3, p 421 (DE-627)718627156 (DE-600)2662250-6 20751729 nnns volume:14 year:2024 number:3, p 421 https://doi.org/10.3390/life14030421 kostenfrei https://doaj.org/article/eadadb2686624bfdae95bc990fc35325 kostenfrei https://www.mdpi.com/2075-1729/14/3/421 kostenfrei https://doaj.org/toc/2075-1729 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024 3, p 421
allfields_unstemmed	10.3390/life14030421 doi (DE-627)DOAJ100474608 (DE-599)DOAJeadadb2686624bfdae95bc990fc35325 DE-627 ger DE-627 rakwb eng Mateusz K. Mateuszczyk verfasserin aut Extra-Anogenital Giant Cutaneous Squamous Cell Carcinomas 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Extra-anogenital giant cSCCs are rare but have worse outcomes compared to smaller tumors. Prompted by limited data, the authors conducted a retrospective study to gather more information about giant cSCCs to optimize clinical care. We identified seven cases of giant cSCCs from a review of cSCC cases treated in the Unit of Dermatosurgery between 2016 and 2022. Most patients were male (85.71%) with a mean age of 80.29 ± 12.22 years. UV radiation was the most common risk factor (five cases) followed by smoking (three cases) and hidradenitis suppurativa (one case). Most giant cases were located in the head area (71.4%) and the diameter of lesions ranged from 6 to 18 cm. All patients corresponded to tumor stage T3, and 42.86% of patients had lymph node metastases. Surgical excision was the treatment of choice in most cases (85.71%), while a combination of cemiplimab and RP1 was used in some cases due to the ineffectiveness of treatment or contraindications to other therapies. The authors emphasize the importance of early detection and prevention of modifiable risk factors, such as UV radiation, and a multidisciplinary approach to treatment. Other therapies, including immunotherapy, may become increasingly important. giant cutaneous squamous cell carcinoma cutaneous squamous cell carcinoma squamous cell carcinoma Science Q Iwona Chlebicka verfasserin aut Magdalena Łyko verfasserin aut Joanna Maj verfasserin aut Jacek C. Szepietowski verfasserin aut In Life MDPI AG, 2012 14(2024), 3, p 421 (DE-627)718627156 (DE-600)2662250-6 20751729 nnns volume:14 year:2024 number:3, p 421 https://doi.org/10.3390/life14030421 kostenfrei https://doaj.org/article/eadadb2686624bfdae95bc990fc35325 kostenfrei https://www.mdpi.com/2075-1729/14/3/421 kostenfrei https://doaj.org/toc/2075-1729 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024 3, p 421
allfieldsGer	10.3390/life14030421 doi (DE-627)DOAJ100474608 (DE-599)DOAJeadadb2686624bfdae95bc990fc35325 DE-627 ger DE-627 rakwb eng Mateusz K. Mateuszczyk verfasserin aut Extra-Anogenital Giant Cutaneous Squamous Cell Carcinomas 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Extra-anogenital giant cSCCs are rare but have worse outcomes compared to smaller tumors. Prompted by limited data, the authors conducted a retrospective study to gather more information about giant cSCCs to optimize clinical care. We identified seven cases of giant cSCCs from a review of cSCC cases treated in the Unit of Dermatosurgery between 2016 and 2022. Most patients were male (85.71%) with a mean age of 80.29 ± 12.22 years. UV radiation was the most common risk factor (five cases) followed by smoking (three cases) and hidradenitis suppurativa (one case). Most giant cases were located in the head area (71.4%) and the diameter of lesions ranged from 6 to 18 cm. All patients corresponded to tumor stage T3, and 42.86% of patients had lymph node metastases. Surgical excision was the treatment of choice in most cases (85.71%), while a combination of cemiplimab and RP1 was used in some cases due to the ineffectiveness of treatment or contraindications to other therapies. The authors emphasize the importance of early detection and prevention of modifiable risk factors, such as UV radiation, and a multidisciplinary approach to treatment. Other therapies, including immunotherapy, may become increasingly important. giant cutaneous squamous cell carcinoma cutaneous squamous cell carcinoma squamous cell carcinoma Science Q Iwona Chlebicka verfasserin aut Magdalena Łyko verfasserin aut Joanna Maj verfasserin aut Jacek C. Szepietowski verfasserin aut In Life MDPI AG, 2012 14(2024), 3, p 421 (DE-627)718627156 (DE-600)2662250-6 20751729 nnns volume:14 year:2024 number:3, p 421 https://doi.org/10.3390/life14030421 kostenfrei https://doaj.org/article/eadadb2686624bfdae95bc990fc35325 kostenfrei https://www.mdpi.com/2075-1729/14/3/421 kostenfrei https://doaj.org/toc/2075-1729 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024 3, p 421
allfieldsSound	10.3390/life14030421 doi (DE-627)DOAJ100474608 (DE-599)DOAJeadadb2686624bfdae95bc990fc35325 DE-627 ger DE-627 rakwb eng Mateusz K. Mateuszczyk verfasserin aut Extra-Anogenital Giant Cutaneous Squamous Cell Carcinomas 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Extra-anogenital giant cSCCs are rare but have worse outcomes compared to smaller tumors. Prompted by limited data, the authors conducted a retrospective study to gather more information about giant cSCCs to optimize clinical care. We identified seven cases of giant cSCCs from a review of cSCC cases treated in the Unit of Dermatosurgery between 2016 and 2022. Most patients were male (85.71%) with a mean age of 80.29 ± 12.22 years. UV radiation was the most common risk factor (five cases) followed by smoking (three cases) and hidradenitis suppurativa (one case). Most giant cases were located in the head area (71.4%) and the diameter of lesions ranged from 6 to 18 cm. All patients corresponded to tumor stage T3, and 42.86% of patients had lymph node metastases. Surgical excision was the treatment of choice in most cases (85.71%), while a combination of cemiplimab and RP1 was used in some cases due to the ineffectiveness of treatment or contraindications to other therapies. The authors emphasize the importance of early detection and prevention of modifiable risk factors, such as UV radiation, and a multidisciplinary approach to treatment. Other therapies, including immunotherapy, may become increasingly important. giant cutaneous squamous cell carcinoma cutaneous squamous cell carcinoma squamous cell carcinoma Science Q Iwona Chlebicka verfasserin aut Magdalena Łyko verfasserin aut Joanna Maj verfasserin aut Jacek C. Szepietowski verfasserin aut In Life MDPI AG, 2012 14(2024), 3, p 421 (DE-627)718627156 (DE-600)2662250-6 20751729 nnns volume:14 year:2024 number:3, p 421 https://doi.org/10.3390/life14030421 kostenfrei https://doaj.org/article/eadadb2686624bfdae95bc990fc35325 kostenfrei https://www.mdpi.com/2075-1729/14/3/421 kostenfrei https://doaj.org/toc/2075-1729 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024 3, p 421
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authorswithroles_txt_mv	Mateusz K. Mateuszczyk @@aut@@ Iwona Chlebicka @@aut@@ Magdalena Łyko @@aut@@ Joanna Maj @@aut@@ Jacek C. Szepietowski @@aut@@
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author	Mateusz K. Mateuszczyk
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topic_title	Extra-Anogenital Giant Cutaneous Squamous Cell Carcinomas giant cutaneous squamous cell carcinoma cutaneous squamous cell carcinoma squamous cell carcinoma
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title	Extra-Anogenital Giant Cutaneous Squamous Cell Carcinomas
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title_full	Extra-Anogenital Giant Cutaneous Squamous Cell Carcinomas
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title_sort	extra-anogenital giant cutaneous squamous cell carcinomas
title_auth	Extra-Anogenital Giant Cutaneous Squamous Cell Carcinomas
abstract	Extra-anogenital giant cSCCs are rare but have worse outcomes compared to smaller tumors. Prompted by limited data, the authors conducted a retrospective study to gather more information about giant cSCCs to optimize clinical care. We identified seven cases of giant cSCCs from a review of cSCC cases treated in the Unit of Dermatosurgery between 2016 and 2022. Most patients were male (85.71%) with a mean age of 80.29 ± 12.22 years. UV radiation was the most common risk factor (five cases) followed by smoking (three cases) and hidradenitis suppurativa (one case). Most giant cases were located in the head area (71.4%) and the diameter of lesions ranged from 6 to 18 cm. All patients corresponded to tumor stage T3, and 42.86% of patients had lymph node metastases. Surgical excision was the treatment of choice in most cases (85.71%), while a combination of cemiplimab and RP1 was used in some cases due to the ineffectiveness of treatment or contraindications to other therapies. The authors emphasize the importance of early detection and prevention of modifiable risk factors, such as UV radiation, and a multidisciplinary approach to treatment. Other therapies, including immunotherapy, may become increasingly important.
abstractGer	Extra-anogenital giant cSCCs are rare but have worse outcomes compared to smaller tumors. Prompted by limited data, the authors conducted a retrospective study to gather more information about giant cSCCs to optimize clinical care. We identified seven cases of giant cSCCs from a review of cSCC cases treated in the Unit of Dermatosurgery between 2016 and 2022. Most patients were male (85.71%) with a mean age of 80.29 ± 12.22 years. UV radiation was the most common risk factor (five cases) followed by smoking (three cases) and hidradenitis suppurativa (one case). Most giant cases were located in the head area (71.4%) and the diameter of lesions ranged from 6 to 18 cm. All patients corresponded to tumor stage T3, and 42.86% of patients had lymph node metastases. Surgical excision was the treatment of choice in most cases (85.71%), while a combination of cemiplimab and RP1 was used in some cases due to the ineffectiveness of treatment or contraindications to other therapies. The authors emphasize the importance of early detection and prevention of modifiable risk factors, such as UV radiation, and a multidisciplinary approach to treatment. Other therapies, including immunotherapy, may become increasingly important.
abstract_unstemmed	Extra-anogenital giant cSCCs are rare but have worse outcomes compared to smaller tumors. Prompted by limited data, the authors conducted a retrospective study to gather more information about giant cSCCs to optimize clinical care. We identified seven cases of giant cSCCs from a review of cSCC cases treated in the Unit of Dermatosurgery between 2016 and 2022. Most patients were male (85.71%) with a mean age of 80.29 ± 12.22 years. UV radiation was the most common risk factor (five cases) followed by smoking (three cases) and hidradenitis suppurativa (one case). Most giant cases were located in the head area (71.4%) and the diameter of lesions ranged from 6 to 18 cm. All patients corresponded to tumor stage T3, and 42.86% of patients had lymph node metastases. Surgical excision was the treatment of choice in most cases (85.71%), while a combination of cemiplimab and RP1 was used in some cases due to the ineffectiveness of treatment or contraindications to other therapies. The authors emphasize the importance of early detection and prevention of modifiable risk factors, such as UV radiation, and a multidisciplinary approach to treatment. Other therapies, including immunotherapy, may become increasingly important.
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title_short	Extra-Anogenital Giant Cutaneous Squamous Cell Carcinomas
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