History of Neonatal Screening of Congenital Hypothyroidism in Portugal

Congenital hypothyroidism (CH) leads to growth and development delays and is preventable with early treatment. Neonatal screening for CH was initiated in Portugal in 1981. This study examines the history of CH screening in the country. Data were obtained from annual reports and from the national dat...
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Autor*in:	Maria José Costeira [verfasserIn] Patrício Costa [verfasserIn] Susana Roque [verfasserIn] Ivone Carvalho [verfasserIn] Laura Vilarinho [verfasserIn] Joana Almeida Palha [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	neonatal screening congenital hypothyroidism thyroid hormones iodine

Übergeordnetes Werk:	In: International Journal of Neonatal Screening - MDPI AG, 2015, 10(2024), 1, p 16
Übergeordnetes Werk:	volume:10 ; year:2024 ; number:1, p 16

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/ijns10010016

Katalog-ID:	DOAJ100491103

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allfieldsSound	10.3390/ijns10010016 doi (DE-627)DOAJ100491103 (DE-599)DOAJ5d5808367a8e49a88ec226af05399338 DE-627 ger DE-627 rakwb eng RJ1-570 Maria José Costeira verfasserin aut History of Neonatal Screening of Congenital Hypothyroidism in Portugal 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Congenital hypothyroidism (CH) leads to growth and development delays and is preventable with early treatment. Neonatal screening for CH was initiated in Portugal in 1981. This study examines the history of CH screening in the country. Data were obtained from annual reports and from the national database of neonatal screening laboratory. The CH screening strategy primarily relies on the thyroid-stimulating hormone (TSH), followed by total thyroxine measurement as the second tier for confirmation. The TSH cutoff started at 90 mIU/L, decreasing to the actual 10 mIU/L. The coverage of the screening program has increased rapidly; although voluntary, it reached about 90% in 6 years and became universal in 10 years. Guideline and cutoff updates led to the identification of over 200 additional cases, resulting in specific retesting protocols for preterm and very-low-birth-weight babies. The actual decision tree considers CH when TSH levels are above 40 mIU/L. Data from the CH screening also provide an indication of the iodine status of the population, which is presently indicative of iodine insufficiency. The Portuguese neonatal screening for CH is a history of success. It has rapidly and continuously adapted to changes in knowledge and has become a universal voluntary practice within a few years. neonatal screening congenital hypothyroidism thyroid hormones iodine Pediatrics Patrício Costa verfasserin aut Susana Roque verfasserin aut Ivone Carvalho verfasserin aut Laura Vilarinho verfasserin aut Joana Almeida Palha verfasserin aut In International Journal of Neonatal Screening MDPI AG, 2015 10(2024), 1, p 16 (DE-627)842239928 (DE-600)2840820-2 2409515X nnns volume:10 year:2024 number:1, p 16 https://doi.org/10.3390/ijns10010016 kostenfrei https://doaj.org/article/5d5808367a8e49a88ec226af05399338 kostenfrei https://www.mdpi.com/2409-515X/10/1/16 kostenfrei https://doaj.org/toc/2409-515X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2024 1, p 16
language	English
source	In International Journal of Neonatal Screening 10(2024), 1, p 16 volume:10 year:2024 number:1, p 16
sourceStr	In International Journal of Neonatal Screening 10(2024), 1, p 16 volume:10 year:2024 number:1, p 16
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container_title	International Journal of Neonatal Screening
authorswithroles_txt_mv	Maria José Costeira @@aut@@ Patrício Costa @@aut@@ Susana Roque @@aut@@ Ivone Carvalho @@aut@@ Laura Vilarinho @@aut@@ Joana Almeida Palha @@aut@@
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title	History of Neonatal Screening of Congenital Hypothyroidism in Portugal
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title_auth	History of Neonatal Screening of Congenital Hypothyroidism in Portugal
abstract	Congenital hypothyroidism (CH) leads to growth and development delays and is preventable with early treatment. Neonatal screening for CH was initiated in Portugal in 1981. This study examines the history of CH screening in the country. Data were obtained from annual reports and from the national database of neonatal screening laboratory. The CH screening strategy primarily relies on the thyroid-stimulating hormone (TSH), followed by total thyroxine measurement as the second tier for confirmation. The TSH cutoff started at 90 mIU/L, decreasing to the actual 10 mIU/L. The coverage of the screening program has increased rapidly; although voluntary, it reached about 90% in 6 years and became universal in 10 years. Guideline and cutoff updates led to the identification of over 200 additional cases, resulting in specific retesting protocols for preterm and very-low-birth-weight babies. The actual decision tree considers CH when TSH levels are above 40 mIU/L. Data from the CH screening also provide an indication of the iodine status of the population, which is presently indicative of iodine insufficiency. The Portuguese neonatal screening for CH is a history of success. It has rapidly and continuously adapted to changes in knowledge and has become a universal voluntary practice within a few years.
abstractGer	Congenital hypothyroidism (CH) leads to growth and development delays and is preventable with early treatment. Neonatal screening for CH was initiated in Portugal in 1981. This study examines the history of CH screening in the country. Data were obtained from annual reports and from the national database of neonatal screening laboratory. The CH screening strategy primarily relies on the thyroid-stimulating hormone (TSH), followed by total thyroxine measurement as the second tier for confirmation. The TSH cutoff started at 90 mIU/L, decreasing to the actual 10 mIU/L. The coverage of the screening program has increased rapidly; although voluntary, it reached about 90% in 6 years and became universal in 10 years. Guideline and cutoff updates led to the identification of over 200 additional cases, resulting in specific retesting protocols for preterm and very-low-birth-weight babies. The actual decision tree considers CH when TSH levels are above 40 mIU/L. Data from the CH screening also provide an indication of the iodine status of the population, which is presently indicative of iodine insufficiency. The Portuguese neonatal screening for CH is a history of success. It has rapidly and continuously adapted to changes in knowledge and has become a universal voluntary practice within a few years.
abstract_unstemmed	Congenital hypothyroidism (CH) leads to growth and development delays and is preventable with early treatment. Neonatal screening for CH was initiated in Portugal in 1981. This study examines the history of CH screening in the country. Data were obtained from annual reports and from the national database of neonatal screening laboratory. The CH screening strategy primarily relies on the thyroid-stimulating hormone (TSH), followed by total thyroxine measurement as the second tier for confirmation. The TSH cutoff started at 90 mIU/L, decreasing to the actual 10 mIU/L. The coverage of the screening program has increased rapidly; although voluntary, it reached about 90% in 6 years and became universal in 10 years. Guideline and cutoff updates led to the identification of over 200 additional cases, resulting in specific retesting protocols for preterm and very-low-birth-weight babies. The actual decision tree considers CH when TSH levels are above 40 mIU/L. Data from the CH screening also provide an indication of the iodine status of the population, which is presently indicative of iodine insufficiency. The Portuguese neonatal screening for CH is a history of success. It has rapidly and continuously adapted to changes in knowledge and has become a universal voluntary practice within a few years.
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History of Neonatal Screening of Congenital Hypothyroidism in Portugal

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Zugang & Verfügbarkeit

Vorhandene Bände

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