Comparison of Transoral and Transcervical Ultrasonography with MRI for the Diagnostic Work-Up of Oropharynx Tumors: A Protocol for a Multicenter Clinical Trial (SPOTUS)

This study protocol for a prospective, multicenter, diagnostic, clinical trial describes the integration of transoral and transcervical ultrasonography (US) in the initial clinical work-up of patients referred to tertiary head and neck cancer centers with suspected oropharyngeal cancer. The study ev...
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Autor*in:	Martin Garset-Zamani [verfasserIn] Gitte Bjørn Hvilsom [verfasserIn] Thomas Kjærgaard [verfasserIn] Christina Caroline Plaschke [verfasserIn] Christoffer Holst Hahn [verfasserIn] Mikkel Kaltoft [verfasserIn] Padraig O’Leary [verfasserIn] Natalie Lassen Frid [verfasserIn] Rikke Norling [verfasserIn] Danijela Dejanovic [verfasserIn] Johanna Maria Hall [verfasserIn] Tina Klitmøller Agander [verfasserIn] Signe Bergliot Nielsen [verfasserIn] Annette Kjær Ersbøll [verfasserIn] Irene Wessel [verfasserIn] Christian von Buchwald [verfasserIn] Tobias Todsen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	oropharyngeal cancer palatine tonsil lingual tonsil base of tongue tonsil cancer oropharyngeal squamous cell carcinoma

Übergeordnetes Werk:	In: Diagnostics - MDPI AG, 2012, 14(2024), 6, p 577
Übergeordnetes Werk:	volume:14 ; year:2024 ; number:6, p 577

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/diagnostics14060577

Katalog-ID:	DOAJ100526993

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allfields	10.3390/diagnostics14060577 doi (DE-627)DOAJ100526993 (DE-599)DOAJ3fb5a6b83d564efd9abfe129fb856853 DE-627 ger DE-627 rakwb eng R5-920 Martin Garset-Zamani verfasserin aut Comparison of Transoral and Transcervical Ultrasonography with MRI for the Diagnostic Work-Up of Oropharynx Tumors: A Protocol for a Multicenter Clinical Trial (SPOTUS) 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study protocol for a prospective, multicenter, diagnostic, clinical trial describes the integration of transoral and transcervical ultrasonography (US) in the initial clinical work-up of patients referred to tertiary head and neck cancer centers with suspected oropharyngeal cancer. The study evaluates the blinded detection rate of oropharyngeal tumors and their US-estimated size and T-stage before histopathology and cross-sectional imaging are available. Magnetic resonance imaging (MRI) scans will be prospectively rated while blinded to T-site histopathology and US. The primary outcome measures of diagnostic accuracy, including sensitivity, specificity, positive and negative predictive values, and overall accuracy, will be reported for both US and MRI. A sub-analysis of prospectively rated 18F-Fluorodeoxyglucose (FDG) positron emission tomography/computerized tomography (PET/CT) scans in patients with clinically suspected unknown primary tumors will also be compared to US and MRI. Secondary outcome measures, including a comparison of tumor size estimation between US, MRI, and CT, will also be reported. This prospective multicenter study will provide clinically impactful information regarding the use of transoral and transcervical US for the diagnostic work-up of oropharyngeal cancer. oropharyngeal cancer palatine tonsil lingual tonsil base of tongue tonsil cancer oropharyngeal squamous cell carcinoma Medicine (General) Gitte Bjørn Hvilsom verfasserin aut Thomas Kjærgaard verfasserin aut Christina Caroline Plaschke verfasserin aut Christoffer Holst Hahn verfasserin aut Mikkel Kaltoft verfasserin aut Padraig O’Leary verfasserin aut Natalie Lassen Frid verfasserin aut Rikke Norling verfasserin aut Danijela Dejanovic verfasserin aut Johanna Maria Hall verfasserin aut Tina Klitmøller Agander verfasserin aut Signe Bergliot Nielsen verfasserin aut Annette Kjær Ersbøll verfasserin aut Irene Wessel verfasserin aut Christian von Buchwald verfasserin aut Tobias Todsen verfasserin aut In Diagnostics MDPI AG, 2012 14(2024), 6, p 577 (DE-627)718627814 (DE-600)2662336-5 20754418 nnns volume:14 year:2024 number:6, p 577 https://doi.org/10.3390/diagnostics14060577 kostenfrei https://doaj.org/article/3fb5a6b83d564efd9abfe129fb856853 kostenfrei https://www.mdpi.com/2075-4418/14/6/577 kostenfrei https://doaj.org/toc/2075-4418 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024 6, p 577
spelling	10.3390/diagnostics14060577 doi (DE-627)DOAJ100526993 (DE-599)DOAJ3fb5a6b83d564efd9abfe129fb856853 DE-627 ger DE-627 rakwb eng R5-920 Martin Garset-Zamani verfasserin aut Comparison of Transoral and Transcervical Ultrasonography with MRI for the Diagnostic Work-Up of Oropharynx Tumors: A Protocol for a Multicenter Clinical Trial (SPOTUS) 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study protocol for a prospective, multicenter, diagnostic, clinical trial describes the integration of transoral and transcervical ultrasonography (US) in the initial clinical work-up of patients referred to tertiary head and neck cancer centers with suspected oropharyngeal cancer. The study evaluates the blinded detection rate of oropharyngeal tumors and their US-estimated size and T-stage before histopathology and cross-sectional imaging are available. Magnetic resonance imaging (MRI) scans will be prospectively rated while blinded to T-site histopathology and US. The primary outcome measures of diagnostic accuracy, including sensitivity, specificity, positive and negative predictive values, and overall accuracy, will be reported for both US and MRI. A sub-analysis of prospectively rated 18F-Fluorodeoxyglucose (FDG) positron emission tomography/computerized tomography (PET/CT) scans in patients with clinically suspected unknown primary tumors will also be compared to US and MRI. Secondary outcome measures, including a comparison of tumor size estimation between US, MRI, and CT, will also be reported. This prospective multicenter study will provide clinically impactful information regarding the use of transoral and transcervical US for the diagnostic work-up of oropharyngeal cancer. oropharyngeal cancer palatine tonsil lingual tonsil base of tongue tonsil cancer oropharyngeal squamous cell carcinoma Medicine (General) Gitte Bjørn Hvilsom verfasserin aut Thomas Kjærgaard verfasserin aut Christina Caroline Plaschke verfasserin aut Christoffer Holst Hahn verfasserin aut Mikkel Kaltoft verfasserin aut Padraig O’Leary verfasserin aut Natalie Lassen Frid verfasserin aut Rikke Norling verfasserin aut Danijela Dejanovic verfasserin aut Johanna Maria Hall verfasserin aut Tina Klitmøller Agander verfasserin aut Signe Bergliot Nielsen verfasserin aut Annette Kjær Ersbøll verfasserin aut Irene Wessel verfasserin aut Christian von Buchwald verfasserin aut Tobias Todsen verfasserin aut In Diagnostics MDPI AG, 2012 14(2024), 6, p 577 (DE-627)718627814 (DE-600)2662336-5 20754418 nnns volume:14 year:2024 number:6, p 577 https://doi.org/10.3390/diagnostics14060577 kostenfrei https://doaj.org/article/3fb5a6b83d564efd9abfe129fb856853 kostenfrei https://www.mdpi.com/2075-4418/14/6/577 kostenfrei https://doaj.org/toc/2075-4418 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024 6, p 577
allfields_unstemmed	10.3390/diagnostics14060577 doi (DE-627)DOAJ100526993 (DE-599)DOAJ3fb5a6b83d564efd9abfe129fb856853 DE-627 ger DE-627 rakwb eng R5-920 Martin Garset-Zamani verfasserin aut Comparison of Transoral and Transcervical Ultrasonography with MRI for the Diagnostic Work-Up of Oropharynx Tumors: A Protocol for a Multicenter Clinical Trial (SPOTUS) 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study protocol for a prospective, multicenter, diagnostic, clinical trial describes the integration of transoral and transcervical ultrasonography (US) in the initial clinical work-up of patients referred to tertiary head and neck cancer centers with suspected oropharyngeal cancer. The study evaluates the blinded detection rate of oropharyngeal tumors and their US-estimated size and T-stage before histopathology and cross-sectional imaging are available. Magnetic resonance imaging (MRI) scans will be prospectively rated while blinded to T-site histopathology and US. The primary outcome measures of diagnostic accuracy, including sensitivity, specificity, positive and negative predictive values, and overall accuracy, will be reported for both US and MRI. A sub-analysis of prospectively rated 18F-Fluorodeoxyglucose (FDG) positron emission tomography/computerized tomography (PET/CT) scans in patients with clinically suspected unknown primary tumors will also be compared to US and MRI. Secondary outcome measures, including a comparison of tumor size estimation between US, MRI, and CT, will also be reported. This prospective multicenter study will provide clinically impactful information regarding the use of transoral and transcervical US for the diagnostic work-up of oropharyngeal cancer. oropharyngeal cancer palatine tonsil lingual tonsil base of tongue tonsil cancer oropharyngeal squamous cell carcinoma Medicine (General) Gitte Bjørn Hvilsom verfasserin aut Thomas Kjærgaard verfasserin aut Christina Caroline Plaschke verfasserin aut Christoffer Holst Hahn verfasserin aut Mikkel Kaltoft verfasserin aut Padraig O’Leary verfasserin aut Natalie Lassen Frid verfasserin aut Rikke Norling verfasserin aut Danijela Dejanovic verfasserin aut Johanna Maria Hall verfasserin aut Tina Klitmøller Agander verfasserin aut Signe Bergliot Nielsen verfasserin aut Annette Kjær Ersbøll verfasserin aut Irene Wessel verfasserin aut Christian von Buchwald verfasserin aut Tobias Todsen verfasserin aut In Diagnostics MDPI AG, 2012 14(2024), 6, p 577 (DE-627)718627814 (DE-600)2662336-5 20754418 nnns volume:14 year:2024 number:6, p 577 https://doi.org/10.3390/diagnostics14060577 kostenfrei https://doaj.org/article/3fb5a6b83d564efd9abfe129fb856853 kostenfrei https://www.mdpi.com/2075-4418/14/6/577 kostenfrei https://doaj.org/toc/2075-4418 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024 6, p 577
allfieldsGer	10.3390/diagnostics14060577 doi (DE-627)DOAJ100526993 (DE-599)DOAJ3fb5a6b83d564efd9abfe129fb856853 DE-627 ger DE-627 rakwb eng R5-920 Martin Garset-Zamani verfasserin aut Comparison of Transoral and Transcervical Ultrasonography with MRI for the Diagnostic Work-Up of Oropharynx Tumors: A Protocol for a Multicenter Clinical Trial (SPOTUS) 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study protocol for a prospective, multicenter, diagnostic, clinical trial describes the integration of transoral and transcervical ultrasonography (US) in the initial clinical work-up of patients referred to tertiary head and neck cancer centers with suspected oropharyngeal cancer. The study evaluates the blinded detection rate of oropharyngeal tumors and their US-estimated size and T-stage before histopathology and cross-sectional imaging are available. Magnetic resonance imaging (MRI) scans will be prospectively rated while blinded to T-site histopathology and US. The primary outcome measures of diagnostic accuracy, including sensitivity, specificity, positive and negative predictive values, and overall accuracy, will be reported for both US and MRI. A sub-analysis of prospectively rated 18F-Fluorodeoxyglucose (FDG) positron emission tomography/computerized tomography (PET/CT) scans in patients with clinically suspected unknown primary tumors will also be compared to US and MRI. Secondary outcome measures, including a comparison of tumor size estimation between US, MRI, and CT, will also be reported. This prospective multicenter study will provide clinically impactful information regarding the use of transoral and transcervical US for the diagnostic work-up of oropharyngeal cancer. oropharyngeal cancer palatine tonsil lingual tonsil base of tongue tonsil cancer oropharyngeal squamous cell carcinoma Medicine (General) Gitte Bjørn Hvilsom verfasserin aut Thomas Kjærgaard verfasserin aut Christina Caroline Plaschke verfasserin aut Christoffer Holst Hahn verfasserin aut Mikkel Kaltoft verfasserin aut Padraig O’Leary verfasserin aut Natalie Lassen Frid verfasserin aut Rikke Norling verfasserin aut Danijela Dejanovic verfasserin aut Johanna Maria Hall verfasserin aut Tina Klitmøller Agander verfasserin aut Signe Bergliot Nielsen verfasserin aut Annette Kjær Ersbøll verfasserin aut Irene Wessel verfasserin aut Christian von Buchwald verfasserin aut Tobias Todsen verfasserin aut In Diagnostics MDPI AG, 2012 14(2024), 6, p 577 (DE-627)718627814 (DE-600)2662336-5 20754418 nnns volume:14 year:2024 number:6, p 577 https://doi.org/10.3390/diagnostics14060577 kostenfrei https://doaj.org/article/3fb5a6b83d564efd9abfe129fb856853 kostenfrei https://www.mdpi.com/2075-4418/14/6/577 kostenfrei https://doaj.org/toc/2075-4418 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024 6, p 577
allfieldsSound	10.3390/diagnostics14060577 doi (DE-627)DOAJ100526993 (DE-599)DOAJ3fb5a6b83d564efd9abfe129fb856853 DE-627 ger DE-627 rakwb eng R5-920 Martin Garset-Zamani verfasserin aut Comparison of Transoral and Transcervical Ultrasonography with MRI for the Diagnostic Work-Up of Oropharynx Tumors: A Protocol for a Multicenter Clinical Trial (SPOTUS) 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study protocol for a prospective, multicenter, diagnostic, clinical trial describes the integration of transoral and transcervical ultrasonography (US) in the initial clinical work-up of patients referred to tertiary head and neck cancer centers with suspected oropharyngeal cancer. The study evaluates the blinded detection rate of oropharyngeal tumors and their US-estimated size and T-stage before histopathology and cross-sectional imaging are available. Magnetic resonance imaging (MRI) scans will be prospectively rated while blinded to T-site histopathology and US. The primary outcome measures of diagnostic accuracy, including sensitivity, specificity, positive and negative predictive values, and overall accuracy, will be reported for both US and MRI. A sub-analysis of prospectively rated 18F-Fluorodeoxyglucose (FDG) positron emission tomography/computerized tomography (PET/CT) scans in patients with clinically suspected unknown primary tumors will also be compared to US and MRI. Secondary outcome measures, including a comparison of tumor size estimation between US, MRI, and CT, will also be reported. This prospective multicenter study will provide clinically impactful information regarding the use of transoral and transcervical US for the diagnostic work-up of oropharyngeal cancer. oropharyngeal cancer palatine tonsil lingual tonsil base of tongue tonsil cancer oropharyngeal squamous cell carcinoma Medicine (General) Gitte Bjørn Hvilsom verfasserin aut Thomas Kjærgaard verfasserin aut Christina Caroline Plaschke verfasserin aut Christoffer Holst Hahn verfasserin aut Mikkel Kaltoft verfasserin aut Padraig O’Leary verfasserin aut Natalie Lassen Frid verfasserin aut Rikke Norling verfasserin aut Danijela Dejanovic verfasserin aut Johanna Maria Hall verfasserin aut Tina Klitmøller Agander verfasserin aut Signe Bergliot Nielsen verfasserin aut Annette Kjær Ersbøll verfasserin aut Irene Wessel verfasserin aut Christian von Buchwald verfasserin aut Tobias Todsen verfasserin aut In Diagnostics MDPI AG, 2012 14(2024), 6, p 577 (DE-627)718627814 (DE-600)2662336-5 20754418 nnns volume:14 year:2024 number:6, p 577 https://doi.org/10.3390/diagnostics14060577 kostenfrei https://doaj.org/article/3fb5a6b83d564efd9abfe129fb856853 kostenfrei https://www.mdpi.com/2075-4418/14/6/577 kostenfrei https://doaj.org/toc/2075-4418 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024 6, p 577
language	English
source	In Diagnostics 14(2024), 6, p 577 volume:14 year:2024 number:6, p 577
sourceStr	In Diagnostics 14(2024), 6, p 577 volume:14 year:2024 number:6, p 577
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	oropharyngeal cancer palatine tonsil lingual tonsil base of tongue tonsil cancer oropharyngeal squamous cell carcinoma Medicine (General)
isfreeaccess_bool	true
container_title	Diagnostics
authorswithroles_txt_mv	Martin Garset-Zamani @@aut@@ Gitte Bjørn Hvilsom @@aut@@ Thomas Kjærgaard @@aut@@ Christina Caroline Plaschke @@aut@@ Christoffer Holst Hahn @@aut@@ Mikkel Kaltoft @@aut@@ Padraig O’Leary @@aut@@ Natalie Lassen Frid @@aut@@ Rikke Norling @@aut@@ Danijela Dejanovic @@aut@@ Johanna Maria Hall @@aut@@ Tina Klitmøller Agander @@aut@@ Signe Bergliot Nielsen @@aut@@ Annette Kjær Ersbøll @@aut@@ Irene Wessel @@aut@@ Christian von Buchwald @@aut@@ Tobias Todsen @@aut@@
publishDateDaySort_date	2024-01-01T00:00:00Z
hierarchy_top_id	718627814
id	DOAJ100526993
language_de	englisch
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callnumber-first	R - Medicine
author	Martin Garset-Zamani
spellingShingle	Martin Garset-Zamani misc R5-920 misc oropharyngeal cancer misc palatine tonsil misc lingual tonsil misc base of tongue misc tonsil cancer misc oropharyngeal squamous cell carcinoma misc Medicine (General) Comparison of Transoral and Transcervical Ultrasonography with MRI for the Diagnostic Work-Up of Oropharynx Tumors: A Protocol for a Multicenter Clinical Trial (SPOTUS)
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topic_title	R5-920 Comparison of Transoral and Transcervical Ultrasonography with MRI for the Diagnostic Work-Up of Oropharynx Tumors: A Protocol for a Multicenter Clinical Trial (SPOTUS) oropharyngeal cancer palatine tonsil lingual tonsil base of tongue tonsil cancer oropharyngeal squamous cell carcinoma
topic	misc R5-920 misc oropharyngeal cancer misc palatine tonsil misc lingual tonsil misc base of tongue misc tonsil cancer misc oropharyngeal squamous cell carcinoma misc Medicine (General)
topic_unstemmed	misc R5-920 misc oropharyngeal cancer misc palatine tonsil misc lingual tonsil misc base of tongue misc tonsil cancer misc oropharyngeal squamous cell carcinoma misc Medicine (General)
topic_browse	misc R5-920 misc oropharyngeal cancer misc palatine tonsil misc lingual tonsil misc base of tongue misc tonsil cancer misc oropharyngeal squamous cell carcinoma misc Medicine (General)
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title	Comparison of Transoral and Transcervical Ultrasonography with MRI for the Diagnostic Work-Up of Oropharynx Tumors: A Protocol for a Multicenter Clinical Trial (SPOTUS)
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title_full	Comparison of Transoral and Transcervical Ultrasonography with MRI for the Diagnostic Work-Up of Oropharynx Tumors: A Protocol for a Multicenter Clinical Trial (SPOTUS)
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author_browse	Martin Garset-Zamani Gitte Bjørn Hvilsom Thomas Kjærgaard Christina Caroline Plaschke Christoffer Holst Hahn Mikkel Kaltoft Padraig O’Leary Natalie Lassen Frid Rikke Norling Danijela Dejanovic Johanna Maria Hall Tina Klitmøller Agander Signe Bergliot Nielsen Annette Kjær Ersbøll Irene Wessel Christian von Buchwald Tobias Todsen
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title_sort	comparison of transoral and transcervical ultrasonography with mri for the diagnostic work-up of oropharynx tumors: a protocol for a multicenter clinical trial (spotus)
callnumber	R5-920
title_auth	Comparison of Transoral and Transcervical Ultrasonography with MRI for the Diagnostic Work-Up of Oropharynx Tumors: A Protocol for a Multicenter Clinical Trial (SPOTUS)
abstract	This study protocol for a prospective, multicenter, diagnostic, clinical trial describes the integration of transoral and transcervical ultrasonography (US) in the initial clinical work-up of patients referred to tertiary head and neck cancer centers with suspected oropharyngeal cancer. The study evaluates the blinded detection rate of oropharyngeal tumors and their US-estimated size and T-stage before histopathology and cross-sectional imaging are available. Magnetic resonance imaging (MRI) scans will be prospectively rated while blinded to T-site histopathology and US. The primary outcome measures of diagnostic accuracy, including sensitivity, specificity, positive and negative predictive values, and overall accuracy, will be reported for both US and MRI. A sub-analysis of prospectively rated 18F-Fluorodeoxyglucose (FDG) positron emission tomography/computerized tomography (PET/CT) scans in patients with clinically suspected unknown primary tumors will also be compared to US and MRI. Secondary outcome measures, including a comparison of tumor size estimation between US, MRI, and CT, will also be reported. This prospective multicenter study will provide clinically impactful information regarding the use of transoral and transcervical US for the diagnostic work-up of oropharyngeal cancer.
abstractGer	This study protocol for a prospective, multicenter, diagnostic, clinical trial describes the integration of transoral and transcervical ultrasonography (US) in the initial clinical work-up of patients referred to tertiary head and neck cancer centers with suspected oropharyngeal cancer. The study evaluates the blinded detection rate of oropharyngeal tumors and their US-estimated size and T-stage before histopathology and cross-sectional imaging are available. Magnetic resonance imaging (MRI) scans will be prospectively rated while blinded to T-site histopathology and US. The primary outcome measures of diagnostic accuracy, including sensitivity, specificity, positive and negative predictive values, and overall accuracy, will be reported for both US and MRI. A sub-analysis of prospectively rated 18F-Fluorodeoxyglucose (FDG) positron emission tomography/computerized tomography (PET/CT) scans in patients with clinically suspected unknown primary tumors will also be compared to US and MRI. Secondary outcome measures, including a comparison of tumor size estimation between US, MRI, and CT, will also be reported. This prospective multicenter study will provide clinically impactful information regarding the use of transoral and transcervical US for the diagnostic work-up of oropharyngeal cancer.
abstract_unstemmed	This study protocol for a prospective, multicenter, diagnostic, clinical trial describes the integration of transoral and transcervical ultrasonography (US) in the initial clinical work-up of patients referred to tertiary head and neck cancer centers with suspected oropharyngeal cancer. The study evaluates the blinded detection rate of oropharyngeal tumors and their US-estimated size and T-stage before histopathology and cross-sectional imaging are available. Magnetic resonance imaging (MRI) scans will be prospectively rated while blinded to T-site histopathology and US. The primary outcome measures of diagnostic accuracy, including sensitivity, specificity, positive and negative predictive values, and overall accuracy, will be reported for both US and MRI. A sub-analysis of prospectively rated 18F-Fluorodeoxyglucose (FDG) positron emission tomography/computerized tomography (PET/CT) scans in patients with clinically suspected unknown primary tumors will also be compared to US and MRI. Secondary outcome measures, including a comparison of tumor size estimation between US, MRI, and CT, will also be reported. This prospective multicenter study will provide clinically impactful information regarding the use of transoral and transcervical US for the diagnostic work-up of oropharyngeal cancer.
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title_short	Comparison of Transoral and Transcervical Ultrasonography with MRI for the Diagnostic Work-Up of Oropharynx Tumors: A Protocol for a Multicenter Clinical Trial (SPOTUS)
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Comparison of Transoral and Transcervical Ultrasonography with MRI for the Diagnostic Work-Up of Oropharynx Tumors: A Protocol for a Multicenter Clinical Trial (SPOTUS)

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