<i<Drosophila</i< Importin Alpha 1 (Dα1) Is Required to Maintain Germline Stem Cells in the Testis Niche
Stem cell maintenance and differentiation can be regulated via the differential activity of transcription factors within stem cells and their progeny. For these factors to be active, they need to be transported from their site of synthesis in the cytoplasm into the nucleus. A tissue-specific require...
Ausführliche Beschreibung
Autor*in: |
James Heaney [verfasserIn] Jiamin Zhao [verfasserIn] Franca Casagranda [verfasserIn] Kate L. Loveland [verfasserIn] Nicole A. Siddall [verfasserIn] Gary R. Hime [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2024 |
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Übergeordnetes Werk: |
In: Cells - MDPI AG, 2012, 13(2024), 6, p 494 |
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Übergeordnetes Werk: |
volume:13 ; year:2024 ; number:6, p 494 |
Links: |
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DOI / URN: |
10.3390/cells13060494 |
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Katalog-ID: |
DOAJ100535208 |
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10.3390/cells13060494 doi (DE-627)DOAJ100535208 (DE-599)DOAJa8249005d3f44940b20e8942b5c8782c DE-627 ger DE-627 rakwb eng QH573-671 James Heaney verfasserin aut <i<Drosophila</i< Importin Alpha 1 (Dα1) Is Required to Maintain Germline Stem Cells in the Testis Niche 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Stem cell maintenance and differentiation can be regulated via the differential activity of transcription factors within stem cells and their progeny. For these factors to be active, they need to be transported from their site of synthesis in the cytoplasm into the nucleus. A tissue-specific requirement for factors involved in nuclear importation is a potential mechanism to regulate stem cell differentiation. We have undertaken a characterization of male sterile importin alpha 1 (<i<Dα1</i<) null alleles in <i<Drosophila</i< and found that Dα1 is required for maintaining germline stem cells (GSCs) in the testis niche. The loss of GSCs can be rescued by ectopic expression of Dα1 within the germline but the animals are still infertile, indicating a second role for Dα1 in spermatogenesis. Expression of a Dα1 dominant negative transgene in GSCs confirmed a functional requirement for Dα1 in GSC maintenance but expression of the transgene in differentiating spermatogonia did not exhibit a phenotype indicating a specific role for Dα1 within GSCs. Our data indicate that Dα1 is utilized as a regulatory protein within GSCs to facilitate nuclear importation of proteins that maintain the stem cell pool. <i<Drosophila</i< spermatogenesis importin Cytology Jiamin Zhao verfasserin aut Franca Casagranda verfasserin aut Kate L. Loveland verfasserin aut Nicole A. Siddall verfasserin aut Gary R. Hime verfasserin aut In Cells MDPI AG, 2012 13(2024), 6, p 494 (DE-627)718622081 (DE-600)2661518-6 20734409 nnns volume:13 year:2024 number:6, p 494 https://doi.org/10.3390/cells13060494 kostenfrei https://doaj.org/article/a8249005d3f44940b20e8942b5c8782c kostenfrei https://www.mdpi.com/2073-4409/13/6/494 kostenfrei https://doaj.org/toc/2073-4409 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2024 6, p 494 |
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10.3390/cells13060494 doi (DE-627)DOAJ100535208 (DE-599)DOAJa8249005d3f44940b20e8942b5c8782c DE-627 ger DE-627 rakwb eng QH573-671 James Heaney verfasserin aut <i<Drosophila</i< Importin Alpha 1 (Dα1) Is Required to Maintain Germline Stem Cells in the Testis Niche 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Stem cell maintenance and differentiation can be regulated via the differential activity of transcription factors within stem cells and their progeny. For these factors to be active, they need to be transported from their site of synthesis in the cytoplasm into the nucleus. A tissue-specific requirement for factors involved in nuclear importation is a potential mechanism to regulate stem cell differentiation. We have undertaken a characterization of male sterile importin alpha 1 (<i<Dα1</i<) null alleles in <i<Drosophila</i< and found that Dα1 is required for maintaining germline stem cells (GSCs) in the testis niche. The loss of GSCs can be rescued by ectopic expression of Dα1 within the germline but the animals are still infertile, indicating a second role for Dα1 in spermatogenesis. Expression of a Dα1 dominant negative transgene in GSCs confirmed a functional requirement for Dα1 in GSC maintenance but expression of the transgene in differentiating spermatogonia did not exhibit a phenotype indicating a specific role for Dα1 within GSCs. Our data indicate that Dα1 is utilized as a regulatory protein within GSCs to facilitate nuclear importation of proteins that maintain the stem cell pool. <i<Drosophila</i< spermatogenesis importin Cytology Jiamin Zhao verfasserin aut Franca Casagranda verfasserin aut Kate L. Loveland verfasserin aut Nicole A. Siddall verfasserin aut Gary R. Hime verfasserin aut In Cells MDPI AG, 2012 13(2024), 6, p 494 (DE-627)718622081 (DE-600)2661518-6 20734409 nnns volume:13 year:2024 number:6, p 494 https://doi.org/10.3390/cells13060494 kostenfrei https://doaj.org/article/a8249005d3f44940b20e8942b5c8782c kostenfrei https://www.mdpi.com/2073-4409/13/6/494 kostenfrei https://doaj.org/toc/2073-4409 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2024 6, p 494 |
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10.3390/cells13060494 doi (DE-627)DOAJ100535208 (DE-599)DOAJa8249005d3f44940b20e8942b5c8782c DE-627 ger DE-627 rakwb eng QH573-671 James Heaney verfasserin aut <i<Drosophila</i< Importin Alpha 1 (Dα1) Is Required to Maintain Germline Stem Cells in the Testis Niche 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Stem cell maintenance and differentiation can be regulated via the differential activity of transcription factors within stem cells and their progeny. For these factors to be active, they need to be transported from their site of synthesis in the cytoplasm into the nucleus. A tissue-specific requirement for factors involved in nuclear importation is a potential mechanism to regulate stem cell differentiation. We have undertaken a characterization of male sterile importin alpha 1 (<i<Dα1</i<) null alleles in <i<Drosophila</i< and found that Dα1 is required for maintaining germline stem cells (GSCs) in the testis niche. The loss of GSCs can be rescued by ectopic expression of Dα1 within the germline but the animals are still infertile, indicating a second role for Dα1 in spermatogenesis. Expression of a Dα1 dominant negative transgene in GSCs confirmed a functional requirement for Dα1 in GSC maintenance but expression of the transgene in differentiating spermatogonia did not exhibit a phenotype indicating a specific role for Dα1 within GSCs. Our data indicate that Dα1 is utilized as a regulatory protein within GSCs to facilitate nuclear importation of proteins that maintain the stem cell pool. <i<Drosophila</i< spermatogenesis importin Cytology Jiamin Zhao verfasserin aut Franca Casagranda verfasserin aut Kate L. Loveland verfasserin aut Nicole A. Siddall verfasserin aut Gary R. Hime verfasserin aut In Cells MDPI AG, 2012 13(2024), 6, p 494 (DE-627)718622081 (DE-600)2661518-6 20734409 nnns volume:13 year:2024 number:6, p 494 https://doi.org/10.3390/cells13060494 kostenfrei https://doaj.org/article/a8249005d3f44940b20e8942b5c8782c kostenfrei https://www.mdpi.com/2073-4409/13/6/494 kostenfrei https://doaj.org/toc/2073-4409 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2024 6, p 494 |
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10.3390/cells13060494 doi (DE-627)DOAJ100535208 (DE-599)DOAJa8249005d3f44940b20e8942b5c8782c DE-627 ger DE-627 rakwb eng QH573-671 James Heaney verfasserin aut <i<Drosophila</i< Importin Alpha 1 (Dα1) Is Required to Maintain Germline Stem Cells in the Testis Niche 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Stem cell maintenance and differentiation can be regulated via the differential activity of transcription factors within stem cells and their progeny. For these factors to be active, they need to be transported from their site of synthesis in the cytoplasm into the nucleus. A tissue-specific requirement for factors involved in nuclear importation is a potential mechanism to regulate stem cell differentiation. We have undertaken a characterization of male sterile importin alpha 1 (<i<Dα1</i<) null alleles in <i<Drosophila</i< and found that Dα1 is required for maintaining germline stem cells (GSCs) in the testis niche. The loss of GSCs can be rescued by ectopic expression of Dα1 within the germline but the animals are still infertile, indicating a second role for Dα1 in spermatogenesis. Expression of a Dα1 dominant negative transgene in GSCs confirmed a functional requirement for Dα1 in GSC maintenance but expression of the transgene in differentiating spermatogonia did not exhibit a phenotype indicating a specific role for Dα1 within GSCs. Our data indicate that Dα1 is utilized as a regulatory protein within GSCs to facilitate nuclear importation of proteins that maintain the stem cell pool. <i<Drosophila</i< spermatogenesis importin Cytology Jiamin Zhao verfasserin aut Franca Casagranda verfasserin aut Kate L. Loveland verfasserin aut Nicole A. Siddall verfasserin aut Gary R. Hime verfasserin aut In Cells MDPI AG, 2012 13(2024), 6, p 494 (DE-627)718622081 (DE-600)2661518-6 20734409 nnns volume:13 year:2024 number:6, p 494 https://doi.org/10.3390/cells13060494 kostenfrei https://doaj.org/article/a8249005d3f44940b20e8942b5c8782c kostenfrei https://www.mdpi.com/2073-4409/13/6/494 kostenfrei https://doaj.org/toc/2073-4409 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2024 6, p 494 |
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10.3390/cells13060494 doi (DE-627)DOAJ100535208 (DE-599)DOAJa8249005d3f44940b20e8942b5c8782c DE-627 ger DE-627 rakwb eng QH573-671 James Heaney verfasserin aut <i<Drosophila</i< Importin Alpha 1 (Dα1) Is Required to Maintain Germline Stem Cells in the Testis Niche 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Stem cell maintenance and differentiation can be regulated via the differential activity of transcription factors within stem cells and their progeny. For these factors to be active, they need to be transported from their site of synthesis in the cytoplasm into the nucleus. A tissue-specific requirement for factors involved in nuclear importation is a potential mechanism to regulate stem cell differentiation. We have undertaken a characterization of male sterile importin alpha 1 (<i<Dα1</i<) null alleles in <i<Drosophila</i< and found that Dα1 is required for maintaining germline stem cells (GSCs) in the testis niche. The loss of GSCs can be rescued by ectopic expression of Dα1 within the germline but the animals are still infertile, indicating a second role for Dα1 in spermatogenesis. Expression of a Dα1 dominant negative transgene in GSCs confirmed a functional requirement for Dα1 in GSC maintenance but expression of the transgene in differentiating spermatogonia did not exhibit a phenotype indicating a specific role for Dα1 within GSCs. Our data indicate that Dα1 is utilized as a regulatory protein within GSCs to facilitate nuclear importation of proteins that maintain the stem cell pool. <i<Drosophila</i< spermatogenesis importin Cytology Jiamin Zhao verfasserin aut Franca Casagranda verfasserin aut Kate L. Loveland verfasserin aut Nicole A. Siddall verfasserin aut Gary R. Hime verfasserin aut In Cells MDPI AG, 2012 13(2024), 6, p 494 (DE-627)718622081 (DE-600)2661518-6 20734409 nnns volume:13 year:2024 number:6, p 494 https://doi.org/10.3390/cells13060494 kostenfrei https://doaj.org/article/a8249005d3f44940b20e8942b5c8782c kostenfrei https://www.mdpi.com/2073-4409/13/6/494 kostenfrei https://doaj.org/toc/2073-4409 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2024 6, p 494 |
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<i<Drosophila</i< Importin Alpha 1 (Dα1) Is Required to Maintain Germline Stem Cells in the Testis Niche |
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Stem cell maintenance and differentiation can be regulated via the differential activity of transcription factors within stem cells and their progeny. For these factors to be active, they need to be transported from their site of synthesis in the cytoplasm into the nucleus. A tissue-specific requirement for factors involved in nuclear importation is a potential mechanism to regulate stem cell differentiation. We have undertaken a characterization of male sterile importin alpha 1 (<i<Dα1</i<) null alleles in <i<Drosophila</i< and found that Dα1 is required for maintaining germline stem cells (GSCs) in the testis niche. The loss of GSCs can be rescued by ectopic expression of Dα1 within the germline but the animals are still infertile, indicating a second role for Dα1 in spermatogenesis. Expression of a Dα1 dominant negative transgene in GSCs confirmed a functional requirement for Dα1 in GSC maintenance but expression of the transgene in differentiating spermatogonia did not exhibit a phenotype indicating a specific role for Dα1 within GSCs. Our data indicate that Dα1 is utilized as a regulatory protein within GSCs to facilitate nuclear importation of proteins that maintain the stem cell pool. |
abstractGer |
Stem cell maintenance and differentiation can be regulated via the differential activity of transcription factors within stem cells and their progeny. For these factors to be active, they need to be transported from their site of synthesis in the cytoplasm into the nucleus. A tissue-specific requirement for factors involved in nuclear importation is a potential mechanism to regulate stem cell differentiation. We have undertaken a characterization of male sterile importin alpha 1 (<i<Dα1</i<) null alleles in <i<Drosophila</i< and found that Dα1 is required for maintaining germline stem cells (GSCs) in the testis niche. The loss of GSCs can be rescued by ectopic expression of Dα1 within the germline but the animals are still infertile, indicating a second role for Dα1 in spermatogenesis. Expression of a Dα1 dominant negative transgene in GSCs confirmed a functional requirement for Dα1 in GSC maintenance but expression of the transgene in differentiating spermatogonia did not exhibit a phenotype indicating a specific role for Dα1 within GSCs. Our data indicate that Dα1 is utilized as a regulatory protein within GSCs to facilitate nuclear importation of proteins that maintain the stem cell pool. |
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Stem cell maintenance and differentiation can be regulated via the differential activity of transcription factors within stem cells and their progeny. For these factors to be active, they need to be transported from their site of synthesis in the cytoplasm into the nucleus. A tissue-specific requirement for factors involved in nuclear importation is a potential mechanism to regulate stem cell differentiation. We have undertaken a characterization of male sterile importin alpha 1 (<i<Dα1</i<) null alleles in <i<Drosophila</i< and found that Dα1 is required for maintaining germline stem cells (GSCs) in the testis niche. The loss of GSCs can be rescued by ectopic expression of Dα1 within the germline but the animals are still infertile, indicating a second role for Dα1 in spermatogenesis. Expression of a Dα1 dominant negative transgene in GSCs confirmed a functional requirement for Dα1 in GSC maintenance but expression of the transgene in differentiating spermatogonia did not exhibit a phenotype indicating a specific role for Dα1 within GSCs. Our data indicate that Dα1 is utilized as a regulatory protein within GSCs to facilitate nuclear importation of proteins that maintain the stem cell pool. |
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