Gene Expression of GABA<sub<A</sub< Receptor Subunits and Association with Patient Survival in Glioma

Rapid neuronal inhibition in the brain is mediated by γ-aminobutyric acid (GABA) activation of GABA<sub<A</sub< receptors. The <i<GABRA5</i< gene, which encodes the α5 subunit of the GABA<sub<A</sub< receptor, has been implicated in an aggressive subgroup of medulloblastoma (MB), a type of pediatric brain tumor. However, the possible role of GABA<sub<A</sub< receptor subunits in glioma remains poorly understood. Here, we examined the expression of genes encoding GABA<sub<A</sub< receptor subunits in different types of glioma, and its possible association with patient prognosis assessed by overall survival (OS). Data were obtained from the French and The Cancer Genome Atlas Brain Lower Grade Glioma (TCGA-LGG) datasets and analyzed for expression of GABA<sub<A</sub< receptor subunit genes. OS was calculated using the Kaplan–Meier estimate. We found that genes <i<GABRA2</i<, <i<GABRA3</i<, <i<GABRB3</i<, <i<GABRG1</i<, and <i<GABRG2</i< showed a significant association with OS, with higher gene expression indicating better prognosis. In patients with GBM, high expression of <i<GABRA2</i< was associated with shorter OS, whereas, in contrast, higher levels of <i<GABRB3</i< were associated with better prognosis indicated by longer OS. In patients with lower grade gliomas, <i<GABRA3</i<, <i<GABRB3</i<, <i<GABRG1</i<, and <i<GABRG2</i<, were associated with longer OS. High <i<GABRB3</i< expression was related to longer survival when low grade glioma types were analyzed separately. Our results suggest an overall association between higher expression of most genes encoding GABA<sub<A</sub< receptor subunits and better prognosis in different types of glioma. Our findings support the possibility that down-regulation of GABA<sub<A</sub< receptors in glioma contributes to promoting tumor progression by reducing negative inhibition. These findings might contribute to further evaluation of GABA<sub<A</sub< receptors as a therapeutic target in glioma. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Rafael Badalotti [verfasserIn] Matheus Dalmolin [verfasserIn] Osvaldo Malafaia [verfasserIn] Jurandir M. Ribas Filho [verfasserIn] Rafael Roesler [verfasserIn] Marcelo A. C. Fernandes [verfasserIn] Gustavo R. Isolan [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	GABA GABA glioma glioblastoma brain tumor

Übergeordnetes Werk:	In: Brain Sciences - MDPI AG, 2012, 14(2024), 3, p 275
Übergeordnetes Werk:	volume:14 ; year:2024 ; number:3, p 275

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/brainsci14030275

Katalog-ID:	DOAJ10054133X

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allfields	10.3390/brainsci14030275 doi (DE-627)DOAJ10054133X (DE-599)DOAJ7c6517376ccb45e79111004727b2b92e DE-627 ger DE-627 rakwb eng RC321-571 Rafael Badalotti verfasserin aut Gene Expression of GABA<sub<A</sub< Receptor Subunits and Association with Patient Survival in Glioma 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Rapid neuronal inhibition in the brain is mediated by γ-aminobutyric acid (GABA) activation of GABA<sub<A</sub< receptors. The <i<GABRA5</i< gene, which encodes the α5 subunit of the GABA<sub<A</sub< receptor, has been implicated in an aggressive subgroup of medulloblastoma (MB), a type of pediatric brain tumor. However, the possible role of GABA<sub<A</sub< receptor subunits in glioma remains poorly understood. Here, we examined the expression of genes encoding GABA<sub<A</sub< receptor subunits in different types of glioma, and its possible association with patient prognosis assessed by overall survival (OS). Data were obtained from the French and The Cancer Genome Atlas Brain Lower Grade Glioma (TCGA-LGG) datasets and analyzed for expression of GABA<sub<A</sub< receptor subunit genes. OS was calculated using the Kaplan–Meier estimate. We found that genes <i<GABRA2</i<, <i<GABRA3</i<, <i<GABRB3</i<, <i<GABRG1</i<, and <i<GABRG2</i< showed a significant association with OS, with higher gene expression indicating better prognosis. In patients with GBM, high expression of <i<GABRA2</i< was associated with shorter OS, whereas, in contrast, higher levels of <i<GABRB3</i< were associated with better prognosis indicated by longer OS. In patients with lower grade gliomas, <i<GABRA3</i<, <i<GABRB3</i<, <i<GABRG1</i<, and <i<GABRG2</i<, were associated with longer OS. High <i<GABRB3</i< expression was related to longer survival when low grade glioma types were analyzed separately. Our results suggest an overall association between higher expression of most genes encoding GABA<sub<A</sub< receptor subunits and better prognosis in different types of glioma. Our findings support the possibility that down-regulation of GABA<sub<A</sub< receptors in glioma contributes to promoting tumor progression by reducing negative inhibition. These findings might contribute to further evaluation of GABA<sub<A</sub< receptors as a therapeutic target in glioma. GABA<sub<A</sub< receptor subunit gene GABA<sub<A</sub< receptor glioma glioblastoma brain tumor Neurosciences. Biological psychiatry. Neuropsychiatry Matheus Dalmolin verfasserin aut Osvaldo Malafaia verfasserin aut Jurandir M. Ribas Filho verfasserin aut Rafael Roesler verfasserin aut Marcelo A. C. Fernandes verfasserin aut Gustavo R. Isolan verfasserin aut In Brain Sciences MDPI AG, 2012 14(2024), 3, p 275 (DE-627)687718139 (DE-600)2651993-8 20763425 nnns volume:14 year:2024 number:3, p 275 https://doi.org/10.3390/brainsci14030275 kostenfrei https://doaj.org/article/7c6517376ccb45e79111004727b2b92e kostenfrei https://www.mdpi.com/2076-3425/14/3/275 kostenfrei https://doaj.org/toc/2076-3425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024 3, p 275
spelling	10.3390/brainsci14030275 doi (DE-627)DOAJ10054133X (DE-599)DOAJ7c6517376ccb45e79111004727b2b92e DE-627 ger DE-627 rakwb eng RC321-571 Rafael Badalotti verfasserin aut Gene Expression of GABA<sub<A</sub< Receptor Subunits and Association with Patient Survival in Glioma 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Rapid neuronal inhibition in the brain is mediated by γ-aminobutyric acid (GABA) activation of GABA<sub<A</sub< receptors. The <i<GABRA5</i< gene, which encodes the α5 subunit of the GABA<sub<A</sub< receptor, has been implicated in an aggressive subgroup of medulloblastoma (MB), a type of pediatric brain tumor. However, the possible role of GABA<sub<A</sub< receptor subunits in glioma remains poorly understood. Here, we examined the expression of genes encoding GABA<sub<A</sub< receptor subunits in different types of glioma, and its possible association with patient prognosis assessed by overall survival (OS). Data were obtained from the French and The Cancer Genome Atlas Brain Lower Grade Glioma (TCGA-LGG) datasets and analyzed for expression of GABA<sub<A</sub< receptor subunit genes. OS was calculated using the Kaplan–Meier estimate. We found that genes <i<GABRA2</i<, <i<GABRA3</i<, <i<GABRB3</i<, <i<GABRG1</i<, and <i<GABRG2</i< showed a significant association with OS, with higher gene expression indicating better prognosis. In patients with GBM, high expression of <i<GABRA2</i< was associated with shorter OS, whereas, in contrast, higher levels of <i<GABRB3</i< were associated with better prognosis indicated by longer OS. In patients with lower grade gliomas, <i<GABRA3</i<, <i<GABRB3</i<, <i<GABRG1</i<, and <i<GABRG2</i<, were associated with longer OS. High <i<GABRB3</i< expression was related to longer survival when low grade glioma types were analyzed separately. Our results suggest an overall association between higher expression of most genes encoding GABA<sub<A</sub< receptor subunits and better prognosis in different types of glioma. Our findings support the possibility that down-regulation of GABA<sub<A</sub< receptors in glioma contributes to promoting tumor progression by reducing negative inhibition. These findings might contribute to further evaluation of GABA<sub<A</sub< receptors as a therapeutic target in glioma. GABA<sub<A</sub< receptor subunit gene GABA<sub<A</sub< receptor glioma glioblastoma brain tumor Neurosciences. Biological psychiatry. Neuropsychiatry Matheus Dalmolin verfasserin aut Osvaldo Malafaia verfasserin aut Jurandir M. Ribas Filho verfasserin aut Rafael Roesler verfasserin aut Marcelo A. C. Fernandes verfasserin aut Gustavo R. Isolan verfasserin aut In Brain Sciences MDPI AG, 2012 14(2024), 3, p 275 (DE-627)687718139 (DE-600)2651993-8 20763425 nnns volume:14 year:2024 number:3, p 275 https://doi.org/10.3390/brainsci14030275 kostenfrei https://doaj.org/article/7c6517376ccb45e79111004727b2b92e kostenfrei https://www.mdpi.com/2076-3425/14/3/275 kostenfrei https://doaj.org/toc/2076-3425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024 3, p 275
allfields_unstemmed	10.3390/brainsci14030275 doi (DE-627)DOAJ10054133X (DE-599)DOAJ7c6517376ccb45e79111004727b2b92e DE-627 ger DE-627 rakwb eng RC321-571 Rafael Badalotti verfasserin aut Gene Expression of GABA<sub<A</sub< Receptor Subunits and Association with Patient Survival in Glioma 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Rapid neuronal inhibition in the brain is mediated by γ-aminobutyric acid (GABA) activation of GABA<sub<A</sub< receptors. The <i<GABRA5</i< gene, which encodes the α5 subunit of the GABA<sub<A</sub< receptor, has been implicated in an aggressive subgroup of medulloblastoma (MB), a type of pediatric brain tumor. However, the possible role of GABA<sub<A</sub< receptor subunits in glioma remains poorly understood. Here, we examined the expression of genes encoding GABA<sub<A</sub< receptor subunits in different types of glioma, and its possible association with patient prognosis assessed by overall survival (OS). Data were obtained from the French and The Cancer Genome Atlas Brain Lower Grade Glioma (TCGA-LGG) datasets and analyzed for expression of GABA<sub<A</sub< receptor subunit genes. OS was calculated using the Kaplan–Meier estimate. We found that genes <i<GABRA2</i<, <i<GABRA3</i<, <i<GABRB3</i<, <i<GABRG1</i<, and <i<GABRG2</i< showed a significant association with OS, with higher gene expression indicating better prognosis. In patients with GBM, high expression of <i<GABRA2</i< was associated with shorter OS, whereas, in contrast, higher levels of <i<GABRB3</i< were associated with better prognosis indicated by longer OS. In patients with lower grade gliomas, <i<GABRA3</i<, <i<GABRB3</i<, <i<GABRG1</i<, and <i<GABRG2</i<, were associated with longer OS. High <i<GABRB3</i< expression was related to longer survival when low grade glioma types were analyzed separately. Our results suggest an overall association between higher expression of most genes encoding GABA<sub<A</sub< receptor subunits and better prognosis in different types of glioma. Our findings support the possibility that down-regulation of GABA<sub<A</sub< receptors in glioma contributes to promoting tumor progression by reducing negative inhibition. These findings might contribute to further evaluation of GABA<sub<A</sub< receptors as a therapeutic target in glioma. GABA<sub<A</sub< receptor subunit gene GABA<sub<A</sub< receptor glioma glioblastoma brain tumor Neurosciences. Biological psychiatry. Neuropsychiatry Matheus Dalmolin verfasserin aut Osvaldo Malafaia verfasserin aut Jurandir M. Ribas Filho verfasserin aut Rafael Roesler verfasserin aut Marcelo A. C. Fernandes verfasserin aut Gustavo R. Isolan verfasserin aut In Brain Sciences MDPI AG, 2012 14(2024), 3, p 275 (DE-627)687718139 (DE-600)2651993-8 20763425 nnns volume:14 year:2024 number:3, p 275 https://doi.org/10.3390/brainsci14030275 kostenfrei https://doaj.org/article/7c6517376ccb45e79111004727b2b92e kostenfrei https://www.mdpi.com/2076-3425/14/3/275 kostenfrei https://doaj.org/toc/2076-3425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024 3, p 275
allfieldsGer	10.3390/brainsci14030275 doi (DE-627)DOAJ10054133X (DE-599)DOAJ7c6517376ccb45e79111004727b2b92e DE-627 ger DE-627 rakwb eng RC321-571 Rafael Badalotti verfasserin aut Gene Expression of GABA<sub<A</sub< Receptor Subunits and Association with Patient Survival in Glioma 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Rapid neuronal inhibition in the brain is mediated by γ-aminobutyric acid (GABA) activation of GABA<sub<A</sub< receptors. The <i<GABRA5</i< gene, which encodes the α5 subunit of the GABA<sub<A</sub< receptor, has been implicated in an aggressive subgroup of medulloblastoma (MB), a type of pediatric brain tumor. However, the possible role of GABA<sub<A</sub< receptor subunits in glioma remains poorly understood. Here, we examined the expression of genes encoding GABA<sub<A</sub< receptor subunits in different types of glioma, and its possible association with patient prognosis assessed by overall survival (OS). Data were obtained from the French and The Cancer Genome Atlas Brain Lower Grade Glioma (TCGA-LGG) datasets and analyzed for expression of GABA<sub<A</sub< receptor subunit genes. OS was calculated using the Kaplan–Meier estimate. We found that genes <i<GABRA2</i<, <i<GABRA3</i<, <i<GABRB3</i<, <i<GABRG1</i<, and <i<GABRG2</i< showed a significant association with OS, with higher gene expression indicating better prognosis. In patients with GBM, high expression of <i<GABRA2</i< was associated with shorter OS, whereas, in contrast, higher levels of <i<GABRB3</i< were associated with better prognosis indicated by longer OS. In patients with lower grade gliomas, <i<GABRA3</i<, <i<GABRB3</i<, <i<GABRG1</i<, and <i<GABRG2</i<, were associated with longer OS. High <i<GABRB3</i< expression was related to longer survival when low grade glioma types were analyzed separately. Our results suggest an overall association between higher expression of most genes encoding GABA<sub<A</sub< receptor subunits and better prognosis in different types of glioma. Our findings support the possibility that down-regulation of GABA<sub<A</sub< receptors in glioma contributes to promoting tumor progression by reducing negative inhibition. These findings might contribute to further evaluation of GABA<sub<A</sub< receptors as a therapeutic target in glioma. GABA<sub<A</sub< receptor subunit gene GABA<sub<A</sub< receptor glioma glioblastoma brain tumor Neurosciences. Biological psychiatry. Neuropsychiatry Matheus Dalmolin verfasserin aut Osvaldo Malafaia verfasserin aut Jurandir M. Ribas Filho verfasserin aut Rafael Roesler verfasserin aut Marcelo A. C. Fernandes verfasserin aut Gustavo R. Isolan verfasserin aut In Brain Sciences MDPI AG, 2012 14(2024), 3, p 275 (DE-627)687718139 (DE-600)2651993-8 20763425 nnns volume:14 year:2024 number:3, p 275 https://doi.org/10.3390/brainsci14030275 kostenfrei https://doaj.org/article/7c6517376ccb45e79111004727b2b92e kostenfrei https://www.mdpi.com/2076-3425/14/3/275 kostenfrei https://doaj.org/toc/2076-3425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024 3, p 275
allfieldsSound	10.3390/brainsci14030275 doi (DE-627)DOAJ10054133X (DE-599)DOAJ7c6517376ccb45e79111004727b2b92e DE-627 ger DE-627 rakwb eng RC321-571 Rafael Badalotti verfasserin aut Gene Expression of GABA<sub<A</sub< Receptor Subunits and Association with Patient Survival in Glioma 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Rapid neuronal inhibition in the brain is mediated by γ-aminobutyric acid (GABA) activation of GABA<sub<A</sub< receptors. The <i<GABRA5</i< gene, which encodes the α5 subunit of the GABA<sub<A</sub< receptor, has been implicated in an aggressive subgroup of medulloblastoma (MB), a type of pediatric brain tumor. However, the possible role of GABA<sub<A</sub< receptor subunits in glioma remains poorly understood. Here, we examined the expression of genes encoding GABA<sub<A</sub< receptor subunits in different types of glioma, and its possible association with patient prognosis assessed by overall survival (OS). Data were obtained from the French and The Cancer Genome Atlas Brain Lower Grade Glioma (TCGA-LGG) datasets and analyzed for expression of GABA<sub<A</sub< receptor subunit genes. OS was calculated using the Kaplan–Meier estimate. We found that genes <i<GABRA2</i<, <i<GABRA3</i<, <i<GABRB3</i<, <i<GABRG1</i<, and <i<GABRG2</i< showed a significant association with OS, with higher gene expression indicating better prognosis. In patients with GBM, high expression of <i<GABRA2</i< was associated with shorter OS, whereas, in contrast, higher levels of <i<GABRB3</i< were associated with better prognosis indicated by longer OS. In patients with lower grade gliomas, <i<GABRA3</i<, <i<GABRB3</i<, <i<GABRG1</i<, and <i<GABRG2</i<, were associated with longer OS. High <i<GABRB3</i< expression was related to longer survival when low grade glioma types were analyzed separately. Our results suggest an overall association between higher expression of most genes encoding GABA<sub<A</sub< receptor subunits and better prognosis in different types of glioma. Our findings support the possibility that down-regulation of GABA<sub<A</sub< receptors in glioma contributes to promoting tumor progression by reducing negative inhibition. These findings might contribute to further evaluation of GABA<sub<A</sub< receptors as a therapeutic target in glioma. GABA<sub<A</sub< receptor subunit gene GABA<sub<A</sub< receptor glioma glioblastoma brain tumor Neurosciences. Biological psychiatry. Neuropsychiatry Matheus Dalmolin verfasserin aut Osvaldo Malafaia verfasserin aut Jurandir M. Ribas Filho verfasserin aut Rafael Roesler verfasserin aut Marcelo A. C. Fernandes verfasserin aut Gustavo R. Isolan verfasserin aut In Brain Sciences MDPI AG, 2012 14(2024), 3, p 275 (DE-627)687718139 (DE-600)2651993-8 20763425 nnns volume:14 year:2024 number:3, p 275 https://doi.org/10.3390/brainsci14030275 kostenfrei https://doaj.org/article/7c6517376ccb45e79111004727b2b92e kostenfrei https://www.mdpi.com/2076-3425/14/3/275 kostenfrei https://doaj.org/toc/2076-3425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024 3, p 275
language	English
source	In Brain Sciences 14(2024), 3, p 275 volume:14 year:2024 number:3, p 275
sourceStr	In Brain Sciences 14(2024), 3, p 275 volume:14 year:2024 number:3, p 275
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	GABA<sub<A</sub< receptor subunit gene GABA<sub<A</sub< receptor glioma glioblastoma brain tumor Neurosciences. Biological psychiatry. Neuropsychiatry
isfreeaccess_bool	true
container_title	Brain Sciences
authorswithroles_txt_mv	Rafael Badalotti @@aut@@ Matheus Dalmolin @@aut@@ Osvaldo Malafaia @@aut@@ Jurandir M. Ribas Filho @@aut@@ Rafael Roesler @@aut@@ Marcelo A. C. Fernandes @@aut@@ Gustavo R. Isolan @@aut@@
publishDateDaySort_date	2024-01-01T00:00:00Z
hierarchy_top_id	687718139
id	DOAJ10054133X
language_de	englisch
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callnumber-first	R - Medicine
author	Rafael Badalotti
spellingShingle	Rafael Badalotti misc RC321-571 misc GABA<sub<A</sub< receptor subunit gene misc GABA<sub<A</sub< receptor misc glioma misc glioblastoma misc brain tumor misc Neurosciences. Biological psychiatry. Neuropsychiatry Gene Expression of GABA<sub<A</sub< Receptor Subunits and Association with Patient Survival in Glioma
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topic_title	RC321-571 Gene Expression of GABA<sub<A</sub< Receptor Subunits and Association with Patient Survival in Glioma GABA<sub<A</sub< receptor subunit gene GABA<sub<A</sub< receptor glioma glioblastoma brain tumor
topic	misc RC321-571 misc GABA<sub<A</sub< receptor subunit gene misc GABA<sub<A</sub< receptor misc glioma misc glioblastoma misc brain tumor misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc GABA<sub<A</sub< receptor subunit gene misc GABA<sub<A</sub< receptor misc glioma misc glioblastoma misc brain tumor misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_browse	misc RC321-571 misc GABA<sub<A</sub< receptor subunit gene misc GABA<sub<A</sub< receptor misc glioma misc glioblastoma misc brain tumor misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Gene Expression of GABA<sub<A</sub< Receptor Subunits and Association with Patient Survival in Glioma
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title_full	Gene Expression of GABA<sub<A</sub< Receptor Subunits and Association with Patient Survival in Glioma
author_sort	Rafael Badalotti
journal	Brain Sciences
journalStr	Brain Sciences
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author_browse	Rafael Badalotti Matheus Dalmolin Osvaldo Malafaia Jurandir M. Ribas Filho Rafael Roesler Marcelo A. C. Fernandes Gustavo R. Isolan
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author-letter	Rafael Badalotti
doi_str_mv	10.3390/brainsci14030275
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title_sort	gene expression of gaba<sub<a</sub< receptor subunits and association with patient survival in glioma
callnumber	RC321-571
title_auth	Gene Expression of GABA<sub<A</sub< Receptor Subunits and Association with Patient Survival in Glioma
abstract	Rapid neuronal inhibition in the brain is mediated by γ-aminobutyric acid (GABA) activation of GABA<sub<A</sub< receptors. The <i<GABRA5</i< gene, which encodes the α5 subunit of the GABA<sub<A</sub< receptor, has been implicated in an aggressive subgroup of medulloblastoma (MB), a type of pediatric brain tumor. However, the possible role of GABA<sub<A</sub< receptor subunits in glioma remains poorly understood. Here, we examined the expression of genes encoding GABA<sub<A</sub< receptor subunits in different types of glioma, and its possible association with patient prognosis assessed by overall survival (OS). Data were obtained from the French and The Cancer Genome Atlas Brain Lower Grade Glioma (TCGA-LGG) datasets and analyzed for expression of GABA<sub<A</sub< receptor subunit genes. OS was calculated using the Kaplan–Meier estimate. We found that genes <i<GABRA2</i<, <i<GABRA3</i<, <i<GABRB3</i<, <i<GABRG1</i<, and <i<GABRG2</i< showed a significant association with OS, with higher gene expression indicating better prognosis. In patients with GBM, high expression of <i<GABRA2</i< was associated with shorter OS, whereas, in contrast, higher levels of <i<GABRB3</i< were associated with better prognosis indicated by longer OS. In patients with lower grade gliomas, <i<GABRA3</i<, <i<GABRB3</i<, <i<GABRG1</i<, and <i<GABRG2</i<, were associated with longer OS. High <i<GABRB3</i< expression was related to longer survival when low grade glioma types were analyzed separately. Our results suggest an overall association between higher expression of most genes encoding GABA<sub<A</sub< receptor subunits and better prognosis in different types of glioma. Our findings support the possibility that down-regulation of GABA<sub<A</sub< receptors in glioma contributes to promoting tumor progression by reducing negative inhibition. These findings might contribute to further evaluation of GABA<sub<A</sub< receptors as a therapeutic target in glioma.
abstractGer	Rapid neuronal inhibition in the brain is mediated by γ-aminobutyric acid (GABA) activation of GABA<sub<A</sub< receptors. The <i<GABRA5</i< gene, which encodes the α5 subunit of the GABA<sub<A</sub< receptor, has been implicated in an aggressive subgroup of medulloblastoma (MB), a type of pediatric brain tumor. However, the possible role of GABA<sub<A</sub< receptor subunits in glioma remains poorly understood. Here, we examined the expression of genes encoding GABA<sub<A</sub< receptor subunits in different types of glioma, and its possible association with patient prognosis assessed by overall survival (OS). Data were obtained from the French and The Cancer Genome Atlas Brain Lower Grade Glioma (TCGA-LGG) datasets and analyzed for expression of GABA<sub<A</sub< receptor subunit genes. OS was calculated using the Kaplan–Meier estimate. We found that genes <i<GABRA2</i<, <i<GABRA3</i<, <i<GABRB3</i<, <i<GABRG1</i<, and <i<GABRG2</i< showed a significant association with OS, with higher gene expression indicating better prognosis. In patients with GBM, high expression of <i<GABRA2</i< was associated with shorter OS, whereas, in contrast, higher levels of <i<GABRB3</i< were associated with better prognosis indicated by longer OS. In patients with lower grade gliomas, <i<GABRA3</i<, <i<GABRB3</i<, <i<GABRG1</i<, and <i<GABRG2</i<, were associated with longer OS. High <i<GABRB3</i< expression was related to longer survival when low grade glioma types were analyzed separately. Our results suggest an overall association between higher expression of most genes encoding GABA<sub<A</sub< receptor subunits and better prognosis in different types of glioma. Our findings support the possibility that down-regulation of GABA<sub<A</sub< receptors in glioma contributes to promoting tumor progression by reducing negative inhibition. These findings might contribute to further evaluation of GABA<sub<A</sub< receptors as a therapeutic target in glioma.
abstract_unstemmed	Rapid neuronal inhibition in the brain is mediated by γ-aminobutyric acid (GABA) activation of GABA<sub<A</sub< receptors. The <i<GABRA5</i< gene, which encodes the α5 subunit of the GABA<sub<A</sub< receptor, has been implicated in an aggressive subgroup of medulloblastoma (MB), a type of pediatric brain tumor. However, the possible role of GABA<sub<A</sub< receptor subunits in glioma remains poorly understood. Here, we examined the expression of genes encoding GABA<sub<A</sub< receptor subunits in different types of glioma, and its possible association with patient prognosis assessed by overall survival (OS). Data were obtained from the French and The Cancer Genome Atlas Brain Lower Grade Glioma (TCGA-LGG) datasets and analyzed for expression of GABA<sub<A</sub< receptor subunit genes. OS was calculated using the Kaplan–Meier estimate. We found that genes <i<GABRA2</i<, <i<GABRA3</i<, <i<GABRB3</i<, <i<GABRG1</i<, and <i<GABRG2</i< showed a significant association with OS, with higher gene expression indicating better prognosis. In patients with GBM, high expression of <i<GABRA2</i< was associated with shorter OS, whereas, in contrast, higher levels of <i<GABRB3</i< were associated with better prognosis indicated by longer OS. In patients with lower grade gliomas, <i<GABRA3</i<, <i<GABRB3</i<, <i<GABRG1</i<, and <i<GABRG2</i<, were associated with longer OS. High <i<GABRB3</i< expression was related to longer survival when low grade glioma types were analyzed separately. Our results suggest an overall association between higher expression of most genes encoding GABA<sub<A</sub< receptor subunits and better prognosis in different types of glioma. Our findings support the possibility that down-regulation of GABA<sub<A</sub< receptors in glioma contributes to promoting tumor progression by reducing negative inhibition. These findings might contribute to further evaluation of GABA<sub<A</sub< receptors as a therapeutic target in glioma.
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title_short	Gene Expression of GABA<sub<A</sub< Receptor Subunits and Association with Patient Survival in Glioma
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Gene Expression of GABA<sub<A</sub< Receptor Subunits and Association with Patient Survival in Glioma

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