The significance of Hippo pathway protein expression in oral squamous cell carcinoma

IntroductionThe Hippo pathway consists of mammalian sterile 20-like kinase 1/2 (MST1/2), large tumor suppressor 1/2 (LATS1/2), and yes-associated protein (YAP)1. Herein, we present the first report on the significance of major Hippo pathway protein expression in oral squamous cell carcinoma (OSCC).M...
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Autor*in:	Yusuke Amano [verfasserIn] Daisuke Matsubara [verfasserIn] Atsushi Kihara [verfasserIn] Taichiro Yoshimoto [verfasserIn] Noriyoshi Fukushima [verfasserIn] Hiroshi Nishino [verfasserIn] Yoshiyuki Mori [verfasserIn] Toshiro Niki [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	Hippo pathway MST1/2 YAP1 PRMT oral squamous cell carcinoma

Übergeordnetes Werk:	In: Frontiers in Medicine - Frontiers Media S.A., 2014, 11(2024)
Übergeordnetes Werk:	volume:11 ; year:2024

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fmed.2024.1247625

Katalog-ID:	DOAJ100810993

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520			\|a IntroductionThe Hippo pathway consists of mammalian sterile 20-like kinase 1/2 (MST1/2), large tumor suppressor 1/2 (LATS1/2), and yes-associated protein (YAP)1. Herein, we present the first report on the significance of major Hippo pathway protein expression in oral squamous cell carcinoma (OSCC).MethodsThe analyses included oral epithelial dysplasia (OED, n = 7), carcinoma in situ (CIS, n = 14), and oral squamous cell carcinoma (OSCC, n = 109).ResultsCytoplasmic expression of MST1, LATS1, and LATS2 was low in OED, CIS, and OSCC. The cytoplasmic expression of MST2 was high in OED (5/7 cases), CIS (9/14 cases), and poorly differentiated OSCC (8/8 cases) but was low/lost in a proportion of differentiated OSCC (60/101 cases). The expression of YAP1 was associated with differentiation; low YAP expression was significantly more frequent in well-differentiated OSCC (35/71 cases), compared to moderately and poorly differentiated OSCC (11/38 cases). An infiltrative invasion pattern was associated with a high expression of MST2 and high expression of YAP1. The high expression of YAP1 was associated with features of epithelial-to-mesenchymal transition (EMT), such as the loss of E-cadherin and high expression of vimentin, laminin 5, and Slug. High expression of protein arginine methyltransferase (PRMT) 1 or 5, which positively regulates YAP activity, was associated with the high expression of YAP1 (p < 0.0001).ConclusionAmong the major Hippo pathway proteins, MST2 displayed a distinctive expression pattern in a significant proportion of differentiated OSCC, suggesting a possible differential role for MST2 depending on the course of OSCC progression. A high YAP1 expression may indicate aggressive OSCC with EMT via PRMTs at the invasive front.
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700	0		\|a Toshiro Niki \|e verfasserin \|4 aut
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allfields	10.3389/fmed.2024.1247625 doi (DE-627)DOAJ100810993 (DE-599)DOAJ936860388cd4499888d34154fd362794 DE-627 ger DE-627 rakwb eng R5-920 Yusuke Amano verfasserin aut The significance of Hippo pathway protein expression in oral squamous cell carcinoma 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionThe Hippo pathway consists of mammalian sterile 20-like kinase 1/2 (MST1/2), large tumor suppressor 1/2 (LATS1/2), and yes-associated protein (YAP)1. Herein, we present the first report on the significance of major Hippo pathway protein expression in oral squamous cell carcinoma (OSCC).MethodsThe analyses included oral epithelial dysplasia (OED, n = 7), carcinoma in situ (CIS, n = 14), and oral squamous cell carcinoma (OSCC, n = 109).ResultsCytoplasmic expression of MST1, LATS1, and LATS2 was low in OED, CIS, and OSCC. The cytoplasmic expression of MST2 was high in OED (5/7 cases), CIS (9/14 cases), and poorly differentiated OSCC (8/8 cases) but was low/lost in a proportion of differentiated OSCC (60/101 cases). The expression of YAP1 was associated with differentiation; low YAP expression was significantly more frequent in well-differentiated OSCC (35/71 cases), compared to moderately and poorly differentiated OSCC (11/38 cases). An infiltrative invasion pattern was associated with a high expression of MST2 and high expression of YAP1. The high expression of YAP1 was associated with features of epithelial-to-mesenchymal transition (EMT), such as the loss of E-cadherin and high expression of vimentin, laminin 5, and Slug. High expression of protein arginine methyltransferase (PRMT) 1 or 5, which positively regulates YAP activity, was associated with the high expression of YAP1 (p < 0.0001).ConclusionAmong the major Hippo pathway proteins, MST2 displayed a distinctive expression pattern in a significant proportion of differentiated OSCC, suggesting a possible differential role for MST2 depending on the course of OSCC progression. A high YAP1 expression may indicate aggressive OSCC with EMT via PRMTs at the invasive front. Hippo pathway MST1/2 YAP1 PRMT oral squamous cell carcinoma Medicine (General) Daisuke Matsubara verfasserin aut Daisuke Matsubara verfasserin aut Atsushi Kihara verfasserin aut Taichiro Yoshimoto verfasserin aut Noriyoshi Fukushima verfasserin aut Hiroshi Nishino verfasserin aut Yoshiyuki Mori verfasserin aut Toshiro Niki verfasserin aut In Frontiers in Medicine Frontiers Media S.A., 2014 11(2024) (DE-627)789482991 (DE-600)2775999-4 2296858X nnns volume:11 year:2024 https://doi.org/10.3389/fmed.2024.1247625 kostenfrei https://doaj.org/article/936860388cd4499888d34154fd362794 kostenfrei https://www.frontiersin.org/articles/10.3389/fmed.2024.1247625/full kostenfrei https://doaj.org/toc/2296-858X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2024
spelling	10.3389/fmed.2024.1247625 doi (DE-627)DOAJ100810993 (DE-599)DOAJ936860388cd4499888d34154fd362794 DE-627 ger DE-627 rakwb eng R5-920 Yusuke Amano verfasserin aut The significance of Hippo pathway protein expression in oral squamous cell carcinoma 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionThe Hippo pathway consists of mammalian sterile 20-like kinase 1/2 (MST1/2), large tumor suppressor 1/2 (LATS1/2), and yes-associated protein (YAP)1. Herein, we present the first report on the significance of major Hippo pathway protein expression in oral squamous cell carcinoma (OSCC).MethodsThe analyses included oral epithelial dysplasia (OED, n = 7), carcinoma in situ (CIS, n = 14), and oral squamous cell carcinoma (OSCC, n = 109).ResultsCytoplasmic expression of MST1, LATS1, and LATS2 was low in OED, CIS, and OSCC. The cytoplasmic expression of MST2 was high in OED (5/7 cases), CIS (9/14 cases), and poorly differentiated OSCC (8/8 cases) but was low/lost in a proportion of differentiated OSCC (60/101 cases). The expression of YAP1 was associated with differentiation; low YAP expression was significantly more frequent in well-differentiated OSCC (35/71 cases), compared to moderately and poorly differentiated OSCC (11/38 cases). An infiltrative invasion pattern was associated with a high expression of MST2 and high expression of YAP1. The high expression of YAP1 was associated with features of epithelial-to-mesenchymal transition (EMT), such as the loss of E-cadherin and high expression of vimentin, laminin 5, and Slug. High expression of protein arginine methyltransferase (PRMT) 1 or 5, which positively regulates YAP activity, was associated with the high expression of YAP1 (p < 0.0001).ConclusionAmong the major Hippo pathway proteins, MST2 displayed a distinctive expression pattern in a significant proportion of differentiated OSCC, suggesting a possible differential role for MST2 depending on the course of OSCC progression. A high YAP1 expression may indicate aggressive OSCC with EMT via PRMTs at the invasive front. Hippo pathway MST1/2 YAP1 PRMT oral squamous cell carcinoma Medicine (General) Daisuke Matsubara verfasserin aut Daisuke Matsubara verfasserin aut Atsushi Kihara verfasserin aut Taichiro Yoshimoto verfasserin aut Noriyoshi Fukushima verfasserin aut Hiroshi Nishino verfasserin aut Yoshiyuki Mori verfasserin aut Toshiro Niki verfasserin aut In Frontiers in Medicine Frontiers Media S.A., 2014 11(2024) (DE-627)789482991 (DE-600)2775999-4 2296858X nnns volume:11 year:2024 https://doi.org/10.3389/fmed.2024.1247625 kostenfrei https://doaj.org/article/936860388cd4499888d34154fd362794 kostenfrei https://www.frontiersin.org/articles/10.3389/fmed.2024.1247625/full kostenfrei https://doaj.org/toc/2296-858X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2024
allfields_unstemmed	10.3389/fmed.2024.1247625 doi (DE-627)DOAJ100810993 (DE-599)DOAJ936860388cd4499888d34154fd362794 DE-627 ger DE-627 rakwb eng R5-920 Yusuke Amano verfasserin aut The significance of Hippo pathway protein expression in oral squamous cell carcinoma 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionThe Hippo pathway consists of mammalian sterile 20-like kinase 1/2 (MST1/2), large tumor suppressor 1/2 (LATS1/2), and yes-associated protein (YAP)1. Herein, we present the first report on the significance of major Hippo pathway protein expression in oral squamous cell carcinoma (OSCC).MethodsThe analyses included oral epithelial dysplasia (OED, n = 7), carcinoma in situ (CIS, n = 14), and oral squamous cell carcinoma (OSCC, n = 109).ResultsCytoplasmic expression of MST1, LATS1, and LATS2 was low in OED, CIS, and OSCC. The cytoplasmic expression of MST2 was high in OED (5/7 cases), CIS (9/14 cases), and poorly differentiated OSCC (8/8 cases) but was low/lost in a proportion of differentiated OSCC (60/101 cases). The expression of YAP1 was associated with differentiation; low YAP expression was significantly more frequent in well-differentiated OSCC (35/71 cases), compared to moderately and poorly differentiated OSCC (11/38 cases). An infiltrative invasion pattern was associated with a high expression of MST2 and high expression of YAP1. The high expression of YAP1 was associated with features of epithelial-to-mesenchymal transition (EMT), such as the loss of E-cadherin and high expression of vimentin, laminin 5, and Slug. High expression of protein arginine methyltransferase (PRMT) 1 or 5, which positively regulates YAP activity, was associated with the high expression of YAP1 (p < 0.0001).ConclusionAmong the major Hippo pathway proteins, MST2 displayed a distinctive expression pattern in a significant proportion of differentiated OSCC, suggesting a possible differential role for MST2 depending on the course of OSCC progression. A high YAP1 expression may indicate aggressive OSCC with EMT via PRMTs at the invasive front. Hippo pathway MST1/2 YAP1 PRMT oral squamous cell carcinoma Medicine (General) Daisuke Matsubara verfasserin aut Daisuke Matsubara verfasserin aut Atsushi Kihara verfasserin aut Taichiro Yoshimoto verfasserin aut Noriyoshi Fukushima verfasserin aut Hiroshi Nishino verfasserin aut Yoshiyuki Mori verfasserin aut Toshiro Niki verfasserin aut In Frontiers in Medicine Frontiers Media S.A., 2014 11(2024) (DE-627)789482991 (DE-600)2775999-4 2296858X nnns volume:11 year:2024 https://doi.org/10.3389/fmed.2024.1247625 kostenfrei https://doaj.org/article/936860388cd4499888d34154fd362794 kostenfrei https://www.frontiersin.org/articles/10.3389/fmed.2024.1247625/full kostenfrei https://doaj.org/toc/2296-858X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2024
allfieldsGer	10.3389/fmed.2024.1247625 doi (DE-627)DOAJ100810993 (DE-599)DOAJ936860388cd4499888d34154fd362794 DE-627 ger DE-627 rakwb eng R5-920 Yusuke Amano verfasserin aut The significance of Hippo pathway protein expression in oral squamous cell carcinoma 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionThe Hippo pathway consists of mammalian sterile 20-like kinase 1/2 (MST1/2), large tumor suppressor 1/2 (LATS1/2), and yes-associated protein (YAP)1. Herein, we present the first report on the significance of major Hippo pathway protein expression in oral squamous cell carcinoma (OSCC).MethodsThe analyses included oral epithelial dysplasia (OED, n = 7), carcinoma in situ (CIS, n = 14), and oral squamous cell carcinoma (OSCC, n = 109).ResultsCytoplasmic expression of MST1, LATS1, and LATS2 was low in OED, CIS, and OSCC. The cytoplasmic expression of MST2 was high in OED (5/7 cases), CIS (9/14 cases), and poorly differentiated OSCC (8/8 cases) but was low/lost in a proportion of differentiated OSCC (60/101 cases). The expression of YAP1 was associated with differentiation; low YAP expression was significantly more frequent in well-differentiated OSCC (35/71 cases), compared to moderately and poorly differentiated OSCC (11/38 cases). An infiltrative invasion pattern was associated with a high expression of MST2 and high expression of YAP1. The high expression of YAP1 was associated with features of epithelial-to-mesenchymal transition (EMT), such as the loss of E-cadherin and high expression of vimentin, laminin 5, and Slug. High expression of protein arginine methyltransferase (PRMT) 1 or 5, which positively regulates YAP activity, was associated with the high expression of YAP1 (p < 0.0001).ConclusionAmong the major Hippo pathway proteins, MST2 displayed a distinctive expression pattern in a significant proportion of differentiated OSCC, suggesting a possible differential role for MST2 depending on the course of OSCC progression. A high YAP1 expression may indicate aggressive OSCC with EMT via PRMTs at the invasive front. Hippo pathway MST1/2 YAP1 PRMT oral squamous cell carcinoma Medicine (General) Daisuke Matsubara verfasserin aut Daisuke Matsubara verfasserin aut Atsushi Kihara verfasserin aut Taichiro Yoshimoto verfasserin aut Noriyoshi Fukushima verfasserin aut Hiroshi Nishino verfasserin aut Yoshiyuki Mori verfasserin aut Toshiro Niki verfasserin aut In Frontiers in Medicine Frontiers Media S.A., 2014 11(2024) (DE-627)789482991 (DE-600)2775999-4 2296858X nnns volume:11 year:2024 https://doi.org/10.3389/fmed.2024.1247625 kostenfrei https://doaj.org/article/936860388cd4499888d34154fd362794 kostenfrei https://www.frontiersin.org/articles/10.3389/fmed.2024.1247625/full kostenfrei https://doaj.org/toc/2296-858X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2024
allfieldsSound	10.3389/fmed.2024.1247625 doi (DE-627)DOAJ100810993 (DE-599)DOAJ936860388cd4499888d34154fd362794 DE-627 ger DE-627 rakwb eng R5-920 Yusuke Amano verfasserin aut The significance of Hippo pathway protein expression in oral squamous cell carcinoma 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionThe Hippo pathway consists of mammalian sterile 20-like kinase 1/2 (MST1/2), large tumor suppressor 1/2 (LATS1/2), and yes-associated protein (YAP)1. Herein, we present the first report on the significance of major Hippo pathway protein expression in oral squamous cell carcinoma (OSCC).MethodsThe analyses included oral epithelial dysplasia (OED, n = 7), carcinoma in situ (CIS, n = 14), and oral squamous cell carcinoma (OSCC, n = 109).ResultsCytoplasmic expression of MST1, LATS1, and LATS2 was low in OED, CIS, and OSCC. The cytoplasmic expression of MST2 was high in OED (5/7 cases), CIS (9/14 cases), and poorly differentiated OSCC (8/8 cases) but was low/lost in a proportion of differentiated OSCC (60/101 cases). The expression of YAP1 was associated with differentiation; low YAP expression was significantly more frequent in well-differentiated OSCC (35/71 cases), compared to moderately and poorly differentiated OSCC (11/38 cases). An infiltrative invasion pattern was associated with a high expression of MST2 and high expression of YAP1. The high expression of YAP1 was associated with features of epithelial-to-mesenchymal transition (EMT), such as the loss of E-cadherin and high expression of vimentin, laminin 5, and Slug. High expression of protein arginine methyltransferase (PRMT) 1 or 5, which positively regulates YAP activity, was associated with the high expression of YAP1 (p < 0.0001).ConclusionAmong the major Hippo pathway proteins, MST2 displayed a distinctive expression pattern in a significant proportion of differentiated OSCC, suggesting a possible differential role for MST2 depending on the course of OSCC progression. A high YAP1 expression may indicate aggressive OSCC with EMT via PRMTs at the invasive front. Hippo pathway MST1/2 YAP1 PRMT oral squamous cell carcinoma Medicine (General) Daisuke Matsubara verfasserin aut Daisuke Matsubara verfasserin aut Atsushi Kihara verfasserin aut Taichiro Yoshimoto verfasserin aut Noriyoshi Fukushima verfasserin aut Hiroshi Nishino verfasserin aut Yoshiyuki Mori verfasserin aut Toshiro Niki verfasserin aut In Frontiers in Medicine Frontiers Media S.A., 2014 11(2024) (DE-627)789482991 (DE-600)2775999-4 2296858X nnns volume:11 year:2024 https://doi.org/10.3389/fmed.2024.1247625 kostenfrei https://doaj.org/article/936860388cd4499888d34154fd362794 kostenfrei https://www.frontiersin.org/articles/10.3389/fmed.2024.1247625/full kostenfrei https://doaj.org/toc/2296-858X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2024
language	English
source	In Frontiers in Medicine 11(2024) volume:11 year:2024
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institution	findex.gbv.de
topic_facet	Hippo pathway MST1/2 YAP1 PRMT oral squamous cell carcinoma Medicine (General)
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authorswithroles_txt_mv	Yusuke Amano @@aut@@ Daisuke Matsubara @@aut@@ Atsushi Kihara @@aut@@ Taichiro Yoshimoto @@aut@@ Noriyoshi Fukushima @@aut@@ Hiroshi Nishino @@aut@@ Yoshiyuki Mori @@aut@@ Toshiro Niki @@aut@@
publishDateDaySort_date	2024-01-01T00:00:00Z
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callnumber-first	R - Medicine
author	Yusuke Amano
spellingShingle	Yusuke Amano misc R5-920 misc Hippo pathway misc MST1/2 misc YAP1 misc PRMT misc oral squamous cell carcinoma misc Medicine (General) The significance of Hippo pathway protein expression in oral squamous cell carcinoma
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topic_title	R5-920 The significance of Hippo pathway protein expression in oral squamous cell carcinoma Hippo pathway MST1/2 YAP1 PRMT oral squamous cell carcinoma
topic	misc R5-920 misc Hippo pathway misc MST1/2 misc YAP1 misc PRMT misc oral squamous cell carcinoma misc Medicine (General)
topic_unstemmed	misc R5-920 misc Hippo pathway misc MST1/2 misc YAP1 misc PRMT misc oral squamous cell carcinoma misc Medicine (General)
topic_browse	misc R5-920 misc Hippo pathway misc MST1/2 misc YAP1 misc PRMT misc oral squamous cell carcinoma misc Medicine (General)
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title	The significance of Hippo pathway protein expression in oral squamous cell carcinoma
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title_full	The significance of Hippo pathway protein expression in oral squamous cell carcinoma
author_sort	Yusuke Amano
journal	Frontiers in Medicine
journalStr	Frontiers in Medicine
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author_browse	Yusuke Amano Daisuke Matsubara Atsushi Kihara Taichiro Yoshimoto Noriyoshi Fukushima Hiroshi Nishino Yoshiyuki Mori Toshiro Niki
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author-letter	Yusuke Amano
doi_str_mv	10.3389/fmed.2024.1247625
author2-role	verfasserin
title_sort	significance of hippo pathway protein expression in oral squamous cell carcinoma
callnumber	R5-920
title_auth	The significance of Hippo pathway protein expression in oral squamous cell carcinoma
abstract	IntroductionThe Hippo pathway consists of mammalian sterile 20-like kinase 1/2 (MST1/2), large tumor suppressor 1/2 (LATS1/2), and yes-associated protein (YAP)1. Herein, we present the first report on the significance of major Hippo pathway protein expression in oral squamous cell carcinoma (OSCC).MethodsThe analyses included oral epithelial dysplasia (OED, n = 7), carcinoma in situ (CIS, n = 14), and oral squamous cell carcinoma (OSCC, n = 109).ResultsCytoplasmic expression of MST1, LATS1, and LATS2 was low in OED, CIS, and OSCC. The cytoplasmic expression of MST2 was high in OED (5/7 cases), CIS (9/14 cases), and poorly differentiated OSCC (8/8 cases) but was low/lost in a proportion of differentiated OSCC (60/101 cases). The expression of YAP1 was associated with differentiation; low YAP expression was significantly more frequent in well-differentiated OSCC (35/71 cases), compared to moderately and poorly differentiated OSCC (11/38 cases). An infiltrative invasion pattern was associated with a high expression of MST2 and high expression of YAP1. The high expression of YAP1 was associated with features of epithelial-to-mesenchymal transition (EMT), such as the loss of E-cadherin and high expression of vimentin, laminin 5, and Slug. High expression of protein arginine methyltransferase (PRMT) 1 or 5, which positively regulates YAP activity, was associated with the high expression of YAP1 (p < 0.0001).ConclusionAmong the major Hippo pathway proteins, MST2 displayed a distinctive expression pattern in a significant proportion of differentiated OSCC, suggesting a possible differential role for MST2 depending on the course of OSCC progression. A high YAP1 expression may indicate aggressive OSCC with EMT via PRMTs at the invasive front.
abstractGer	IntroductionThe Hippo pathway consists of mammalian sterile 20-like kinase 1/2 (MST1/2), large tumor suppressor 1/2 (LATS1/2), and yes-associated protein (YAP)1. Herein, we present the first report on the significance of major Hippo pathway protein expression in oral squamous cell carcinoma (OSCC).MethodsThe analyses included oral epithelial dysplasia (OED, n = 7), carcinoma in situ (CIS, n = 14), and oral squamous cell carcinoma (OSCC, n = 109).ResultsCytoplasmic expression of MST1, LATS1, and LATS2 was low in OED, CIS, and OSCC. The cytoplasmic expression of MST2 was high in OED (5/7 cases), CIS (9/14 cases), and poorly differentiated OSCC (8/8 cases) but was low/lost in a proportion of differentiated OSCC (60/101 cases). The expression of YAP1 was associated with differentiation; low YAP expression was significantly more frequent in well-differentiated OSCC (35/71 cases), compared to moderately and poorly differentiated OSCC (11/38 cases). An infiltrative invasion pattern was associated with a high expression of MST2 and high expression of YAP1. The high expression of YAP1 was associated with features of epithelial-to-mesenchymal transition (EMT), such as the loss of E-cadherin and high expression of vimentin, laminin 5, and Slug. High expression of protein arginine methyltransferase (PRMT) 1 or 5, which positively regulates YAP activity, was associated with the high expression of YAP1 (p < 0.0001).ConclusionAmong the major Hippo pathway proteins, MST2 displayed a distinctive expression pattern in a significant proportion of differentiated OSCC, suggesting a possible differential role for MST2 depending on the course of OSCC progression. A high YAP1 expression may indicate aggressive OSCC with EMT via PRMTs at the invasive front.
abstract_unstemmed	IntroductionThe Hippo pathway consists of mammalian sterile 20-like kinase 1/2 (MST1/2), large tumor suppressor 1/2 (LATS1/2), and yes-associated protein (YAP)1. Herein, we present the first report on the significance of major Hippo pathway protein expression in oral squamous cell carcinoma (OSCC).MethodsThe analyses included oral epithelial dysplasia (OED, n = 7), carcinoma in situ (CIS, n = 14), and oral squamous cell carcinoma (OSCC, n = 109).ResultsCytoplasmic expression of MST1, LATS1, and LATS2 was low in OED, CIS, and OSCC. The cytoplasmic expression of MST2 was high in OED (5/7 cases), CIS (9/14 cases), and poorly differentiated OSCC (8/8 cases) but was low/lost in a proportion of differentiated OSCC (60/101 cases). The expression of YAP1 was associated with differentiation; low YAP expression was significantly more frequent in well-differentiated OSCC (35/71 cases), compared to moderately and poorly differentiated OSCC (11/38 cases). An infiltrative invasion pattern was associated with a high expression of MST2 and high expression of YAP1. The high expression of YAP1 was associated with features of epithelial-to-mesenchymal transition (EMT), such as the loss of E-cadherin and high expression of vimentin, laminin 5, and Slug. High expression of protein arginine methyltransferase (PRMT) 1 or 5, which positively regulates YAP activity, was associated with the high expression of YAP1 (p < 0.0001).ConclusionAmong the major Hippo pathway proteins, MST2 displayed a distinctive expression pattern in a significant proportion of differentiated OSCC, suggesting a possible differential role for MST2 depending on the course of OSCC progression. A high YAP1 expression may indicate aggressive OSCC with EMT via PRMTs at the invasive front.
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title_short	The significance of Hippo pathway protein expression in oral squamous cell carcinoma
url	https://doi.org/10.3389/fmed.2024.1247625 https://doaj.org/article/936860388cd4499888d34154fd362794 https://www.frontiersin.org/articles/10.3389/fmed.2024.1247625/full https://doaj.org/toc/2296-858X
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author2	Daisuke Matsubara Atsushi Kihara Taichiro Yoshimoto Noriyoshi Fukushima Hiroshi Nishino Yoshiyuki Mori Toshiro Niki
author2Str	Daisuke Matsubara Atsushi Kihara Taichiro Yoshimoto Noriyoshi Fukushima Hiroshi Nishino Yoshiyuki Mori Toshiro Niki
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up_date	2024-07-03T16:49:27.458Z
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