Bone marrow lesions: two pillars concept

A common magnetic resonance imaging pattern of bone marrow lesion has been described in numerous pathological entities. However, despite intensive research, its etiopathological pathways and repercussions on disease progression remain controversial. From our current knowledge, subchondral bone repre...
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Autor*in:	Alan Ivković [verfasserIn] Filip Vuletić [verfasserIn] Tadija Petrović [verfasserIn] Frane Bukvić [verfasserIn] Saša Janković [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Bone marrow lesions subchondral bone pathology MRI bone remodelling

Übergeordnetes Werk:	In: Acta Clinica Croatica - Sestre Milosrdnice University hospital, Institute of Clinical Medical Research, 2018, 62.(2023), Supplement 3, Seite 106-114
Übergeordnetes Werk:	volume:62. ; year:2023 ; number:Supplement 3 ; pages:106-114

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Katalog-ID:	DOAJ101022654

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spelling	(DE-627)DOAJ101022654 (DE-599)DOAJe8d6ff1f84ea46c497036f970b86accc DE-627 ger DE-627 rakwb eng Alan Ivković verfasserin aut Bone marrow lesions: two pillars concept 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A common magnetic resonance imaging pattern of bone marrow lesion has been described in numerous pathological entities. However, despite intensive research, its etiopathological pathways and repercussions on disease progression remain controversial. From our current knowledge, subchondral bone represents an active site of remodelling fulfilling both mechanical and biological joint requirements. Alteration of bone remodelling activity, as one of the major characteristics of bone marrow lesions, can potentially lead to biological and structural impairment of the affected tissue and consequently the entire joint. The discovered close connection between subchondral bone biology and its structural changes together with parallel changes in overlying cartilage is setting the scene for a potentially new concept. In this “Two Pillar“ concept both structure and biology of subchondral bone (and its biomechanical and biochemical interference with the layer above) represent the foundations of the structure and function of articular cartilage. In light of the proposed concept, we will review current knowledge on aetiology, pathogenesis, and clinical presentation of BML and correlate it to existing and emerging treatment options. Bone marrow lesions subchondral bone pathology MRI bone remodelling Medicine R Filip Vuletić verfasserin aut Tadija Petrović verfasserin aut Frane Bukvić verfasserin aut Saša Janković verfasserin aut In Acta Clinica Croatica Sestre Milosrdnice University hospital, Institute of Clinical Medical Research, 2018 62.(2023), Supplement 3, Seite 106-114 (DE-627)343513757 (DE-600)2073072-X 13339451 nnns volume:62. year:2023 number:Supplement 3 pages:106-114 https://doaj.org/article/e8d6ff1f84ea46c497036f970b86accc kostenfrei https://hrcak.srce.hr/file/447660 kostenfrei https://doaj.org/toc/0353-9466 Journal toc kostenfrei https://doaj.org/toc/1333-9451 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 62. 2023 Supplement 3 106-114
allfields_unstemmed	(DE-627)DOAJ101022654 (DE-599)DOAJe8d6ff1f84ea46c497036f970b86accc DE-627 ger DE-627 rakwb eng Alan Ivković verfasserin aut Bone marrow lesions: two pillars concept 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A common magnetic resonance imaging pattern of bone marrow lesion has been described in numerous pathological entities. However, despite intensive research, its etiopathological pathways and repercussions on disease progression remain controversial. From our current knowledge, subchondral bone represents an active site of remodelling fulfilling both mechanical and biological joint requirements. Alteration of bone remodelling activity, as one of the major characteristics of bone marrow lesions, can potentially lead to biological and structural impairment of the affected tissue and consequently the entire joint. The discovered close connection between subchondral bone biology and its structural changes together with parallel changes in overlying cartilage is setting the scene for a potentially new concept. In this “Two Pillar“ concept both structure and biology of subchondral bone (and its biomechanical and biochemical interference with the layer above) represent the foundations of the structure and function of articular cartilage. In light of the proposed concept, we will review current knowledge on aetiology, pathogenesis, and clinical presentation of BML and correlate it to existing and emerging treatment options. Bone marrow lesions subchondral bone pathology MRI bone remodelling Medicine R Filip Vuletić verfasserin aut Tadija Petrović verfasserin aut Frane Bukvić verfasserin aut Saša Janković verfasserin aut In Acta Clinica Croatica Sestre Milosrdnice University hospital, Institute of Clinical Medical Research, 2018 62.(2023), Supplement 3, Seite 106-114 (DE-627)343513757 (DE-600)2073072-X 13339451 nnns volume:62. year:2023 number:Supplement 3 pages:106-114 https://doaj.org/article/e8d6ff1f84ea46c497036f970b86accc kostenfrei https://hrcak.srce.hr/file/447660 kostenfrei https://doaj.org/toc/0353-9466 Journal toc kostenfrei https://doaj.org/toc/1333-9451 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 62. 2023 Supplement 3 106-114
allfieldsGer	(DE-627)DOAJ101022654 (DE-599)DOAJe8d6ff1f84ea46c497036f970b86accc DE-627 ger DE-627 rakwb eng Alan Ivković verfasserin aut Bone marrow lesions: two pillars concept 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A common magnetic resonance imaging pattern of bone marrow lesion has been described in numerous pathological entities. However, despite intensive research, its etiopathological pathways and repercussions on disease progression remain controversial. From our current knowledge, subchondral bone represents an active site of remodelling fulfilling both mechanical and biological joint requirements. Alteration of bone remodelling activity, as one of the major characteristics of bone marrow lesions, can potentially lead to biological and structural impairment of the affected tissue and consequently the entire joint. The discovered close connection between subchondral bone biology and its structural changes together with parallel changes in overlying cartilage is setting the scene for a potentially new concept. In this “Two Pillar“ concept both structure and biology of subchondral bone (and its biomechanical and biochemical interference with the layer above) represent the foundations of the structure and function of articular cartilage. In light of the proposed concept, we will review current knowledge on aetiology, pathogenesis, and clinical presentation of BML and correlate it to existing and emerging treatment options. Bone marrow lesions subchondral bone pathology MRI bone remodelling Medicine R Filip Vuletić verfasserin aut Tadija Petrović verfasserin aut Frane Bukvić verfasserin aut Saša Janković verfasserin aut In Acta Clinica Croatica Sestre Milosrdnice University hospital, Institute of Clinical Medical Research, 2018 62.(2023), Supplement 3, Seite 106-114 (DE-627)343513757 (DE-600)2073072-X 13339451 nnns volume:62. year:2023 number:Supplement 3 pages:106-114 https://doaj.org/article/e8d6ff1f84ea46c497036f970b86accc kostenfrei https://hrcak.srce.hr/file/447660 kostenfrei https://doaj.org/toc/0353-9466 Journal toc kostenfrei https://doaj.org/toc/1333-9451 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 62. 2023 Supplement 3 106-114
allfieldsSound	(DE-627)DOAJ101022654 (DE-599)DOAJe8d6ff1f84ea46c497036f970b86accc DE-627 ger DE-627 rakwb eng Alan Ivković verfasserin aut Bone marrow lesions: two pillars concept 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A common magnetic resonance imaging pattern of bone marrow lesion has been described in numerous pathological entities. However, despite intensive research, its etiopathological pathways and repercussions on disease progression remain controversial. From our current knowledge, subchondral bone represents an active site of remodelling fulfilling both mechanical and biological joint requirements. Alteration of bone remodelling activity, as one of the major characteristics of bone marrow lesions, can potentially lead to biological and structural impairment of the affected tissue and consequently the entire joint. The discovered close connection between subchondral bone biology and its structural changes together with parallel changes in overlying cartilage is setting the scene for a potentially new concept. In this “Two Pillar“ concept both structure and biology of subchondral bone (and its biomechanical and biochemical interference with the layer above) represent the foundations of the structure and function of articular cartilage. In light of the proposed concept, we will review current knowledge on aetiology, pathogenesis, and clinical presentation of BML and correlate it to existing and emerging treatment options. Bone marrow lesions subchondral bone pathology MRI bone remodelling Medicine R Filip Vuletić verfasserin aut Tadija Petrović verfasserin aut Frane Bukvić verfasserin aut Saša Janković verfasserin aut In Acta Clinica Croatica Sestre Milosrdnice University hospital, Institute of Clinical Medical Research, 2018 62.(2023), Supplement 3, Seite 106-114 (DE-627)343513757 (DE-600)2073072-X 13339451 nnns volume:62. year:2023 number:Supplement 3 pages:106-114 https://doaj.org/article/e8d6ff1f84ea46c497036f970b86accc kostenfrei https://hrcak.srce.hr/file/447660 kostenfrei https://doaj.org/toc/0353-9466 Journal toc kostenfrei https://doaj.org/toc/1333-9451 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 62. 2023 Supplement 3 106-114
language	English
source	In Acta Clinica Croatica 62.(2023), Supplement 3, Seite 106-114 volume:62. year:2023 number:Supplement 3 pages:106-114
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topic_facet	Bone marrow lesions subchondral bone pathology MRI bone remodelling Medicine R
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author	Alan Ivković
spellingShingle	Alan Ivković misc Bone marrow lesions misc subchondral bone pathology misc MRI misc bone remodelling misc Medicine misc R Bone marrow lesions: two pillars concept
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topic_title	Bone marrow lesions: two pillars concept Bone marrow lesions subchondral bone pathology MRI bone remodelling
topic	misc Bone marrow lesions misc subchondral bone pathology misc MRI misc bone remodelling misc Medicine misc R
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title	Bone marrow lesions: two pillars concept
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title_auth	Bone marrow lesions: two pillars concept
abstract	A common magnetic resonance imaging pattern of bone marrow lesion has been described in numerous pathological entities. However, despite intensive research, its etiopathological pathways and repercussions on disease progression remain controversial. From our current knowledge, subchondral bone represents an active site of remodelling fulfilling both mechanical and biological joint requirements. Alteration of bone remodelling activity, as one of the major characteristics of bone marrow lesions, can potentially lead to biological and structural impairment of the affected tissue and consequently the entire joint. The discovered close connection between subchondral bone biology and its structural changes together with parallel changes in overlying cartilage is setting the scene for a potentially new concept. In this “Two Pillar“ concept both structure and biology of subchondral bone (and its biomechanical and biochemical interference with the layer above) represent the foundations of the structure and function of articular cartilage. In light of the proposed concept, we will review current knowledge on aetiology, pathogenesis, and clinical presentation of BML and correlate it to existing and emerging treatment options.
abstractGer	A common magnetic resonance imaging pattern of bone marrow lesion has been described in numerous pathological entities. However, despite intensive research, its etiopathological pathways and repercussions on disease progression remain controversial. From our current knowledge, subchondral bone represents an active site of remodelling fulfilling both mechanical and biological joint requirements. Alteration of bone remodelling activity, as one of the major characteristics of bone marrow lesions, can potentially lead to biological and structural impairment of the affected tissue and consequently the entire joint. The discovered close connection between subchondral bone biology and its structural changes together with parallel changes in overlying cartilage is setting the scene for a potentially new concept. In this “Two Pillar“ concept both structure and biology of subchondral bone (and its biomechanical and biochemical interference with the layer above) represent the foundations of the structure and function of articular cartilage. In light of the proposed concept, we will review current knowledge on aetiology, pathogenesis, and clinical presentation of BML and correlate it to existing and emerging treatment options.
abstract_unstemmed	A common magnetic resonance imaging pattern of bone marrow lesion has been described in numerous pathological entities. However, despite intensive research, its etiopathological pathways and repercussions on disease progression remain controversial. From our current knowledge, subchondral bone represents an active site of remodelling fulfilling both mechanical and biological joint requirements. Alteration of bone remodelling activity, as one of the major characteristics of bone marrow lesions, can potentially lead to biological and structural impairment of the affected tissue and consequently the entire joint. The discovered close connection between subchondral bone biology and its structural changes together with parallel changes in overlying cartilage is setting the scene for a potentially new concept. In this “Two Pillar“ concept both structure and biology of subchondral bone (and its biomechanical and biochemical interference with the layer above) represent the foundations of the structure and function of articular cartilage. In light of the proposed concept, we will review current knowledge on aetiology, pathogenesis, and clinical presentation of BML and correlate it to existing and emerging treatment options.
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