The CA125 level postoperative change rule and its prognostic significance in patients with resectable pancreatic cancer

Abstract Background The relationship between postoperative CA125 level changes and early recurrence after curative resection of resectable PDAC is still unclear. Methods The electronic medical records and follow-up data of patients with resectable pancreatic cancer were evaluated. Dynamic CA125 dete...
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Autor*in:	Xin Luo [verfasserIn] Xianchao Lin [verfasserIn] Ronggui Lin [verfasserIn] Yuanyuan Yang [verfasserIn] Congfei Wang [verfasserIn] Haizong Fang [verfasserIn] Heguang Huang [verfasserIn] Fengchun Lu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Resectable pancreatic cancer CA125 Early recurrence

Übergeordnetes Werk:	In: BMC Cancer - BMC, 2003, 23(2023), 1, Seite 9
Übergeordnetes Werk:	volume:23 ; year:2023 ; number:1 ; pages:9

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12885-023-11346-8

Katalog-ID:	DOAJ101099436

Internformat


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245	1	4	\|a The CA125 level postoperative change rule and its prognostic significance in patients with resectable pancreatic cancer
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520			\|a Abstract Background The relationship between postoperative CA125 level changes and early recurrence after curative resection of resectable PDAC is still unclear. Methods The electronic medical records and follow-up data of patients with resectable pancreatic cancer were evaluated. Dynamic CA125 detection was used to identify the rules for postoperative CA125 level change and its prognostic value in patients with resectable pancreatic cancer. Results The study included a total of 118 patients with resectable pancreatic cancer who underwent curative resection. Early postoperative CA125 levels were significantly higher than those before surgery (P < 0.05). It decreased gradually in the group without early recurrence (P < 0.05) but not in the early recurrence group (P<0.05). There was no correlation between early postoperative CA125 levels and early recurrence (P < 0.05). CA125 levels three months after surgery were associated with an increased risk of early recurrence (P = 0.038, 95% CI (1.001–1.025)). The cutoff CA125 level at 3 months after surgery for predicting early recurrence was 22.035. Patients with CA125 levels < 22.035 three months postoperatively had similar DFS and OS, regardless of whether the value was exceeded in the early postoperative period, but these values were significantly better than those of patients with CA125 levels < 22.035 at 3 months postoperatively (p < 0.05). Conclusions Patients with different prognoses have different patterns of CA125 level changes. Elevations in CA125 levels < 3 months postoperatively, rather than early postoperative elevation, were associated with a poor prognosis.
650		4	\|a Resectable pancreatic cancer
650		4	\|a CA125
650		4	\|a Early recurrence
653		0	\|a Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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700	0		\|a Haizong Fang \|e verfasserin \|4 aut
700	0		\|a Heguang Huang \|e verfasserin \|4 aut
700	0		\|a Fengchun Lu \|e verfasserin \|4 aut
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allfields	10.1186/s12885-023-11346-8 doi (DE-627)DOAJ101099436 (DE-599)DOAJ4efeb362581147788765575cb0e154a9 DE-627 ger DE-627 rakwb eng RC254-282 Xin Luo verfasserin aut The CA125 level postoperative change rule and its prognostic significance in patients with resectable pancreatic cancer 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The relationship between postoperative CA125 level changes and early recurrence after curative resection of resectable PDAC is still unclear. Methods The electronic medical records and follow-up data of patients with resectable pancreatic cancer were evaluated. Dynamic CA125 detection was used to identify the rules for postoperative CA125 level change and its prognostic value in patients with resectable pancreatic cancer. Results The study included a total of 118 patients with resectable pancreatic cancer who underwent curative resection. Early postoperative CA125 levels were significantly higher than those before surgery (P < 0.05). It decreased gradually in the group without early recurrence (P < 0.05) but not in the early recurrence group (P<0.05). There was no correlation between early postoperative CA125 levels and early recurrence (P < 0.05). CA125 levels three months after surgery were associated with an increased risk of early recurrence (P = 0.038, 95% CI (1.001–1.025)). The cutoff CA125 level at 3 months after surgery for predicting early recurrence was 22.035. Patients with CA125 levels < 22.035 three months postoperatively had similar DFS and OS, regardless of whether the value was exceeded in the early postoperative period, but these values were significantly better than those of patients with CA125 levels < 22.035 at 3 months postoperatively (p < 0.05). Conclusions Patients with different prognoses have different patterns of CA125 level changes. Elevations in CA125 levels < 3 months postoperatively, rather than early postoperative elevation, were associated with a poor prognosis. Resectable pancreatic cancer CA125 Early recurrence Neoplasms. Tumors. Oncology. Including cancer and carcinogens Xianchao Lin verfasserin aut Ronggui Lin verfasserin aut Yuanyuan Yang verfasserin aut Congfei Wang verfasserin aut Haizong Fang verfasserin aut Heguang Huang verfasserin aut Fengchun Lu verfasserin aut In BMC Cancer BMC, 2003 23(2023), 1, Seite 9 (DE-627)326643710 (DE-600)2041352-X 14712407 nnns volume:23 year:2023 number:1 pages:9 https://doi.org/10.1186/s12885-023-11346-8 kostenfrei https://doaj.org/article/4efeb362581147788765575cb0e154a9 kostenfrei https://doi.org/10.1186/s12885-023-11346-8 kostenfrei https://doaj.org/toc/1471-2407 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 9
spelling	10.1186/s12885-023-11346-8 doi (DE-627)DOAJ101099436 (DE-599)DOAJ4efeb362581147788765575cb0e154a9 DE-627 ger DE-627 rakwb eng RC254-282 Xin Luo verfasserin aut The CA125 level postoperative change rule and its prognostic significance in patients with resectable pancreatic cancer 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The relationship between postoperative CA125 level changes and early recurrence after curative resection of resectable PDAC is still unclear. Methods The electronic medical records and follow-up data of patients with resectable pancreatic cancer were evaluated. Dynamic CA125 detection was used to identify the rules for postoperative CA125 level change and its prognostic value in patients with resectable pancreatic cancer. Results The study included a total of 118 patients with resectable pancreatic cancer who underwent curative resection. Early postoperative CA125 levels were significantly higher than those before surgery (P < 0.05). It decreased gradually in the group without early recurrence (P < 0.05) but not in the early recurrence group (P<0.05). There was no correlation between early postoperative CA125 levels and early recurrence (P < 0.05). CA125 levels three months after surgery were associated with an increased risk of early recurrence (P = 0.038, 95% CI (1.001–1.025)). The cutoff CA125 level at 3 months after surgery for predicting early recurrence was 22.035. Patients with CA125 levels < 22.035 three months postoperatively had similar DFS and OS, regardless of whether the value was exceeded in the early postoperative period, but these values were significantly better than those of patients with CA125 levels < 22.035 at 3 months postoperatively (p < 0.05). Conclusions Patients with different prognoses have different patterns of CA125 level changes. Elevations in CA125 levels < 3 months postoperatively, rather than early postoperative elevation, were associated with a poor prognosis. Resectable pancreatic cancer CA125 Early recurrence Neoplasms. Tumors. Oncology. Including cancer and carcinogens Xianchao Lin verfasserin aut Ronggui Lin verfasserin aut Yuanyuan Yang verfasserin aut Congfei Wang verfasserin aut Haizong Fang verfasserin aut Heguang Huang verfasserin aut Fengchun Lu verfasserin aut In BMC Cancer BMC, 2003 23(2023), 1, Seite 9 (DE-627)326643710 (DE-600)2041352-X 14712407 nnns volume:23 year:2023 number:1 pages:9 https://doi.org/10.1186/s12885-023-11346-8 kostenfrei https://doaj.org/article/4efeb362581147788765575cb0e154a9 kostenfrei https://doi.org/10.1186/s12885-023-11346-8 kostenfrei https://doaj.org/toc/1471-2407 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 9
allfields_unstemmed	10.1186/s12885-023-11346-8 doi (DE-627)DOAJ101099436 (DE-599)DOAJ4efeb362581147788765575cb0e154a9 DE-627 ger DE-627 rakwb eng RC254-282 Xin Luo verfasserin aut The CA125 level postoperative change rule and its prognostic significance in patients with resectable pancreatic cancer 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The relationship between postoperative CA125 level changes and early recurrence after curative resection of resectable PDAC is still unclear. Methods The electronic medical records and follow-up data of patients with resectable pancreatic cancer were evaluated. Dynamic CA125 detection was used to identify the rules for postoperative CA125 level change and its prognostic value in patients with resectable pancreatic cancer. Results The study included a total of 118 patients with resectable pancreatic cancer who underwent curative resection. Early postoperative CA125 levels were significantly higher than those before surgery (P < 0.05). It decreased gradually in the group without early recurrence (P < 0.05) but not in the early recurrence group (P<0.05). There was no correlation between early postoperative CA125 levels and early recurrence (P < 0.05). CA125 levels three months after surgery were associated with an increased risk of early recurrence (P = 0.038, 95% CI (1.001–1.025)). The cutoff CA125 level at 3 months after surgery for predicting early recurrence was 22.035. Patients with CA125 levels < 22.035 three months postoperatively had similar DFS and OS, regardless of whether the value was exceeded in the early postoperative period, but these values were significantly better than those of patients with CA125 levels < 22.035 at 3 months postoperatively (p < 0.05). Conclusions Patients with different prognoses have different patterns of CA125 level changes. Elevations in CA125 levels < 3 months postoperatively, rather than early postoperative elevation, were associated with a poor prognosis. Resectable pancreatic cancer CA125 Early recurrence Neoplasms. Tumors. Oncology. Including cancer and carcinogens Xianchao Lin verfasserin aut Ronggui Lin verfasserin aut Yuanyuan Yang verfasserin aut Congfei Wang verfasserin aut Haizong Fang verfasserin aut Heguang Huang verfasserin aut Fengchun Lu verfasserin aut In BMC Cancer BMC, 2003 23(2023), 1, Seite 9 (DE-627)326643710 (DE-600)2041352-X 14712407 nnns volume:23 year:2023 number:1 pages:9 https://doi.org/10.1186/s12885-023-11346-8 kostenfrei https://doaj.org/article/4efeb362581147788765575cb0e154a9 kostenfrei https://doi.org/10.1186/s12885-023-11346-8 kostenfrei https://doaj.org/toc/1471-2407 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 9
allfieldsGer	10.1186/s12885-023-11346-8 doi (DE-627)DOAJ101099436 (DE-599)DOAJ4efeb362581147788765575cb0e154a9 DE-627 ger DE-627 rakwb eng RC254-282 Xin Luo verfasserin aut The CA125 level postoperative change rule and its prognostic significance in patients with resectable pancreatic cancer 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The relationship between postoperative CA125 level changes and early recurrence after curative resection of resectable PDAC is still unclear. Methods The electronic medical records and follow-up data of patients with resectable pancreatic cancer were evaluated. Dynamic CA125 detection was used to identify the rules for postoperative CA125 level change and its prognostic value in patients with resectable pancreatic cancer. Results The study included a total of 118 patients with resectable pancreatic cancer who underwent curative resection. Early postoperative CA125 levels were significantly higher than those before surgery (P < 0.05). It decreased gradually in the group without early recurrence (P < 0.05) but not in the early recurrence group (P<0.05). There was no correlation between early postoperative CA125 levels and early recurrence (P < 0.05). CA125 levels three months after surgery were associated with an increased risk of early recurrence (P = 0.038, 95% CI (1.001–1.025)). The cutoff CA125 level at 3 months after surgery for predicting early recurrence was 22.035. Patients with CA125 levels < 22.035 three months postoperatively had similar DFS and OS, regardless of whether the value was exceeded in the early postoperative period, but these values were significantly better than those of patients with CA125 levels < 22.035 at 3 months postoperatively (p < 0.05). Conclusions Patients with different prognoses have different patterns of CA125 level changes. Elevations in CA125 levels < 3 months postoperatively, rather than early postoperative elevation, were associated with a poor prognosis. Resectable pancreatic cancer CA125 Early recurrence Neoplasms. Tumors. Oncology. Including cancer and carcinogens Xianchao Lin verfasserin aut Ronggui Lin verfasserin aut Yuanyuan Yang verfasserin aut Congfei Wang verfasserin aut Haizong Fang verfasserin aut Heguang Huang verfasserin aut Fengchun Lu verfasserin aut In BMC Cancer BMC, 2003 23(2023), 1, Seite 9 (DE-627)326643710 (DE-600)2041352-X 14712407 nnns volume:23 year:2023 number:1 pages:9 https://doi.org/10.1186/s12885-023-11346-8 kostenfrei https://doaj.org/article/4efeb362581147788765575cb0e154a9 kostenfrei https://doi.org/10.1186/s12885-023-11346-8 kostenfrei https://doaj.org/toc/1471-2407 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 9
allfieldsSound	10.1186/s12885-023-11346-8 doi (DE-627)DOAJ101099436 (DE-599)DOAJ4efeb362581147788765575cb0e154a9 DE-627 ger DE-627 rakwb eng RC254-282 Xin Luo verfasserin aut The CA125 level postoperative change rule and its prognostic significance in patients with resectable pancreatic cancer 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The relationship between postoperative CA125 level changes and early recurrence after curative resection of resectable PDAC is still unclear. Methods The electronic medical records and follow-up data of patients with resectable pancreatic cancer were evaluated. Dynamic CA125 detection was used to identify the rules for postoperative CA125 level change and its prognostic value in patients with resectable pancreatic cancer. Results The study included a total of 118 patients with resectable pancreatic cancer who underwent curative resection. Early postoperative CA125 levels were significantly higher than those before surgery (P < 0.05). It decreased gradually in the group without early recurrence (P < 0.05) but not in the early recurrence group (P<0.05). There was no correlation between early postoperative CA125 levels and early recurrence (P < 0.05). CA125 levels three months after surgery were associated with an increased risk of early recurrence (P = 0.038, 95% CI (1.001–1.025)). The cutoff CA125 level at 3 months after surgery for predicting early recurrence was 22.035. Patients with CA125 levels < 22.035 three months postoperatively had similar DFS and OS, regardless of whether the value was exceeded in the early postoperative period, but these values were significantly better than those of patients with CA125 levels < 22.035 at 3 months postoperatively (p < 0.05). Conclusions Patients with different prognoses have different patterns of CA125 level changes. Elevations in CA125 levels < 3 months postoperatively, rather than early postoperative elevation, were associated with a poor prognosis. Resectable pancreatic cancer CA125 Early recurrence Neoplasms. Tumors. Oncology. Including cancer and carcinogens Xianchao Lin verfasserin aut Ronggui Lin verfasserin aut Yuanyuan Yang verfasserin aut Congfei Wang verfasserin aut Haizong Fang verfasserin aut Heguang Huang verfasserin aut Fengchun Lu verfasserin aut In BMC Cancer BMC, 2003 23(2023), 1, Seite 9 (DE-627)326643710 (DE-600)2041352-X 14712407 nnns volume:23 year:2023 number:1 pages:9 https://doi.org/10.1186/s12885-023-11346-8 kostenfrei https://doaj.org/article/4efeb362581147788765575cb0e154a9 kostenfrei https://doi.org/10.1186/s12885-023-11346-8 kostenfrei https://doaj.org/toc/1471-2407 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 9
language	English
source	In BMC Cancer 23(2023), 1, Seite 9 volume:23 year:2023 number:1 pages:9
sourceStr	In BMC Cancer 23(2023), 1, Seite 9 volume:23 year:2023 number:1 pages:9
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Resectable pancreatic cancer CA125 Early recurrence Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	BMC Cancer
authorswithroles_txt_mv	Xin Luo @@aut@@ Xianchao Lin @@aut@@ Ronggui Lin @@aut@@ Yuanyuan Yang @@aut@@ Congfei Wang @@aut@@ Haizong Fang @@aut@@ Heguang Huang @@aut@@ Fengchun Lu @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	326643710
id	DOAJ101099436
language_de	englisch
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Methods The electronic medical records and follow-up data of patients with resectable pancreatic cancer were evaluated. Dynamic CA125 detection was used to identify the rules for postoperative CA125 level change and its prognostic value in patients with resectable pancreatic cancer. Results The study included a total of 118 patients with resectable pancreatic cancer who underwent curative resection. Early postoperative CA125 levels were significantly higher than those before surgery (P < 0.05). It decreased gradually in the group without early recurrence (P < 0.05) but not in the early recurrence group (P<0.05). There was no correlation between early postoperative CA125 levels and early recurrence (P < 0.05). CA125 levels three months after surgery were associated with an increased risk of early recurrence (P = 0.038, 95% CI (1.001–1.025)). The cutoff CA125 level at 3 months after surgery for predicting early recurrence was 22.035. Patients with CA125 levels < 22.035 three months postoperatively had similar DFS and OS, regardless of whether the value was exceeded in the early postoperative period, but these values were significantly better than those of patients with CA125 levels < 22.035 at 3 months postoperatively (p < 0.05). Conclusions Patients with different prognoses have different patterns of CA125 level changes. Elevations in CA125 levels < 3 months postoperatively, rather than early postoperative elevation, were associated with a poor prognosis.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Resectable pancreatic cancer</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">CA125</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Early recurrence</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Neoplasms. Tumors. Oncology. 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callnumber-first	R - Medicine
author	Xin Luo
spellingShingle	Xin Luo misc RC254-282 misc Resectable pancreatic cancer misc CA125 misc Early recurrence misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens The CA125 level postoperative change rule and its prognostic significance in patients with resectable pancreatic cancer
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topic_title	RC254-282 The CA125 level postoperative change rule and its prognostic significance in patients with resectable pancreatic cancer Resectable pancreatic cancer CA125 Early recurrence
topic	misc RC254-282 misc Resectable pancreatic cancer misc CA125 misc Early recurrence misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc Resectable pancreatic cancer misc CA125 misc Early recurrence misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc Resectable pancreatic cancer misc CA125 misc Early recurrence misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	The CA125 level postoperative change rule and its prognostic significance in patients with resectable pancreatic cancer
ctrlnum	(DE-627)DOAJ101099436 (DE-599)DOAJ4efeb362581147788765575cb0e154a9
title_full	The CA125 level postoperative change rule and its prognostic significance in patients with resectable pancreatic cancer
author_sort	Xin Luo
journal	BMC Cancer
journalStr	BMC Cancer
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author_browse	Xin Luo Xianchao Lin Ronggui Lin Yuanyuan Yang Congfei Wang Haizong Fang Heguang Huang Fengchun Lu
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class	RC254-282
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title_sort	ca125 level postoperative change rule and its prognostic significance in patients with resectable pancreatic cancer
callnumber	RC254-282
title_auth	The CA125 level postoperative change rule and its prognostic significance in patients with resectable pancreatic cancer
abstract	Abstract Background The relationship between postoperative CA125 level changes and early recurrence after curative resection of resectable PDAC is still unclear. Methods The electronic medical records and follow-up data of patients with resectable pancreatic cancer were evaluated. Dynamic CA125 detection was used to identify the rules for postoperative CA125 level change and its prognostic value in patients with resectable pancreatic cancer. Results The study included a total of 118 patients with resectable pancreatic cancer who underwent curative resection. Early postoperative CA125 levels were significantly higher than those before surgery (P < 0.05). It decreased gradually in the group without early recurrence (P < 0.05) but not in the early recurrence group (P<0.05). There was no correlation between early postoperative CA125 levels and early recurrence (P < 0.05). CA125 levels three months after surgery were associated with an increased risk of early recurrence (P = 0.038, 95% CI (1.001–1.025)). The cutoff CA125 level at 3 months after surgery for predicting early recurrence was 22.035. Patients with CA125 levels < 22.035 three months postoperatively had similar DFS and OS, regardless of whether the value was exceeded in the early postoperative period, but these values were significantly better than those of patients with CA125 levels < 22.035 at 3 months postoperatively (p < 0.05). Conclusions Patients with different prognoses have different patterns of CA125 level changes. Elevations in CA125 levels < 3 months postoperatively, rather than early postoperative elevation, were associated with a poor prognosis.
abstractGer	Abstract Background The relationship between postoperative CA125 level changes and early recurrence after curative resection of resectable PDAC is still unclear. Methods The electronic medical records and follow-up data of patients with resectable pancreatic cancer were evaluated. Dynamic CA125 detection was used to identify the rules for postoperative CA125 level change and its prognostic value in patients with resectable pancreatic cancer. Results The study included a total of 118 patients with resectable pancreatic cancer who underwent curative resection. Early postoperative CA125 levels were significantly higher than those before surgery (P < 0.05). It decreased gradually in the group without early recurrence (P < 0.05) but not in the early recurrence group (P<0.05). There was no correlation between early postoperative CA125 levels and early recurrence (P < 0.05). CA125 levels three months after surgery were associated with an increased risk of early recurrence (P = 0.038, 95% CI (1.001–1.025)). The cutoff CA125 level at 3 months after surgery for predicting early recurrence was 22.035. Patients with CA125 levels < 22.035 three months postoperatively had similar DFS and OS, regardless of whether the value was exceeded in the early postoperative period, but these values were significantly better than those of patients with CA125 levels < 22.035 at 3 months postoperatively (p < 0.05). Conclusions Patients with different prognoses have different patterns of CA125 level changes. Elevations in CA125 levels < 3 months postoperatively, rather than early postoperative elevation, were associated with a poor prognosis.
abstract_unstemmed	Abstract Background The relationship between postoperative CA125 level changes and early recurrence after curative resection of resectable PDAC is still unclear. Methods The electronic medical records and follow-up data of patients with resectable pancreatic cancer were evaluated. Dynamic CA125 detection was used to identify the rules for postoperative CA125 level change and its prognostic value in patients with resectable pancreatic cancer. Results The study included a total of 118 patients with resectable pancreatic cancer who underwent curative resection. Early postoperative CA125 levels were significantly higher than those before surgery (P < 0.05). It decreased gradually in the group without early recurrence (P < 0.05) but not in the early recurrence group (P<0.05). There was no correlation between early postoperative CA125 levels and early recurrence (P < 0.05). CA125 levels three months after surgery were associated with an increased risk of early recurrence (P = 0.038, 95% CI (1.001–1.025)). The cutoff CA125 level at 3 months after surgery for predicting early recurrence was 22.035. Patients with CA125 levels < 22.035 three months postoperatively had similar DFS and OS, regardless of whether the value was exceeded in the early postoperative period, but these values were significantly better than those of patients with CA125 levels < 22.035 at 3 months postoperatively (p < 0.05). Conclusions Patients with different prognoses have different patterns of CA125 level changes. Elevations in CA125 levels < 3 months postoperatively, rather than early postoperative elevation, were associated with a poor prognosis.
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title_short	The CA125 level postoperative change rule and its prognostic significance in patients with resectable pancreatic cancer
url	https://doi.org/10.1186/s12885-023-11346-8 https://doaj.org/article/4efeb362581147788765575cb0e154a9 https://doaj.org/toc/1471-2407
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The CA125 level postoperative change rule and its prognostic significance in patients with resectable pancreatic cancer

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